Regulation of proliferation in developing human tooth germs by MSX homeodomain proteins and cyclin-dependent kinase inhibitor p19^INK4d

REFERENCES

• Kero D, Novakovic J, Vukojevic K, Petricevic J, Kalibovic Govorko D, Biocina-Lukenda D, Saraga-Babic M. Expression of Ki-67, Oct-4, gamma-tubulin and alpha-tubulin in human tooth development. Arch Oral Biol. 2014; 59:1119-29. doi:10.1016/j.archoralbio.2014.05.025.
   PubMed Web of Science ®Google Scholar
• Sharpe PT. Neural crest and tooth morphogenesis. Adv Dent Res. 2001; 15:4-7. doi:10.1177/08959374010150011001.
   PubMedGoogle Scholar
• Thesleff I. Epithelial-mesenchymal signalling regulating tooth morphogenesis. J Cell Sci. 2003; 116:1647-8. doi:10.1242/jcs.00410.
   PubMed Web of Science ®Google Scholar
• Thesleff I, Mikkola M. The role of growth factors in tooth development. Int Rev Cytology. 2002; 217:93-135. doi:10.1016/S0074-7696(02)17013-6.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Davenport JR, Croyle MJ, Haycraft CJ, Yoder BK. Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest; A journal of technical methods and pathology. 2005; 85:45-64. doi:10.1038/labinvest.3700207.
   PubMed Web of Science ®Google Scholar
• Hu G, Lee H, Price SM, Shen MM, Abate-Shen C. Msx homeobox genes inhibit differentiation through upregulation of cyclin D1. Development. 2001; 128:2373-84.
   PubMed Web of Science ®Google Scholar
• Bendall AJ, Abate-Shen C. Roles for Msx and Dlx homeoproteins in vertebrate development. Gene. 2000; 247:17-31. doi:10.1016/S0378-1119(00)00081-0.
   PubMed Web of Science ®Google Scholar
• Menezes ME, Mitra A, Shevde LA, Samant RS. DNAJB6 governs a novel regulatory loop determining Wnt/beta-catenin signalling activity. Biochem J. 2012; 444:573-80. doi:10.1042/BJ20120205.
   PubMed Web of Science ®Google Scholar
• Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D. A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998; 125:3005-14.
   PubMed Web of Science ®Google Scholar
• Bei M. Molecular genetics of tooth development. Current Opinion Gene Dev. 2009; 19:504-10. doi:10.1016/j.gde.2009.09.002.
   PubMed Web of Science ®Google Scholar
• Lallemand Y, Bensoussan V, Cloment CS, Robert B. Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 2009; 331:189-98. doi:10.1016/j.ydbio.2009.04.038.
   PubMed Web of Science ®Google Scholar
• Lallemand Y, Nicola MA, Ramos C, Bach A, Cloment CS, Robert B. Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development. 2005; 132:3003-14. doi:10.1242/dev.01877.
   PubMed Web of Science ®Google Scholar
• Jernvall J, Thesleff I. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev. 2000; 92:19-29. doi:10.1016/S0925-4773(99)00322-6.
   PubMed Web of Science ®Google Scholar
• Maas R, Bei M. The genetic control of early tooth development. Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists. 1997; 8:4-39. doi:10.1177/10454411970080010101.
   PubMedGoogle Scholar
• Ohazama A, Haycraft CJ, Seppala M, Blackburn J, Ghafoor S, Cobourne M, Martinelli DC, Fan CM, Peterkova R, Lesot H, et al. Primary cilia regulate Shh activity in the control of molar tooth number. Development. 2009; 136:897-903. doi:10.1242/dev.027979.
   PubMed Web of Science ®Google Scholar
• Thesleff I, Tummers M. Tooth organogenesis and regeneration. StemBook[Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-2009 Jan 31. doi:10.3824/stembook.1.37.1.
   Google Scholar
• Kero D, Saraga-Babic M. Odontogenesis – A Masterful Orchestration of Functional Redundancy or What Makes Tooth Bioengineering an Intrinsically Difficult Concept. J Stem Cell Res Therapeutics. 2016; 1:7. doi:10.15406/jsrt.2016.01.00022.
   Google Scholar
• Thesleff I, Sharpe P. Signalling networks regulating dental development. Mech Dev. 1997; 67:111-23. doi:10.1016/S0925-4773(97)00115-9.
   PubMed Web of Science ®Google Scholar
• Yamashiro T, Tummers M, Thesleff I. Expression of bone morphogenetic proteins and Msx genes during root formation. J Dent Res. 2003; 82:172-6. doi:10.1177/154405910308200305.
   PubMed Web of Science ®Google Scholar
• Cobourne MT, Sharpe PT. Making up the numbers: The molecular control of mammalian dental formula. Semin Cell Dev Biol. 2010; 21:314-24. doi:10.1016/j.semcdb.2010.01.007.
   PubMed Web of Science ®Google Scholar
• Abid MF, Simpson MA, Petridis C, Cobourne MT, Sharpe PT. Non-syndromic severe hypodontia caused by a novel frameshift insertion mutation in the homeobox of the MSX1 gene. Arch Oral Biol. 2017; 75:8-13. doi:10.1016/j.archoralbio.2016.11.018.
   PubMed Web of Science ®Google Scholar
• Lidral AC, Reising BC. The role of MSX1 in human tooth agenesis. J Dent Res. 2002; 81:274-8. doi:10.1177/154405910208100410.
   PubMed Web of Science ®Google Scholar
• Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, et al. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet. 2000; 24:391-5. doi:10.1038/74231.
   PubMed Web of Science ®Google Scholar
• Han J, Ito Y, Yeo JY, Sucov HM, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003; 261:183-96. doi:10.1016/S0012-1606(03)00300-2.
   PubMed Web of Science ®Google Scholar
• Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB life 2007; 59:419-26. doi:10.1080/15216540701488358.
   PubMed Web of Science ®Google Scholar
• Guo J, Sheng G, Warner BW. Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. J Biol Chem. 2005; 280:35992-8. doi:10.1074/jbc.M504583200.
   PubMed Web of Science ®Google Scholar
• Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell. 1999; 98:859-69. doi:10.1016/S0092-8674(00)81519-6.
   PubMed Web of Science ®Google Scholar
• Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica et biophysica acta. 2002; 1602:73-87.
   PubMed Web of Science ®Google Scholar
• Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006; 7:667-77. doi:10.1038/nrm1987.
   PubMed Web of Science ®Google Scholar
• Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 1997; 15:203-11. doi:10.1038/sj.onc.1201178.
   PubMed Web of Science ®Google Scholar
• Zhao M, Gupta V, Raj L, Roussel M, Bei M. A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol. 2013; 33:3099-112. doi:10.1128/MCB.00524-13.
   PubMed Web of Science ®Google Scholar
• avideau JL, Demri P, Hotton D, Gu TT, MacDougall M, Sharpe P, Forest N, Berdal A. Comparative study of MSX-2, DLX-5, and DLX-7 gene expression during early human tooth development. Pediatr Res. 1999; 46:650-6. doi:10.1203/00006450-199912000-00015.
   PubMed Web of Science ®Google Scholar
• Lin D, Huang Y, He F, Gu S, Zhang G, Chen Y, Zhang Y. Expression survey of genes critical for tooth development in the human embryonic tooth germ. Developmental dynamics: An official publication of the American Association of Anatomists. 2007; 236:1307-12. doi:10.1002/dvdy.21127.
   PubMed Web of Science ®Google Scholar
• Newberry EP, Latifi T, Battaile JT, Towler DA. Structure-function analysis of Msx2-mediated transcriptional suppression. Biochemistry. 1997; 36:10451-62. doi:10.1021/bi971008x.
   PubMed Web of Science ®Google Scholar
• Miletich I, Sharpe PT. Normal and abnormal dental development. Hum Mol Genet. 2003; 12(Spec No 1):R69-73. doi:10.1093/hmg/ddg085.
   PubMed Web of Science ®Google Scholar
• Mizokami Y, Egashira N, Takekoshi S, Itoh J, Itoh Y, Osamura RY, Matsumae M. Expression of MSX1 in human normal pituitaries and pituitary adenomas. Endocr Pathol. 2008; 19:54-61. doi:10.1007/s12022-008-9021-7.
   PubMed Web of Science ®Google Scholar
• Bai F, Chan HL, Smith MD, Kiyokawa H, Pei XH. p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Mol Cell Biol. 2014; 34:2121-34. doi:10.1128/MCB.01363-13.
   PubMed Web of Science ®Google Scholar
• Murray AW. Recycling the cell cycle: cyclins revisited. Cell 2004; 116:221-34. doi:10.1016/S0092-8674(03)01080-8.
   PubMed Web of Science ®Google Scholar
• Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne RJ, Rehg JE, Eberhart C, Sherr CJ, Roussel MF. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res. 2003; 63:5420-7.
   PubMed Web of Science ®Google Scholar
• Forget A, Ayrault O, den Besten W, Kuo ML, Sherr CJ, Roussel MF. Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d. Cell Cycle. 2008; 7:3737-46. doi:10.4161/cc.7.23.7187.
   PubMed Web of Science ®Google Scholar
• Savatier P, Huang S, Szekely L, Wiman KG, Samarut J. Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts. Oncogene. 1994; 9:809-18.
   PubMed Web of Science ®Google Scholar
• Cosgrove RA, Philpott A. Cell cycling and differentiation do not require the retinoblastoma protein during early Xenopus development. Developmental Biol. 2007; 303:311-24. doi:10.1016/j.ydbio.2006.11.015.
   PubMed Web of Science ®Google Scholar
• Kero D, Cigic L, Medvedec Mikic I, Galic T, Cubela M, Vukojevic K, Saraga-Babic M. Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ – an immunohistochemical study. Organogenesis. 2016; 12:152-67. doi:10.1080/15476278.2016.1197460.
   PubMed Web of Science ®Google Scholar
• Kero D, Kalibovic Govorko D, Medvedec Mikic I, Vukojevic K, Cigic L, Saraga-Babic M. Analysis of expression patterns of IGF-1, caspase-3 and HSP-70 in developing human tooth germs. Arch Oral Biol. 2015; 60:1533-44. doi:10.1016/j.archoralbio.2015.07.004.
   PubMed Web of Science ®Google Scholar
• Williams JR. The Declaration of Helsinki and public health. Bull World Health Organ 2008; 86:650-2. doi:10.2471/BLT.08.050955.
   PubMed Web of Science ®Google Scholar
• O'Rahilly R. Guide to the staging of human embryos. Anat Anz. 1972; 130:556-9.
   PubMedGoogle Scholar
• Dunn KW, Kamocka MM, McDonald JH. A practical guide to evaluating colocalization in biological microscopy. Am J Physiol Cell Physiol 2011; 300:C723-42. doi:10.1152/ajpcell.00462.2010.
   PubMed Web of Science ®Google Scholar
• Zinchuk V, Zinchuk O. Quantitative colocalization analysis of confocal fluorescence microscopy images. Curr Protoc Cell Biol. 2008; Chapter 4:Unit 4 19. doi:10.1002/0471143030.cb0419s39.
   PubMedGoogle Scholar
• Adler J, Parmryd I. Colocalization analysis in fluorescence microscopy. Methods Mol Biol. 2013; 931:97-109. doi:10.1007/978-1-62703-056-4_5.
   PubMedGoogle Scholar