Controversies around the function of LARP1

References

• Bousquet-Antonelli C, Deragon JM. A comprehensive analysis of the La-motif protein superfamily. RNA. 2009;15:750–764.
   PubMed Web of Science ®Google Scholar
• Deragon JM, Bousquet-Antonelli C. The role of LARP1 in translation and beyond. Wiley interdiscip rev RNA. 2015;6:399–417.
   PubMed Web of Science ®Google Scholar
• Blagden SP, Gatt MK, Archambault V, et al. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev Biol. 2009;334:186–197.
   PubMed Web of Science ®Google Scholar
• Aoki K, Adachi S, Homoto M, et al. LARP1 specifically recognizes the 3ʹ terminus of poly(A) mRNA. FEBS Lett. 2013;587:2173–2178.
   PubMed Web of Science ®Google Scholar
• Tcherkezian J, Cargnello M, Romeo Y, et al. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5ʹTOP mRNA translation. Genes Dev. 2014;28:357–371.
   PubMed Web of Science ®Google Scholar
• Meyuhas O, Kahan T. The race to decipher the top secrets of TOP mRNAs. Biochim Biophys Acta. 2015;1849:801–811.
   PubMed Web of Science ®Google Scholar
• Fonseca BD, Zakaria C, Jia JJ, et al. La-related Protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996–16020.
   PubMed Web of Science ®Google Scholar
• Lahr RM, Fonseca BD, Ciotti GE, et al. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife. 2017;6.
   Web of Science ®Google Scholar
• Hong S, Freeberg MA, Han T, et al. LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs. Elife. 2017;6:pii: e25237.
   Web of Science ®Google Scholar
• Philippe L, Vasseur JJ, Debart F, et al. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. Nucleic Acids Res. 2018;46:1457–1469.
   PubMed Web of Science ®Google Scholar
• Hsu PP, Kang SA, Rameseder J, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332:1317–1322.
   PubMed Web of Science ®Google Scholar
• Yu Y, Yoon SO, Poulogiannis G, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011;332:1322–1326.
   PubMed Web of Science ®Google Scholar
• Fonseca BD, Lahr RM, Damgaard CK, et al. LARP1 on TOP of ribosome production. Wiley interdiscip rev RNA. 2018; e1480.
   PubMed Web of Science ®Google Scholar
• Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, et al. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol. 2009;29:640–649.
   PubMed Web of Science ®Google Scholar
• Miloslavski R, Cohen E, Avraham A, et al. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol. 2014;6:255–266.
   PubMed Web of Science ®Google Scholar
• Patursky-Polischuk I, Kasir J, Miloslavski R, et al. Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs. PloS One. 2014;9:e109410.
   PubMed Web of Science ®Google Scholar
• Ogami K, Oishi Y, Nogimori T, et al. LARP1 facilitates translational recovery after amino acid refeeding by preserving long poly(A)-tailed TOP mRNAs. bioRxiv 2019:716217.
   Google Scholar
• Mura M, Hopkins TG, Michael T, et al. LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene 2014;34:5025–5036.
   Google Scholar
• Xie C, Huang L, Xie S, et al. LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma. J Transl Med. 2013;11:272.
   PubMed Web of Science ®Google Scholar
• Ye L, Lin ST, Mi YS, et al. Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target. Tumour Biol. 2016;37:14585–14594.
   PubMedGoogle Scholar
• Xu Z, Xu J, Lu H, et al. LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma. Oncol Rep. 2017;38:3659–3667.
   PubMed Web of Science ®Google Scholar
• Stavraka C, Blagden S. The La-related proteins, a family with connections to cancer. Biomolecules. 2015;5:2701–2722.
   PubMed Web of Science ®Google Scholar
• Gentilella A, Moron-Duran FD, Fuentes P, et al. Autogenous control of 5ʹTOP mRNA stability by 40S ribosomes. Mol Cell. 2017;67:55–70 e4.
   PubMed Web of Science ®Google Scholar
• Yang R, Gaidamakov SA, Xie J, et al. La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. Mol Cell Biol. 2011;31:542–556.
   PubMed Web of Science ®Google Scholar
• Nilsson J, Sengupta J, Frank J, et al. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 2004;5:1137–1141.
   PubMed Web of Science ®Google Scholar
• Wigington CP, Williams KR, Meers MP, et al. Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley interdiscip rev RNA. 2014;5:601–622.
   PubMed Web of Science ®Google Scholar
• Ghandi M, Huang FW, Jane-Valbuena J, et al. Next-generation characterization of the cancer cell line encyclopedia. Nature. 2019;569:503–508.
   PubMed Web of Science ®Google Scholar
• Cassidy KC, Lahr RM, Kaminsky JC, et al. Capturing the mechanism underlying TOP mRNA binding to LARP1. Structure. 2019;27:1771–81 e5.
   PubMed Web of Science ®Google Scholar
• Lahr RM, Mack SM, Héroux A, et al. The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5ʹTOP sequence. Nucleic Acids Res. 2015;43:8077–8088.
   PubMed Web of Science ®Google Scholar
• Al-Ashtal HA, Rubottom CM, Leeper TC, et al. The LARP1 La-Module recognizes both ends of TOP mRNAs. RNA Biol. 2019;10;Oct:1–11.
   Google Scholar
• Burrows C, Abd Latip N, Lam SJ, et al. The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res. 2010;38:5542–5553.
   PubMed Web of Science ®Google Scholar
• Wells SE, Hillner PE, Vale RD, et al. Circularization of mRNA by eukaryotic translation initiation factors. Mol Cell. 1998;2:135–140.
   PubMed Web of Science ®Google Scholar
• Afonina ZA, Myasnikov AG, Shirokov VA, et al. Formation of circular polyribosomes on eukaryotic mRNA without cap-structure and poly(A)-tail: a cryo electron tomography study. Nucleic Acids Res. 2014;42:9461–9469.
   PubMed Web of Science ®Google Scholar
• Adivarahan S, Livingston N, Nicholson B, et al. Spatial organization of single mRNPs at different stages of the gene expression pathway. Mol Cell. 2018;72:727–738 e5.
   PubMed Web of Science ®Google Scholar
• Wilbertz JH, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response. Mol Cell. 2019;73:946–958 e7.
   PubMed Web of Science ®Google Scholar
• Nykamp K, Lee MH, Kimble J. C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA. 2008;14:1378–1389.
   PubMed Web of Science ®Google Scholar
• Choe J, Lin S, Zhang W, et al. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018;561:556–560.
   PubMed Web of Science ®Google Scholar
• Fonseca BD, Jia JJ, Hollensen AK et al. LARP1 is a major phosphorylation substrate of mTORC1. BioRxiv, 2018. 491274
   Google Scholar
• Hopkins TG, Mura M, Al-Ashtal HA, et al. The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic Acids Res. 2016;44:1227–1246.
   PubMed Web of Science ®Google Scholar
• Kato M, Goto Y, Matsushita R, et al. MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer. Int J Oncol. 2015;47:710–718.
   PubMed Web of Science ®Google Scholar
• Selcuklu SD, Donoghue MT, Rehmet K, et al. MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells. J Biol Chem. 2012;287:29516–29528.
   PubMed Web of Science ®Google Scholar
• Scaturro P, Stukalov A, Haas DA, et al. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018;561:253–257.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Chin WX, Han Q, et al. Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication. PLoS Pathog. 2016;12(1):e1005357.
   PubMed Web of Science ®Google Scholar
• Hsieh AC, Liu Y, Edlind MP, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012;485:55–61.
   PubMed Web of Science ®Google Scholar
• Thoreen CC, Chantranupong L, Keys HR, et al. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012;485(7396):109–113.
   PubMed Web of Science ®Google Scholar
• Stavraka C, Mura M, Fischer R, et al. Protein interactions involving LARP1 in chemotherapy resistant ovarian cancer cells. Cancer Res (Proc AACR). 2017;77:B44.
   Web of Science ®Google Scholar
• Leprivier G, Rotblat B, Khan D, et al. Stress-mediated translational control in cancer cells. Biochim Biophys Acta. 2015;1849(7):845–860.
   PubMed Web of Science ®Google Scholar
• Lawrence RE, Zoncu R. The lysosome as a cellular centre for signalling, metabolism and quality control. Nat Cell Biol. 2019;21(2):133–142.
   PubMed Web of Science ®Google Scholar
• Stokes MP, Rush J, Macneill J, et al. Profiling of UV-induced ATM/ATR signalling pathways. Proc Natl Acad Sci U S A. 2007;104:19855–19860.
   PubMed Web of Science ®Google Scholar
• Dephoure N, Zhou C, Villén J, et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008;105:10762–10767.
   PubMed Web of Science ®Google Scholar
• Haneke K, Schott J, Lindner D, et al. (In print). CDK1 couples proliferation with protein synthesis. bioRxiv; 2019.
   Google Scholar
• Zhang Y, Wang ZH, Liu Y, et al. PINK1 inhibits local protein synthesis to limit transmission of deleterious mitochondrial DNA mutations. Mol Cell. 2019;73; 6:1127–1137.E5.
   Web of Science ®Google Scholar
• Brandt M, Grazioso TP, Fawal M-A, et al. mTORC1 inactivation promotes colitis-induced colorectal cancer but protects from APC loss-dependent tumorigenesis. Cell Metab. 2018;27(1):118–135.e8.
   PubMed Web of Science ®Google Scholar
• Dobbin ZC, Landen CN. The importance of the PI3K/AKT/MTOR pathway in the progression of ovarian cancer. Int J Mol Sci. 2013;15;14(4):8213–8227.
   Web of Science ®Google Scholar
• Wander SA, Hennessy BT, Slingerland JM. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest. 2011;121(4):1231–1241.
   PubMed Web of Science ®Google Scholar
• Kim LC, Cook RS, Chen J. MTORC1 and mTORC2 in cancer and the tumor microenvironment. Oncogene. 2017;36(16):2191–2201.
   PubMed Web of Science ®Google Scholar
• Xie J, Wang X, Proud CG. mTOR inhibitors in cancer therapy. F1000Res. 2016;5(F1000 Faculty Rev):2078.
   Google Scholar
• Maraia RJ, Mattijssen S, Cruz-Gallardo I, et al. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA. 2017;8(6):e1430.
   PubMed Web of Science ®Google Scholar
• Yamashita R, Suzuki Y, Takeuchi N, et al. Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics. Nucleic Acids Res. 2008;36(11):3707–3715.
   PubMed Web of Science ®Google Scholar
• Gentilella A, Thomas G. The director’s cut. Nature. 2012;485:p50–51.
   PubMed Web of Science ®Google Scholar
• Alfano C, Sanfelice D, Babon J, et al. Structural analysis of cooperative rnaRNA binding by the lLa motif and central rrmRRM domain of human lLa protein. Nat Struct Mol Biol. 2004;4:323-–329.
   Google Scholar
• Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6:pl1.
   Web of Science ®Google Scholar
• Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012. DOI:10.1158/2159-8290.CD-12-0095.
   PubMed Web of Science ®Google Scholar