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Review

The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications

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Article: 2177484 | Received 15 Sep 2022, Accepted 03 Feb 2023, Published online: 22 Feb 2023

References

  • Guo H, Callaway J, Ting JY . Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21:677–14. https://doi.org/10.1038/nm.3893.
  • Zheng D, Liwinski T, Elinav E. Inflammasome activation and regulation: toward a better understanding of complex mechanisms. Cell Discov. 2020;6:36. https://doi.org/10.1038/s41421-020-0167-x.
  • Sun Q, Fan J, Billiar TR, et al. Inflammasome and autophagy regulation - a two-way street. Mol Med. 2017;23:188–95. https://doi.org/10.2119/molmed.2017.00077.
  • Krakauer T. Inflammasomes, autophagy, and cell death: the Trinity of innate host defense against intracellular bacteria. Mediators Inflamm. 2019;2471215:1–10. https://doi.org/10.1155/2019/2471215.
  • Swanson KV, Deng M, Ting JP-Y. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat. Rev. Immunol. 2019;8:477–89. https://doi.org/10.1038/s41577-019-0165-0.
  • Laer L, Huizing E, Verstreken M, et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat Genet. 1998;20:194–97. https://doi.org/10.1038/2503.
  • Zou J, Zheng Y, Huang Y, et al. The versatile gasdermin family: their function and roles in diseases. Front. Immunol. 2021;12:751533. https://doi.org/10.3389/fimmu.2021.751533.
  • Saeki N, Kuwahara Y, Sasaki H, et al. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mammalian Genome. 2000;11:718–24. https://doi.org/10.1007/s003350010138.
  • Tamura M, Tanaka S, Fujii T, et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics. 2007;89:618–29. https://doi.org/10.1016/j.ygeno.2007.01.003.
  • Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nat. 2015;526:660–665. https://doi.org/10.1038/nature15514.
  • Kayagaki N, Stowe I, Lee B, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nat. 2015;526:666–71. https://doi.org/10.1038/nature15541.
  • He W, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 2015;25:1285–98. https://doi.org/10.1038/cr.2015.139.
  • Taghavi S, Askari R. Liver trauma.Treasure island (FL). StatPearls Publishing; 2022.
  • Badger SA, Barclay R, Campbell P, et al. Management of liver trauma. World J Surg. 2009;33:2522–37. https://doi.org/10.1007/s00268-009-0215-z.
  • Rodríguez-Antonio I, López-Sánchez GN, Uribe M, et al. Role of the inflammasome, gasdermin D, and pyroptosis in non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2021;36:2720–27. https://doi.org/10.1111/jgh.15561.
  • Xu B, Jiang M, Chu Y, et al. Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. J Hepatol. 2018;68:773–82. https://doi.org/10.1016/j.jhep.2017.11.040.
  • Yin K, Zhou X, Jiang W, et al. Jiangzhi ligan decoction inhibits GSDMD-Mediated canonical/noncanonical pyroptosis pathways and alleviates high-fat diet-induced nonalcoholic fatty liver disease. Disease Markers. 2021;9963534:1–11. https://doi.org/10.1155/2021/9963534.
  • Beier JI, Banales JM. Pyroptosis: an inflammatory link between NAFLD and NASH with potential therapeutic implications. J. Hepatol. 2021;68:643–45. https://doi.org/10.1016/j.jhep.2018.01.017.
  • Gaul S, Leszczynska A, Alegre F, et al. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021;74:156–67.
  • Wang J, Shi K, An N, et al. Direct inhibition of GSDMD by PEITC reduces hepatocyte pyroptosis and alleviates acute liver injury in mice. Front. Immunol. 2022;13:825428. https://doi.org/10.3389/fimmu.2022.825428.
  • Wu Y-L, Ou W, Lin S, et al. GSDMD inhibitor NECROSULFONAMIDE protects mice from galactosamine/lipopolysaccharide-induced acute liver failure via pyrotosis pathway. J Clin Transl Hepatol. 2020:73. https://doi.org/10.1016/s0168-8278(20.
  • Li J, Hao JH, Yao D, et al. Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia. CNS Neurosci Ther. 2020;26:925–39.
  • Ye B, Chen X, Dai S, et al. Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Des Devel Ther. 2019;13:975–90. https://doi.org/10.2147/DDDT.S195412.
  • Gao J, Chen Y, Wang H, et al. Gasdermin D deficiency in vascular smooth muscle cells ameliorates abdominal aortic aneurysm through reducing putrescine synthesis. Adv Sci. 2022:e2204038. https://doi.org/10.1002/advs.202204038.
  • Luo YP, Jiang L, Kang K, et al. Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1. Int Immunopharmacol. 2014;20:24–32. https://doi.org/10.1016/j.intimp.2014.02.017.
  • Yang JW, Mao B, Tao RJ, et al. Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. J Cell Mol Med. 2020;24:12716–25. https://doi.org/10.1111/jcmm.15849.
  • Zhang XP, Zhang WT, Qiu Y, et al. Cyclic helix B peptide alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation in alveolar macrophages. Int Immunopharmacol. 2020;88:106849. https://doi.org/10.1016/j.intimp.2020.106849.
  • Shao XF, Li B, Shen J, et al. Ghrelin alleviates traumatic brain injury-induced acute lung injury through pyroptosis/NF-κB pathway. Int Immunopharmacol. 2020;79:106175. https://doi.org/10.1016/j.intimp.2019.106175.
  • Vats R, Kaminski TW, Brzoska T, et al. Liver-to-lung microembolic NETs promote gasdermin D-dependent inflammatory lung injury in sickle cell disease. Blood. 2022;140:1020–37. https://doi.org/10.1182/blood.2021014552.
  • Xiao C, Zhao H, Zhu H, et al. Tisp40 induces tubular epithelial cell GSDMD-mediated pyroptosis in renal ischemia-reperfusion injury via NF-κB signaling. Front. Physiol. 2020;11:906. https://doi.org/10.3389/fphys.2020.00906.
  • Ma C, Yang D, Wang B, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6:eaaz6717. https://doi.org/10.1126/sciadv.aaz6717.
  • Wang N, Kong R, Han W, et al. Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro. Int Immunopharmacol. 2022;111:109058. https://doi.org/10.1016/j.intimp.2022.109058.
  • Rathkey JK, Zhao J, Liu Z, et al. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci Immunol. 2018;3:eaat2738. https://doi.org/10.1126/sciimmunol.aat2738.
  • de Rivero Vaccari JP. Carbon monoxide releasing molecule-3 inhibits inflammasome activation: a potential therapy for spinal cord injury. EBioMedicine. 2019;40:17–18. https://doi.org/10.1016/j.ebiom.2019.01.020.
  • Yang C, Sun P, Deng M, et al. Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis. Cell Death Dis. 2019;10:481. https://doi.org/10.1038/s41419-019-1719-6.
  • Sun P, Zhong J, Liao H, et al. Hepatocytes are resistant to cell death from canonical and non-canonical inflammasome-activated pyroptosis. Cmgh. 2020;13:739–57. https://doi.org/10.1016/j.jcmgh.2021.11.009.
  • Xingyu L, Jiang C, Jiayan H, et al. Gasdermin D–mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy. Hepatol Commun. 2022;6:2340–53. https://doi.org/10.1002/hep4.1973.
  • Yamagishi R, Kamachi F, Nakamura M, et al. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol. 2022;7:eabl7209. https://doi.org/10.1126/sciimmunol.abl7209.
  • Li J, Zhao J, Xu M, et al. Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury. Cell Death Dis. 2020;11:244. https://doi.org/10.1038/s41419-020-2437-9.
  • Yang X, Cheng X, Tang Y, et al. Bacterial endotoxin activates the coagulation cascade through gasdermin d-dependent phosphatidylserine exposure. Immunity. 2019;51:983–996.e6.
  • Wang K, Sun Z, Ru J, et al. Ablation of GSDMD improves outcome of ischemic stroke through blocking canonical and non-canonical inflammasomes dependent pyroptosis in microglia. Front. Neurol. 2020;11:577927. https://doi.org/10.3389/fneur.2020.577927.
  • Zhou K, Shi L, Wang Y, et al. Recent advances of the NLRP3 inflammasome in central nervous system disorders. J. Immunol. Res. 2016;9238290:1–9. https://doi.org/10.1155/2016/9238290.
  • Shao BZ, Cao Q, Liu C. Targeting NLRP3 inflammasome in the treatment of CNS diseases. Front. Mol. Neurosci. 2018;11:320. https://doi.org/10.3389/fnmol.2018.00320.
  • Walsh J, Muruve D, Power C. Inflammasomes in the CNS. Nat Rev Neurosci. 2014;15:84–97. https://doi.org/10.1038/nrn3638.
  • Song L, Pei L, Yao S, et al. NLRP3 inflammasome in neurological diseases, from functions to therapies. Front. Cell. Neurosci. 2017;11:63. https://doi.org/10.3389/fncel.2017.00063.
  • Zhang D, Qian J, Zhang P, et al. Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro. Journal of Neuroscience Research. 2019;97:645–60. https://doi.org/10.1002/jnr.24385.
  • Yuan B, Zhou XM, You ZQ, et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dois. 2021;11:76. https://doi.org/10.1038/s41419-020-2248-z.
  • Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9:7204–18. https://doi.org/10.18632/oncotarget.23208.
  • Okada S. The pathophysiological role of acute inflammation after spinal cord injury. Inflamm and regener. 2016;36:20. https://doi.org/10.1186/s41232-016-0026-1.
  • Dai W, Wang X, Teng H, et al. Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. Int Immunopharmacol. 2019;66:215–23. https://doi.org/10.1016/j.intimp.2018.11.029.
  • Xu S, Wang J, Zhong J, et al. CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling. Clin Transl Med. 2021;11:e269. https://doi.org/10.1002/ctm2.269.
  • Al Mamun A, Wu Y, Monalisa I, et al. Role of pyroptosis in spinal cord injury and its therapeutic implications. J Advanced Res. 2020;28:97–109. https://doi.org/10.1016/j.jare.2020.08.004.
  • Wang SN, Guo XY, Tang J, et al. Expression and localization of absent in melanoma 2 in the injured spinal cord. Neural Regen Res. 2019;14:542–52. https://doi.org/10.4103/1673-5374.245481.
  • Jiang K, Tu Z, Chen K, et al. Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction. J Clin Invest. 2022;132:e151268. https://doi.org/10.1172/JCI151268.
  • Han B, Xu J, Shi X. et al. DL-3-n-Butylphthalide attenuates myocardial hypertrophy by targeting gasdermin D and inhibiting gasdermin D mediated inflammation. Front Pharmacol. 2021;12:688140. https://doi.org/10.3389/fphar.2021.688140.
  • Wang Y, Liu Q, Zheng Q, et al. Dihydromyricetin Alleviates sepsis-induced acute lung injury through inhibiting NLRP3 inflammasome-dependent pyroptosis in mice model. Inflamm. 2019;42:1301–10. https://doi.org/10.1007/s10753-019-00990-7.
  • Wu J, Zhang J, Zhao J, et al. Treatment of severe acute pancreatitis and related lung injury by targeting gasdermin D-mediated pyroptosis. Front.Cell Dev. Biol. 2021;9:780142. https://doi.org/10.3389/fcell.2021.780142.
  • Lin T, Song J, Pan X, et al. Downregulating Gasdermin D reduces severe acute pancreatitis associated with pyroptosis. Med Sci Monit. 2021;27:e927968. https://doi.org/10.12659/MSM.927968.
  • Silva C, Wanderley C, Veras FP, et al. Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. Blood. 2021;138:2702–13. https://doi.org/10.1182/blood.2021011525.
  • Jiang S, Zhang H, Li X, et al. Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway. J Steroid Biochem Mol Biol. 2021;206:105789. https://doi.org/10.1016/j.jsbmb.2020.105789.
  • Chen F, Lu J, Yang X, et al. Acetylbritannilactone attenuates contrast-induced acute kidney injury through its anti-pyroptosis effects. Biosci Rep. 2020;40:BSR20193253. https://doi.org/10.1042/BSR20193253.
  • Lei Q, Yi T, Chen C. NF-κB-Gasdermin D (GSDMD) axis couples oxidative stress and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis following myocardial infarction. Med Sci Monit. 2018;24:6044–52. https://doi.org/10.12659/MSM.908529.
  • Shi H, Gao Y, Dong Z, et al. GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I/R injury. Circ Res. 2021;129:383–96. https://doi.org/10.1161/CIRCRESAHA.120.318629.
  • Dai S, Ye B, Zhong L, et al. GSDMD mediates LPS-induced septic myocardial dysfunction by regulating ROS-dependent NLRP3 inflammasome Activation. Front Cell and Dev Biol. 2021;9:779432. https://doi.org/10.3389/fcell.2021.779432.
  • Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell. Mol. Life Sci. 2021;78:1233–61. https://doi.org/10.1007/s00018-020-03656-y.
  • Zhang KZ, Shen XY, Wang M, et al. Retinol-Binding Protein WM. 4 promotes cardiac injury after myocardial infarction via inducing cardiomyocyte pyroptosis through an interaction with NLRP3. Journal of the American Heart Association. 2021;10:e022011. https://doi.org/10.1161/JAHA.121.022011.
  • Wu Y, Pan B, Zhang Z, et al. Caspase-4/11-mediated pulmonary artery endothelial cell pyroptosis contributes to pulmonary arterial hypertension. Hypertension. 2021;79:536–48. https://doi.org/10.1161/HYPERTENSIONAHA.121.17868.
  • Jia C, Zhang J, Chen H, et al. Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. Cell Death Dis. 2019;10:778. https://doi.org/10.1038/s41419-019-2021-3.
  • Wang Q, Wu J, Zeng Y, et al. Pyroptosis: A pro-inflammatory type of cell death in cardiovascular disease. Clinic Chimic Acta. 2020;510:62–72. https://doi.org/10.1016/j.cca.2020.06.044.
  • Yang F, Qin Y, Lv J, et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy. Cell Death Dis. 2018;9:1000. https://doi.org/10.1038/s41419-018-1029-4.
  • Zheng D, Shi Z, Yang M, et al. NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury. Chemosphere. 2021;267:128867. https://doi.org/10.1016/j.chemosphere.2020.128867.
  • Puylaert P, Van Praet M, Vaes F, et al. Gasdermin D deficiency limits the transition of atherosclerotic plaques to an inflammatory phenotype in ApoE knock-out mice. Biomedicines. 2022;10:1171. https://doi.org/10.3390/biomedicines10051171.
  • Mitra S, Exline M, Habyarimana F, et al. Microparticulate caspase HF. 1 Regulates gasdermin D and pulmonary vascular endothelial cell injury. Am Journal Respir Cell Mol Biol. 2018;59:56–64. https://doi.org/10.1165/rcmb.2017-0393OC.
  • Chavez L, Meguro J, Chen S, et al. Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury. J Neuroinflammation. 2021;18:310. https://doi.org/10.1186/s12974-021-02364-z.
  • Martínez MC, Tesse A, Zobairi F, et al. Shed membrane microparticles from circulating and vascular cells in regulating vascular function. Am J Physiol Heart Circ Physiol. 2005;28:H1004–H1009. https://doi.org/10.1152/ajpheart.00842.2004.
  • Martin S, Tesse A, Hugel B, et al. Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation. 2004;109:1653–59. https://doi.org/10.1161/01.CIR.0000124065.31211.6E.
  • Wu DD, Pan PH, Liu B, et al. Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice. Chin Med J (Eng). 2015;128:2638–45. https://doi.org/10.4103/0366-6999.166039.
  • He X, Qian Y, Li Z, et al. TLR4-Upregulated IL-1β and IL-1RI promote alveolar macrophage pyroptosis and lung inflammation through an autocrine mechanism. Sci Rep. 2016;6:31663. https://doi.org/10.1038/srep31663.
  • Wu D, Pan P, Su X, et al. Interferon regulatory factor-1 mediates alveolar macrophage pyroptosis during LPS-induced acute lung injury in mice. Shock. 2016;46:329–38. https://doi.org/10.1097/SHK.0000000000000595.
  • Yang J, Zhao Y, Zhang P, et al. Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS. Cell Death Dis. 2016;7:e2363. https://doi.org/10.1038/cddis.2016.274.
  • Hu Q, Zhang T, Yi L, et al. Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. BioFactors. 2018;44:123–36. https://doi.org/10.1002/biof.1395.
  • Li D, Li C, Wang T, et al. Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury. Int Immunopharmacol. 2021;100:108106. https://doi.org/10.1016/j.intimp.2021.108106.
  • Xu WJ, Wang XX, Jin JJ, et al. Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. Am J Physiol Lung Cell Mol Physiol. 2019;316:L567–L577. https://doi.org/10.1152/ajplung.00190.2018.
  • Gao H, Cao M, Yao Y. Dysregulated microbiota-driven GASDERMIN D activation promotes colitis development by mediating IL-18 release. Front Immunol. 2022;12:750841. https://doi.org/10.3389/fimmu.2021.750841.
  • Bulek K, Zhao J, Liao Y. Epithelial-derived Gasdermin d mediates nonlytic il-1β release during experimental colitis. J Clin Invest. 2020;130:4218–34. https://doi.org/10.1172/jci138103.
  • Fattinger SA, Maurer L, Geiser P, et al. Gasdermin D is the only Gasdermin that provides non-redundant protection against acute salmonella gut infection. bioRxiv. 2022. https://doi.org/10.1101/2022.11.24.517575.
  • Abdel-Wahab B, Alkahtani S, Alqahtani A, et al. Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats. Environ Sci Pollut Res. 2022;29:37644–59. https://doi.org/10.1007/s11356-021-18252-1.
  • Wang WJ, Chen D, Jiang MZ, et al. Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins. J Dig Dis. 2018;19:74–83. https://doi.org/10.1111/1751-2980.12576.
  • Rana N, Privitera G, Kondolf HC, et al. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell. 2022;185:283–98. https://doi.org/10.1016/j.cell.2021.12.024.
  • Privitera G, Pizarro TT. Live or let die: translational insights and clinical perspectives of gasdermin B-dependent intestinal epithelial cell fate. Clinical and Translational Medicine. 2022;12:e787. [Accessed 24 April 2022]. https://doi.org/10.1002/ctm2.787.
  • Ivanov AI, Rana N, Privitera G, et al. The enigmatic roles of epithelial gasdermin B: recent discoveries and controversies. Trends Cell Biol. 2023;33:48–59. https://doi.org/10.1016/j.tcb.2022.06.006.
  • Xi R, Montague J, Lin X, et al. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Proc Natl Acad of Sci U S A. 2021;118:e2026307118. [Accessed 29 April 2022]. https://doi.org/10.1073/pnas.2026307118.
  • Li Y, Xia W, Wu M, et al. Activation of GSDMD contributes to acute kidney injury induced by cisplatin. Am J Physiol. Renal Physiol. 2020;318:F96–F106. https://doi.org/10.1152/ajprenal.00351.2019.
  • Miao N, Yin F, Xie H, et al. The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury. Kidney Int. 2019;96:1105–20. https://doi.org/10.1016/j.kint.2019.04.035.
  • Wang X, Blanco LP, Carmona-Rivera C, et al. Effects of gasdermin D in modulating murine lupus and its associated organ damage. Arthritis Rheumatol. 2020;72:2118–29. https://doi.org/10.1002/art.41444.
  • Yang T, Sun K, Wang C, et al. Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes. Arthritis Res Ther. 2021;23:286. https://doi.org/10.1186/s13075-021-02668-8.
  • Wang K, Wu W, Jiang X, et al. Multi-Omics Analysis JX. Reveals the protection of gasdermin D in concanavalin A-induced autoimmune hepatitis. Microbiol Spectr. 2022;10:e0171722. https://doi.org/10.1128/spectrum.01717-22.
  • Zhang Z, Zhang Y, Xia S, et al. Gasdermin e suppresses tumour growth by activating anti-tumour immunity. Nat. 2020;579:415–20. https://doi.org/10.1038/s41586-020-2071-9.
  • Zhou B, Abbott DW. Gasdermin e permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. Cell Rep. 2021;35:108998. https://doi.org/10.1016/j.celrep.2021.108998.
  • Wang Y, Peng J, Xie X, et al. Gasdermin e-mediated programmed cell death: an unpaved path to tumor suppression. J Cancer. 2021;12:5241–48. https://doi.org/10.7150/jca.48989.
  • Das S, Miller M, Beppu AK, et al. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016;113:13132–37. https://doi.org/10.1073/pnas.1610433113.
  • Söderman J, Berglind L, Almer S. Gene expression-Genotype AS Analysis implicates GSDMA, GSDMB, and LRRC3C as contributors to inflammatory bowel disease susceptibility. BioMed Res Int. 2015:834805. https://doi.org/10.1155/2015/834805.
  • J-yuan Z, Zhou B, R-yue S, et al. The metabolite α-kg induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Res. 2021;31:980–97. https://doi.org/10.1038/s41422-021-00506-9.
  • Hu JJ, Liu X, Xia S, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020;21:736–45. https://doi.org/10.1038/s41590-020-0669-6.