2,113
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury

&
Pages 28-33 | Received 12 Jun 2018, Accepted 21 Aug 2018, Published online: 21 Jan 2019

References

  • Chan C, Smyth M, Martinet L. 2014. Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ. 21:5–14.
  • Cho T, Uetrecht J. 2016. How reactive metabolites induce an immune response that sometimes leads to an idiosyncratic drug reaction. Chem Res Toxicol. 30:295–314.
  • Dambach D, Watson L, Gray K, Durham S, Laskin D. 2002. Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology. 35:1093–1103.
  • Deshmane S, Kremlev S, Amini S, Sawaya B. 2009. Monocyte chemoattractant protein-1 (MCP-1): An overview. J Interferon Cytokine Res. 29:313–326.
  • Foureau D, Walling T, Maddukuri V, Anderson W, Culbreath K, Kleiner D, Ahrens W, Jacobs C, Watkins P, Fontana R, et al. 2015. Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis. Clin Exp Immunol. 180:40–51.
  • Geissmann F, Jung S, Littman D. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 19:71–82.
  • Kato R, Uetrecht J. 2017. Supernatant from hepatocyte cultures with drugs that cause idiosyncratic liver injury activates macrophage inflammasomes. Chem Res Toxicol. 30:1327–1332.
  • Mack M, Cihak J, Simonis C, Luckow B, Proudfoot AE, Plachý J, Brühl H, Frink M, Anders HJ, Vielhauer V, Pfirstinger J, Stangassinger M, Schlöndorff D. 2001. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol. 166:4697–4704.
  • Mak A, Kato R, Weston K, Hayes A, Uetrecht J. 2018. Editor’s highlight: An impaired immune tolerance animal model distinguishes the potential of troglitazone/pioglitazone and tolcapone/entacapone to cause IDILI. Toxicol. Sci. 161:412–420.
  • Mak A, Uetrecht J. 2015a. The combination of anti-CTLA-4 and PD1−/− mice unmasks the potential of isoniazid and nevirapine to cause liver injury. Chem Res Toxicol. 28:2287–2291.
  • Mak A, Uetrecht J. 2015b. The role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4. Chem Res Toxicol. 28:1567–1573.
  • Metushi I, Cai P, Dervovic D, Liu F, Lobach A, Nakagawa T, Uetrecht J. 2015. Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset. J Immunotoxicol. 12:247–260.
  • Metushi I, Hayes M, Uetrecht J. 2015. Treatment of PD-1−/− mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients. Hepatology. 61:1332–1342.
  • Weston J, Uetrecht J. 2014. Activation of inflammasomes by agents causing idiosyncratic skin reactions: A possible biomarker. Chem Res Toxicol. 27:949–951.