Factors and molecules that could impact cell differentiation in the embryo generated by nuclear transfer

REFERENCES

• Bromhall JD. Nuclear transplantation in the rabbit egg. Nature. 1975;258:719–22. doi:10.1038/258719a0. PMID:1207752.
   PubMed Web of Science ®Google Scholar
• De Robertis EM, Gurdon JB. Gene activation in somatic nuclei after injection into amphibian oocytes. Proc Natl Acad Sci U S A. 1977;74:2470–4. doi:10.1073/pnas.74.6.2470. PMID:267940.
   PubMed Web of Science ®Google Scholar
• Hochedlinger K, Jaenisch R. Nuclear reprogramming and pluripotency. Nature. 2006;441:1061–7. doi:10.1038/nature04955. PMID:16810240.
   PubMed Web of Science ®Google Scholar
• Gurdon JB, Wilmut I. Nuclear transfer to eggs and oocytes. Cold Spring Harbor Perspect Biol. 2011;3:1–14. doi:10.1101/cshperspect.a002659.
   Web of Science ®Google Scholar
• Kikyo N, Wolffe AP. Reprogramming nuclei: insights from cloning, nuclear transfer and heterokaryons. J Cell Sci. 2000;113(Pt 1):11–20. PMID:10591621.
   PubMed Web of Science ®Google Scholar
• Santos AR Jr, Nascimento VA, Genari SC, Lombello CB. Mechanisms of cell regeneration — From differentiation to maintenance of cell phenotype. In: Cell and Biomaterials in Regenerative Medicine; 2014. p. 37–69.
   Google Scholar
• Tsunoda Y, Kato Y. Recent progress and problems in animal cloning. Differentiation. 2002;69:158–61. doi:10.1046/j.1432-0436.2002.690405.x. PMID:11841470.
   PubMed Web of Science ®Google Scholar
• Yang X, Smith SL, Tian XC, Lewin HA, Renard JP, Wakayama T. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet. 2007;39:295–303. doi:10.1038/ng1973. PMID:17325680.
   PubMed Web of Science ®Google Scholar
• Gurdon JB, Byrne JA, Simonsson S. Nuclear reprogramming and stem cell creation. Proc Natl Acad Sci U S A. 2003;100(Suppl):11819–22. doi:10.1073/pnas.1834207100. PMID:12920185.
   PubMed Web of Science ®Google Scholar
• Santos F, Wendy D. Epigenetic reprogramming during early development in mammals. Reproduction. 2004;127:643–51. doi:10.1530/rep.1.00221. PMID:15175501.
   PubMed Web of Science ®Google Scholar
• Bird A. DNA methylation patterns and epigenetic memory. Gene Dev. 2002;16:6–21. doi:10.1101/gad.947102.
   PubMed Web of Science ®Google Scholar
• Morgan HD, Santos F, Green K, Dean W, Reik W. Epigenetic reprogramming in mammals. Hum Mol Genet. 2005;14(Review Issue 1):R47–58. doi:10.1093/hmg/ddi114. PMID:15809273.
   PubMed Web of Science ®Google Scholar
• Meissner A, Jaenisch R. Mammalian nuclear transfer. Dev Dyn. 2006;235:2460–9. doi:10.1002/dvdy.20915. PMID:16881069.
   PubMed Web of Science ®Google Scholar
• Wilmut I, Bai Y, Taylor J. Somatic cell nuclear transfer: origins, the present position and future opportunities. Philos Trans R Soc Lond B Biol Sci. 2015;370:2014366. doi:10.1098/rstb.2014.0366.
   Web of Science ®Google Scholar
• Wakayama T. Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency? J Reprod Dev. 2007;53:13–26. doi:10.1262/jrd.18120. PMID:17332696.
   PubMed Web of Science ®Google Scholar
• Kocabas AM, Crosby J, Ross PJ, Otu HH, Beyhan Z, Can H, Tam WL, Rosa GJM, Halgren RG, Lim B, et al. The transcriptome of human oocytes. Proc Natl Acad Sci U S A. 2006;103:14027–32. doi:10.1073/pnas.0603227103. PMID:16968779.
   PubMed Web of Science ®Google Scholar
• Bermúdez MG, Wells D, Malter H, Munné S, Cohen J, Steuerwald NM. Expression profiles of individual human oocytes using microarray technology. Reprod Biomed Online. 2004;8:325–37. doi:10.1016/S1472-6483(10)60913-3. PMID:15038899.
   PubMed Web of Science ®Google Scholar
• Dobson AT, Raja R, Abeyta MJ, Taylor T, Shen S, Haqq C, Reijo Pera RA. The unique transcriptome through day 3 of human preimplantation development. Hum Mol Genet. 2004;13:1461–70. doi:10.1093/hmg/ddh157. PMID:15150160.
   PubMed Web of Science ®Google Scholar
• Li SSL, Liu YH, Tseng CN, Singh S. Analysis of gene expression in single human oocytes and preimplantation embryos. Biochem Biophys Res Commun. 2006;340:48–53. doi:10.1016/j.bbrc.2005.11.149. PMID:16343430.
   PubMed Web of Science ®Google Scholar
• Tada M, Takahama Y, Abe K, Nakatsuji N, Tada T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol. 2001;11:1553–8. doi:10.1016/S0960-9822(01)00459-6. PMID:11591326.
   PubMed Web of Science ®Google Scholar
• Byrne JA, Simonsson S, Western PS, Gurdon JB. Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. Curr Biol. 2003;13:1206–13. doi:10.1016/S0960-9822(03)00462-7. PMID:12867031.
   PubMed Web of Science ®Google Scholar
• Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem. Science. 2005;309:1369–73. doi:10.1126/science.1116447. PMID:16123299.
   PubMed Web of Science ®Google Scholar
• Adona PR, Leal CLV, Biase FH, De Bem TH, Mesquita LG, Meirelles FV, Ferraz AL, Furlan LR, Monzani PS, Guemra S. In vitro maturation alters gene expression in bovine oocytes. Zygote. 2016;24:624–33. doi:10.1017/S0967199415000672. PMID:26885679.
   PubMed Web of Science ®Google Scholar
• Hosseini SM, Moulavi F, Asgari V, Shirazi A, Abazari-Kia AH, Ghanaei HR, Nasr-Esfahani MH. Simple, fast, and efficient method of manual oocyte enucleation using a pulled Pasteur pipette. In Vitro Cell Dev Biol Anim. 2013;49:569–75. doi:10.1007/s11626-013-9630-4. PMID:23824953.
   PubMed Web of Science ®Google Scholar
• Markoulaki S, Meissner A, Jaenisch R. Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse. Methods. 2008;45:101–14. doi:10.1016/j.ymeth.2008.04.002. PMID:18593608.
   PubMed Web of Science ®Google Scholar
• Li GP, White KL, Bunch TD. Review of enucleation methods and procedures used in animal cloning: state of the art. Cloning Stem Cells. 2004;6:5–13. doi:10.1089/15362300460743781. PMID:15107241.
   PubMedGoogle Scholar
• Gao S, Gasparrini B, McGarry M, Ferrier T, Fletcher J, Harkness L, De Sousa P, Wilmut I. Germinal vesicle material is essential for nucleus remodeling after nuclear transfer. Bio Reprod. 2002;67:928–34. doi:10.1095/biolreprod.102.004606. PMID:12193404.
   PubMed Web of Science ®Google Scholar
• Mullins LJ, Wilmut I, Mullins JJ. Nuclear transfer in rodents. J Physiol. 2004;554:4–12. doi:10.1113/jphysiol.2003.049742. PMID:14678485.
   PubMed Web of Science ®Google Scholar
• Dominko T, Chan A, Simerly C, Luetjens CM, Hewitson L, Martinovich C, Schatten G. Dynamic imaging of the metaphase II spindle and maternal chromosomes in bovine oocytes: implications for enucleation efficiency verification, avoidance of parthenogenesis, and successful embryogenesis. Biol Reprod. 2000;62:150–4. doi:10.1095/biolreprod62.1.150. PMID:10611079.
   PubMed Web of Science ®Google Scholar
• Meng L, Rutledge J, Zhu Y, Kidder GM, Khamsi F, Armstrong DT. Role of germinal vesicle on protein synthesis in rat oocyte during in vitro maturation. Mol Reprod Dev. 1996;43:228–35. doi:10.1002/(SICI)1098-2795(199602)43:2%3c228::AID-MRD12%3e3.0.CO;2-. PMID:8824921.
   PubMed Web of Science ®Google Scholar
• Kubota C, Yang X, Dinnyes A, Todoroki J, Yamakuchi H, Mizoshita K, Inohae S, Tabara N. In vitro and in vivo survival of frozen-thawed bovine oocytes after IVF, nuclear transfer, and parthenogenetic activation. Mol Reprod Dev. 1998;51:281–6. doi:10.1002/(SICI)1098-2795(199811)51:3%3c281::AID-MRD7%3e3.0.CO;2-L. PMID:9771648.
   PubMed Web of Science ®Google Scholar
• Dinnyes A, Dai Y, Jiang S, Yang X. High developmental rates of vitrified bovine oocytes following parthenogenetic activation, in vitro fertilization, and somatic cell nuclear transfer. Biol Reprod. 2000;63:513–8. doi:10.1095/biolreprod63.2.513. PMID:10906058.
   PubMed Web of Science ®Google Scholar
• Li G, Chen D, Lian LI, Sun Q, Wang M, Liu J, Li JS, Zhi-Ming H. Viable Rabbits Derived From Reconstructed oocytes by germinal vesicle transfer after intracytoplasmic sperm injection (ICSI). Mol Reprod Dev. 2001;58:180–5. doi:10.1002/1098-2795(200102)58:2%3c180::AID-MRD7%3e3.0.CO;2-7. PMID:11139230.
   PubMed Web of Science ®Google Scholar
• Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature. 1996;380:64–6. doi:10.1038/380064a0. PMID:8598906.
   PubMed Web of Science ®Google Scholar
• Bordignon V, Smith LC. Telophase enucleation: An improved method to prepare recipient cytoplasts for use in bovine nuclear transfer. Mol Reprod Dev. 1998;49:29–36. doi:10.1002/(SICI)1098-2795(199801)49:1%3c29::AID-MRD4%3e3.0.CO;2-Q. PMID:9406193.
   PubMed Web of Science ®Google Scholar
• Liu JL, Sung LY, Barber M, Yang XZ. Hypertonic medium treatment for localization of nuclear material in bovine metaphase II oocytes. Biol Reprod. 2002;66:1342–9. doi:10.1095/biolreprod66.5.1342. PMID:11967196.
   PubMed Web of Science ®Google Scholar
• Fulka J Jr, Moor RM. Noninvasive chemical enucleation of mouse oocytes. Mol Reprod Dev. 1993;34:427–30. doi:10.1002/mrd.1080340412. PMID:8471262.
   PubMed Web of Science ®Google Scholar
• Ibánez E, Albertini DF, Overström EW. Demecolcine-Induced Oocyte Enucleation for Somatic Cell Cloning: Coordination Between Cell-Cycle Egress, Kinetics of Cortical Cytoskeletal Interactions, and Second Polar Body Extrusion. Biol Reprod. 2003;68:1249–58. doi:10.1095/biolreprod.102.008292. PMID:12606412.
   PubMed Web of Science ®Google Scholar
• Fulka J, Loi P, Fulka H, Ptak G, Nagai T. Nucleus transfer in mammals: Noninvasive approaches for the preparation of cytoplasts. Trends Biotechnol. 2004;22:279–83. doi:10.1016/j.tibtech.2004.04.002. PMID:15158056.
   PubMed Web of Science ®Google Scholar
• Wang MK, Liu JL, Li GP, Lian L, Chen DY. Sucrose pretreatment for enucleation: An efficient and non-damage method for removing the spindle of the mouse MII oocyte. Mol Reprod Dev. 2001;58:432–6. doi:10.1002/1098-2795(20010401)58:4%3c432::AID-MRD11%3e3.0.CO;2-Y. PMID:11241780.
   PubMed Web of Science ®Google Scholar
• Liu L, Oldenbourg R, Trimarchi JR, Keefe DL. A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes. Nat Biotechnol. 2000;18:223–5. doi:10.1038/72692. PMID:10657133.
   PubMed Web of Science ®Google Scholar
• Liu JL, Wang MK, Sun QY, Xu Z, Chen DY. Effect of telophase enucleation on bovine somatic nuclear transfer. Theriogenology. 2000;54:989–98. doi:10.1016/S0093-691X(00)00407-6. PMID:11097050.
   PubMed Web of Science ®Google Scholar
• Vajta G, Lewis IM, Poul H, Thouas GA, Trounson AO. Somatic cell cloning without micromanipulators. Cloning. 2001;3:89–95. doi:10.1089/15204550152475590. PMID:11900643.
   PubMedGoogle Scholar
• Rodríguez L, Navarrete FI, Tovar H, Cox JF, Castro FO. High developmental potential in vitro and in vivo of cattle embryos cloned without micromanipulators. J Assist Reprod Genet. 2008;25:13–6. doi:10.1007/s10815-007-9194-x. PMID:18205035.
   PubMed Web of Science ®Google Scholar
• Tatham BG, Sathananthan AH, Dharmawardena V, Munesinghe DY, Lewis I, Trounson AO. Centrifugation of bovine oocytes for nuclear micromanipulation and sperm microinjection. Hum Reprod (Oxford, England). 1996;11:1499–503. doi:10.1093/oxfordjournals.humrep.a019425. PMID:8671492.
   PubMed Web of Science ®Google Scholar
• Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature. 1998;394:369–74. doi:10.1038/28615. PMID:9690471.
   PubMed Web of Science ®Google Scholar
• Kato Y, Tani T, Tsunoda Y. Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows. J Reprod Fertil. 2000;120:231–7. PMID:11058438.
   PubMedGoogle Scholar
• Alberio R, Campbell KH, Johnson AD. Reprogramming somatic cells into stem cells. Reproduction. 2006;132:709–20. doi:10.1530/rep.1.01077. PMID:17071772.
   PubMed Web of Science ®Google Scholar
• Ogura A, Inoue K, Takano K, Wakayama T, Yanagimachi R. Birth of mice after nuclear transfer by electrofusion using tail tip cells. Mol Reprod Dev. 2000;57:55–9. doi:10.1002/1098-2795(200009)57:1%3c55::AID-MRD8%3e3.0.CO;2-W. PMID:10954856.
   PubMed Web of Science ®Google Scholar
• Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM, Yanagimachi R, Jaenisch R. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A. 2001;98:6209–14. doi:10.1073/pnas.101118898. PMID:11331774.
   PubMed Web of Science ®Google Scholar
• Egli D, Rosains J, Birkhoff G, Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature. 2007;447:679–85. doi:10.1038/nature05879. PMID:17554301.
   PubMed Web of Science ®Google Scholar
• Wakayama T, Rodriguez I, Perry AC, Yanagimachi R, Mombaerts P. Mice cloned from embryonic stem cells. Proc Natl Acad Sci U S A. 1999;96:14984–9. doi:10.1073/pnas.96.26.14984. PMID:10611324.
   PubMed Web of Science ®Google Scholar
• Amano T, Tani T, Kato Y, Tsunoda Y. Mouse cloned from embryonic stem (ES) cells synchronized in metaphase with nocodazole. J Exp Zool. 2001;289:139–45. doi:10.1002/1097-010X(20010201)289:2%3c139::AID-JEZ7%3e3.0.CO;2-6. PMID:11169501.
   PubMedGoogle Scholar
• Kato Y, Tsunoda Y. Role of the donor nuclei in cloning efficiency: can the ooplasm reprogram any nucleus? Int J Dev Biol. 2010;54:1623–29. doi:10.1387/ijdb.103203yk. PMID:21404183.
   PubMed Web of Science ®Google Scholar
• Ideta A, Urakawa M, Aoyagi Y, Saeki K. Early development in utero of bovine nuclear transfer embryos using early G1 and G0 phase cells. Cloning Stem Cell. 2007;9:571–80. doi:10.1089/clo.2007.0017. PMID:18154517.
   PubMedGoogle Scholar
• Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KHS. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385:810–3. doi:10.1038/385810a0. PMID:9039911.
   PubMed Web of Science ®Google Scholar
• Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol. 2001;17:387–403. doi:10.1146/annurev.cellbio.17.1.387. PMID:11687494.
   PubMed Web of Science ®Google Scholar
• Smith AG. Embryo derived stem cells : Of Mice and Men. Annu Rev Cell Dev Biol. 2001;17:435–62. doi:10.1146/annurev.cellbio.17.1.435. PMID:11687496.
   PubMed Web of Science ®Google Scholar
• Machado L, Santos AR Jr. Stem cells and cell therapy : From basic sciences to clinical perspectives. J Biomed Sci Eng. 2013;2013:683–92. doi:10.4236/jbise.2013.66083.
   Google Scholar
• Qi SD, Smith PD, Choong PF. Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons. ANZ J Surg. 2014;84:417–23. doi:10.1111/ans.12419.
   PubMed Web of Science ®Google Scholar
• Tachibana M, Amato P, Sparman M, Gutierrez NM, Ma H, Kang E, Fulati A, Lee H, Masterson K, Larson J, et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013;153:1228–38. doi:10.1016/j.cell.2013.05.006. PMID:23683578.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Jouneau A, Brochard V, Adenot P, Renard JP. Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei. Biol Reprod. 2001;65:412–9.
   PubMed Web of Science ®Google Scholar
• Gao S, McGarry M, Ferrier T, Pallante B, Gasparrini B, Fletcher J, Harkness L, De Sousa P, McWhir J, Wilmut I. Effect of Cell Confluence on Production of Cloned Mice Using an Inbred Embryonic Stem Cell Line. Biol Reprod. 2003;68:595–603. doi:10.1095/biolreprod.102.005819. PMID:12533424.
   PubMed Web of Science ®Google Scholar
• Telford NA, Watson AJ, Schultz GA. Transition from maternal to embryonic control in early mammalian development : A comparison of several species. Mol Reprod Dev. 1990;26:90–100. doi:10.1002/mrd.1080260113. PMID:2189447.
   PubMed Web of Science ®Google Scholar
• Kanka J. Gene expression and chromatin structure in the pre-implantation embryo. Theriogenology. 2003;59:3–19. doi:10.1016/S0093-691X(02)01267-0. PMID:12499014.
   PubMed Web of Science ®Google Scholar
• Brambrink T, Hochedlinger K, Bell G, Jaenisch R. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci U S A. 2006;103:933–8. doi:10.1073/pnas.0510485103. PMID:16418286.
   PubMed Web of Science ®Google Scholar
• Smith LC, Suzuki J Jr, Goff AK, Filion F, Therrien J, Murphy BD, Kohan-Ghadr HR, Lefebvre R, Brisville AC, Buczinski S, Fecteau G, et al. Developmental and epigenetic anomalies in cloned cattle. Reprod Domest Anim. 2012;47:107–14. doi:10.1111/j.1439-0531.2012.02063.x. PMID:22827358.
   PubMed Web of Science ®Google Scholar
• Watanabe S. Effect of calf death loss on cloned cattle herd derived from somatic cell nuclear transfer: clones with congenital defects would be removed by the death loss. Anim Sci J. 2013;84:631–38. doi:10.1111/asj.12087. PMID:23829575.
   PubMed Web of Science ®Google Scholar
• Loi P, Iuso D, Czernik M, Ogura A. A new, dynamic era for somatic cell nuclear transfer? Trends Biotechnol. 2016;34:791–97. doi:10.1016/j.tibtech.2016.03.008. PMID:27118511.
   PubMed Web of Science ®Google Scholar
• Duan L, Wang Z, Shen J, Shan Z, Shen X, Wu Y, Sun R, Li T, Yuan R, Zhao Q, et al. Comparison of reprogramming genes in induced pluripotent stem cells and nuclear transfer cloned embryos. Stem Cell Rev Rep. 2014;10:548–60. doi:10.1007/s12015-014-9516-1. PMID:24828831.
   PubMed Web of Science ®Google Scholar
• Dalbies-Tran R. Use of heterologous complementary DNA array screening to analyze bovine oocyte transcriptome and its evolution during in vitro maturation. Biol Reprod. 2003;68:252–61. doi:10.1095/biolreprod.102.007872. PMID:12493721.
   PubMed Web of Science ®Google Scholar
• Qiu JJ, Zhang WW, Wu ZL, Wang YH, Qian M, Li YP. Delay of ZGA initiation occurred in 2-cell blocked mouse embryos. Cell Res. 2003;13:179–85. doi:10.1038/sj.cr.7290162. PMID:12862318.
   PubMed Web of Science ®Google Scholar
• Chen T, Zang Y, Jiang Y, Liu J, Schatten H, Chen D, Sun Q. Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm by not by donor intrinsic property in cloned embryos. Mol Reprod Dev. 2006;73:313–17. doi:10.1002/mrd.20421. PMID:16362970.
   PubMed Web of Science ®Google Scholar
• Lagutina I, Fulka H, Lazzari G, Galli C. Interspecies somatic cell nuclear transfer: advancements and problems. Cell Reprogram. 2013;15:374–84. doi:10.1089/cell.2013.0036. PMID:24033141.
   PubMed Web of Science ®Google Scholar
• Cibelli JB, Kocabas AM, Beyhan Z, Ross PJ. Cellular reprogramming for the creation of patient-specific embryonic stem cells. Stem Cell Rev. 2006;2:289–95. doi:10.1007/BF02698055. PMID:17848715.
   PubMed Web of Science ®Google Scholar
• Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Scholer H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379–91. doi:10.1016/S0092-8674(00)81769-9. PMID:9814708.
   PubMed Web of Science ®Google Scholar
• Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643–55. doi:10.1016/S0092-8674(03)00392-1. PMID:12787505.
   PubMed Web of Science ®Google Scholar
• Han F, Li X, Song D, Jiang S, Xu Q, Zhang Y. SCNT versus iPSCs: proteins and small molecules in reprogramming. Int J Dev Biol. 2015;59:179–86. doi:10.1387/ijdb.150042fh. PMID:26505250.
   PubMed Web of Science ®Google Scholar
• Li X, Zhang P, Wei C, Zhang Y. Generation of pluripotent stem cells via protein transduction. Int J Dev Biol. 2014;58:21–27. doi:10.1387/ijdb.140007XL. PMID:24860991.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76. doi:10.1016/j.cell.2006.07.024. PMID:16904174.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–72. doi:10.1016/j.cell.2007.11.019. PMID:18035408.
   PubMed Web of Science ®Google Scholar
• Kang L, Kou Z, Zhang Y, Gao S. Induced pluripotent stem cells (iPSCs)-a new era of reprogramming. J Genet Genomics. 2010;37:415–21. doi:10.1016/S1673-8527(09)60060-6. PMID:20659705.
   PubMed Web of Science ®Google Scholar
• Teng HF, Kuo YL, Loo MR, Li CL, Chu TW, Suo H, Liu HS, Lin KH, Chen SL. Valproic acid enhances Oct4 promoter activity in myogenic cells. J Cell Biochem. 2010;110:995–1004. doi:10.1002/jcb.22613. PMID:20564199.
   PubMed Web of Science ®Google Scholar
• David L, Polo JM. Phases of reprogramming. Stem Cell Res. 2014;12:754–61. doi:10.1016/j.scr.2014.03.007. PMID:24735951.
   PubMed Web of Science ®Google Scholar
• Niemann H. Epigenetic reprogramming in mammalian species after SCNT-based cloning. Theriogenology. 2016;86:80–90. doi:10.1016/j.theriogenology.2016.04.021. PMID:27160443.
   PubMed Web of Science ®Google Scholar
• Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W. Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci U S A. 2001;98:13734–38. doi:10.1073/pnas.241522698. PMID:11717434.
   PubMed Web of Science ®Google Scholar
• Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science. 2001;293:1089–93. doi:10.1126/science.1063443. PMID:11498579.
   PubMed Web of Science ®Google Scholar
• Dinnyes A, Tian XC, Yang X. Epigenetic regulation of foetal development in nuclear transfer animal models. Reprod Domest Anim. 2008;43:302–09. doi:10.1111/j.1439-0531.2008.01178.x. PMID:18638139.
   PubMed Web of Science ®Google Scholar
• Urrego R, Rodriguez-Osorio N, Niemann H. Epigenetic disorders and altered gene expression after use of assisted reproductive technologies in domestic cattle. Epigenetics. 2014;9:803–15. doi:10.4161/epi.28711. PMID:24709985.
   PubMed Web of Science ®Google Scholar
• Kungulovski G, Jeltsch A. Epigenome editing: state of the art, concepts, and perspectives. Trends Genet. 2016;32:101–13. doi:10.1016/j.tig.2015.12.001. PMID:26732754.
   PubMed Web of Science ®Google Scholar
• Sepulveda-Rincon L, Solanas EL, Serrano-Revuelta E, Ruddick L, Maalouf WE, Beaujean N. Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology. 2016;86:91–98. doi:10.1016/j.theriogenology.2016.04.022. PMID:27156679.
   PubMed Web of Science ®Google Scholar
• Golbabapour S, Abdulla MA, Hajrezaei M. A concise review on epigenetic regulation: insight into molecular mechanisms. Int J Mol Sci. 2011;12:8661–94. doi:10.3390/ijms12128661. PMID:22272098.
   PubMed Web of Science ®Google Scholar
• Triantaphyllopoulos K, Ikonomopoulos I, Bannister AJ. Epigenetics and inheritance of phenotype variation in livestock. Epigenetics Chromatin. 2016;9:31. doi:10.1186/s13072-016-0081-5.
   PubMed Web of Science ®Google Scholar
• Reik W, Santos F, Mitsuya K, Morgan H, Dean W. Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment? Philos Trans R Soc Lond B Biol Sci. 2003;358:1403–09. doi:10.1098/rstb.2003.1326.
   PubMed Web of Science ®Google Scholar
• Eilertsen KJ, Power RA, Harkins LL, Misica P. Targeting cellular memory to reprogram the epigenome, restore potential, and improve somatic cell nuclear transfer. Anim Reprod Sci. 2007;98:129–46. doi:10.1016/j.anireprosci.2006.10.019. PMID:17166676.
   PubMed Web of Science ®Google Scholar
• Zhao J, Whyte J, Prather RS. Effect of epigenetic regulation during swine embryogenesis and on cloning by nuclear transfer. Cell Tissue Res. 2010;341:13–21. doi:10.1007/s00441-010-1000-x. PMID:20563602.
   PubMed Web of Science ®Google Scholar
• Leung A, Schones DE, Natarajan R. Using epigenetic mechanisms to understand the impact of common disease causing alleles. Curr Opin Immunol. 2012;24:558–63. doi:10.1016/j.coi.2012.07.004. PMID:22857822.
   PubMed Web of Science ®Google Scholar
• Niemann H, Tian XC, King WA, Lee RSF. Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning. Reproduction. 2008;135:151–63. doi:10.1530/REP-07-0397. PMID:18239046.
   PubMed Web of Science ®Google Scholar
• Hochedlinger K, Jaenisch R. Nuclear transplantation, embryonic stem cells and the potential for cell therapy. N Eng J Med. 2003;349:275–86. doi:10.1056/NEJMra035397. PMID:12867612.
   PubMed Web of Science ®Google Scholar
• Han YM, Kang YK, Koo DB, Lee KK. Nuclear reprogramming of cloned embryos produced in vitro. Theriogenology. 2003;59:33–44. doi:10.1016/S0093-691X(02)01271-2. PMID:12499016.
   PubMed Web of Science ®Google Scholar
• Dean W, Santos F, Reik W. Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Semin Cell Dev Biol. 2003;14:93–100. doi:10.1016/S1084-9521(02)00141-6.
   PubMed Web of Science ®Google Scholar
• Bestor TH. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J. 1992;11:2611–7. PMID:1628623.
   PubMed Web of Science ®Google Scholar
• Hsieh CL. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol. 1999;19:8211–8. doi:10.1128/MCB.19.12.8211. PMID:10567546.
   PubMed Web of Science ®Google Scholar
• Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH. Dnmt3L and the establishment of maternal genomic imprints. Science. 2001;294:2536–9. doi:10.1126/science.1065848. PMID:11719692.
   PubMed Web of Science ®Google Scholar
• Bourc´his D, Bouhis DL, Patin D, Niveleau A, Comizzoli P, Renard JP, Viegas-Péquignot E. Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos. Curr Biol. 2001;11:1542–46. doi:10.1016/S0960-9822(01)00480-8. PMID:11591324.
   PubMed Web of Science ®Google Scholar
• Kang YK, Koo DB, Park JS, Choi YH, Chung AS, Lee KK, Han YM. Aberrant methylation of donor genome in cloned bovine embryos. Nat Genet. 2001;28:173–7. doi:10.1038/88903. PMID:11381267.
   PubMed Web of Science ®Google Scholar
• Kang YK, Koo DB, Park JS, Choi YH, Kim HN, Chang WK, Lee KK, Han YM. Typical demethylation events in cloned pig embryos: Clues on species-specific differences in epigenetic reprogramming of a cloned donor genome. J Biol Chem. 2001;276:39980–4. doi:10.1074/jbc.M106516200. PMID:11524426.
   PubMed Web of Science ®Google Scholar
• Santos F, Zakhartchenko V, Stojkovic M, Peters A, Jenuwein T, Wolf E, Reik W, Dean W. Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol. 2003;13:1116–21. doi:10.1016/S0960-9822(03)00419-6. PMID:12842010.
   PubMed Web of Science ®Google Scholar
• Kimmins S, Sassone-Corsi P. Chromatin remodelling and epigenetic features of germ cells. Nature. 2005;434:583–89. doi:10.1038/nature03368. PMID:15800613.
   PubMed Web of Science ®Google Scholar
• Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693–705. doi:10.1016/j.cell.2007.02.005. PMID:17320507.
   PubMed Web of Science ®Google Scholar
• Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites. Cell. 2002;111:185–96. doi:10.1016/S0092-8674(02)00975-3. PMID:12408863.
   PubMed Web of Science ®Google Scholar
• Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev. 2004;18:1592–605. doi:10.1101/gad.1200204.
   PubMed Web of Science ®Google Scholar
• Keefer CL. Artificial cloning of domestic animals. Proc Natl Acad Sci. 2015;112:8874–8. doi:10.1073/pnas.1501718112.
   PubMed Web of Science ®Google Scholar
• Enright BP, Sung LY, Chang CC, Yang X, Tian XC. Methylation and Acetylation Characteristics of Cloned Bovine Embryos from Donor Cells Treated with 5-aza-2′-Deoxycytidine. Biol Reprod. 2005;72:944–8. doi:10.1095/biolreprod.104.033225. PMID:15601924.
   PubMed Web of Science ®Google Scholar
• Huan YJ, Zhu J, Xie BT, Wang JY, Liu SC, Zhou Y, Kong QR, He HB, Liu ZH. Treating cloned embryos, but not donor cells, with 5-aza-2´-deoxycytidine enhances the developmental competence of porcine cloned embryos. J Reprod Dev. 2013;59:442–49. doi:10.1262/jrd.2013-026. PMID:23748715.
   PubMed Web of Science ®Google Scholar
• Jeong YIK, Park CH, Kim SH, Jeong YW, Lee JY, Woo PS, Lee SY, Hyun SH, Kim YW, Shin T, et al. Effects of trichostatin A on in vitro development of porcine embryos derived from somatic cell nuclear transfer. Asian-Australas J Anim Sci. 2013;26:1680–8. doi:10.5713/ajas.2013.13029. PMID:25049758.
   PubMed Web of Science ®Google Scholar
• Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003;130:1673–80. doi:10.1242/dev.00366. PMID:12620990.
   PubMed Web of Science ®Google Scholar
• Hai T, Hao J, Wang L, Jouneau A, Zhou Q. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histones deacetylase inhibitor TSA. Cell Reprogram. 2011;13:47–56. doi:10.1089/cell.2010.0042. PMID:21241188.
   PubMed Web of Science ®Google Scholar
• Wang Y, Su J, Wang L, Xu W, Quan F, Liu J, Zhang Y. The effects of 5-aza-2′- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. Cell Reprogram. 2011;13:297–306. doi:10.1089/cell.2010.0098. PMID:21486115.
   PubMed Web of Science ®Google Scholar
• Iager AE, Ragina NP, Ross PJ, Beyhan Z, Cunniff K, Rodriguez RM, Cibelli JB. Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. Cloning Stem Cell. 2008;10:371–79. doi:10.1089/clo.2007.0002. PMID:18419249.
   PubMedGoogle Scholar
• Thuan NV, Bui HT, Kim JH, Hikichi T, Wakayama S, Kishigami S, Mizutani E, Wakayama T. The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice. Reproduction. 2009;138:309–17. doi:10.1530/REP-08-0299. PMID:19433501.
   PubMed Web of Science ®Google Scholar
• Bui HT, Wakayama S, Kishigami S, Park KK, Kim JH, Thuan NV, Wakayama T. Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. Biol Reprod. 2010;83:454–63. doi:10.1095/biolreprod.109.083337. PMID:20505166.
   PubMed Web of Science ®Google Scholar
• Xu W, Li Z, Yu B, He X, Shi J, Zhou R, Kiu D, Wu Z. Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer. PLoS One. 2013;8:e64705. doi:10.1371/journal.pone.0064705.
   PubMed Web of Science ®Google Scholar
• Hou L, Ma F, Yang J, Riaz H, Wang Y, Wu W, Xia X, Ma Z, Zhou Y, Zhang L, et al. Effect of histones deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2014;16:253–65. doi:10.1089/cell.2013.0058. PMID:24960409.
   PubMed Web of Science ®Google Scholar
• Huang Y, Tang X, Xie W, Zhou Y, Li D, Yao C, Zhou Y, Zhu J, Lai L, Ouyang H, et al. Histone deacetylase inhibitor significantly improved the cloning efficiency of porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2011;13:513–20. PMID:22029418.
   PubMed Web of Science ®Google Scholar
• Xu W, Wang Y, Li Y, Wang L, Xiong X, Su J, Zhang Y. Valporic acid improves the in vitro development competence of bovine somatic cell nuclear transfer embryos. Cell Reprogram. 2012;14:138–45. PMID:22372575.
   PubMed Web of Science ®Google Scholar
• Sangalli JR, Chiaratti MR, De Bem THC, de Araújo RR, Bressan FF, Sampaio RV, Perecin F, Smith LC, King WA, Meirelles FV. Development to term of cloned cattle derived from donor cells treated with valporic acid. PLoS One. 2014;9:e101022. doi:10.1371/journal.pone.0101022.
   PubMed Web of Science ®Google Scholar
• Wrenzycki C, Herrmann D, Keskintepe L, Martins A Jr, Sirisathien S, Brackett B, Niemann H. Effect of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos. Hum Reprod. 2001;16:893–901. doi:10.1093/humrep/16.5.893. PMID:11331635.
   PubMed Web of Science ®Google Scholar
• Young LE, Fernandes K, McEvoy TG, Butterwith SC, Gutierrez CG, Carolan C, Broadbent PJ, Robinson JJ, Wilmut I, Sinclair KD. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet. 2001;27:153–54. doi:10.1038/84769. PMID:11175780.
   PubMed Web of Science ®Google Scholar
• Farin PW, Piedrahita JA, Farin CE. Errors in development of fetuses and placentas from in vitro-produced bovine embryos. Theriogenology. 2006;65:178–91. doi:10.1016/j.theriogenology.2005.09.022. PMID:16266745.
   PubMed Web of Science ®Google Scholar
• Lonergan P, Fair T, Corcoran D, Evans ACO. Effect of culture environment on gene expression and developmental characteristics in IVF-derived embryos. Theriogenology. 2006;65:137–52. doi:10.1016/j.theriogenology.2005.09.028. PMID:16289260.
   PubMed Web of Science ®Google Scholar
• Rizos D, Gutiérrez-Adán A, Pérez-Garnelo S, De la Fuente J, Boland MP, Lonergan P. Bovine embryo culture in the presence or absence of serum: implications for blastocyst development, cryotolerance, and messenger RNA expression. Biol Reprod. 2003;68:236–43. doi:10.1095/biolreprod.102.007799. PMID:12493719.
   PubMed Web of Science ®Google Scholar
• Rizos D, Lonergan P, Boland MP, Arroyo-García R, Pintado B, De la Fuente J, Gutiérrez-Adán A. Analysis of differential messenger RNA expression between bovine blastocysts produced in different culture systems: Implications for blastocyst quality. Biol Reprod. 2002;66:589–95. doi:10.1095/biolreprod66.3.589. PMID:11870062.
   PubMed Web of Science ®Google Scholar
• Farin CE, Farin PW, Piedrahita JA. Development of fetuses from in vitro-produced and cloned bovine embryos. J Anim Sci. 2004;82:E53–62. PMID:15471815.
   PubMedGoogle Scholar
• Lee K, Redel BK, Spate LEE, Teson J, Brown AN, Park K, Walters E, Samuel M, Murphy CN, Prather RS. Piglets produced from cloned blastocysts cultured in vitro with GM-CSF. Mol Reprod Dev. 2013;80:145–54. doi:10.1002/mrd.22143. PMID:23239239.
   PubMed Web of Science ®Google Scholar
• Chesné P, Adenot PG, Viglietta C, Baratte M, Boulanger L, Renard JP. Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat Biotechnol. 2002;20:366–69. doi:10.1038/nbt0402-366. PMID:11923842.
   PubMed Web of Science ®Google Scholar
• Hansen PJ, Dobbs KB, Denicol AC, Siqueira LGB. Sex and the preimplantation embryo: implications of sexual dimorphism in the preimplantation period for maternal programming of embryonic development. Cell Tissue Res. 2016;363:237–47. doi:10.1007/s00441-015-2287-4. PMID:26391275.
   PubMed Web of Science ®Google Scholar
• Serrano A, Decara JM, Fernández-Gonzalez R, Lopez-Cardona AP, Pavón FJ, Orio L, Alen F, Gutierrez-Adan A, de Fonseca FR. Hyperplastic Obesity and Liver Steatosis as Long-Term Consequences of Suboptimal In Vitro Culture of Mouse Embryos. Biol Reprod. 2014;91:1–14. doi:10.1095/biolreprod.114.117879.
   Web of Science ®Google Scholar
• Sjöblom C, Roberts CT, Wikland M, Robertson SA. Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis. Endocrinology. 2005;146:2142–53. doi:10.1210/en.2004-1260. PMID:15705781.
   PubMed Web of Science ®Google Scholar
• Loureiro B, Bonilla L, Block J, Fear JM, Bonilla AQS, Hansen PJ. Colony-stimulating factor 2 (CSF-2) improves development and posttransfer survival of bovine embryos produced in vitro. Endocrinology. 2009;150:5046–54. doi:10.1210/en.2009-0481. PMID:19797121.
   PubMed Web of Science ®Google Scholar
• Block J, Hansen PJ, Loureiro B, Bonilla L. Improving post-transfer survival of bovine embryos produced in vitro: Actions of insulin-like growth factor-1, colony stimulating factor-2 and hyaluronan. Theriogenology. 2011;76:1602–9. doi:10.1016/j.theriogenology.2011.07.025. PMID:21890189.
   PubMed Web of Science ®Google Scholar
• Loureiro B, Block J, Favoreto MG, Carambula S, Pennington KA, Ealy AD, Hansen PJ. Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-Τ secretion, and gene expression. Reproduction. 2011;141:617–24. doi:10.1530/REP-10-0511. PMID:21339286.
   PubMed Web of Science ®Google Scholar
• Banrezes B, Sainte-Beuve T, Canon E, Schultz RM, Cancela J, Ozil JP. Adult body weight is programmed by a redox-regulated and energy-dependent process during the pronuclear stage in mouse. PLoS ONE. 2011;6:1–11. doi:10.1371/journal.pone.0029388.
   Web of Science ®Google Scholar
• Vajta G, Gjerris M. Science and technology of farm animal cloning: State of the art. Anim Reprod Sci. 2006;92:211–30. doi:10.1016/j.anireprosci.2005.12.001. PMID:16406426.
   PubMed Web of Science ®Google Scholar
• McEvoy TG, Robinson JJ, Ashworth CJ, Rooke JA, Sinclair KD. Feed and forage toxicants affecting embryo survival and fetal development. Theriogenology. 2001;55:113–29. doi:10.1016/S0093-691X(00)00450-7. PMID:11198077.
   PubMed Web of Science ®Google Scholar
• McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005;85:571–633. doi:10.1152/physrev.00053.2003. PMID:15788706.
   PubMed Web of Science ®Google Scholar
• Hill JR, Roussel AJ, Cibelli JB, Edwards JF, Hooper NL, Miller MW, Thompson JA, Looney CR, Westhusin ME, Robl JM, et al. Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies). Theriogenology. 1999;51:1451–65. doi:10.1016/S0093-691X(99)00089-8. PMID:10729073.
   PubMed Web of Science ®Google Scholar
• Wells DN, Misica PM, Tervit HR. Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells. Biol Reprod. 1999;60:996–1005. doi:10.1095/biolreprod60.4.996. PMID:10084977.
   PubMed Web of Science ®Google Scholar
• Koo DB, Kang YK, Choi YH, Park JS, Kim HN, Oh KB, Son DS, Park H, Lee KK, Han YM. Aberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts. Biol Reprod. 2002;67:487–92. doi:10.1095/biolreprod67.2.487. PMID:12135886.
   PubMed Web of Science ®Google Scholar
• Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N, et al. Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells. Science. 2000;288:665–9. doi:10.1126/science.288.5466.665. PMID:10784448.
   PubMed Web of Science ®Google Scholar
• Chavatte-Palmer P, Heyman Y, Richard C, Monget P, LeBourhis D, Kann G, Chilliard Y, Vignon X, Renard JP. Clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells. Biol Reprod. 2002;66:1596–603. doi:10.1095/biolreprod66.6.1596. PMID:12021036.
   PubMed Web of Science ®Google Scholar
• Chavatte-Palmer P, Remy D, Cordonnier N, Richard C, Issenman H, Laigre P, Heyman Y, Mialot JP. Health status of cloned cattle at different ages. Cloning Stem Cell. 2004;6:94–100. doi:10.1089/1536230041372274. PMID:15268782.
   PubMedGoogle Scholar
• Sado T, Sakaguchi T. Species-specific differences in X chromosome inactivation in mammals. Reproduction. 2013;146:R131–9. doi:10.1530/REP-13-0173. PMID:23847260.
   PubMed Web of Science ®Google Scholar
• Oikawa M, Inoue K, Shiura H, Matoba S, Kamimura S, Hirose M, Mekada K, Yoshiki A, Tanaka S, Abe K, et al. Understanding the X chromosome inactivation cycle in mice. Epigenetics. 2014;9:204–11. doi:10.4161/epi.26939. PMID:24172050.
   PubMed Web of Science ®Google Scholar
• Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, et al. Impeding Xist Expression from the active X chromosome improves mouse somatic cell nuclear transfer. Science. 2010;330:496–9. doi:10.1126/science.1194174. PMID:20847234.
   PubMed Web of Science ®Google Scholar
• Matoba S, Inoue K, Kohda T, Sugimoto M, Mizutani E, Ogonuki N, Nakamura T, Abe K, Nakano T, Ishino F, et al. RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. Proc Natl Acad Sci U S A. 2011;108:20621–6. doi:10.1073/pnas.1112664108. PMID:22065773.
   PubMed Web of Science ®Google Scholar
• Jiang L, Jobst P, Lai L, Samuel M, Prather RS, Ayares D, Yang X, Tian XC. Expression of X-linked genes in deceased neonates and surviving cloned female piglets. Mol Reprod Dev. 2008;75:265–73. doi:10.1002/mrd.20758. PMID:17474099.
   PubMed Web of Science ®Google Scholar
• Park CH, Jeong YH, Jeong YI, Lee SY, Jeong YW, Shin T, Kim NH, Jeung EB, Hyun SH, Lee CK, et al. X-Linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts. PLoS ONE. 2012;7:1–12. doi:10.1371/journal.pone.0051398.
   Web of Science ®Google Scholar
• Yuan L, Wang A, Yao C, Huang Y, Duan F, Lv Q, Wang D, Ouyang H, Li Z, Lai L. Aberrant expression of xist in aborted porcine fetuses derived from somatic cell nuclear transfer embryos. Int J Mol Sci. 2014;15:21631–43. doi:10.3390/ijms151221631. PMID:25429426.
   PubMed Web of Science ®Google Scholar
• Zeng F, Huang Z, Yuan Y, Shi J, Cai G. Effects of RNAi-mediated knockdown of Xist on the developmental efficiency of cloned male 1 porcine embryos. J Reprod Dev. 2016;62:591–7. doi:10.1262/jrd.2016-095. PMID:27569767.
   PubMed Web of Science ®Google Scholar