Molecular determinants and heterogeneity underlying host response to EV-A71 infection at single-cell resolution

References

• Ooi MH, Wong SC, Lewthwaite P, et al. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol. 2010;9(11):1097–1105.
   PubMed Web of Science ®Google Scholar
• Solomon T, Lewthwaite P, Perera D, et al. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010;10:778–790.
   PubMed Web of Science ®Google Scholar
• Nishimura Y, Shimojima M, Tano Y, et al. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. Nat Med. 2009;15(7):794–797.
   PubMed Web of Science ®Google Scholar
• Yamayoshi S, Yamashita Y, Li J, et al. Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat Med. 2009;15(7):798–801.
   PubMed Web of Science ®Google Scholar
• Yang SL, Chou YT, Wu CN, et al. Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity. J Virol. 2011;85:11809–11820.
   PubMed Web of Science ®Google Scholar
• Yeung ML, Jia L, Yip CCY, et al. Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. J Clin Invest. 2018;128:5163–5177.
   PubMed Web of Science ®Google Scholar
• Baggen J, Thibaut HJ, Strating J, et al. The life cycle of non-polio enteroviruses and how to target it. Nat Rev Microbiol. 2018;16:368–381.
   PubMed Web of Science ®Google Scholar
• Chen KR, Ling P. Interplays between Enterovirus A71 and the innate immune system. J Biomed Sci. 2019;26:95.
   PubMed Web of Science ®Google Scholar
• Chen W, Du M, Hu X, et al. Long noncoding RNA cytoskeleton regulator RNA promotes cell invasion and metastasis by titrating miR-613 to regulate ANXA2 in nasopharyngeal carcinoma. Cancer Med. 2020;9(3):1209–1219.
   PubMed Web of Science ®Google Scholar
• Kuo RL, Kung SH, Hsu YY, et al. Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death. J Gen Virol. 2002;83:1367–1376.
   PubMed Web of Science ®Google Scholar
• Liu YC, Kuo RL, Lin JY, et al. Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8. PLoS Pathog. 2014;10:e1004199.
   PubMed Web of Science ®Google Scholar
• Weng KF, Li ML, Hung CT, et al. Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation. PLoS Pathog. 2009;5:e1000593.
   PubMed Web of Science ®Google Scholar
• Drummond CG, Bolock AM, Ma C, et al. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017;114(7):1672–1677.
   PubMed Web of Science ®Google Scholar
• Kuo RL, Lin YH, Wang RY, et al. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication. J Proteome Res. 2015;14:1818–1830.
   PubMed Web of Science ®Google Scholar
• Leong WF, Chow VT. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell Microbiol. 2006;8:565–580.
   PubMed Web of Science ®Google Scholar
• Shih SR, Stollar V, Lin JY, et al. Identification of genes involved in the host response to enterovirus 71 infection. J Neurovirol. 2004;10:293–304.
   PubMed Web of Science ®Google Scholar
• Russell AB, Trapnell C, Bloom JD. Extreme heterogeneity of influenza virus infection in single cells. Elife. 2018;7. DOI:10.7554/eLife.32303
   Web of Science ®Google Scholar
• Ramos I, Smith G, Ruf-Zamojski F, et al. Innate immune response to influenza virus at Single-Cell resolution in human epithelial cells revealed paracrine induction of interferon lambda 1. J Virol. 2019;93(20).
   Web of Science ®Google Scholar
• Carpenter S. Long noncoding RNA: novel links between gene expression and innate immunity. Virus Res. 2016;212:137–145.
   PubMed Web of Science ®Google Scholar
• Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2012;81:145–166.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang C, Qin L, et al. Characterization of critical functions of long Non-Coding RNAs and mRNAs in Rhabdomyosarcoma cells and mouse skeletal muscle infected by Enterovirus 71 Using RNA-Seq. Viruses. 2018;10(10).
   Web of Science ®Google Scholar
• Yin Z, Guan D, Fan Q, et al. lncRNA expression signatures in response to enterovirus 71 infection. Biochem Biophys Res Commun. 2013;430:629–633.
   PubMed Web of Science ®Google Scholar
• Good C, Wells AI, Coyne CB. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5(3):eaau4255.
   PubMed Web of Science ®Google Scholar
• Huang HI, Lin JY, Chiang HC, et al. Exosomes facilitate transmission of Enterovirus A71 from human intestinal epithelial cells. J Infect Dis. 2020. DOI:10.1093/infdis/jiaa174
   Web of Science ®Google Scholar
• Mithal A, Capilla A, Heinze D, et al. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020;11(1):215.
   PubMed Web of Science ®Google Scholar
• Spence JR, Mayhew CN, Rankin SA, et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011;470(7332):105–109.
   PubMed Web of Science ®Google Scholar
• Forbester JL, Hannan N, Vallier L, et al. Derivation of intestinal organoids from human induced pluripotent stem cells for use as an infection system. Methods Mol Biol. 2019;1576:157–169.
   PubMedGoogle Scholar
• Feng Q, Langereis MA, Lork M, et al. Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J Virol. 2014;88(6):3369–3378.
   PubMed Web of Science ®Google Scholar
• Kuo RL, Chen CJ, Wang RYL, et al. Role of enteroviral RNA-Dependent RNA polymerase in regulation of MDA5-mediated beta interferon activation. J Virol. 2019;93(10).
   Web of Science ®Google Scholar
• Lee YP, Wang YF, Wang JR, et al. Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice. J Med Virol. 2012;84:1779–1789.
   PubMed Web of Science ®Google Scholar
• Chen WM, Huang MD, Sun DP, et al. Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer. Oncotarget. 2016;7:9773–9787.
   PubMedGoogle Scholar
• Li M, Wang Q, Xue F, et al. lncRNA-CYTOR works as an oncogene through the CYTOR/miR-3679-5p/MACC1 axis in colorectal cancer. DNA Cell Biol. 2019;38:572–582.
   PubMed Web of Science ®Google Scholar
• Liang J, Wei X, Liu Z, et al. Long noncoding RNA CYTOR in cancer: A TCGA data review. Clin Chim Acta. 2018;483:227–233.
   PubMed Web of Science ®Google Scholar