Regulation of the p53 expression profile by hnRNP K under stress conditions

References

• Aylon Y, Oren M. The paradox of p53: what, how, and why? Cold Spring Harb Perspect Med. 2016;6(10):a026328.
   PubMed Web of Science ®Google Scholar
• Aubrey BJ, Kelly GL, Janic A, et al. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104–113.
   PubMed Web of Science ®Google Scholar
• Strudwick S, Carastro LM, Stagg T, et al. Differential transcription-coupled translational inhibition of human p53 expression: a potentially important mechanism of regulating p53 expression in normal versus tumor tissue. Mol Cancer Res. 2003;1(6):463–474.
   PubMed Web of Science ®Google Scholar
• Hafner A, Bulyk ML, Jambhekar A, et al. The multiple mechanisms that regulate p53 activity and cell fate. Nat Rev Mol Cell Biol. 2019;20(4):199–210.
   PubMed Web of Science ®Google Scholar
• Vieler M, Sanyal S. p53 isoforms and their implications in cancer. Cancers (Basel). 2018;10(9). DOI:10.3390/cancers10090288
   PubMed Web of Science ®Google Scholar
• Khoury MP, Bourdon JC. p53 isoforms: an intracellular microprocessor? Genes Cancer. 2011;2(4):453–465.
   PubMedGoogle Scholar
• Gorska A, Blaszczyk L, Dutkiewicz M, et al. Length variants of the 5ʹ untranslated region of p53 mRNA and their impact on the efficiency of translation initiation of p53 and its N-truncated isoform DeltaNp53. RNA Biol. 2013;10(11):1726–1740.
   PubMed Web of Science ®Google Scholar
• Zydowicz-Machtel P, Swiatkowska A, Popenda L, et al. Variants of the 5ʹ-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency. Sci Rep. 2018;8(1):1533.
   PubMedGoogle Scholar
• Swiatkowska A, Zydowicz P, Gorska A, et al. The role of structural elements of the 5ʹ-terminal region of p53 mRNA in translation under stress conditions assayed by the antisense oligonucleotide approach. PLoS One. 2015;10(10):e0141676.
   PubMed Web of Science ®Google Scholar
• Gorska A, Swiatkowska A, Dutkiewicz M, et al. Modulation of p53 expression using antisense oligonucleotides complementary to the 5ʹ-terminal region of p53 mRNA in vitro and in the living cells. PLoS One. 2013;8(11):e78863.
   PubMed Web of Science ®Google Scholar
• Haronikova L, Olivares-Illana V, Wang L, et al. The p53 mRNA: an integral part of the cellular stress response. Nucleic Acids Res. 2019;47(7):3257–3271.
   PubMed Web of Science ®Google Scholar
• Swiatkowska A, Zydowicz P, Sroka J, et al. The role of the 5ʹ terminal region of p53 mRNA in the p53 gene expression. Acta Biochim Pol. 2016;63(4):645–651.
   PubMed Web of Science ®Google Scholar
• Grover R, Ray PS, Das S. Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms. Cell Cycle. 2008;7(14):2189–2198.
   PubMed Web of Science ®Google Scholar
• Grover R, Sharathchandra A, Ponnuswamy A, et al. Effect of mutations on the p53 IRES RNA structure: implications for de-regulation of the synthesis of p53 isoforms. RNA Biol. 2011;8(1):132–142.
   PubMed Web of Science ®Google Scholar
• Khan D, Sharathchandra A, Ponnuswamy A, et al. Effect of a natural mutation in the 5ʹ untranslated region on the translational control of p53 mRNA. Oncogene. 2013;32(35):4148–4159.
   PubMed Web of Science ®Google Scholar
• Takagi M, Absalon MJ, McLure KG, et al. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005;123(1):49–63.
   PubMed Web of Science ®Google Scholar
• Candeias MM, Malbert-Colas L, Powell DJ, et al. P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol. 2008;10(9):1098–1105.
   PubMed Web of Science ®Google Scholar
• Makeyev AV, Liebhaber SA. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA. 2002;8(3):265–278.
   PubMed Web of Science ®Google Scholar
• Kim JH, Hahm B, Kim YK, et al. Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. J Mol Biol. 2000;298(3):395–405.
   PubMed Web of Science ®Google Scholar
• Moumen A, Masterson P, O’Connor MJ, et al. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell. 2005;123(6):1065–1078.
   PubMed Web of Science ®Google Scholar
• Michlewski G, Caceres JF. RNase-assisted RNA chromatography. RNA. 2010;16(8):1673–1678.
   PubMed Web of Science ®Google Scholar
• Bakun M, Karczmarski J, Poznanski J, et al. An integrated LC-ESI-MS platform for quantitation of serum peptide ladders. Application for colon carcinoma study. Proteomics Clin Appl. 2009;3(8):932–946.
   PubMed Web of Science ®Google Scholar
• Chen J, Guo K, Kastan MB. Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. J Biol Chem. 2012;287(20):16467–16476.
   PubMed Web of Science ®Google Scholar
• Barberi-Heyob M, Vedrine PO, Merlin JL, et al. Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. Int J Oncol. 2004;24(4):951–958.
   PubMed Web of Science ®Google Scholar
• Mosner J, Mummenbrauer T, Bauer C, et al. Negative feedback regulation of wild-type p53 biosynthesis. Embo J. 1995;14(18):4442–4449.
   PubMed Web of Science ®Google Scholar
• Bonnal S, Pileur F, Orsini C, et al. Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA. J Biol Chem. 2005;280(6):4144–4153.
   PubMed Web of Science ®Google Scholar
• Ray PS, Das S. La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic Acids Res. 2002;30(20):4500–4508.
   PubMed Web of Science ®Google Scholar
• Evans JR, Mitchell SA, Spriggs KA, et al. Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. Oncogene. 2003;22(39):8012–8020.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay NK, Kim J, Cinar B, et al. Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res. 2009;69(6):2210–2218.
   PubMed Web of Science ®Google Scholar
• Bomsztyk K, Denisenko O, Ostrowski J. hnRNP K: one protein multiple processes. Bioessays. 2004;26(6):629–638.
   PubMed Web of Science ®Google Scholar
• Dominguez D, Freese P, Alexis MS, et al. Sequence, structure, and context preferences of human RNA binding proteins. Mol Cell. 2018;70(5):854–67 e9.
   PubMed Web of Science ®Google Scholar
• Kim DY, Kim W, Lee KH, et al. hnRNP Q regulates translation of p53 in normal and stress conditions. Cell Death Differ. 2013;20(2):226–234.
   PubMed Web of Science ®Google Scholar
• Szpotkowska J, Swiatkowska A, Ciesiolka J. Length and secondary structure of the 5ʹ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies. RNA Biol. 2019;16(1):25–41.
   PubMed Web of Science ®Google Scholar
• Mlynarczyk C, Fahraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A). Nat Commun. 2014;5(1):5067.
   PubMedGoogle Scholar
• Barboro P, Ferrari N, Balbi C. Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression. Cancer Lett. 2014;352(2):152–159.
   PubMed Web of Science ®Google Scholar
• Lin WC, Chuang YC, Chang YS, et al. Endoplasmic reticulum stress stimulates p53 expression through NF-kappaB activation. PLoS One. 2012;7(7):e39120.
   PubMed Web of Science ®Google Scholar
• Ostrowski J, Kawata Y, Schullery DS, et al. Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci. Nucleic Acids Res. 2003;31(14):3954–3962.
   PubMed Web of Science ®Google Scholar
• Michelotti EF, Michelotti GA, Aronsohn AI, et al. Heterogeneous nuclear ribonucleoprotein K is a transcription factor. Mol Cell Biol. 1996;16(5):2350–2360.
   PubMed Web of Science ®Google Scholar
• Ritchie SA, Pasha MK, Batten DJ, et al. Identification of the SRC pyrimidine-binding protein (SPy) as hnRNP K: implications in the regulation of SRC1A transcription. Nucleic Acids Res. 2003;31(5):1502–1513.
   PubMed Web of Science ®Google Scholar
• Saldana-Meyer R, Recillas-Targa F. Transcriptional and epigenetic regulation of the p53 tumor suppressor gene. Epigenetics. 2011;6(9):1068–1077.
   PubMed Web of Science ®Google Scholar
• Dintilhac A, Bernues J. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. J Biol Chem. 2002;277(9):7021–7028.
   PubMed Web of Science ®Google Scholar
• Youn JH, Shin JS. Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J Immunol. 2006;177(11):7889–7897.
   PubMed Web of Science ®Google Scholar
• Debaize L, Troadec MB. The master regulator FUBP1: its emerging role in normal cell function and malignant development. Cell Mol Life Sci. 2019;76(2):259–281.
   PubMed Web of Science ®Google Scholar
• Rabenhorst U, Thalheimer FB, Gerlach K, et al. Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal. Cell Rep. 2015;11(12):1847–1855.
   PubMed Web of Science ®Google Scholar
• Dixit U, Pandey AK, Liu Z, et al. FUSE binding protein 1 facilitates persistent hepatitis C virus replication in hepatoma cells by regulating tumor suppressor p53. J Virol. 2015;89(15):7905–7921.
   PubMed Web of Science ®Google Scholar
• Frost JR, Mendez M, Soriano AM, et al. Adenovirus 5 E1A-mediated suppression of p53 via FUBP1. J Virol. 2018;92(14):14.
   Web of Science ®Google Scholar
• Dixit U, Liu Z, Pandey AK, et al. Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53. BMC Cancer. 2014;14:925.
   PubMed Web of Science ®Google Scholar
• Ostareck DH, Ostareck-Lederer A, Shatsky IN, et al. Lipoxygenase mRNA silencing in erythroid differentiation: the 3ʹUTR regulatory complex controls 60S ribosomal subunit joining. Cell. 2001;104(2):281–290.
   PubMed Web of Science ®Google Scholar
• Li J, Lee B, Lee AS. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem. 2006;281(11):7260–7270.
   PubMed Web of Science ®Google Scholar
• Candeias MM, Powell DJ, Roubalova E, et al. Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene. 2006;25(52):6936–6947.
   PubMed Web of Science ®Google Scholar
• Qu L, Huang S, Baltzis D, et al. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 2004;18(3):261–277.
   PubMed Web of Science ®Google Scholar
• Rahman-Roblick R, Roblick UJ, Hellman U, et al. p53 targets identified by protein expression profiling. Proc Natl Acad Sci U S A. 2007;104(13):5401–5406.
   PubMed Web of Science ®Google Scholar
• Qin G, Tu X, Li H, et al. Long noncoding RNA p53-stabilizing and activating RNA promotes p53 signaling by inhibiting heterogeneous nuclear ribonucleoprotein K deSUMOylation and suppresses hepatocellular carcinoma. Hepatology. 2019. DOI:10.1002/hep.30793
   Web of Science ®Google Scholar
• Dangelmaier E, Lazar SB, Lal A. Long noncoding RNAs: p53’s secret weapon in the fight against cancer? PLoS Biol. 2019;17(2):e3000143.
   PubMed Web of Science ®Google Scholar
• Huarte M, Guttman M, Feldser D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010;142(3):409–419.
   PubMed Web of Science ®Google Scholar
• Ostareck-Lederer A, Ostareck DH, Cans C, et al. c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol. 2002;22(13):4535–4543.
   PubMed Web of Science ®Google Scholar
• Inoue A, Sawata SY, Taira K, et al. Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis. Proc Natl Acad Sci U S A. 2007;104(21):8983–8988.
   PubMed Web of Science ®Google Scholar
• Blaszczyk L, Ciesiolka J. Secondary structure and the role in translation initiation of the 5ʹ-terminal region of p53 mRNA. Biochemistry. 2011;50(33):7080–7092.
   PubMed Web of Science ®Google Scholar
• Figlerowicz M, Urbanowicz A, Lewandowski D, et al. Functional insights into recombinant TROSPA protein from Ixodes ricinus. PLoS One. 2013;8(10):e76848.
   PubMed Web of Science ®Google Scholar