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Brief Communication

Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus

, , , , , , & ORCID Icon show all
Pages 1001-1009 | Received 26 Feb 2019, Accepted 10 May 2019, Published online: 04 Jun 2019

References

  • Djebali S, Davis CA, Merkel A, et al. Landscape of transcription in human cells. Nature. 2012;489:101–108.
  • Marchese F, Raimondi I, Huarte M. The multidimensional mechanisms of long noncoding RNA function. Genome Biol. 2017;18:206–219.
  • Guttman M, Rinn JL. Modular regulatory principles of large non-coding RNAs. Nature. 2012;482:339–346.
  • Cabili MN, Trapnell C, Goff L, et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 2011;25:1915–1927.
  • Cheng H, Dufu K, Lee CS, et al. Human mRNA export machinery recruited to the 5ʹ end of mRNA. Cell. 2006;127:1389–1400.
  • Wu H, Yang L, Chen LL. the diversity of long noncoding RNAs and their generation. Trends Genet. 2017;33:540–552.
  • Hacisuleyman E, Goff LA, Trapnell C, et al. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol. 2014;21:198–206.
  • Wutz A, Rasmussen TP, Jaenisch R. Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet. 2002;30:167–174.
  • Hasegawa Y, Brockdorff N, Kawano S, et al. The matrix protein hnRNP U is required for chromosomal localization of Xist RNA. Dev Cell. 2010;19:469–476.
  • Miyagawa R, Tano K, Mizuno R, et al. Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles. Rna. 2012;18:738–751.
  • Zhang B, Gunawardane L, Niazi F, et al. A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA. Mol Cell Biol. 2014;34:2318–2329.
  • Takemura R, Takeiwa T, Taniguchi I, et al. Multiple factors in the early splicing complex are involved in the nuclear retention of pre-mRNAs in mammalian cells. Genes Cells. 2011;16:1035–1049.
  • Lee ES, Akef A, Mahadevan K, et al. The consensus 5ʹ splice site motif inhibits mRNA nuclear export. PLoS One. 2015;10:e0122743–e0122743.
  • Yoshimoto R, Kaida D, Furuno M, et al. Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A. RNA. 2017;23:47–57.
  • Cabili MN, Dunagin MC, McClanahan PD, et al. Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biol. 2015;16:20.
  • van Heesch S, van Iterson M, Jacobi J, et al. Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes. Genome Biol. 2014;15:R6.
  • Gudenas BL, Wang L. Prediction of LncRNA subcellular localization with deep learning from sequence features. Sci Rep. 2018;8:16385.
  • Shukla CJ, McCorkindale AL, Gerhardinger C, et al. High-throughput identification of RNA nuclear enrichment sequences. Embo J. 2018;37:e98452.
  • Lubelsky Y, Ulitsky I. Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells. Nature. 2018;555:107–111.
  • Chu C, Zhang QC, Da Rocha ST, et al. Systematic discovery of Xist RNA binding proteins. Cell. 2015;161:404–416.
  • Engreitz JM, Sirokman K, McDonel P, et al. RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent pre-mRNAs and chromatin sites. Cell. 2014;159:188–199.
  • Lei H, Dias AP, Reed R. Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci U S A. 2011;108:17985–17990.
  • Lei H, Zhai B, Yin S, et al. Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export. Nucleic Acids Res. 2013;41:2517–2525.
  • Folco EG, Lei H, Hsu JL, et al. Small-scale nuclear extracts for functional assays of gene-expression machineries. J Vis Exp. 2012;e4140.
  • Li X, Tao J, Han J, et al. The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress. Protein Cell. 2014;5:182–185.

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