Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2

References

• Mugridge JS, Coller J, Gross JD. Structural and molecular mechanisms for the control of eukaryotic 5ʹ-3ʹ mRNA decay. Nat Struct Mol Biol. 2018 Dec;25(12):1077–1085.
   PubMed Web of Science ®Google Scholar
• Collart MA. The Ccr4-Not complex is a key regulator of eukaryotic gene expression. Wiley Interdiscip Rev RNA. 2016 July;7(4):438–454.
   PubMed Web of Science ®Google Scholar
• Boland A, Chen Y, Raisch T, et al. Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol. 2013 Nov;20(11):1289–U218.
   PubMed Web of Science ®Google Scholar
• Chen Y, Boland A, Kuzuoglu-Ozturk D, et al. A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Mol Cell. 2014 Jun;54(5):737–750.
   PubMed Web of Science ®Google Scholar
• Bawankar P, Loh B, Wohlbold L, et al. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol. 2013 Feb;10(2):228–244.
   PubMed Web of Science ®Google Scholar
• Petit AP, Wohlbold L, Bawankar P, et al. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res. 2012 Nov;40(21):11058–11072.
   PubMed Web of Science ®Google Scholar
• Basquin J, Roudko VV, Rode M, et al. Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction. Mol Cell. 2012 Oct;48(2):207–218.
   PubMed Web of Science ®Google Scholar
• Bhaskar V, Roudko V, Basquin J, et al. Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex. Nat Struct Mol Biol. 2013 Nov;20(11):1281–1288.
   PubMed Web of Science ®Google Scholar
• Ito K, Takahashi A, Morita M, et al. The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. Protein Cell. 2011 Sep;2(9):755–763.
   PubMed Web of Science ®Google Scholar
• Zheng X, Dumitru R, Lackford BL, et al. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells. 2012 May;30(5):910–922.
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Suzuki T, Sato T, et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018 Feb;11(516):516.
   Web of Science ®Google Scholar
• Takahashi A, Takaoka S, Kobori S, et al. The CCR4-NOT deadenylase complex maintains adipocyte identity. Int J Mol Sci. 2019 Oct;20(21):21.
   Web of Science ®Google Scholar
• Takahashi A, Suzuki T, Soeda S, et al. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Sci Alliance. 2020 May;3(5):5.
   Web of Science ®Google Scholar
• Mostafa D, Takahashi A, Yanagiya A, et al. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Mar;17(3):403–416.
   PubMed Web of Science ®Google Scholar
• Chicoine J, Benoit P, Gamberi C, et al. Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression. Dev Cell. 2007 Nov;13(5):691–704.
   PubMed Web of Science ®Google Scholar
• Ito K, Inoue T, Yokoyama K, et al. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells. 2011 Apr;16(4):368–379.
   PubMed Web of Science ®Google Scholar
• Morita M, Oike Y, Nagashima T, et al. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3± mice. EMBO J. 2011 Sep;30(22):4678–4691.
   PubMed Web of Science ®Google Scholar
• Watanabe C, Morita M, Hayata T, et al. Stability of mRNA influences osteoporotic bone mass via CNOT3. Proc Natl Acad Sci U S A. 2014 Feb;111(7):2692–2697.
   PubMed Web of Science ®Google Scholar
• Inoue T, Morita M, Hijikata A, et al. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med. 2015 Aug;212(9):1465–1479.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Kikuguchi C, Sharma S, et al. CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins. Sci Rep. 2015 Oct;5(1):14779.
   PubMedGoogle Scholar
• Suzuki T, Kikuguchi C, Nishijima S, et al. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019;146:4.
   Web of Science ®Google Scholar
• Mostafa D, Yanagiya A, Georgiadou E, et al. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Commun Biol. 2020 Aug;3(1):476.
   PubMed Web of Science ®Google Scholar
• Ito-Kureha T, Miyao T, Nishijima S, et al. The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nat Commun. 2020 Dec;11(1):6169.
   PubMed Web of Science ®Google Scholar
• Temme C, Zhang L, Kremmer E, et al. Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA. 2010 Jul;16(7):1356–1370.
   PubMed Web of Science ®Google Scholar
• Buschauer R, Matsuo Y, Sugiyama T, et al. The Ccr4-Not complex monitors the translating ribosome for codon optimality. Science. 2020 Apr;368:6488.
   Web of Science ®Google Scholar
• Garces RG, Gillon W, Pai EF. Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties. Protein Sci. 2007 Feb;16(2):176–188.
   PubMed Web of Science ®Google Scholar
• Keskeny C, Raisch T, Sgromo A, et al. A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes Dev. 2019 Feb 01;33(3–4):236–252.
   PubMed Web of Science ®Google Scholar
• Sgromo A, Raisch T, Bawankar P, et al. A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Nat Commun. 2017 Feb 06;8:14307.
   PubMed Web of Science ®Google Scholar
• Sgromo A, Raisch T, Backhaus C, et al. Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. RNA. 2018 Mar;24(3):381–395.
   PubMed Web of Science ®Google Scholar
• Raisch T, Chang CT, Levdansky Y, et al. Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation. Nat Commun. 2019 July;10(1):3173.
   PubMedGoogle Scholar
• Leppek K, Schott J, Reitter S, et al. Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs. Cell. 2013 May;153(4):869–881.
   PubMed Web of Science ®Google Scholar
• Adachi S, Homoto M, Tanaka R, et al. ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. Nucleic Acids Res. 2014 Sep;42(15):10037–10049.
   PubMed Web of Science ®Google Scholar
• Fabian MR, Frank F, Rouya C, et al. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat Struct Mol Biol. 2013 Jun;20(6):735-+.
   PubMed Web of Science ®Google Scholar
• Sanduja S, Blanco FF, Dixon DA. The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):42–57.
   PubMed Web of Science ®Google Scholar
• Mahtani KR, Brook M, Dean JL, et al. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol. 2001 Oct;21(19):6461–6469.
   PubMed Web of Science ®Google Scholar
• Carballo E, Cao H, Lai WS, et al. Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. J Biol Chem. 2001 Nov;276(45):42580–42587.
   PubMed Web of Science ®Google Scholar
• Chrestensen CA, Schroeder MJ, Shabanowitz J, et al. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem. 2004 Mar;279(11):10176–10184.
   PubMed Web of Science ®Google Scholar
• Maitra S, Chou CF, Luber CA, et al. The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2. RNA. 2008 May;14(5):950–959.
   PubMed Web of Science ®Google Scholar
• Hitti E, Iakovleva T, Brook M, et al. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol. 2006 Mar;26(6):2399–2407.
   PubMed Web of Science ®Google Scholar
• Cao H, Dzineku F, Blackshear PJ. Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. Arch Biochem Biophys. 2003 Apr;412(1):106–120.
   PubMed Web of Science ®Google Scholar
• Cuenda A, Rouse J, Doza YN, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995 May 08;364(2):229–233.
   PubMed Web of Science ®Google Scholar
• Bennett BL, Sasaki DT, Murray BW, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13681–13686.
   PubMed Web of Science ®Google Scholar
• Consortium U. UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res. 2021 Jan 08;49(D1):D480–D489.
   PubMed Web of Science ®Google Scholar
• Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83.
   PubMed Web of Science ®Google Scholar
• Diskin R, Askari N, Capone R, et al. Active mutants of the human p38alpha mitogen-activated protein kinase. J Biol Chem. 2004 Nov 05;279(45):47040–47049.
   PubMed Web of Science ®Google Scholar
• Anderson DR, Meyers MJ, Vernier WF, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647–2654.
   PubMed Web of Science ®Google Scholar
• Yi H, Park J, Ha M, et al. PABP cooperates with the CCR4-NOT complex to promote mRNA deadenylation and block precocious decay. Mol Cell. 2018 Jun;70(6):1081-+.
   Web of Science ®Google Scholar
• Aslam A, Mittal S, Koch F, et al. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Mol Biol Cell. 2009 Sep;20(17):3840–3850.
   PubMed Web of Science ®Google Scholar
• Mittal S, Aslam A, Doidge R, et al. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Mol Biol Cell. 2011 Mar;22(6):748–758.
   PubMed Web of Science ®Google Scholar
• Moriya H, Shimizu-Yoshida Y, Omori A, et al. Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev. 2001 May 15;15(10):1217–1228.
   PubMed Web of Science ®Google Scholar
• Torres M. Mitogen-activated protein kinase pathways in redox signaling. Front Biosci. 2003 Jan 01;8(8):d369–91.
   PubMedGoogle Scholar
• Rodriguez-Gil A, Ritter O, Hornung J, et al. HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 2016 Jun;27(12):1969–1980.
   PubMed Web of Science ®Google Scholar
• Wu CC, Peterson A, Zinshteyn B, et al. Ribosome collisions trigger general stress responses to regulate cell fate. Cell. 2020 07; 182(2): 404–416.e14.
   PubMed Web of Science ®Google Scholar
• Sharma S, Poetz F, Bruer M, et al. Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 and HDAC1/2. Mol Cell. 2016 Sep;63(6):927–938.
   PubMed Web of Science ®Google Scholar