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Short Report

Evaluation of decontamination efficacy of four antineoplastics (ifosfamide, 5-fluorouracil, irinotecan, and methotrexate) after deliberate contamination

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References

  • Adé A, Chauchat L, Ouellette Frève J-F, Gagné S, Caron N, Bussières J-F. 2017. Comparison of decontamination efficacy of cleaning solutions on a biological safety cabinet workbench contaminated by cyclophosphamide. Can J Hosp Pharm. 70(6):407–414. doi:10.4212/cjhp.v70i6.1708
  • Anastasi M, Rudaz S, Queruau Lamerie T, Odou P, Bonnabry P, Fleury-Souverain S. 2015. Efficacy of two cleaning solutions for the decontamination of 10 antineoplastic agents in the biosafety cabinets of a hospital pharmacy. Ann Occup Hyg. 59(7):895–908. doi:10.1093/annhyg/mev031
  • Böhlandt A, Groeneveld S, Fischer E, Schierl R. 2015. Cleaning efficiencies of three cleaning agents on four different surfaces after contamination by gemcitabine and 5-fluorouracile. J Occup Environ Hyg. 12(6):384–392. doi:10.1080/15459624.2015.1009985
  • Connor TH, Lawson CC, Polovich M, McDiarmid MA. 2014. Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence. J Occup Environ Med. 56(9):901–910. doi:10.1097/JOM.0000000000000249
  • Cox J, Speed V, O'Neal S, Hasselwander T, Sherwood C, Eckel SF, Zamboni WC. 2017. Development and evaluation of a novel product to remove surface contamination of hazardous drugs. J Oncol Pharm Pract. 23(2):103–115. doi:10.1177/1078155215621151
  • Federici M, Raffaelli J, Paolucci D, Schierl R, Krämer I. 2019. Efficacy of four cleaning solutions for the decontamination of selected cytotoxic drugs on the different surfaces of an automated compounding system. J Occup Environ Hyg. 16(1):6–15. doi:10.1080/15459624.2018.1526384
  • Hilliquin D, Tanguay C, Gagné S, Caron NJ, Bussières J-F. 2019. Cross-sectional evaluation of surface contamination with antineoplastic drugs in Canadian health care centres. Can J Hosp Pharm. 72(5):377–384.
  • Hon C-Y, Chua PP, Danyluk Q, Astrakianakis G. 2014. Examining factors that influence the effectiveness of cleaning antineoplastic drugs from drug preparation surfaces: a pilot study. J Oncol Pharm Pract. 20(3):210–216. doi:10.1177/1078155213497070
  • Hornung RW, Reed LD. 1990. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg. 5(1):46–51. doi:10.1080/1047322X.1990.10389587
  • Lê LMM, Jolivot PA, Sadou Yaye H, Rieutord A, Bellanger A, Pradeau D, Barbault-Foucher S, Caudron E. 2013. Effectiveness of cleaning of workplace cytotoxic surface. Int Arch Occup Environ Health. 86(3):333–341. doi:10.1007/s00420-012-0769-1
  • Lee S-G, Ambados F, TkaczukPhD M, Jankewicz G. 2009. Paclitaxel exposure and its effective decontamination. J Pharm Pract Res. 39(3):181–185. doi:10.1002/j.2055-2335.2009.tb00449.x
  • McDiarmid MA, Rogers B, Oliver MS. 2014. Chromosomal effects of non-alkylating drug exposure in oncology personnel: chromosomal effects of non-alkylating drug. Environ Mol Mutagen. 55(4):369–374. doi:10.1002/em.21852
  • National Association of Pharmacy Regulatory Authorities. 2016. Model standards for pharmacy compounding of hazardous sterile preparations. https://napra.ca/sites/default/files/2017-09/Mdl_Stnds_Pharmacy_Compounding_Hazardous_Sterile_Preparations_Nov2016_Revised_b.pdf.
  • National Institute for Occupational Safety and Health. 2004. NIOSH alert - preventing occupational exposures to antineoplastic and other hazardous drugs in health care, settings. https://www.cdc.gov/niosh/docs/2004-165/pdfs/2004-165.pdf.
  • Negri S, Oddone E, Morandi F, Sottani C, Gardinali F, Lillo A, Pastoris O, Dacrema V, Losurdo A, Grignani E, et al. 2019. Validation of cleaning procedures used in an Italian hospital pharmacy for antineoplastic drug decontamination: a new tool for industrial hygiene. Med Lav. 110:93–101.
  • Ordre des pharmaciens du Québec. 2014. Normes 2014.02 - préparation de produits stériles dangereux en pharmacie. https://www.opq.org/doc/media/1847_38_fr-ca_0_norme201402_prod_striles_dang_oct2017.pdf.
  • Queruau Lamerie T, Nussbaumer S, Décaudin B, Fleury-Souverain S, Goossens JF, Bonnabry P, Odou P. 2013. Evaluation of decontamination efficacy of cleaning solutions on stainless steel and glass surfaces contaminated by 10 antineoplastic agents. Ann Occup Hyg. 57(4):456–469. doi:10.1093/annhyg/mes087
  • Roberts S, Khammo N, McDonnell G, Sewell GJ. 2006. Studies on the decontamination of surfaces exposed to cytotoxic drugs in chemotherapy workstations. J Oncol Pharm Pract. 12(2):95–104. doi:10.1177/1078155206070439
  • Roland C, Adé A, Ouellette-Frève J-F, Gagné S, Caron N, Bussières J-F. 2017. Pilot study evaluating the efficacy of four cleaning solutions and two types of mops in delimited areas of a floor contaminated with cyclophosphamide. Pharm Technol Hosp Pharm. 2(3):99–106.
  • Simon N, Odou P, Decaudin B, Bonnabry P, Fleury-Souverain S. 2019. Efficiency of degradation or desorption methods in antineoplastic drug decontamination: a critical review. J Oncol Pharm Pract. 25(4):929–946. doi:10.1177/1078155219831427
  • Simon N, Odou P, Decaudin B, Bonnabry P, Fleury-Souverain S. 2020. Chemical decontamination of hazardous drugs: a comparison of solution performances. Ann Work Expos Health. 64(2):114–124. doi:10.1093/annweh/wxz093
  • Soubieux A, Palamini M, Tanguay C, Bussières J-F. 2020. Evaluation of decontamination strategies for cyclophosphamide. J Oncol Pharm Pract. 26(2):413–422. doi:10.1177/1078155219865931
  • United States Pharmacopeia. 2017. USP General Chapter <800> Hazardous drugs – handling in healthcare settings.
  • Valero-García S, Poveda-Andrés JL. 2018. Hazardous drugs levels in compounding area surfaces of hospital pharmacies services: multicentric study. Farm Hosp. 42(4):152–158. doi:10.7399/fh.10935
  • Vasseur M, Simon N, Picher C, Richeval C, Soichot M, Humbert L, Barthélémy C, Fleury-Souverain S, Bonnabry P, Décaudin B, et al. 2018. A decontamination process adding a tensioactive agent and isopropanol to a closed-system drug transfer device for better control of isolator contamination. A prospective, parallel study. PLOS One. 13(8):e0201335. doi:10.1371/journal.pone.0201335
  • Viegas S, Oliveira d. AC, Carolino E, Pádua M. 2018. Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure. Arh Hig Rada Toksikol. 69(3):238–249. doi:10.2478/aiht-2018-69-3137

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