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Review

Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis

, , , &
Pages 391-401 | Received 29 Aug 2016, Accepted 16 Oct 2016, Published online: 01 Dec 2016

References

  • He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522-31; PMID:15211354; http://dx.doi.org/10.1038/nrg1379
  • Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev 2009; 23:781-3; PMID:19339683; http://dx.doi.org/10.1101/gad.1787609
  • Malumbres M. miRNAs and cancer: An epigenetics view. Mol Aspects Med 2013; 34:863-74; PMID:22771542; http://dx.doi.org/10.1016/j.mam.2012.06.005
  • Fabris L, Calin GA. Circulating free xeno-microRNAs - The new kids on the block. Mol Oncol 2016; 10:503-8; PMID:26860056; http://dx.doi.org/10.1016/j.molonc.2016.01.005
  • Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 2004; 23:4051-60; PMID:15372072; http://dx.doi.org/10.1038/sj.emboj.7600385
  • Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432:235-40; PMID:15531877; http://dx.doi.org/10.1038/nature03120
  • Takeiwa T, Taniguchi I, Ohno M. Exportin-5 mediates nuclear export of SRP RNA in vertebrates. Genes Cells 2015; 20:281-91; PMID:25656399; http://dx.doi.org/10.1111/gtc.12218
  • Meijer HA, Smith EM, Bushell M. Regulation of miRNA strand selection: follow the leader? Biochem Soc Trans 2014; 42:1135-40; PMID:25110015; http://dx.doi.org/10.1042/BST20140142
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-33; PMID:19167326; http://dx.doi.org/10.1016/j.cell.2009.01.002
  • Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9:102-14; PMID:18197166; http://dx.doi.org/10.1038/nrg2290
  • Klopfleisch R, Weiss ATA, Gruber AD. Excavation of a buried treasure–DNA, mRNA, miRNA and protein analysis in formalin fixed, paraffin embedded tissues. Histol Histopathol 2011; 26:797-810; PMID:21472693; http://dx.doi.org/10.14670/HH-26.797
  • Axtell MJ, Westholm JO, Lai EC. Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biol 2011; 12:221; PMID:21554756; http://dx.doi.org/10.1186/gb-2011-12-4-221
  • Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007; 318:1931-4; PMID:18048652; http://dx.doi.org/10.1126/science.1149460
  • Fabbri M, Ivan M, Cimmino A, Negrini M, Calin GA. Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther 2007; 7:1009-19; PMID:17665990; http://dx.doi.org/10.1517/14712598.7.7.1009
  • Perge P, Nagy Z, Igaz I, Igaz P. Suggested roles for microRNA in tumors. Biomol Concepts 2015; 6:149-55; PMID:25870972; http://dx.doi.org/10.1515/bmc-2015-0002
  • Chen CZ. MicroRNAs as oncogenes and tumor suppressors. N Engl J Med 2005; 353:1768-71; PMID:16251533; http://dx.doi.org/10.1056/NEJMp058190
  • Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, Galas DJ, Wang K. The microRNA spectrum in 12 body fluids. Clin Chem 2010; 56:1733-41; PMID:20847327; http://dx.doi.org/10.1373/clinchem.2010.147405
  • Redis RS, Calin S, Yang Y, You MJ, Calin GA. Cell-to-cell miRNA transfer: from body homeostasis to therapy. Pharmacol Ther 2012; 136:169-74; PMID:22903157; http://dx.doi.org/10.1016/j.pharmthera.2012.08.003
  • Reid G, Kirschner MB, van Zandwijk N. Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 2011; 80:193-208; PMID:21145252; http://dx.doi.org/10.1016/j.critrevonc.2010.11.004
  • Collino F, Deregibus MC, Bruno S, Sterpone L, Aghemo G, Viltono L, Tetta C, Camussi G. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One 2010; 5:e11803; PMID:20668554; http://dx.doi.org/10.1371/journal.pone.0011803
  • Pigati L, Yaddanapudi SC, Iyengar R, Kim DJ, Hearn SA, Danforth D, Hastings ML, Duelli DM. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 2010; 5:e13515; PMID:20976003; http://dx.doi.org/10.1371/journal.pone.0013515
  • Guduric-Fuchs J, O'Connor A, Camp B, O'Neill CL, Medina RJ, Simpson DA. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics 2012; 13:357; PMID:22849433; http://dx.doi.org/10.1186/1471-2164-13-357
  • Turchinovich A, Tonevitsky AG, Burwinkel B. Extracellular miRNA: A Collision of Two Paradigms. Trends Biochem Sci 2016; 41:883-92; PMID:27597517; http://dx.doi.org/10.1016/j.tibs.2016.08.004
  • Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008; 3:e3694; PMID:19002258; http://dx.doi.org/10.1371/journal.pone.0003694
  • Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011; 13:423-33; PMID:21423178; http://dx.doi.org/10.1038/ncb2210
  • Camussi G, Deregibus MC, Bruno S, Grange C, Fonsato V, Tetta C. Exosome/microvesicle-mediated epigenetic reprogramming of cells. Am J Cancer Res 2011; 1:98-110; PMID:21969178;
  • Katsuda T, Kosaka N, Ochiya T. The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics 2014; 14:412-25; PMID:24339442; http://dx.doi.org/10.1002/pmic.201300389
  • Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 2014; 25:501-15; PMID:24735924; http://dx.doi.org/10.1016/j.ccr.2014.03.007
  • Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids–the mix of hormones and biomarkers. Nat Rev Clin Oncol 2011; 8:467-77; PMID:21647195; http://dx.doi.org/10.1038/nrclinonc.2011.76
  • Igaz I, Igaz P. Possible role for microRNAs as inter-species mediators of epigenetic information in disease pathogenesis: is the non-coding dark matter of the genome responsible for epigenetic interindividual or interspecies communication? Med Hypotheses 2015; 84:150-4; PMID:25535106; http://dx.doi.org/10.1016/j.mehy.2014.11.021
  • Turchinovich A, Burwinkel B. Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma. RNA Biol 2012; 9:1066-75; PMID:22858679; http://dx.doi.org/10.4161/rna.21083
  • Chevillet JR, Kang Q, Ruf IK, Briggs HA, Vojtech LN, Hughes SM, Cheng HH, Arroyo JD, Meredith EK, Gallichotte EN, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci U S A 2014; 111:14888-93; PMID:25267620; http://dx.doi.org/10.1073/pnas.1408301111
  • Dragovic RA, Gardiner C, Brooks AS, Tannetta DS, Ferguson DJ, Hole P, Carr B, Redman CW, Harris AL, Dobson PJ, et al. Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomedicine 2011; 7:780-8; PMID:21601655; http://dx.doi.org/10.1016/j.nano.2011.04.003
  • Weiland M, Weiland M, Gao XH, Zhou L, Mi QS. Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases. RNA Biol 2012; 9:850-9; PMID:22699556; http://dx.doi.org/10.4161/rna.20378
  • Aucher A, Rudnicka D, Davis DM. MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation. J Immunol 2013; 191:6250-60; PMID:24227773; http://dx.doi.org/10.4049/jimmunol.1301728.
  • Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, et al. Biogenesis, delivery, and function of extracellular RNA. J Extracell vesicles 2015; 4:27494; PMID:26320939; http://dx.doi.org/10.3402/jev.v4.27494
  • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 2012; 109:E2110-6; PMID:22753494; http://dx.doi.org/10.1073/pnas.1209414109
  • Alsaweed M, Hartmann PE, Geddes DT, Kakulas F. MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother. Int J Environ Res Public Health 2015; 12:13981-4020; PMID:26529003; http://dx.doi.org/10.3390/ijerph121113981
  • Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18:997-1006; PMID:18766170; http://dx.doi.org/10.1038/cr.2008.282
  • Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M, Admyre C, Johansson SM, Qazi KR, Filén JJ, et al. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci 2012; 95:4831-41; PMID:22916887; http://dx.doi.org/10.3168/jds.2012-5489
  • Alsaweed M, Lai CT, Hartmann PE, Geddes DT, Kakulas F. Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk. Sci Rep 2016; 6:20680; PMID:26854194; http://dx.doi.org/10.1038/srep20680
  • Melnik BC, Kakulas F, Geddes DT, Hartmann PE, John SM, Carrera-Bastos P, Cordain L, Schmitz G. Milk miRNAs: simple nutrients or systemic functional regulators? Nutr Metab 2016; 13:42; PMID:27330539; http://dx.doi.org/10.1186/s12986-016-0101-2
  • Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence 2010; 1:7; PMID:20226005; http://dx.doi.org/10.1186/1758-907X-1-7
  • Le Guillou S, Sdassi N, Laubier J, Passet B, Vilotte M, Castille J, Laloë D, Polyte J, Bouet S, Jaffrézic F, et al. Overexpression of miR-30b in the developing mouse mammary gland causes a lactation defect and delays involution. PLoS One 2012; 7:e45727; PMID:23029204; http://dx.doi.org/10.1371/journal.pone.0045727
  • Title AC, Denzler R, Stoffel M. Uptake and Function Studies of Maternal Milk-derived MicroRNAs. J Biol Chem 2015; 290:23680-91; PMID:26240150; http://dx.doi.org/10.1074/jbc.M115.676734
  • Naqvi AR, Fordham JB, Nares S. miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells. J Immunol 2015; 194:1916-27;PMID:25601927; http://dx.doi.org/10.4049/jimmunol.1401893
  • Laubier J, Castille J, Le Guillou S, Le Provost F. No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. RNA Biol 2015; 12:26-9; PMID:25763824; http://dx.doi.org/10.1080/15476286.2015.1017212
  • Kopp F, Wagner E, Roidl A. The proto-oncogene KRAS is targeted by miR-200c. Oncotarget 2014; 5:185-95; PMID:24368337; http://dx.doi.org/10.18632/oncotarget.1427
  • Salunkhe VA, Esguerra JL, Ofori JK, Mollet IG, Braun M, Stoffel M, Wendt A, Eliasson L. Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells. Acta Physiol (Oxf) 2015; 213:882-92; PMID:25627423; http://dx.doi.org/10.1111/apha.12460
  • Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nat Genet 2011; 43:854-9; PMID:21857679; http://dx.doi.org/10.1038/ng.905
  • Mullokandov G, Baccarini A, Ruzo A, Jayaprakash AD, Tung N, Israelow B, Evans MJ, Sachidanandam R, Brown BD. High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods 2012; 9:840-6; PMID:22751203; http://dx.doi.org/10.1038/nmeth.2078
  • Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J. Breastfeeding and maternal and infant health outcomes in developed countries. Evid Rep Technol Assess 2007; 1-186; PMID:17764214;
  • Melnik BC, John SM, Carrera-Bastos P, Schmitz G. Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation. Clin Transl Allergy 2016; 6:18; PMID:27175277; http://dx.doi.org/10.1186/s13601-016-0108-9
  • Melnik BC, John SM, Schmitz G. Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? J Transl Med 2014; 12:43; PMID:24521175; http://dx.doi.org/10.1186/1479-5876-12-43
  • Jutel M, Akdis CA. T-cell subset regulation in atopy. Curr Allergy Asthma Rep 2011; 11:139-45; PMID:21271314; http://dx.doi.org/10.1007/s11882-011-0178-7
  • Igaz I, Igaz P. Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids. EXS 2015; 106:281-8; PMID:26608210; http://dx.doi.org/10.1007/978-3-0348-0955-9_14
  • Snow JW, Hale AE, Isaacs SK, Baggish AL, Chan SY. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol 2013; 10:1107-16; PMID:23669076; http://dx.doi.org/10.4161/rna.24909
  • Wolf T, Baier SR, Zempleni J. The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells. J Nutr 2015; 145:2201-6; PMID:26269243; http://dx.doi.org/10.3945/jn.115.218586
  • Izumi H, Tsuda M, Sato Y, Kosaka N, Ochiya T, Iwamoto H, Namba K, Takeda Y, Argyropoulos C, Wang K, et al. Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages. J Dairy Sci 2015; 98:2920-33; PMID:25726110; http://dx.doi.org/10.3168/jds.2012-5489
  • Kusuma RJ, Manca S, Friemel T, Sukreet S, Nguyen C, Zempleni J, Abu-Halima M, Hammadeh M, Schmitt J, Leidinger P, et al. Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis. Am J Physiol Cell Physiol 2016; 310:C800-7; PMID:26984735; http://dx.doi.org/10.1152/ajpcell.00169.2015
  • Howard KM, Jati Kusuma R, Baier SR, Friemel T, Markham L, Vanamala J, Zempleni J. Loss of miRNAs during processing and storage of cow's (Bos taurus) milk. J Agric Food Chem 2015; 63:588-92; PMID:25565082; http://dx.doi.org/10.1021/jf505526w
  • Lucey JA. Raw Milk Consumption: Risks and Benefits. Nutr Today 2015; 50:189-93; PMID:27340300; http://dx.doi.org/10.1097/NT.0000000000000108
  • Baier SR, Nguyen C, Xie F, Wood JR, Zempleni J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr 2014; 144:1495-500; PMID:25122645; http://dx.doi.org/10.3945/jn.114.196436
  • Witwer KW. Diet-responsive mammalian miRNAs are likely endogenous. J Nutr 2014; 144:1880-1; PMID:25332488; http://dx.doi.org/10.3945/jn.114.202523
  • Baier SR, Xie F, Zempleni J. Reply to Witwer. J Nutr 2014; 144:1882; PMID:25332489; http://dx.doi.org/10.3945/jn.114.202606
  • Griffiths-Jones S. miRBase: microRNA Sequences and Annotation. In: Current Protocols in Bioinformatics. 2010; 12.9.1:12.9.10; PMID:20205188, http://dx.doi.org/10.1002/0471250953.bi1209s29
  • Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem 2009; 284:15676-84; PMID:19342382; http://dx.doi.org/10.1074/jbc.M809787200
  • Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E, Botta C, Paolino FM, Del Giudice T, Iuliano E, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 2013; 228:1506-15; PMID:23254643; http://dx.doi.org/10.1002/jcp.24306
  • Melnik BC. The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. Curr Diabetes Rev 2015; 11:46-62; PMID:25587719; http://dx.doi.org/10.2174/1573399811666150114100653
  • Melnik BC, John SM, Schmitz G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J 2013; 12:103; PMID:23883112; http://dx.doi.org/10.1186/1475-2891-12-103
  • Lei BX, Liu ZH, Li ZJ, Li C, Deng Y-F. miR-21 induces cell proliferation and suppresses the chemosensitivity in glioblastoma cells via downregulation of FOXO1. Int J Clin Exp Med 2014; 7:2060-6; PMID:25232387
  • Mersey BD, Jin P, Danner DJ. Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell. Hum Mol Genet 2005; 14:3371-7; PMID:16203741; http://dx.doi.org/10.1093/hmg/ddi368
  • Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008; 283:14910-4; PMID:18411277; http://dx.doi.org/10.1074/jbc.C800074200
  • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008; 9:582-9; PMID:18483486; http://dx.doi.org/10.1038/embor.2008.74
  • Auerbach A, Vyas G, Li A, Halushka M, Witwer K. Uptake of dietary milk miRNAs by adult humans: a validation study. F1000Research 2016; 5:721; PMID:27158459; http://dx.doi.org/10.12688/f1000research.8548.1
  • Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC. Intake of Dairy Products, Calcium, and Vitamin D and Risk of Breast Cancer. CancerSpectrum Knowl Environ 2002; 94:1301-10; PMID:12208895; http://dx.doi.org/10.1093/jnci/94.17.1301
  • Cho E, Smith-Warner SA, Spiegelman D, Beeson WL, van den Brandt PA, Colditz GA, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, et al. Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies. JNCI J Natl Cancer Inst 2004; 96:1015-22; PMID:15240785; http://dx.doi.org/10.1093/jnci/djh185
  • Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 2012; 22:107-26; PMID:21931358; http://dx.doi.org/10.1038/cr.2011.158
  • Witwer KW. XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles. RNA Biol 2012; 9:1147-54; PMID:22951590; http://dx.doi.org/10.4161/rna.21619
  • Semenov DV, Baryakin DN, Brenner EV, Kurilshikov AM, Vasiliev GV, Bryzgalov LA, Chikova ED, Filippova JA, Kuligina EV, Richter VA. Unbiased approach to profile the variety of small non-coding RNA of human blood plasma with massively parallel sequencing technology. Expert Opin Biol Ther 2012; 12 Suppl 1:S43-51; PMID:22509727; http://dx.doi.org/10.1517/14712598.2012.679653
  • Yu B, Yang Z, Li J, Minakhina S, Yang M, Padgett RW, Steward R, Chen X. Methylation as a crucial step in plant microRNA biogenesis. Science 2005; 307:932-5; PMID:15705854; http://dx.doi.org/10.1126/science.1107130
  • Liang H, Huang L, Cao J, Zen K, Chen X, Zhang CY. Regulation of mammalian gene expression by exogenous microRNAs. Wiley Interdiscip Rev RNA 2012; 3:733-42; PMID:22740375, http://dx.doi.org/10.1002/wrna.1127
  • Wilund KR, Yi M, Campagna F, Arca M, Zuliani G, Fellin R, Ho YK, Garcia JV, Hobbs HH, Cohen JC. Molecular mechanisms of autosomal recessive hypercholesterolemia. Hum Mol Genet 2002; 11:3019-30; PMID:12417523, http://dx.doi.org/10.1093/hmg/11.24.3019
  • Verhoeven V, Van der Auwera A, Van Gaal L, Remmen R, Apers S, Stalpaert M, Wens J, Hermans N. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: A double blind, placebo controlled randomized trial. BMC Complement Altern Med 2015; 15:52; PMID:25879228; http://dx.doi.org/10.1186/s12906-015-0576-9
  • Jolfaie NR, Rouhani MH, Surkan PJ, Siassi F, Azadbakht L. Rice Bran Oil Decreases Total and LDL Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Horm Metab Res 2016; 48:417-26; PMID:27311126; http://dx.doi.org/10.1055/s-0042-105748
  • Hirschi KD. New foods for thought. Trends Plant Sci 2012; 17:123-5;. PMID:22265093; http://dx.doi.org/10.1016/j.tplants.2012.01.004
  • Witwer KW, Hirschi KD. Hirschi KD. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays 2014; 36:394-406; PMID:24436255; http://dx.doi.org/10.1002/bies.201300150
  • Zhang Y, Wiggins BE, Lawrence C, Petrick J, Ivashuta S, Heck G. Analysis of plant-derived miRNAs in animal small RNA datasets. BMC Genomics 2012; 13:381; PMID:22873950; http://dx.doi.org/10.1186/1471-2164-13-381
  • Lukasik A, Zielenkiewicz P. In silico identification of plant miRNAs in mammalian breast milk exosomes–a small step forward? PLoS One 2014; 9:e99963; PMID:24933019; http://dx.doi.org/10.1371/journal.pone.0099963
  • Bağcı C, Allmer J. One Step Forward, Two Steps Back; Xeno-MicroRNAs Reported in Breast Milk Are Artifacts. PLoS One 2016; 11:e0145065; PMID:26824347; http://dx.doi.org/10.1371/journal.pone.0145065
  • Witwer KW, McAlexander MA, Queen SE, Adams RJ. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol 2013; 10:1080-6; PMID:23770773; http://dx.doi.org/10.4161/rna.25246
  • Williams Z, Ben-Dov IZ, Elias R, Mihailovic A, Brown M, Rosenwaks Z, Tuschl T. Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Natl Acad Sci U S A 2013; 110:4255-60; PMID:23440203; http://dx.doi.org/10.1073/pnas.1214046110
  • Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007; 129:1401-14; PMID:17604727; http://dx.doi.org/10.1016/j.cell.2007.04.040
  • Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, Baccarini A, Lazzari G, Galli C, Nadini L. Endogenous microRNA can be broadly exploited to regulatetransgene expression according to tissue, lineage and differentiation state. Nat Biotechnol 2007;25:1457-67; PMID:18026085; http://dx.doi.org/10.1038/nbt1372
  • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806-11;PMID:9486653; http://dx.doi.org/10.1038/35888
  • Mello CC, Conte D. Revealing the world of RNA interference. Nature 2004; 431:338-42; PMID:15372040; http://dx.doi.org/10.1038/nature02872
  • Whangbo JS, Hunter CP. Environmental RNA interference. Trends Genet 2008; 24:297-305; PMID:18450316; http://dx.doi.org/10.1016/j.tig.2008.03.007
  • Winston WM, Molodowitch C, Hunter CP. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. Science 2002; 295:2456-9; PMID:11834782; http://dx.doi.org/ 10.1126/science.1068836
  • Winston WM, Sutherlin M, Wright AJ, Feinberg EH, Hunter CP. Caenorhabditis elegans SID-2 is required for environmental RNA interference. Proc Natl Acad Sci U S A 2007; 104:10565-70; PMID:17563372; http://dx.doi.org/10.1073/pnas.0611282104
  • McEwan DL, Weisman AS, Hunter CP. Uptake of extracellular double-stranded RNA by SID-2. Mol Cell 2012; 47:746-54;. PMID:22902558; http://dx.doi.org/10.1016/j.molcel.2012.07.014
  • Duxbury MS, Ashley SW, Whang EE. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. Biochem Biophys Res Commun 2005; 331:459-63;. PMID:15850781; http://dx.doi.org/10.1016/j.bbrc.2005.03.199
  • Wolfrum C, Shi S, Jayaprakash KN, Jayaraman M, Wang G, Pandey RK, Rajeev KG, Nakayama T, Charrise K, Ndungo EM, et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol 2007; 25:1149-57; PMID:17873866; http://dx.doi.org/10.1038/nbt1339
  • Elhassan MO, Christie J, Duxbury MS. Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. J Biol Chem 2012; 287:5267-77; PMID:22174421; http://dx.doi.org/10.1074/jbc.m111.318865
  • Fabbri M. TLRs as miRNA receptors. Cancer Res 2012; 72:6333-7; PMID:23222301; http://dx.doi.org/10.1158/0008-5472.can-12-3229
  • Igaz I, Igaz P. Tumor surveillance by circulating microRNAs: a hypothesis. Cell Mol Life Sci 2014; 71:4081-7; PMID:25037157; http://dx.doi.org/10.1007/s00018-014-1682-4
  • Chin AR, Fong MY, Somlo G, Wu J, Swiderski P, Wu X, Wang SE. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res 2016; 26:217-28; PMID:26794868; http://dx.doi.org/10.1038/cr.2016.13
  • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121:2750-67; PMID:21633166; http://dx.doi.org/10.1172/jci45014
  • Bilir B, Kucuk O, Moreno CS. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med 2013; 11:280; PMID:24188694; http://dx.doi.org/10.1186/1479-5876-11-280
  • Johnson JP, Kumar P, Koulnis M, Patel M, Simin K. Crucial and novel cancer drivers in a mouse model of triple-negative breast cancer. Cancer Genomics Proteomics 2014; 11:115-26; PMID:24969692
  • Igaz I, Igaz P. Why is microRNA action tissue specific? A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA? Med Hypotheses 2015; 85:530-3; PMID:26198739; http://dx.doi.org/10.1016/j.mehy.2015.07.013
  • Catalgol B, Batirel S, Taga Y, Ozer NK. Resveratrol: French paradox revisited. Front Pharmacol 2012; 3:141; PMID:22822401; http://dx.doi.org/10.3389/fphar.2012.00141
  • Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339:1523-6; PMID:1351198; http://dx.doi.org/10.1016/0140-6736(92)91277-f
  • Criqui M., Ringel B. Does diet or alcohol explain the French paradox? Lancet 1994; 344:1719-23; PMID:7996999; http://dx.doi.org/10.1016/s0140-6736(94)92883-5
  • Karnani M, Annila A. Gaia again. Biosystems 2009; 95:82-7; PMID:18706969; http://dx.doi.org/10.1016/j.biosystems.2008.07.003
  • Lovelock JE. New statements on the Gaia theory. Microbiol 1995; 11:295-304; PMID:7576345
  • Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer 2010; 10:389-402; PMID:20495573; http://dx.doi.org/10.1038/nrc2885
  • McDermott AM, Heneghan HM, Miller N, Kerin MJ. The therapeutic potential of microRNAs: disease modulators and drug targets. Pharm Res 2011; 28:3016-29;PMID:21818713; http://dx.doi.org/10.1007/s11095-011-0550-2
  • Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137:1005-17;. PMID:19524505; http://dx.doi.org/10.1016/j.cell.2009.04.021
  • Wiggins JF, Ruffino L, Kelnar K, Omotola M, Patrawala L, Brown D, Bader AG. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 2010; 70:5923-30; PMID:20570894; http://dx.doi.org/10.1158/0008-5472.can-10-0655
  • Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368:1685-94; PMID:23534542; http://dx.doi.org/10.1056/nejmoa1209026
  • Zhou Z, Li X, Liu J, Dong L, Chen Q, Liu J, Kong H, Zhang Q, Qi X, Hou D, et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res 2015; 25:39-49; PMID:25287280; http://dx.doi.org/10.1038/cr.2014.130
  • Mlotshwa S, Pruss GJ, MacArthur JL, Endres MW, Davis C, Hofseth LJ, Peña MM, Vance V. A novel chemopreventive strategy based on therapeutic microRNAs produced in plants. Cell Res 2015; 25:521-4; PMID:25721325; http://dx.doi.org/10.1038/cr.2015.25
  • Yang MS, Law FC, Wong RN, Mak NK, Wei XY. Interaction between oseltamivir and herbal medicines used for treating avian influenza. Hong Kong Med J 2012; 18 Suppl 6:34-6;. PMID:23249852;
  • Yang J, Farmer LM, Agyekum AA, Hirschi KD. Detection of dietary plant-based small RNAs in animals. Cell Res 2015; 25:517-20; PMID:25721324; http://dx.doi.org/10.1038/cr.2015.26
  • Yang J, Farmer LM, Agyekum AA, Elbaz-Younes I, Hirschi KD. Detection of an abundant plant-based small RNA in healthy consumers. PLoS One 2015; 10:e0137516. PMID:26335106; http://dx.doi.org/10.1371/journal.pone.0137516
  • Bader AG. miR-34 - a microRNA replacement therapy is headed to the clinic. Front Genet 2012; 3:120; PMID:22783274; http://dx.doi.org/10.3389/fgene.2012.00120
  • Takaoka Y, Shimizu Y, Hasegawa H, Ouchi Y, Qiao S, Nagahara M, Ichihara M, Lee JD, Adachi K, Hamaguchi M, et al. Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PLoS One 2012; 7:e42137. PMID:22876303; http://dx.doi.org/10.1371/journal.pone.0042137
  • Bischoff SC. “Gut health”: a new objective in medicine? BMC Med 2011; 9:24;. PMID:21401922; http://dx.doi.org/10.1186/1741-7015-9-24
  • Igaz P. Recent strategies to overcome the hyperacute rejection in pig to human xenotransplantation. Yale J Biol Med 2001; 74:329-40; PMID:11769339

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