Sources to variability in circulating human miRNA signatures

References

• Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843–54.
   PubMed Web of Science ®Google Scholar
• Ambros, V.microRNAs: tiny regulators with great potential. Cell. 2001;107(7):823–6. doi:10.1016/S0092-8674(01)00616-X.
   PubMed Web of Science ®Google Scholar
• Leidinger, P., Backes C, Deutscher S, Schmitt K, Mueller SC, Frese K, Haas J, Ruprecht K, Paul F, Stähler C, et al., A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol. 2013;14(7):R78. doi:10.1186/gb-2013-14-7-r78.
   PubMed Web of Science ®Google Scholar
• Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F, Scheffler M, Huwer H, Lenhof HP, Meese E. miRNAs in lung cancer – studying complex fingerprints in patient's blood cells by microarray experiments. BMC Cancer. 2009;9:353. doi:10.1186/1471-2407-9-353.
   PubMed Web of Science ®Google Scholar
• Leidinger P, Brefort T, Backes C, Krapp M, Galata V, Beier M, Kohlhaas J, Huwer H, Meese E, Keller A. High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer. Oncotarget. 2016;7(4):4611–23. doi:10.18632/oncotarget.6566.
   PubMed Web of Science ®Google Scholar
• Sierzega M, Kaczor M, Kolodziejczyk P, Kulig J, Sanak M, Richter P. Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. Br J Cancer. 2017;117(2):266–273. doi:10.1038/bjc.2017.190.
   PubMed Web of Science ®Google Scholar
• Qu K, Zhang X, Lin T, Liu T, Wang Z, Liu S, Zhou L, Wei J, Chang H, Li K, et al. Circulating miRNA-21-5p as a diagnostic biomarker for pancreatic cancer: evidence from comprehensive miRNA expression profiling analysis and clinical validation. Sci Rep. 2017;7(1):1692. doi:10.1038/s41598-017-01904-z.
   PubMed Web of Science ®Google Scholar
• Xing W, Zeng C. A novel serum microRNA-based identification and classification biomarker of human glioma. Tumour Biol. 2017;39(5):1010428317705339. doi:10.1177/1010428317705339
   Web of Science ®Google Scholar
• Ames H, Halushka MK, Rodriguez FJ. miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. J Neuropathol Exp Neurol. 2017;76(4):246–254. doi:10.1093/jnen/nlx005.
   PubMed Web of Science ®Google Scholar
• Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, et al. Toward the blood-borne miRNome of human diseases. Nat Methods. 2011;8(10):841–3. doi:10.1038/nmeth.1682.
   PubMed Web of Science ®Google Scholar
• Mestdagh P, Hartmann N, Baeriswyl L, Andreasen D, Bernard N, Chen C, Cheo D, D'Andrade P, DeMayo M, Dennis L, et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods. 2014;11(8):809–15. doi:10.1038/nmeth.3014.
   PubMed Web of Science ®Google Scholar
• Keller A, Meese E. Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings? Wiley Interdiscip Rev RNA. 2016;7(2):148–56.
   Google Scholar
• Backes C, Meese E, Keller A. Specific miRNA Disease Biomarkers in Blood, Serum and Plasma: Challenges and Prospects. Mol Diagn Ther. 2016;20(6):509–518. doi:10.1007/s40291-016-0221-4.
   PubMed Web of Science ®Google Scholar
• Witwer KW, Halushka MK. Toward the promise of microRNAs – Enhancing reproducibility and rigor in microRNA research. RNA Biol. 2016;13(11):1103–1116. doi:10.1080/15476286.2016.1236172.
   PubMed Web of Science ®Google Scholar
• Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, Mueller SC, Marquart S, Schrauder MG, Strick R et al. miRNAs can be generally associated with human pathologies as exemplified for miR-144. BMC Med. 2014;12:224. doi:10.1186/s12916-014-0224-0.
   PubMed Web of Science ®Google Scholar
• Halushka MK. MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2016;35(4):543. doi:10.1016/j.healun.2016.01.008.
   PubMed Web of Science ®Google Scholar
• Kent OA, McCall MN, Cornish TC, Halushka MK. Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res. 2014;42(12):7528–38. doi:10.1093/nar/gku461.
   PubMed Web of Science ®Google Scholar
• Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stähler C, Meese E, et al. Distribution of miRNA expression across human tissues. Nucleic Acids Res. 2016;44(8):3865–77. doi:10.1093/nar/gkw116.
   PubMed Web of Science ®Google Scholar
• Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, et al. Deep characterization of blood cell miRNomes by NGS. Cell Mol Life Sci. 2016;73(16):3169–81. doi:10.1007/s00018-016-2154-9.
   PubMed Web of Science ®Google Scholar
• Moldovan L, Batte KE, Trgovcich J, Wisler J, Marsh CB, Piper M. Methodological challenges in utilizing miRNAs as circulating biomarkers. J Cell Mol Med. 2014;18(3):371–90. doi:10.1111/jcmm.12236.
   PubMed Web of Science ®Google Scholar
• Meder B, Backes C, Haas J, Leidinger P, Stähler C, Großmann T, Vogel B, Frese K, Giannitsis E, Katus HA, et al. Influence of the confounding factors age and sex on microRNA profiles from peripheral blood. Clin Chem. 2014;60(9):1200–8. doi:10.1373/clinchem.2014.224238.
   PubMed Web of Science ®Google Scholar
• Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, et al. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495(7439):107–10. doi:10.1038/nature11919.
   PubMed Web of Science ®Google Scholar
• Backes C, Sedaghat-Hamedani F, Frese K, Hart M, Ludwig N, Meder B, Meese E, Keller A. Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies. Anal Chem. 2016;88(4):2088–95. doi:10.1021/acs.analchem.5b03376.
   PubMed Web of Science ®Google Scholar
• Backes C, Khaleeq QT, Meese E, Keller A. miEAA: microRNA enrichment analysis and annotation. Nucleic Acids Res. 2016;44(W1):W110–W116. doi:10.1093/nar/gkw345
   PubMed Web of Science ®Google Scholar
• Backes C, Leidinger P, Altmann G, Wuerstle M, Meder B, Galata V, Mueller SC, Sickert D, Stähler C, Meese E, et al. Influence of next-generation sequencing and storage conditions on miRNA patterns generated from PAXgene blood. Anal Chem. 2015;87(17):8910–6. doi:10.1021/acs.analchem.5b02043.
   PubMed Web of Science ®Google Scholar
• Keller A, Leidinger P, Gislefoss R, Haugen A, Langseth H, Staehler P, Lenhof HP, Meese E. Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis. RNA Biol. 2011;8(3):506–16. doi:10.4161/rna.8.3.14994.
   PubMed Web of Science ®Google Scholar
• Rounge TB, Rounge TB, Lauritzen M, Langseth H, Enerly E, Lyle R, Gislefoss RE. microRNA Biomarker Discovery and High-Throughput DNA Sequencing Are Possible Using Long-term Archived Serum Samples. Cancer Epidemiol Biomarkers Prev. 2015;24(9):1381–7. doi:10.1158/1055-9965.EPI-15-0289.
   PubMed Web of Science ®Google Scholar
• Balzano F, Balzano F, Deiana M, Dei Giudici S, Oggiano A, Baralla A, Pasella S, Mannu A, Pescatori M, Porcu B, Fanciulli G, et al. miRNA Stability in Frozen Plasma Samples. Molecules. 2015;20(10):19030–40. doi:10.3390/molecules201019030.
   PubMed Web of Science ®Google Scholar
• Ameling S, Kacprowski T, Chilukoti RK, Malsch C, Liebscher V, Suhre K, Pietzner M, Friedrich N, Homuth G, Hammer E, et al. Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study. BMC Med Genomics. 2015;8:61. doi:10.1186/s12920-015-0136-7.
   PubMed Web of Science ®Google Scholar
• Langseth H, et al. Cohort Profile: The Janus Serum Bank Cohort in Norway. Int J Epidemiol. 2016;46(2):403–404g. doi:10.1093/ije/dyw027.
   Web of Science ®Google Scholar
• Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30(1):207–10. doi:10.1093/nar/30.1.207.
   PubMed Web of Science ®Google Scholar
• Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 2013;41( Database issue):D991–5. doi:10.1093/nar/gks1193.
   PubMed Web of Science ®Google Scholar