Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation

References

• Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18:31–42.
   PubMed Web of Science ®Google Scholar
• Roundtree IA, Evans ME, Pan T, et al. Dynamic RNA modifications in gene expression regulation. Cell. 2017;169:1187–1200.
   PubMed Web of Science ®Google Scholar
• Aguilo F, Zhang F, Sancho A, et al. Coordination of m6A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming. Cell Stem Cell. 2015;17:689–704.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Y, Yue M, et al. N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018;21:195–206.
   PubMed Web of Science ®Google Scholar
• Wen J, Lv R, Ma H, et al. Zc3h13 regulates Nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal. Mol Cell. 2018;69(1028–1038.e6):1028–1038.e6. .
   Google Scholar
• Bertero A, Brown S, Madrigal P, et al. The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature. 2018;555:256–259.
   PubMed Web of Science ®Google Scholar
• Wu Y, Xie L, Wang M, et al. Mettl3-mediated m 6 A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun. 2018;9. DOI:10.1038/s41467-018-06898-4.
   Web of Science ®Google Scholar
• Shi H, Wei J, He C. Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell. 2019;74:640–650.
   PubMed Web of Science ®Google Scholar
• Su R, Dong L, Li Y, et al. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020;38:1–18.
   PubMed Web of Science ®Google Scholar
• Shen C, Sheng Y, Zhu AC, et al. RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia. Cell Stem Cell. 2020;27(64–80.e9):64–80.e9. .
   PubMedGoogle Scholar
• Batista PJ, Molinie B, Wang J, et al. m6A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014;15:707–719.
   PubMed Web of Science ®Google Scholar
• Mansour AA, Kol N, Hershkovitz V, et al. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015;347:1002–1006.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Y, Toth JI, et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014;16:191–198.
   PubMed Web of Science ®Google Scholar
• Vu LP, Pickering BF, Cheng Y, et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017;23:1369–1376.
   PubMed Web of Science ®Google Scholar
• Ignatova VV, Stolz P, Kaiser S, et al. The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev. 2020;34:715–729.
   PubMed Web of Science ®Google Scholar
• Berlivet S, Scutenaire J, Deragon JM, et al. Readers of the m6A epitranscriptomic code. Biochim Biophys Acta. 2019;1862:329–342.
   PubMed Web of Science ®Google Scholar
• Patil DP, Pickering BF, Jaffrey SR. Reading m6A in the transcriptome: m6A-binding proteins. Trends Cell Biol. 2018;28:113–127.
   PubMed Web of Science ®Google Scholar
• Wu B, Li L, Huang Y, et al. Readers, writers and erasers of N6-methylated adenosine modification. Curr Opin Struct Biol. 2017;47:67–76.
   PubMed Web of Science ®Google Scholar
• Wang X, Lu Z, Gomez A, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117–120.
   PubMed Web of Science ®Google Scholar
• Du H, Zhao Y, He J, et al. YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nat Commun. 2016;7. DOI:10.1038/ncomms12626.
   Web of Science ®Google Scholar
• Wang X, Zhao BS, Roundtree IA, et al. N6-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161:1388–1399.
   PubMed Web of Science ®Google Scholar
• Li A, Chen Y-S, Ping X-L, et al. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Res. 2017;27:444–447.
   PubMed Web of Science ®Google Scholar
• Shi H, Wang X, Lu Z, et al. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Res. 2017;27:315–328.
   PubMed Web of Science ®Google Scholar
• Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA. Cell. 2020;181:1582–1595.
   PubMed Web of Science ®Google Scholar
• Heck AM, Russo J, Wilusz J, et al. YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells. RNA. 2020;26:739–755.
   PubMed Web of Science ®Google Scholar
• Zhao H, Jin Y. Signaling networks in the control of pluripotency. Curr Opin Genet Dev. 2017;46:141–148.
   PubMed Web of Science ®Google Scholar
• Aguilo F, Walsh MJ. The N6-Methyladenosine RNA modification in pluripotency and reprogramming. Curr Opin Genet Dev. 2017;46:77–82.
   PubMed Web of Science ®Google Scholar
• Zhang C, Chen Y, Sun B, et al. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017;549:273–276.
   PubMed Web of Science ®Google Scholar
• Li M, Zhao X, Wang W, et al. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 2018;19:1–16.
   PubMed Web of Science ®Google Scholar
• Wu R, Liu Y, Yao Y, et al. FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism. Biochim Biophys Acta - Mol Cell Biol Lipids. 2018;1863:1323–1330.
   PubMed Web of Science ®Google Scholar
• Paris J, Morgan M, Campos J, et al. Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia. Cell Stem Cell. 2019;25:137–148.
   PubMed Web of Science ®Google Scholar
• Liu X, Qian S. Linking m6A to Wnt signaling. EMBO Rep. 2020;53:436–445.
   Google Scholar
• Han B, Yan S, Wei S, et al. YTHDF1‐mediated translation amplifies Wnt‐driven intestinal stemness. EMBO Rep. 2020;21(4):e49229. .
   PubMed Web of Science ®Google Scholar