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Research Article

Mechanisms of Signal Transduction from Receptors of Type I and Type II Cytokines

Pages 69-76 | Received 11 Nov 2006, Accepted 05 Dec 2006, Published online: 09 Oct 2008

REFERENCES

  • Alexander W. S., Hilton D. J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Ann. Rev. Immunol. 2004; 22: 503–529
  • Ascherman D. P., Migone T. S., Friedmann M. C., Leonard W. J. Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor α chain gene. J. Biol. Chem. 1997; 272: 8704–8709
  • Bourdeau A., Dube N., Tremblay M. L. Cytoplasmic protein tyrosine phosphatases, regulation and function: The roles of PTP1B and TC-PTP. Curr. Opin. Cell Biol. 2005; 17: 203–209
  • Boussiotis V. A., Barber D. L., Nakarai T., Freeman G. J., Gribben J. G., Bernstein G. M., D'Andrea A. D., Ritz J., Nadler L. M. Prevention of T-cell anergy by signaling through the γ c chain of the IL-2 receptor. Science 1994; 266: 1039–1042
  • Cao X., Shores E. W., Hu-Li J., Anver M. R., Kelsall B. L., Russell S. M., Drago J., Noguchi M., Grinberg A., Bloom E. T., Paul W. E., Katz S. I., Love P. E., Leonard W. J. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 1995; 2: 223–238
  • Chida D., Miura O., Yoshimura A., Miyajima A. Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: Functional analysis of signaling molecules by retrovirus-mediated expression. Blood 1999; 93: 1567–1578
  • Chretien S., Varlet P., Verdier F., Gobert S., Cartron J. P., Gisselbrecht S., Mayeux P., Lacombe C. Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. EMBO J. 1996; 15: 4174–4181
  • Constantinescu S. N., Ghaffari S., Lodish H. F. The erythropoietin receptor: Structure, activation and intracellular signal transduction. Trends Endocrinol. Metab. 1999; 10: 18–23
  • D'Cruz L. M., Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T-cells in the absence of interleukin-2 signaling. Nat. Immunol. 2005; 6: 1152–1159
  • de Vos A. M., Ultsch M., Kossiakoff A. A. Human growth hormone and extracellular domain of its receptor. Science 1992; 255: 306–312
  • Fontenot J. D., Gavin M. A., Rudensky A. Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T-cells. Nat. Immunol. 2003; 4: 330–336
  • Fontenot J. D., Rasmussen J. P., Gavin M. A., Rudensky A. Y. A function for interleukin-2 in Foxp3-expressing regulatory T-cells. Nat. Immunol. 2005; 6: 1142–1151
  • Fruman D. A., Meyers R. E., Cantley L. C. Phosphoinositide kinases. Ann. Rev. Biochem. 1998; 67: 481–507
  • Fujii H., Ogasawara K., Otsuka H., Suzuki M., Yamamura K., Yokochi T., Miyazaki T., Suzuki H., Mak T. W., Taki S., Taniguchi T. Functional dissection of the cytoplasmic subregions of the IL-2 receptor β c chain in primary lymphocyte populations. EMBO J. 1998; 17: 6551–6557
  • Gregory R. C., Jiang N., Todokoro K., Crouse J., Pacifici R. E., Wojchowski D. M. Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization. Blood 1998; 92: 1104–1118
  • Haspel R. L., Darnell J. E., Jr. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. Proc. Natl. Acad. Sci. USA 1999; 96: 10188–10193
  • Hoey T., Zhang S., Schmidt N., Yu Q., Ramachandani S., Xu X., Naeger L. K., Sun Y. L., Kaplan D. H. Distinct requirements for the naturally occurring splice form Stat4α and Stat4β in IL-12 responses. EMBO J. 2003; 22: 4237–4248
  • Horak I., Lohler J., Ma A., Smith K. A. Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance. Immunol. Rev. 1995; 148: 35–44
  • Hori S., Nomura T., Sakaguchi S. Control of regulatory T-cell development by the transcription factor Foxp3. Science 2003; 299: 1057–1061
  • Hoshino A., Matsumura S., Kondo K., Hirst J. A., Fujii H. Inducible translocation trap: A system for detecting inducible nuclear translocation. Mol. Cell 2004; 15: 153–159
  • Hoshino A., Saint Fleur S., Fujii H. Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain. Biochem. Biophys. Res. Commun. 2006; 346: 1062–1066
  • Hou X. S., Melnick M. B., Perrimon N. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 1996; 84: 411–419
  • Ihle J. N. STATs: Signal transducers and activators of transcription. Cell 1996; 84: 331–334
  • Ihle J. N. The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 2001; 13: 211–217
  • Iwatsuki K., Endo T., Misawa H., Yokouchi M., Matsumoto A., Ohtsubo M., Mori K. J., Yoshimura A. STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line. J. Biol. Chem. 1997; 272: 8149–8152
  • Kaplan M. H., Schindler U., Smiley S. T., Grusby M. J. Stat6 is required for mediating responses to IL-4 and for development of TH2 cells. Immunity 1996; 4: 313–319
  • Khattri R., Cox T., Yasayko S. A., Ramsdell F. An essential role for Scurfin in CD4+CD25+ T-regulatory cells. Nat. Immunol. 2003; 4: 337–342
  • Kile B. T., Nicola N. A., Alexander W. S. Negative regulators of cytokine signaling. Int. J. Hematol. 2001; 73: 292–298
  • Kim T. K., Maniatis T. Regulation of interferon-γ-activated STAT1 by the ubiquitin-proteasome pathway. Science 1996; 273: 1717–1719
  • Kishimoto T. Interleukin-6: From basic science to medicine—40 years in immunology. Annu. Rev. Immunol. 2005; 23: 1–21
  • Kramer S., Schimpl A., Hunig T. Immunopathology of interleukin (IL) 2-deficient mice: Thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J. Exp. Med. 1995; 182: 1769–1776
  • Leonard W. J. Type I cytokines and interferons and their receptors. Fundamental Immunology, W. E. Paul. Lippincott Williams & Wilkins, Philadelphia, PA 2003; 701–747
  • Levy D. E., Darnell J. E., Jr. Stats: Transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002; 3: 651–662
  • Liu B., Mink S., Wong K. A., Stein N., Getman C., Dempsey P. W., Wu H., Shuai K. PIAS1 selectively inhibits interferon-inducible genes and is imporatnt in innate immunity. Nat. Immunol. 2004; 5: 891–898
  • Maritano D., Sugrue M. L., Tininini S., Dewilde S., Strobl B., Fu X., Murray-Tait V., Chiarle R., Poli V. The STAT3 isoforms α and β have unique and specific functions. Nat. Immunol. 2004; 5: 401–409
  • Miyazaki T., Kawahara A., Fujii H., Nakagawa Y., Minami Y., Liu Z. J., Oishi I., Silvennoinen O., Witthuhn B. A., Ihle J. N., Taniguchi T. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994; 266: 1045–1047
  • Nakajima H., Liu X. W., Wynshaw-Boris A., Rosenthal L. A., Imada K., Finbloom D. S., Hennighausen L., Leonard W. J. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 1997; 7: 691–701
  • Noguchi M., Yi H., Rosenblatt H. M., Filipovich A. H., Adelstein S., Modi A. S., McBride O. W., Leonard W. J. Interleukin-2 receptor γ chain mutation results in X-linked severe combined Immunodeficiency in human. Cell 1993; 73: 147–157
  • O'Shea J. J. Jaks, STATs, cytokine signal transduction, and immunoregulation: Are we there yet?. Immunity 1997; 7: 1–11
  • Qu C. K. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim. Biophys. Acta 2002; 1592: 297–301
  • Russell S. M., Johnston J. A., Noguchi M., Kawamura M., Bacon C. M., Friedmann M., Berg M., McVicar D. W., Witthuhn B. A., Silvennoinen O., Goldman A. S., Schmalstieg F. C., Ihle J. N., O'Shea J. J., Leonard W. J. Interaction of IL-2Rβ and γ c chains with Jak1 and Jak3: Implications for XSCID and XCID. Science 1994; 266: 1042–1045
  • Shimoda K., van Deursen J., Sangster M. Y., Sarawar S. R., Carson R. T., Tripp R. A., Chu C., Quelle F. W., Nosaka T., Vignali D. A., Doherty P. C., Grosveld G., Paul W. E., Ihle J. N. Lack of IL-4-induced TH2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996; 380: 630–633
  • Shuai K., Liu B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 2003; 3: 900–911
  • Smith K. A. Interleukin 2: Inception, impact and implications. Science 1988; 240: 1169–1176
  • Socolovsky M., Faloon A. E. J., Wang S., Brugnara C., Lodish H. F. Fetal anemia and apoptosis of red cell projenitors in Stat5a−/−5b−/− mice: A direct role for Stat5 in Bcl-XL induction. Cell 1999; 98: 181–191
  • Stark G. R., Kerr I. M., Williams B. R., Silverman R. H., Schreiber R. D. How cells respond to interferons. Annu. Rev. Biochem. 1998; 67: 227–264
  • Suzuki H., Kündig T. M., Furlonger C., Wakeman A., Timms E., Matsuyama T., Schmits R., Simard J. J., Ohashi P. S., Griesser H., Taniguchi T., Paige C. J., Mak T. W. Deregulated T-cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 1995; 268: 1472–1476
  • Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., Nakanishi K., Yoshida N., Kishimoto T., Akira S. Essential role of Stat6 in IL-4 signalling. Nature 1996; 380: 627–630
  • Tanaka T., Soriano M. A., Grusby M. J. SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 2005; 22: 729–736
  • Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 1995; 268: 251–255
  • Wakao H., Chida D., Damen J. E., Krystal G., Miyajima A. A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis. Biochem. Biophys. Res. Commun. 1997; 234: 198–205
  • Walter M. R., Windsor W. T., Nagabhushan T. L., Lundell D. J., Lunn C. A., Zauodny P. J., Narula S. K. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 1995; 376: 230–235
  • Wang X., Rickert M., Garcia K. C. Structure of the quaternary complex of interleukin-2 with its α, βâ and γc receptors. Science 2005; 310: 1159–1163
  • Willerford D. M., Chen J., Ferry J. A., Davidson L., Ma A., Alt F. W. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521–530
  • Yan R., Small S., Desplan C., Dearolf C. R., Darnell J. E., Jr. Identification of a Stat gene that functions in Drosophila development. Cell 1996; 84: 421–430
  • Yoshimura A. Negative regulation of cytokine signaling. Clin. Rev. Allergy Immunol. 2005; 28: 205–220

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