1,364
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Predicting skin sensitization potential of organic compounds based on toxicity enhancement to Tetrahymena pyriformis, fathead minnow, and Daphnia magna

, &
Pages 82-89 | Received 31 Jan 2018, Accepted 11 Apr 2018, Published online: 26 Apr 2018

References

  • Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, Marrec-Fairley M, Maxwell G, Ovigne JM, Sakaguchi H, et al. 2010. Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol In Vitro. 24:1465–1473.
  • Aleksic M, Thain E, Roger D, Saib O, Davies M, Li J, Aptula A, Zazzeroni R. 2009. Reactivity profiling: Covalent modification of single nucleophile peptides for skin sensitization risk assessment. Toxicol Sci. 108:401–411.
  • Anderson S, Siegel P, Meade B. 2011. The LLNA: A brief review of recent advances and limitations. J Allergy (Cairo). 2011:424203.
  • Aptula A, Patlewicz G, Roberts D. 2005. Skin sensitization: Reaction mechanistic applicability domains for structure-activity relationships. Chem Res Toxicol. 18:1420–1426.
  • Aptula A, Patlewicz G, Roberts D, Schultz T. 2006. Non-enzymatic glutathione reactivity and in vitro toxicity: A non-animal approach to skin sensitization. Toxicol In Vitro. 20:239–247.
  • Aptula A, Roberts D. 2006. Mechanistic applicability domains for non-animal-based prediction of toxicological endpoints: General principles and application to reactive toxicity. Chem Res Toxicol. 19:1097–1105.
  • Arning J, Matzke M, Stolte S, Nehen F, Bottin-Weber U, Bo¨schen A, Abdulkarim S, Jastorff B, Ranke J. 2009. Analyzing cytotoxic effects of selected isothiazol-3-one biocides using the toxic ratio concept and structure-activity relationship considerations. Chem Res Toxicol. 22:1954–1961.
  • Blaschke U, Eismann K, Böhme A, Paschke A, Schüürmann G. 2011. Structural alerts for the excess toxicity of acrylates, methacrylates, and propiolates derived from their short-term and long-term bacterial toxicity. Chem Res Toxicol. 25:170–180.
  • Blaschke U, Paschke A, Rensch I, Schu¨u¨rmann G, 2010. Acute and chronic toxicity toward the bacteria Vibrio fischeri of organic narcotics and epoxides: Structural alerts for epoxide excess toxicity. Chem Res Toxicol. 23:1936–1946.
  • Bo¨hme A, Thaens D, Paschke A, Schu¨u¨rmann G, 2009. Kinetic Glutathione chemoassay to quantify thiol reactivity of organic electrophiles: Application to α,β-unsaturated ketones, acrylates, and propiolates. Chem Res Toxicol. 22:742–750.
  • Bo¨hme A, Thaens D, Schramm F, Paschke A, Schu¨u¨rmann G, 2010. Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters. Chem Res Toxicol. 23:1905–1912.
  • Ellison C, Cronin M, Madden J, Schultz T. 2008. Definition of the structural domain of the baseline non-polar narcosis model for T. pyriformis. Environ Res. 19:751–783.
  • Emter R, Ellis G, Natsch A. 2010. Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol Appl Pharm. 245:281–290.
  • Fabjan E, Hulzebos E. 2008. An evaluation of selected valid and mechanistically based SARs for skin sensitization. Toxicol In Vitro. 22:468–490.
  • Gerberick F, Ryan C, Kern P, Schlatter H, Dearman R, Kimber I, Patlewicz G, Basketter D. 2005. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis. 16:157–202.
  • Gerberick G, Vassallo J, Bailey R, Chaney J, Morrall S, Lepoittevin J. 2004. Development of a peptide reactivity assay for screening contact allergens. Toxicol Sci. 81:332–343.
  • Gerberick G, Vassallo J, Foertsch L, Price B, Chaney J, Lepoittevin J. 2007. Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach. Toxicol Sci. 97:417–427.
  • Jeong Y, An S, Shin K, Lee T. 2013. Peptide reactivity assay using spectrophotometric method for high-throughput screening of skin sensitization potential of chemical haptens. Toxicol In Vitro. 27:264–271.
  • Kern P, Gerberick G, Ryan C, Kimber I, Aptula A, Basketter D. 2010. Local lymph node data for the evaluation of skin sensitization alternatives: A second compilation. Dermatitis. 21:8–32.
  • mOECD. 1992. Guideline for Testing of Chemicals No. 406, Skin Sensitization. Adopted 17th July.
  • mOECD. 2002. Guideline for Testing of Chemicals No. 429, Skin Sensitization: Local Lymph Node Assay. Adopted 24th April.
  • Natsch A, Gfeller H. 2008. LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential. Toxicol Sci. 106:464–478.
  • Natsch A, Gfeller H, Haupt T, Brunner G. 2012. Chemical reactivity and skin sensitization potential for benzaldehydes: Can Schiff base formation explain everything?. Chem Res Toxicol. 25:2203–2215.
  • Natsch A, Haupt T. 2013. Utility of rat liver S9 fractions to study skin-sensitizing pro-haptens in a modified KeratinoSens assay. Toxicol Sci. 135:356–368.
  • Natsch A, Haupt T, Laue H. 2011. Relating skin sensitizing potency to chemical reactivity: Reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than SNAr- and SN2-reactive chemicals. Chem Res Toxicol. 24:2018–2027.
  • Patlewicz G, Basketter D, Smith C, Hotchkiss S, Roberts D. 2001. Skin-sensitization structure-activity relationships for aldehydes. Contact Dermatitis. 44:331–336.
  • Ramirez T, Mehling A, Kolle SN, Wruck CJ, Teubner W, Eltze T, Aumann A, Urbisch D, van Ravenzwaay B, Landsiedel R. 2014. LuSens: A keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification. Toxicol In Vitro. 28:1482–1497.
  • Roberts D, Aptula A, Patlewicz G. 2006. Mechanistic applicability domains for non-animal based prediction of toxicological endpoints. QSAR analysis of the Schiff base applicability domain for skin sensitization. Chem Res Toxicol. 19:1228–1233.
  • Roberts D, Aptula A, Patlewicz G. 2011. Chemistry-based risk assessment for skin sensitization: Quantitative mechanistic modeling for the SNAr domain. Chem Res Toxicol. 24:1003–1011.
  • Roberts D, Natsch A. 2009. High throughput kinetic profiling approach for covalent binding to peptides: Application to skin sensitization potency of Michael acceptor electrophiles . Chem Res Toxicol. 22:592–603.
  • Roberts D, Patlewicz G, Kern P, Gerberick F, Kimber I, Dearman R, Ryan CA, Basketter D, Aptula A. 2007. Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol. 20:1019–1030.
  • Schramm F, Mu¨ller A, Hammer H, Paschke A, Schu¨u¨rmann G, 2011. Epoxide and thiirane toxicity in vitro with the ciliates Tetrahymena pyriformis: Structural alerts indicating excess toxicity. Environ Sci Technol. 45:5812–5819.
  • Thaens D, Heinzelmann D, Böhme A, Paschke A, Schüürmann G. 2012. Chemoassay screening of DNA-reactive mutagenicity with 4-(4-nitrobenzyl)pyridine - application to epoxides, oxetanes, and sulfur heterocycles. Chem Res Toxicol. 25:2092–2102.
  • van Leeuwen C, van der Zandt P, Aldenberg T, Verhaar H, Hermens J. 1992. Application of QSARs, extrapolation and equilibrium partitioning in aquatic effects assessment. I. Narcotic industrial pollutants. Environ Toxicol Chem. 11:267–282.
  • von der Ohe P, Kühne R, Ebert R-U, Altenburger R, Liess M, Schüürmann G. 2005. A new classification model to discriminate excess toxicity from narcotic effect levels of organic compounds in the acute daphnid assay. Chem Res Toxicol. 18:536–555.