DDX39B promotes translation through regulation of pre-ribosomal RNA levels

References

• Linder P, Jankowsky E. From unwinding to clamping - the DEAD box RNA helicase family. Nat Rev Mol Cell Biol. 2011;12:505–516.
   PubMed Web of Science ®Google Scholar
• Bleichert F, Baserga SJ. The long unwinding road of RNA helicases. Mol Cell. 2007;27:339–352.
   PubMed Web of Science ®Google Scholar
• Shen H. UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export. BMB Rep. 2009;42:185–188.
   PubMed Web of Science ®Google Scholar
• Shen H, Zheng X, Shen J, et al. Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev. 2008;22:1796–1803.
   PubMed Web of Science ®Google Scholar
• Fleckner J, Zhang M, Valcarcel J, et al. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 1997;11:1864–1872.
   PubMed Web of Science ®Google Scholar
• Hautbergue GM, Hung ML, Walsh MJ, et al. UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Curr Biol CB. 2009;19:1918–1924.
   PubMed Web of Science ®Google Scholar
• Luo ML, Zhou Z, Magni K, et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature. 2001;413:644–647.
   PubMed Web of Science ®Google Scholar
• Jensen TH, Boulay J, Rosbash M, et al. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol CB. 2001;11:1711–1715.
   PubMed Web of Science ®Google Scholar
• Li Y, Wang X, Zhang X, et al. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Mol Cell Biol. 2005;25:4023–4033.
   PubMed Web of Science ®Google Scholar
• Strasser K, Masuda S, Mason P, et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002;417:304–308.
   PubMed Web of Science ®Google Scholar
• Folco EG, Lee CS, Dufu K, et al. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PloS One. 2012;7:e43804.
   PubMed Web of Science ®Google Scholar
• Dufu K, Livingstone MJ, Seebacher J, et al. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev. 2010;24:2043–2053.
   PubMed Web of Science ®Google Scholar
• Sugiura T, Sakurai K, Nagano Y. Intracellular characterization of DDX39, a novel growth-associated RNA helicase. Exp Cell Res. 2007;313:782–790.
   PubMed Web of Science ®Google Scholar
• Kota KP, Wagner SR, Huerta E, et al. Binding of ATP to UAP56 is necessary for mRNA export. J Cell Sci. 2008;121:1526–1537.
   PubMed Web of Science ®Google Scholar
• Chang CT, Hautbergue GM, Walsh MJ, et al. Chtop is a component of the dynamic TREX mRNA export complex. EMBO J. 2013;32:473–486.
   PubMed Web of Science ®Google Scholar
• Awasthi S, Verma M, Mahesh A, et al. DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA. Nucleic Acids Res. 2018;46:6304–6317.
   PubMed Web of Science ®Google Scholar
• Sahni A, Wang N, Alexis JD. UAP56 is an important regulator of protein synthesis and growth in cardiomyocytes. Biochem Biophys Res Commun. 2010;393:106–110.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Forys JT, Miceli AP, et al. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. Mol Cell Biol. 2011;31:4676–4691.
   PubMed Web of Science ®Google Scholar
• Zhao Z, Dammert MA, Hoppe S, et al. Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucleic Acids Res. 2016;44:8144–8152.
   PubMed Web of Science ®Google Scholar
• Hein N, Hannan KM, George AJ, et al. The nucleolus: an emerging target for cancer therapy. Trends Mol Med. 2013;19:643–654.
   PubMed Web of Science ®Google Scholar
• Voit R, Seiler J, Grummt I. Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis. PLoS Genet. 2015;11:e1005246.
   PubMed Web of Science ®Google Scholar
• O’Sullivan AC, Sullivan GJ, McStay B. UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat. Mol Cell Biol. 2002;22:657–668.
   PubMed Web of Science ®Google Scholar
• Sugiura T, Nagano Y, Noguchi Y. DDX39, upregulated in lung squamous cell cancer, displays RNA helicase activities and promotes cancer cell growth. Cancer Biol Ther. 2007;6:957–964.
   PubMed Web of Science ®Google Scholar
• Wan Q, Dingerdissen H, Fan Y, et al. BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis. Database. 2015;2015.
   PubMedGoogle Scholar
• Bailey TL, Machanick P. Inferring direct DNA binding from ChIP-seq. Nucleic Acids Res. 2012;40:e128.
   PubMed Web of Science ®Google Scholar
• Momose F, Basler CF, O’Neill RE, et al. Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viral RNA synthesis. J Virol. 2001;75:1899–1908.
   PubMed Web of Science ®Google Scholar
• Wisskirchen C, Ludersdorfer TH, Muller DA, et al. The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection. J Virol. 2011;85:8646–8655.
   PubMed Web of Science ®Google Scholar
• Jalal C, Uhlmann-Schiffler H, Stahl H. Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic Acids Res. 2007;35:3590–3601.
   PubMed Web of Science ®Google Scholar
• Calo E, Flynn RA, Martin L, et al. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature. 2015;518:249–253.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Baysac KC, Yee LF, et al. Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers. Breast Cancer Res BCR. 2014;16:449.
   PubMed Web of Science ®Google Scholar
• Henning D, So RB, Jin R, et al. Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. J Biol Chem. 2003;278:52307–52314.
   PubMed Web of Science ®Google Scholar
• Sekiguchi T, Hayano T, Yanagida M, et al. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Nucleic Acids Res. 2006;34:4593–4608.
   PubMed Web of Science ®Google Scholar
• Srivastava L, Lapik YR, Wang M, et al. Mammalian DEAD box protein Ddx51 acts in 3ʹ end maturation of 28S rRNA by promoting the release of U8 snoRNA. Mol Cell Biol. 2010;30:2947–2956.
   PubMed Web of Science ®Google Scholar