miRNA activation is an endogenous gene expression pathway

References

• Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell. 2009;136(4):642–655.
   PubMed Web of Science ®Google Scholar
• Catalanotto C, Cogoni C, Zardo G. MicroRNA in control of gene expression: an overview of nuclear functions. Int J Mol Sci. 2016;17(10):1712.
   PubMed Web of Science ®Google Scholar
• Chaluvally-Raghavan P, Jeong KJ, Pradeep S, et al. Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer. Cell Rep. 2016;15(7):1493–1504.
   PubMed Web of Science ®Google Scholar
• Dharap A, Pokrzywa C, Murali S, et al. MicroRNA miR-324-3p induces promoter-mediated expression of RelA gene. PLoS one. 2013;8(11):e79467.
   PubMed Web of Science ®Google Scholar
• Gernapudi R, Wolfson B, Zhang Y, et al. MicroRNA 140 promotes expression of long noncoding RNA NEAT1 in adipogenesis. Mol Cell Biol. 2016;36(1):30–38.
   PubMed Web of Science ®Google Scholar
• Hu J, Chen Z, Xia D, et al. Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation. Biochem J. 2012;447:407–416.
   PubMed Web of Science ®Google Scholar
• Huang V, Place RF, Portnoy V, et al. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012;40(4):1695–1707.
   PubMed Web of Science ®Google Scholar
• Huang V, Qin Y, Wang J, et al. RNAa is conserved in mammalian cells. PloS one. 2010;5(1):e8848.
   PubMed Web of Science ®Google Scholar
• Huang V, Zheng J, Qi Z, et al. Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells. PLoS genet. 2013;9(9):e1003821.
   PubMed Web of Science ®Google Scholar
• Huang V.. Endogenous miRNAa: miRNA-Mediated Gene Upregulation. In RNA Activation (pp. .p. 65–79.). 2017. Springer; Singapore:
   Google Scholar
• Janowski BA, Younger ST, Hardy DB, et al. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol. 2007;3(3):166–173.
   PubMed Web of Science ®Google Scholar
• Kang MR, Park KH, Yang JO, et al. miR-6734 up-regulates p21 gene expression and induces cell cycle arrest and apoptosis in colon cancer cells. PLoS one. 2016;11(8):e0160961.
   PubMed Web of Science ®Google Scholar
• Lai EC. Micro RNAs are complementary to 3’ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat genet. 2002;30(4):363.
   PubMed Web of Science ®Google Scholar
• Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843–854.
   PubMed Web of Science ®Google Scholar
• Li C, Ge Q, Liu J, et al. Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. Tumour Biol. 2017a;39(6):1010428317710824.
   Google Scholar
• Li LC, Okino ST, Zhao H, et al. Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA. 2006;103:17337–17342.
   PubMed Web of Science ®Google Scholar
• Li S, Zhu Y, Liang Z, et al. Up-regulation of p16 by miR-877-3p inhibits proliferation of bladder cancer. Oncotarget. 2016;7(32):51773.
   PubMedGoogle Scholar
• Li S, Wang C, Yu X, et al. miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression. Oncol Rep. 2017b;37(1):241–248.
   PubMed Web of Science ®Google Scholar
• Liu M, Roth A, Yu M, et al. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013;27(23):2543–2548.
   PubMed Web of Science ®Google Scholar
• Matsui M, Chu Y, Zhang H, et al. 2013; Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Res.41(22):10086–10109.
   PubMed Web of Science ®Google Scholar
• Ogawa O, Eccles MR, Szeto J, et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature. 1993;362(6422):749.
   PubMed Web of Science ®Google Scholar
• Place RF, Li LC, Pookot D, et al. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA. 2008;105(5):1608–1613.
   PubMed Web of Science ®Google Scholar
• Portnoy V, Lin SHS, Li KH, et al. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell Res. 2016;26:320–335.
   PubMed Web of Science ®Google Scholar
• Schwartz JC. Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA Antisense transcripts are targets for activating small RNAs. Nat. Struct Mol Biol. 2008;15(8): 842–848.
   PubMed Web of Science ®Google Scholar
• Turner M, Jiao A, Slack FJ. Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans Cell Cycle. 2014;13(5):772–781.
   PubMed Web of Science ®Google Scholar
• Wang C, Chen Z, Ge Q, et al. Up-regulation of p21(WAF1/ CIP1) by miRNAs and its implications in bladder cancer cells. FEBS Lett. 2014;588(24):4654–4664.
   PubMed Web of Science ®Google Scholar
• Wang C, Tang K, Li Z, et al. Targeted p21(WAF1/CIP1) activation by miR-1236 inhibits cell proliferation and correlates with favorable survival in renal cell carcinoma. Urol Oncol. 2016;34(2):59 e23–34.
   PubMed Web of Science ®Google Scholar
• Xiao M, Li J, Li W, et al. MicroRNAs Activate Gene Transcription Epigenetically as an Enhancer Trigger. RNA Biol. 2017;14(10): 1326–1334.
   PubMed Web of Science ®Google Scholar
• Yang K, Zheng XY, Qin J, et al. Up-regulation of p21 WAF1/Cip1 by saRNA induces G1-phase arrest and apoptosis in T24 human bladder cancer cells. Cancer Lett. 2008;265(2):206–214.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Fan M, Geng G, et al. A novel HIV-1-encoded microRNA enhances its viral replication by targeting the TATA box region. Retrovirology. 2014a;11:23.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Fan M, Zhang X, et al. Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs. RNA .2014b;20(12):1878–1889.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liu W, Chen Y, et al. A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif. J Immunol. 2018;200(3):1053–1063.
   PubMed Web of Science ®Google Scholar
• Zheng L, Wang L, Gan J, et al. RNA activation: promise as a new weapon against cancer. Cancer Lett. 2014;355(1):18–24.
   PubMed Web of Science ®Google Scholar
• Zisoulis DG, Kai ZS, Chang RK, et al. Auto-regulation of miRNA biogenesis by let-7 and Argonaute. Nature. 2012;486(7404):541.
   PubMed Web of Science ®Google Scholar