591
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Characterizing the Effect of Pentamidine Isethionate on the Immune System Using Mouse Splenocytes as an Experimental Model

, &
Pages 279-285 | Received 21 May 2007, Accepted 28 Aug 2007, Published online: 09 Oct 2008

REFERENCES

  • Andersen R., Boedeker M., Ma M., Goldstein J. C. Adverse reactions associated with pentamidine isethionate in AIDS patients: Recommendations for monitoring therapy. Drug. Intell. Clin. Pharm. 1986; 20: 862–868
  • Antoniou T., Gough K. A. Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: Case report and review of the literature. Pharmacotherapy 2005; 25: 899–903
  • Atsmon J., Dolev E. Drug-induced hypomagnesaemia: Scope and management. Drug. Saf. 2005; 28: 763–788
  • Balslev U., Nielsen T. L. Adverse effects associated with intravenous pentamidine isethionate as treatment of Pneumocystis carinii pneumonia in AIDS patients. Dan. Med. Bull. 1992; 39: 366–368
  • Corsini E., Dykstra C., Craig W. A., Tidwell R. R., Rosenthal G. J. Pneumocystis carinii induction of tumor necrosis factor-α by alveolar macrophages: Modulation by pentamidine isethionate. Immunol. Lett. 1992; 34: 303–308
  • Dean J. H., Murray M. J. Toxic responses of the immune system. Toxicology: The Basic Science of Poisons, 4th Edition, M. O. Amdur, J. Doull, C. D. Klaasen. Pergamon Press, New York 1991; 280–333
  • Delgado G., Puentes F., Moreno A., Patarroyo M. E. Flow cytometry, a useful tool for detecting the lethal effect of pentamidine on Leishmania viannia complex promastigote forms. Pharmacol. Res. 2001; 44: 281–286
  • Descotes J. From clinical to human toxicology: Linking animal research and risk assessment in man. Toxicol. Lett. 2003; 11: 140–141
  • Descotes J. Importance of immunotoxicity in safety assessment: A medical toxicologist's perspective. Toxicol. Lett. 2004; 149: 103–108
  • Descotes J. Immunotoxicology: Role in the safety assessment of drugs. Drug. Saf. 2005; 28: 127–136
  • Eckhardt L. L., Rajamani S., January C. T. Protein trafficking abnormalities: A new mechanism in drug-induced long QT syndrome. Br. J. Pharmacol. 2005; 145: 3–4
  • Ferrante A., Secker K., Thong Y. H. Selective inhibition of the in vitro murine B lymphocyte response by Pentamidine. Int. J. Immunopharmac 1985; 7: 281–285
  • Germolec D. R. Sensitivity and predictivity in immunotoxicity testing: Immune endpoints and disease resistance. Toxicol. Lett. 2004; 149: 109–114
  • Haley P. J. Species differences in the structure and function of the immune system. Toxicology. 2003; 188: 49–71
  • Holladay S. D., Blaylock B. L. The mouse as a model for developmental immunotoxicology. Hum. Exp. Toxicol. 2002; 21: 525–531
  • Lang D. S., Meier K. L., Luster M. I. Comparative effects of immunotoxic chemicals on in vitro proliferative responses of human and rodent lymphocytes. Fundam. Appl. Toxicol. 1993; 21: 535–545
  • Launois P., Himmelrich H., Tacchini-Cottier F., Milon G., Louis J. A. New insight into the mechanisms underlying TH2 cell development and susceptibility to Leishmania major in Balb/c mice. Microbes Infect 1999; 1: 59–64
  • Lightburn E., Morand J. J., Meynard J. B., Kraemer P., Chaudier B., Pages F., Garnotel E., Patte J. H., Banzet S., Dampierre H., Lepage J., Morillon M., Boutin J. P., Hovette P., Chouc C. Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate. Med. Trop. 2003; 63: 35–44
  • Lovik M. Mutant and transgenic mice in immunotoxicology: An introduction. Toxicology. 1997; 119: 65–76
  • Olliario P. L., Guerin P. J., Gerstl S., Haaskjold A. A., Rottingen J. A., Sundar S. Treatment options for visceral leishmaniasis: A systematic review of clinical studies done in India, 1980–2004. Lancet Infect. Dis. 2005; 5: 763–774
  • Pheng S. R., Augera C., Chakrabarti S., Massicotte E., Lamontagne L. Sensitivity to methylmercury-induced autoimmune disease in mice correlates with resistance to apoptosis of activated CD4+ lymphocytes. J. Autoimmun. 2002; 20: 147–160
  • Pheng S. R., Chakrabarti S., Lamontagne L. Dose-dependent apoptosis induced by low concentrations of methylmercury in murine splenic Fas+ T-cell subsets. Toxicology 2000; 149: 115–128
  • Poola N. R., Kalis M., Plakogiannis F. M., Taft D. R. Characterization of pentamidine excretion in the isolated perfused rat kidney. J. Antimicrob. Chemother. 2003; 52: 397–404
  • Rezzani R., Pompili E., Agostini C., Buffoli B., Bonomini F., Nori S., Fumagalli L., Bianchi R. Expression of non-muscle myosin heavy chain in rat heart after immunosuppressive treatment. Int. Immunopharmacol. 2006; 6: 962–967
  • Roth D. R., Roman D., Ulrich P., Mahl A., Junker U., Perenes E. Design and evaluation of immunotoxicity studies. Exp. Toxicol. Pathol. 2006; 57: 367–371
  • Roy M. K., Takenaka M., Kobori M., Nakahara K., Isobe S., Tsushida T. Apoptosis, necrosis and cell proliferation-inhibition by cyclosporine A in U937 cells (a human monocytic cell line). Pharmacol. Res. 2006; 53: 293–302
  • Schulte A., Ruehl-Fehlert C. Regulatory aspects of immunotoxicology. Exp. Toxicol. Pathol. 2006; 57: 385–389
  • Snodin D. J. Regulatory immunotoxicology. Does the published evidence support mandatory non-clinical immune function screening in drug development?. Regul. Toxicol. Pharmacol. 2004; 40: 336–355
  • Spanhaak S. The ICH S8 immunotoxicity guidance. Immune function assessment and toxicological pathology: Autonomous or synergistic methods to predict immunotoxicity?. Exp. Toxicol. Pathol. 2006; 57: 373–376
  • Van Wauwe J., Aerts F., Van Genechten H., Blockx H., Deleersnijder W., Walter H. The inhibitory effect of pentamidine on the production of chemotactic cytokines by in vitro stimulated human blood cells. Inflamm. Res. 1996; 45: 357–363
  • Yang Z., Peng Y., Wang S. Immunosuppressants: Pharmacokinetics, methods of monitoring and role of high performance liquid chromatography/mass spectrometry. Clin. Applied. Immunol. Rev. 2005; 5: 405–430

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.