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Review

Wnt signaling induces epithelial differentiation during cutaneous wound healing

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Pages 95-104 | Received 03 Apr 2015, Accepted 19 Aug 2015, Published online: 23 Oct 2015

REFERENCES

  • Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci Sep 15 2009; 122(Pt 18):3209-13; PMID:19726630; http://dx.doi.org/10.1242/jcs.031187
  • Song C. Hypertrophic scars and keloids in surgery: current concepts. Ann Plast Surg Sep 2014; 73 Suppl 1:S108-118; PMID:25115371
  • Martin P. Wound healing–aiming for perfect skin regeneration. Sci Apr 4 1997; 276(5309):75-81; PMID:9082989; http://dx.doi.org/10.1126/science.276.5309.75
  • Bielefeld KA, Amini-Nik S, Alman BA. Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci Jun 2013; 70(12):2059-81; PMID:23052205; http://dx.doi.org/10.1007/s00018-012-1152-9
  • Lough D, Dai H, Yang M, Reichensperger J, Cox L, Harrison C, Neumeister MW. Stimulation of the follicular bulge LGR5+ and LGR6+ stem cells with the gut-derived human α defensin 5 results in decreased bacterial presence, enhanced wound healing, and hair growth from tissues devoid of adnexal structures. Plast Reconst Surg Nov 2013; 132(5):1159-71; PMID:24165598; http://dx.doi.org/10.1097/PRS.0b013e3182a48af6
  • Morasso MI, Tomic-Canic M. Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing. Biol Cell Mar 2005; 97(3):173-83; PMID:15715523; http://dx.doi.org/10.1042/BC20040098
  • Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, Cotsarelis G. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med Dec 2005; 11(12):1351-4; PMID:16288281; http://dx.doi.org/10.1038/nm1328
  • Fuchs E. Scratching the surface of skin development. Nat Feb 22 2007; 445(7130):834-42; PMID:17314969; http://dx.doi.org/10.1038/nature05659
  • Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol Aug 1 2006; 296(1):164-76; http://dx.doi.org/10.1016/j.ydbio.2006.04.449
  • Lim X, Nusse R. Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol Feb 2013; 5(2):a008029; http://dx.doi.org/10.1101/cshperspect.a008029
  • Ito M, Yang Z, Andl T, Cui C, Kim N, Millar SE, Cotsarelis G. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature May 17 2007; 447(7142):316-20; PMID:17507982; http://dx.doi.org/10.1038/nature05766
  • Fathke C, Wilson L, Shah K, Kim B, Hocking A, Moon R, Isik F Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol 2006; 7:4; PMID:16426441
  • Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science Dec 6 2013; 342(6163):1226-30; PMID:24311688; http://dx.doi.org/10.1126/science.1239730
  • Whyte JL, Smith AA, Liu B, Manzano WR, Evans ND, Dhamdhere GR, Fang MY, Chang HY, Oro AE, Helms JA. Augmenting endogenous Wnt signaling improves skin wound healing. PLoS One 2013; 8(10):e76883; PMID:24204695; http://dx.doi.org/10.1371/journal.pone.0076883
  • Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis Apr 2008; 4(2):68-75; PMID:19279717; http://dx.doi.org/10.4161/org.4.2.5851
  • Schambony A, Kunz M, Gradl D. Cross-regulation of Wnt signaling and cell adhesion. Differentiation Sep 2004; 72(7):307-18; http://dx.doi.org/10.1111/j.1432-0436.2004.07207002.x
  • Myung PS, Takeo M, Ito M, Atit RP. Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Investigative Dermatol Jan 2013; 133(1):31-41; http://dx.doi.org/10.1038/jid.2012.230
  • Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev May 15 2003; 17(10):1189-200; PMID:12756224; http://dx.doi.org/10.1101/gad.1086903
  • Lam AP, Gottardi CJ. β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol Nov 2011; 23(6):562-7; http://dx.doi.org/10.1097/BOR.0b013e32834b3309
  • Carre AL, James AW, MacLeod L, Kong W, Kawai K, Longaker MT, Lorenz HP. Interaction of wingless protein (Wnt), transforming growth factor-beta1, and hyaluronan production in fetal and postnatal fibroblasts. Plast Reconstr Surg Jan 2010; 125(1):74-88; PMID:20048602; http://dx.doi.org/10.1097/PRS.0b013e3181c495d1
  • Stenn KS, Cotsarelis G. Bioengineering the hair follicle: fringe benefits of stem cell technology. Curr Opin Biotechnol Oct 2005; 16(5):493-7; http://dx.doi.org/10.1016/j.copbio.2005.08.002
  • Dorey K, Amaya E. FGF signalling: diverse roles during early vertebrate embryogenesis. Development Nov 2010; 137(22):3731-42; PMID:20978071; http://dx.doi.org/10.1242/dev.037689
  • Gay D, Kwon O, Zhang Z, Spata M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, et al. Fgf9 from dermal gammadelta T cells induces hair follicle neogenesis after wounding. Nat Med Jul 2013; 19(7):916-23; PMID:23727932; http://dx.doi.org/10.1038/nm.3181
  • Cheon SS, Wei Q, Gurung A, Youn A, Bright T, Poon R, Whetstone H, Guha A, Alman BA. Beta-catenin regulates wound size and mediates the effect of TGF-β in cutaneous healing. FASEB J Apr 2006; 20(6):692-701; PMID:16581977; http://dx.doi.org/10.1096/fj.05-4759com
  • Widelitz RB. Wnt signaling in skin organogenesis. Organogenesis Apr 2008; 4(2):123-33; PMID:19279724; http://dx.doi.org/10.4161/org.4.2.5859
  • Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chemistry Jan 21 2000; 275(3):1521-4; http://dx.doi.org/10.1074/jbc.275.3.1521
  • Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, et al. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood Jan 3 2013; 121(1):188-96; PMID:23160460; http://dx.doi.org/10.1182/blood-2012-03-416875
  • Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB. Canonical Wnt signaling negatively regulates platelet function. Proc Natl Acad Sci U S A Nov 24 2009; 106(47):19836-41; PMID:19901330; http://dx.doi.org/10.1073/pnas.0906268106
  • Kim SY, Kim S, Yun-Choi HS, Jho EH. Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway. Mol Cells Oct 2011; 32(4):333-6; PMID:21870110; http://dx.doi.org/10.1007/s10059-011-0134-3
  • Alessandri AL, Sousa LP, Lucas CD, Rossi AG, Pinho V, Teixeira MM. Resolution of inflammation: mechanisms and opportunity for drug development. Pharmacol Ther Aug 2013; 139(2):189-212; PMID:23583354; http://dx.doi.org/10.1016/j.pharmthera.2013.04.006
  • Greaves NS, Ashcroft KJ, Baguneid M, Bayat A. Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci Dec 2013; 72(3):206-17
  • Schaale K, Neumann J, Schneider D, Ehlers S, Reiling N. Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses. European J Cell Biol Jun-Jul 2011; 90(6-7):553-9
  • Staal FJ, Luis TC, Tiemessen MM. WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol Aug 2008; 8(8):581-93; PMID:18617885
  • Nazarko L. Advances in wound debridement techniques. British J Community Nursing Jun 2015; 20 Suppl 6:S6-8
  • Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clinics Dermatol Jan-Feb 2007; 25(1):9-18; PMID:17276196
  • Poon R, Nik SA, Ahn J, Slade L, Alman BA. Beta-catenin and transforming growth factor β have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. BMC Cell Biol 2009; 10:38; PMID:19432963
  • Cheon S, Poon R, Yu C, Khoury M, Shenker R, Fish J, Alman BA. Prolonged β-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab Invest Mar 2005; 85(3):416-25
  • Carothers AM, Rizvi H, Hasson RM, Heit YI, Davids JS, Bertagnolli MM, Cho NL. Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors. Cancer Res Jan 1 2012; 72(1):346-55; PMID:22094874
  • Bielefeld KA, Amini-Nik S, Whetstone H, Poon R, Youn A, Wang J, Alman BA. Fibronectin and β-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem Aug 5 2011; 286(31):27687-97
  • Bowley E, O'Gorman DB, Gan BS. Beta-catenin signaling in fibroproliferative disease. J Surgical Research Mar 2007; 138(1):141-50
  • Singer AJ, Clark RA. Cutaneous wound healing. New England J Medicine Sep 2 1999; 341(10):738-46.
  • Cheon SS, Nadesan P, Poon R, Alman BA. Growth factors regulate β-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. Exp Cell Res Feb 15 2004; 293(2):267-74; PMID:14729464
  • Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature May 15 2008; 453(7193):314-21; PMID:18480812
  • Yates CC, Bodnar R, Wells A. Matrix control of scarring. Cell Mol Life Sci Jun 2011; 68(11):1871-81
  • Sun Z, Wang C, Shi C, Xu X, Qian W, Nie S, Han X. Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. Int J Mol Med May 2014; 33(5):1097-109
  • Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A. Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen Sep 2011; 19 Suppll 1:s10-15; PMID:21793960; http://dx.doi.org/10.1111/j.1524-475X.2011.00708.x
  • Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, et al. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Dev Cell Jan 12 2015; 32(1):82-96; PMID:25584796; http://dx.doi.org/10.1016/j.devcel.2014.11.016
  • Buchanan EP, Longaker MT, Lorenz HP. Fetal skin wound healing. Adv Clin Chem 2009; 48:137-61; http://dx.doi.org/10.1016/S0065-2423(09)48006-5
  • Chen W, Fu X, Ge S, Sun T, Zhou G, Han B, Li H, Sheng Z. Profiling of genes differentially expressed in a rat of early and later gestational ages with high-density oligonucleotide DNA array. Wound Repair Regen Jan-Feb 2007; 15(1):147-55; PMID:17244330; http://dx.doi.org/10.1111/j.1524-475X.2006.00195.x
  • Chen W, Fu XB, Ge SL, Sun TZ, Sheng ZY. Analysis of differentially expressed genes in fetal skin of scarless and scar-forming periods of gestational rats. Chin J Traumatol Apr 2006; 9(2):94-9; PMID:16533435
  • Kishi K, Okabe K, Shimizu R, Kubota Y. Fetal skin possesses the ability to regenerate completely: complete regeneration of skin. Keio J Medicine 2012; 61(4):101-8; http://dx.doi.org/10.2302/kjm.2011-0002-IR
  • Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M. Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo. J Invest Dermatol Jun 2013; 133(6):1479-88; http://dx.doi.org/10.1038/jid.2013.7
  • Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3s phosphorylation of β-catenin. Proc Natl Acad Sci USA Jun 10 2008; 105(23):8032-7; PMID:18509060; http://dx.doi.org/10.1073/pnas.0803025105

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