1,760
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Immunotoxicity profile of natalizumab

, , , , , & show all
Pages 115-129 | Received 20 Jan 2009, Accepted 16 Apr 2009, Published online: 10 Jul 2009

References

  • Arroyo, A. G., Yang, J. T., Rayburn, H., and Hynes, R. O. 1996. Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell 85:997–1008.
  • Arroyo, A. G., Yang, J. T., Rayburn, H., and Hynes, R. O. 1999. α4 integrins regulate the proliferation/differentiation balance of multi-lineage hematopoietic progenitors in vivo. Immunity. 11:555–566.
  • Banerjee, E. R., Latchman, Y. E., Jiang, Y., Priestley, G. V., and Papayannopoulou, T. 2008. Distinct changes in adult lymphopoiesis in Rag2−/- mice fully reconstituted by α4-deficient adult bone marrow cells. Exp. Hematol. 36:1004–1013.
  • Christensen, B. E., Jønsson, V., Matre, R., and Tønder, O. 1978. Traffic of T- and B-lymphocytes in the normal spleen. Scand. J. Haematol. 20:246–257.
  • Danese, S., Semeraro, S., Marini, M., Roberto, I., Armuzzi, A., Papa, A., and Gasbarrini, A. 2005. Adhesion molecules in inflammatory bowel disease: Therapeutic implications for gut inflammation. Dig. Liver. Dis. 37:811–818.
  • Ghosh, S., Goldin, E., Gordon, F. H., Malchow, H. A., Rask-Madsen, J., Rutgeerts, P., Vyhnálek, P., Zádorová, Z., Palmer, T., and Donoghue, S. 2003. Natalizumab for active Crohn’s disease. N. Engl. J. Med. 348:24–32.
  • Gordon, F. H., Lai, C. W., Hamilton, M. I., Allison, M. C., Srivastava, E. D., Fouweather, M. G., Donoghue, S., Greenlees, C., Subhani, J., Amlot, P. L., and Pounder, R. E. 2001. A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn’s disease. Gastroenterology 121:268–274.
  • Heilbronn, R., Albrecht, I., Stephan, S., Bürkle, A., and zur Hausen, H. 1993. Human cytomegalovirus induces JC virus DNA replication in human fibroblasts. Proc. Natl. Acad. Sci. USA 90:11406–11410.
  • Hyams, J. S., Wilson, D. C., Thomas, A., Heuschkel, R., Mitton, S., Mitchell, B., Daniels, R., Libonati, M. A., Zanker, S., and Kugathasan, S. 2007. Natalizumab therapy for moderate to severe Crohn disease in adolescents. J. Pediatr. Gastroenterol. Nutr. 44:185–191.
  • Kleinschmidt-DeMasters, B.K., and Tyler, K.L. 2005. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon β-1a for multiple sclerosis. N. Engl. J. Med. 353:369–374.
  • Knowles, D. M., Cesarman, E., Chadburn, A., Frizzera, G., Chen, J., Rose, E. A., and Michler, R. 1995. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of post-transplantation lymphoproliferative disorders. Blood 85:552–565.
  • Langer-Gould, A., Atlas, S.W., Green, A.J., Bollen, A.W., and Pelletier, D. 2005. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N. Engl. J. Med. 353:375–381.
  • Lasky, L. A. 1996. Hematopoiesis: Wandering progenitor cells. Curr. Biol. 6:1238–1240.
  • Meropol, N. J., Porter, M., Blumenson, L. E., Lindemann, M. J., Perez, R. P., Vaickus, L., Loewen, G. M., Creaven, P. J., Wilkes, K. A., Giedlin, M. A., and Caligiuri, M. A. 1996. Daily subcutaneous injection of low-dose interleukin-2 expands natural killer cells in vivo without significant toxicity. Clin. Cancer. Res. 2:669–677.
  • Miller, D. H., Khan, O. A., Sheremata, W. A., Blumhardt, L. D., Rice, G. P., Libonati, M. A., Willmer-Hulme, A. J., Dalton, C. M., Miszkiel, K. A., and O’Connor, P. W. 2003. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348:15–23.
  • Mirandola, P., Ponti, C., Gobbi, G., Sponzilli, I., Melloni, E., and Vitale, M. 2004. The response of human natural killer cells to interleukin-2. J. Endocrinol. Invest. 27 (S6):146–150.
  • Naume, B., and Espevik, T. 1991. Effects of IL-7 and IL-2 on highly enriched CD56+ natural killer cells. A comparative study. J. Immunol. 147:2208–2214.
  • National Center for Biotechnology Information (NCBI). GenBank accession number XM 001100929. http://www.ncbi.nlm.nih.gov. Accessed 26 March 2009.
  • Oostendorp R. A., and Dörmer, P. 1997. VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. Leuk. Lymphoma 24:423–435.
  • Polman, C. H., O’Connor, P. W., Havrdova, E., Hutchinson, M., Kappos, L., Miller, D. H., Phillips, J. T., Lublin, F. D., Giovannoni, G., Wajgt, A., Toal, M., Lynn, F., Panzara, M. A., and Sandrock, A. W. 2006. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354:899–910.
  • Qian, H., Georges-Labouesse, E., Nyström, A., Domogatskaya, A., Tryggvason, K., Jacobsen, S. E., and Ekblom, M. 2007. Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells. Blood 110:2399–2407.
  • Robinson, B. W., and Morstyn, G. 1987. Natural killer (NK)-resistant human lung cancer cells are lysed by recombinant interleukin-2-activated NK cells. Cell. Immunol. 106:215–222.
  • Rose, D. M., Han, J., and Ginsberg, M. H. 2002. α4 integrins and the immune response. Immunol. Rev. 186:118–124.
  • Rudick, R. A., Stuart, W. H., Calabresi, P. A., Confavreux, C., Galetta, S. L., Radue, E. W., Lublin, F. D., Weinstock-Guttman, B., Wynn, D. R., Lynn, F., Panzara, M. A., and Sandrock, A. W. 2006. Natalizumab plus interferon β-1a for relapsing multiple sclerosis. N. Engl. J. Med. 354:911–923.
  • Sandborn, W. J., Colombel, J. F., Enns, R., Feagan, B. G., Hanauer, S. B., Lawrance, I. C., Panaccione, R., Sanders, M., Schreiber, S., Targan, S., van Deventer, S., Goldblum, R., Despain, D., Hogge, G. S., and Rutgeerts, P. 2005. Natalizumab induction and maintenance therapy for Crohn’s disease. N. Engl. J. Med. 353:1912–1925.
  • Sands, B. E., Kozarek, R., Spainhour, J., Barish, C. F., Becker, S., Goldberg, L., Katz, S., Goldblum, R., Harrigan, R., Hilton, D., and Hanauer, S. B. 2007. Safety and tolerability of concurrent natalizumab treatment for patients with Crohn’s disease not in remission while receiving infliximab. Inflamm. Bowel. Dis. 13:2–11.
  • Schmidtko, J., Wang, R., Wu, C., Mauiyyedi, S., Harris, N., Della Pelle, P., Brousaides, N., Zagachin, L., Ferry, J., Wang, F., Kawai, T., Sachs, D., Cosimi, B.,,and Colvin, R. 2002. Post-transplant lymphoproliferative disorder associated with an Epstein-Barr-related virus in cynomolgus monkeys. Transplantation 73:1431–1439.
  • Stüve, O., Marra, C. M., Bar-Or, A., Niino, M., Cravens, P. D., Cepok, S., Frohman, E. M., Phillips, J. T., Arendt, G., Jerome, K. R., Cook, L., Grand’Maison, F., Hemmer, B., Monson, N. L., and Racke, M. K. 2006. Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch. Neurol. 63:1383–1387.
  • TYSABRI. 2008. [Package insert]. Elan Pharmaceuticals, Inc. South San Francisco, CA; http://www.tysabri.com.
  • Van Assche, G., Van Ranst, M., Sciot, R., Dubois, B., Vermeire, S., Noman, M., Verbeeck, J., Geboes, K., Robberecht, W., and Rutgeerts, P. 2005. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease. N. Engl. J. Med. 353:362–368.
  • Willführ, K. U., Westermann, J., and Pabst, R. 1990. Absolute numbers of lymphocytes subsets migrating through the compartments of the normal and transplanted rat spleen. Eur. J. Immunol. 20:903–911.
  • Yousry, T. A., Major, E. O., Ryschkewitsch, C., Fahle, G., Fischer, S., Hou, J., Curfman, B., Miszkiel, K., Mueller-Lenke, N., Sanchez, E., Barkhof, F., Radue, E. W., Jäger, H. R., and Clifford, D. B. 2006. Evaluation patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. 354:924–933.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.