Assessment of the potential allergenicity of genetically-engineered food crops

References

• Agnes M, Tan A, Jordens R, Geluk A, Roep B, Ottenhoff T, Drijfhout J, Koning F. 1998. Strongly increased efficiency of altered peptide ligands by mannosylation. Int Immunol. 10:1299–1304.
   PubMed Web of Science ®Google Scholar
• Ahrens B, Quarcoo D, Buhner S, Reese G, Vieths S, Hamelmann E. 2014. Development of an animal model to evaluate the allergenicity of food allergens. Int Arch Allergy Immunol. 164:89–96.
   PubMed Web of Science ®Google Scholar
• Akkerdaas J, Totis M, Barnett B, Bell E, Davis T, Edrington T, Glenn K, Graser G, Herman R, Ladics G. 2018. In vitro gastrointestinal digestion protocols for allergenicity assessment: Are more physiological conditions helpful in separating allergens from non-allergens?. Clin Transl Allergy. 8:30–42.
   PubMedGoogle Scholar
• Aldemir H, Bars R, Herouet-Guicheney C. 2009. Murine models for evaluating the allergenicity of novel proteins and foods. Regul Toxicol Pharmacol. 54:52–57.
   PubMed Web of Science ®Google Scholar
• Altmann F. 2007. The role of protein glycosylation in allergy. Int Arch Allergy Immunol. 142:99–115.
   PubMed Web of Science ®Google Scholar
• Altmann F. 2016. Coping with cross-reactive carbohydrate determinants in allergy diagnosis. Allergol J Intl. 25:98–105.
   PubMedGoogle Scholar
• Altschul S, Madden T, Schaffer A, Zhang J, Zhang Z, Miller W, Lipman D. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucl Acids Res. 325:389–3402.
   Google Scholar
• Astwood J, Leach J, Fuchs R. 1996. Stability of food allergens to digestion in vitro. Nat Biotechnol. 14:1269–1273.
   PubMed Web of Science ®Google Scholar
• Astwood J, Fuchs R. 1996. Allergenicity of foods derived from transgenic plants. Monogr Allergy. 32:105–120.
   PubMedGoogle Scholar
• Baxevanis A and Ouellette B, editors. 1998. Bioinformatics: A practical guide to the analysis of genes and proteins. New York: John Wiley & Sons.
   Google Scholar
• Berg J, Tymoczko J, Stryer L, editors. 2002. Protein structure and function. In: Biochemistry. 5th ed., Chapters 3-4, New York: W.H. Freeman and Co.
   Google Scholar
• Besler M, Steinhart H, Paschke A. 2001. Stability of food allergens and allergenicity of processed foods. J Chromatogr B Biomed Sci Appl. 756:207–228.
   PubMed Web of Science ®Google Scholar
• Birmingham N, Parvataneni S, Hassan H, Harkema J, Samineni S, Navuluri L, Kelly C, Gangur V. 2007. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int Arch Allergy Immunol. 144:203–210.
   PubMed Web of Science ®Google Scholar
• Bjorksten B, Crevel R, Hischenhuber C, Lovik M, Samuels F, Strobel S, Taylor S, Wal J, Ward R. 2008. Criteria for identifying allergenic foods of public health importance. Regul Toxicol Pharmacol. 51:42–52.
   PubMed Web of Science ®Google Scholar
• Breiteneder H, Mills E. 2005. Molecular properties of food allergens. J Allergy Clin Immunol. 115:14–23.
   PubMed Web of Science ®Google Scholar
• Breiteneder H, Mills E. 2008. Food allergens: Molecular and immunological characteristics. In: Metcalfe D, Sampson, H, Simon R, editors. Food allergy-adverse reactions to foods and food additives. Cambridge, MA: Blackwell Publishing; p. 43–61.
   Google Scholar
• Bruijnzeel-Koomen C, Ortolani C, Aas K, Bindslev-Jensen C, Bjorksten B, Moneret-Vautrin D, Wuthrich B. 1995. Adverse reactions to food. European Academy of Allergology and Clinical Immunology Subcommittee. Allergy. 50:623–697.
   PubMed Web of Science ®Google Scholar
• Buchanan B, Adamidi C, Lozano R, Yee B, Momma M, Kobrehel K, Ermel R, Frick O. 1997. Thioredoxin-linked mitigation of allergic responses to wheat. Proc Natl Acad Sci USA. 94:5372–5377.
   PubMed Web of Science ®Google Scholar
• Buchanan B, Frick O. 2002. The dog as a model for food allergy. Ann NY Acad Sci. 964:173–183.
   PubMed Web of Science ®Google Scholar
• Camarca A, Anderson R, Mamone G, Fierro O, Facchiano A, Costantini S, Zanzi D, Sidney J, Auricchio S, Sette A. 2009. Intestinal T-cell responses to gluten peptides are largely heterogenous: Implications for a peptide-based therapy in celiac disease. J Immunol. 182:4158–4166.
   PubMed Web of Science ®Google Scholar
• Chassy B. 2010. Can -omics inform a food safety assessment?. Regul Toxicol Pharmacol. 58:S62–S70.
   PubMed Web of Science ®Google Scholar
• Codex Alimentarius Commission (Codex). 2003. Alinorm 03/34: Joint FAO/WHO Food Standard Program, Codex Alimentarius Commission, 25^th Session, Rome, Italy, 30 June-5 July, 2003. Appendix III, Guideline for the Conduct of Food Safety Assessment of Foods Derived from Recombinant-DNA Plants; Appendix IV, Annex on Assessment of Possible Allergenicity. pp. 47–60.
   Google Scholar
• Codex Alimentarius Commission (Codex). 2009. Principles for the risk analysis of foods derived from modern biotechnology (CAC/GL 44-2003) and guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants (CAC/GL 45-2003). In: Foods derived from modern biotechnology. 2nd ed. Rome: FAO/WHO; p. 1–5, 7–33.
   Google Scholar
• Condaminet B, Peguet-Navarro J, Stahl P, Dalbiez-Gauthier C, Schmitt D, Berthier-Vergnes O. 1998. Human epidermal Langerhans cells express the mannose-fucose binding receptor. Eur J Immunol. 28:3541–3551.
   PubMed Web of Science ®Google Scholar
• Cressman R, Ladics G. 2009. Further evaluation of utility of sliding window FASTA in predicting cross-reactivity with allergenic proteins. Regul Toxicol Pharmacol. 54:S20–S25.
   PubMed Web of Science ®Google Scholar
• Crevel R, Ballmer-Weber B, Holzhauser R, Hourihane J, Knulst A, Mackie A, Timmermans F, Taylor S. 2008. Thresholds for food allergens and their value to different stakeholders. Allergy. 63:597–609.
   PubMed Web of Science ®Google Scholar
• Crevel R. 2010. Risk assessment for food allergy. In: Boye J and Godefroy S, editors. Allergen management in the food industry. New York: John Wiley & Sons; p. 421–451.
   Google Scholar
• Davis P, Smales C, James D. 2001. How can thermal processing modify the antigenicity of proteins?. Allergy. 56:56–60.
   PubMed Web of Science ®Google Scholar
• Dearman R, Caddick H, Basketter D, Kimber I. 2000. Divergent antibody isotype responses induced in mice by systemic exposure to proteins: A comparison of ovalbumin with bovine serum albumin. Food Chem Toxicol. 38:351–360.
   PubMed Web of Science ®Google Scholar
• Dearman R, Caddick H, Stone S, Basketter D, Kimber I. 2001. Characterization of antibody responses induced in rodents by exposure to food proteins: Influence of route of exposure. Toxicology. 167:217–231.
   PubMed Web of Science ®Google Scholar
• Dearman R, Kimber I. 2001. Determination of protein allergenicity: Studies in mice. Toxicol Lett. 120:181–186.
   PubMed Web of Science ®Google Scholar
• Dearman R, Skinner R, Herouet C, Labay K, Debruyne E, Kimber I. 2003. Induction of IgE antibody responses by protein allergens: Inter-laboratory comparisons. Food Chem Toxicol. 41:1509–1516.
   PubMed Web of Science ®Google Scholar
• Delaney B. 2015. Safety assessment of foods from genetically-modified crops in countries with developing economies. Food Chem Toxicol. 86:132–143.
   PubMed Web of Science ®Google Scholar
• Delaney B, Goodman R, Ladics G. 2018. Food and feed safety of genetically engineered food crops. Toxicol Sci. 162:361–371.
   PubMed Web of Science ®Google Scholar
• Doerrer N, Ladics G, McClain S, Herouet-Guicheney C, Poulsen L, Privalle L, Stagg N. 2010. Evaluating biological variation in non-transgenic crops. Executive Summary from the International Life Science Institute Workshop on November 16-17, 2009, Paris, France. Regul Toxicol Pharmacol. 58:S2–S7.
   PubMed Web of Science ®Google Scholar
• Dørum S, Arntzen M, Qiao S, Holm A, Koehler C, Thiede B, Sollid L, Fleckenstein B. 2010. The preferred substrates for transglutaminase-2 in a complex wheat gluten digest are peptide fraGEents harboring celiac disease T-cell epitopes. PLoS One. 5:e14056.
   PubMed Web of Science ®Google Scholar
• Ebo D, Hagendorens M, Bridts C, De Clerck L, Stevens W. 2004. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: Mimickers of allergy. Clin Exp Allergy. 34:137–144.
   PubMed Web of Science ®Google Scholar
• EFSA. 2011. Guidance for risk assessment of food and feed from genetically-modified plants. Efsa J. 9:1–50.
   Google Scholar
• Ermel R, Kock M, Griffey S, Reinhart G, Frick O. 1997. The atopic dog: A model for food allergy. Lab Anim Sci. 47:40–49.
   PubMedGoogle Scholar
• FAO/WHO. 2001. Evaluation of allergenicity of genetically-modified foods. Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology. Rome, Italy.
   Google Scholar
• Fernandez A, Mills E, Lovik M, Spoek A, Germini A, Mikalsen A, Wal J. 2013. Endogenous allergens and compositional analysis in the allergenicity assessment of genetically modified plants. Food Chem Toxicol. 62:1–6.
   PubMed Web of Science ®Google Scholar
• Fiocchi A, Restani P, Bernardo L, Martelli A, Ballabio C, D'Auria E, Riva E. 2004. Tolerance of heat-treated kiwi by children with kiwifruit allergy. Pediatr Allergy Immunol. 15:454–458.
   PubMed Web of Science ®Google Scholar
• Franck P, Moneret Vautrin D, Dousset B, Kanny G, Nabet P, Guenard-Bilbaut L, Parisot L. 2002. The allergenicity of soybean-based products is modified by food technologies. Int Arch Allergy Immunol. 128:212–219.
   PubMed Web of Science ®Google Scholar
• Fu T. 2002. Digestion stability as a criterion for protein allergenicity assessment. Ann NY Acad Sci. 964:99–110.
   PubMed Web of Science ®Google Scholar
• Fu T, Abbott U, Hatzos C. 2002. Digestibility of food allergens and non-allergenic proteins in simulated gastric and intestinal fluids: A comparative study. J Agric Food Chem. 50:7154–7160.
   PubMed Web of Science ®Google Scholar
• Garrido-Arandia M, Murua-García A, Palacin A, Tordesillas L, Gómez-Casado C, Blanca-Lopez N, Ramos T, Canto G, Blanco C, Cuesta-Herranz J, et al. 2014. The role of N-glycosylation in kiwi allergy. Food Sci Nutr. 2:260–271.
   PubMedGoogle Scholar
• Gendel S, Jenkins J. 2006. Allergen sequence databases. Mol Nutr Food Res. 50:633–637.
   PubMed Web of Science ®Google Scholar
• Goodman R. 2008. Performing IgE serum testing due to bioinformatics matches in the allergenicity assessment of GE crops. Food Chem Toxicol. 46:S24–S34.
   PubMed Web of Science ®Google Scholar
• Goodman R, Ebisawa M, Ferreira F, Sampson H, van Ree R, Vieths S, Baumert J, Bohle B, Lalithambika S, Wise J. 2016. Allergen online: A peer-reviewed, curated allergen data-base to assess novel food proteins for potential cross-reactivity. Mol Nutr Food Res. 60:1183–1198.
   PubMed Web of Science ®Google Scholar
• Goodman R, Tetteh A. 2011. Suggested improvements for the allergenicity assessment of genetically-modified plants in foods. Curr Allergy Asthma Report. 11:317–324.
   PubMed Web of Science ®Google Scholar
• Goodman R, Vieths S, Sampson H, Hill D, Ebisawa M, Taylor S, van Ree R. 2008. Allergenicity assessment of genetically modified crops-what makes sense? Nat Biotechnol. 26:73–81.
   PubMed Web of Science ®Google Scholar
• Hammond B, Jez J. 2011. Impact of food processing on the safety assessment for proteins introduced into biotechnology-derived soybean and corn crops. Food Chem Toxicol. 49:711–721.
   PubMed Web of Science ®Google Scholar
• Harper B, McClain S, Ganko E. 2012. Interpreting the biological relevance of bioinformatic analyses with T-DNA sequence for protein allergenicity. Regul Toxicol Pharmacol. 63:426–432.
   PubMed Web of Science ®Google Scholar
• Helm R, Ermel R, Frick O. 2003. Nonmurine animal models of food allergy. Environ Health Perspect. 111:239–244.
   PubMed Web of Science ®Google Scholar
• Helm R, Furuta G, Stanley J, Ye J, Cockrell G, Connaughton C, Simpson P, Bannon G, Burks A. 2002. A neonatal swine model for peanut allergy. J Allergy Clin Immunol. 109:136–142.
   PubMed Web of Science ®Google Scholar
• Herman R, Ladics G. 2011. Endogenous allergen up-regulation: Transgenic vs. traditionally bred crops. Food Chem Toxicol. 49:2667–2669.
   PubMed Web of Science ®Google Scholar
• Herman R, Price W. 2013. Unintended compositional changes in genetically-modified (GM) crops: 20 years of research. J Agric Food Chem. 61:11695–11701.
   PubMed Web of Science ®Google Scholar
• Herman R, Schafer B, Korjagin V, Ernest A. 2003. Rapid digestion of Cry34Ab1 and Cry35Ab1 in simulated gastric fluid. J Agric Food Chem. 51:6823–6827.
   PubMed Web of Science ®Google Scholar
• Herman R, Storer N, Gao Y. 2006. Digestion assays in allergenicity assessment of transgenic proteins. Environ Health Perspect. 114:1154–1157.
   PubMed Web of Science ®Google Scholar
• Herman R, Woolhiser M, Ladics G, Korjagin V, Schafer B, Storer N, Green S, Kan L. 2007. Stability of a set of allergens and non-allergens in simulated gastric fluid. Int J Food Sci Nutr. 58:125–141.
   PubMed Web of Science ®Google Scholar
• Herman RA, Song P, ThirumalaiswamySekhar A. 2009. Value of eight-amino-acid matches in predicting the allergenicity status of proteins: An empirical bioinformatic investigation. Clin Mol Allergy. 7:9–15.
   PubMedGoogle Scholar
• Herouet C, Esdaile D, Mallyon B, Debruyne E, Schulz A, Currier T, Hendrickx K, van der Klis R, Rouan D. 2005. Safety evaluation of the phosphinothricin acetyltransferase proteins encoded by the pat and bar sequences that confer tolerance to glufosinate-ammonium herbicide in transgenic plants. Regul Toxicol Pharmacol. 41:134–149.
   PubMed Web of Science ®Google Scholar
• Herouet-Guicheney C, Aldemir H, Bars R, de Barbeyrac D, Kennel P, Rouquie D, Stahl B, Kimber I, Dearman R. 2009. Inter-laboratory comparisons of assessment of the allergenic potential of proteins in mice. J Appl Toxicol. 29:141–148.
   PubMed Web of Science ®Google Scholar
• Hileman R, Silvanovich A, Goodman R, Rice E, Holleschak G, Astwood J, Hefle S. 2002. Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Intl Arch Allergy Immunol. 128:280–291.
   PubMed Web of Science ®Google Scholar
• Hoff M, Son D, Gubesch M, Ahn K, Lee S, Vieths S, Goodman R, Ballmer-Weber B, Bannon G. 2007. Serum testing of genetically-modified soybeans with special emphasis on potential allergenicity of the heterologous protein CP4EPSPS. Mol Nutr Food Res. 51:946–955.
   PubMed Web of Science ®Google Scholar
• Houston NL, Lee D-G, Stevenson SE, Ladics GS, Bannon GA, McClain S, Privalle L, Stagg N, Herouet-Guicheney C, MacIntosh SC, et al. 2011. Quantitation of soybean allergens using tandem mass spectrometry. J Proteome Res. 10:763–773.
   PubMed Web of Science ®Google Scholar
• Hsieh K, Tsai C, Wu C, Lin R. 2003. Epicutaneous exposure to protein antigen and food allergy. Clin Exp Allergy. 33:1067–1075.
   PubMed Web of Science ®Google Scholar
• Huby R, Dearman R, Kimber I. 2000. Why are some proteins allergens?. Toxicol Sci. 55:235–246.
   PubMed Web of Science ®Google Scholar
• Indian Ministry of Science and Technology. Department of Biotechnology, Government of India. 2008. Protocols for food and feed safety assessment of GE crops. Protein Thermal Stability pp 18–21.
   Google Scholar
• Ivanciuc O, Garcia T, Torres M, Schein C, Braun W. 2009. Characteristic motifs for families of allergenic proteins. Mol Immunol. 46:559–568.
   PubMed Web of Science ®Google Scholar
• Ivanciuc O, Midoro-Horiuti T, Schein C, Xie L, Hillman G, Goldblum R, Braun W. 2009. The property distance index PD predicts peptides that cross-react with IgE antibodies. Mol Immunol. 46:559–568.
   PubMed Web of Science ®Google Scholar
• Johnston L, Chien K, Bryce P. 2014. The immunology of food allergy. J Immunol. 192:2529–2534.
   PubMed Web of Science ®Google Scholar
• Kenna J, Evans R. 2000. Digestibility of proteins in simulated gastric fluid. Toxicologist. 54:7–9. Abstract #666).
   Google Scholar
• Knippels L, Penninks A, Smit J, Houben G. 1999a. Immune-mediated effects upon oral challenge of ovalbumin-sensitized Brown Norway rats: Further characterization of a rat food allergy model. Toxicol Appl Pharmacol. 156:161–169.
   PubMed Web of Science ®Google Scholar
• Knippels L, Penninks A, Spanhaak S, Houben G. 1998. Oral sensitization to food proteins: A Brown Norway rat model. Clin Exp Allergy. 28:368–375.
   PubMed Web of Science ®Google Scholar
• Knippels L, Penninks A, van Meeteren M, Houben G. 1999b. Humoral and cellular immune responses in different rat strains on oral exposure to ovalbumin. Food Chem Toxicol. 37:881–888.
   PubMed Web of Science ®Google Scholar
• Knippels L, van der Kleij H, Koppelman S, Houben G, Penninks A. 2000. Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients. Eur J Allergy Clin Immunol. 55:251–258.
   Google Scholar
• Koppelman S, van Koningsveld G, Knulst A, Houben G, Penninks A, Knippels L, Penninks A, Felius A. 2002. Effect of heat-induced aggregation on the IgE binding of patatin (Sol t 1) is dominated by other potato proteins. J Agric Food Chem. 50:1562–1568.
   PubMed Web of Science ®Google Scholar
• Kulis M, Macqueen I, Li Y, Guo R, Zhong X, Burks W. 2012. Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy. J Allergy Clin Immunol. 130:716–723.
   PubMed Web of Science ®Google Scholar
• Ladics G. 2008. Current codex guidelines for assessment of potential protein allergenicity. Food Chem Toxicol. 46:S20–S23.
   PubMed Web of Science ®Google Scholar
• Ladics G, Bannon G, Silvanovich A, Cressman R. 2007. Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergens. Mol Nutr Food Res. 51:985–998.
   PubMed Web of Science ®Google Scholar
• Ladics G, Bardina L, Cressman R, Mattsson J, Sampson H. 2006. Lack of cross-reactivity between the Bacillus thuringiensis-derived protein Cry1F in maize grain and dust mite Der p 7 protein with human sera positive for Der p 7-IgE. Regul Toxicol Pharmacol. 44:136–143.
   PubMed Web of Science ®Google Scholar
• Ladics G, Budziszewski G, Herman R, Herouet-Guicheney C, Joshi S, Lipscomb E, McClain S, Ward J. 2014. Measurement of endogenous allergens in genetically-modified soybeans. Regul Toxicol Pharmacol. 70:75–79.
   PubMed Web of Science ®Google Scholar
• Ladics G, Cressman R, Herouet-Guicheney C, Herman R, Privalle L, Song P, Ward J, McClain S. 2011. Bioinformatics and the allergy assessment of agricultural biotechnology products: Industry practices and recommendations. Regul Toxicol Pharmacol. 60:46–53.
   PubMed Web of Science ®Google Scholar
• Ladics G, Holsapple M, Astwood J, Kimber I, Knippels L, Helm R, Dong W. 2003. Workshop overview: Approaches to the assessment of the allergenic potential of food from genetically-modified crops. Toxicol Sci. 73:8–16.
   PubMed Web of Science ®Google Scholar
• Ladics G, Knippels L, Penninks A, Bannon G, Goodman R, Herouet-Guicheney C. 2010. Review of animal models designed to predict the potential allergenicity of novel proteins in genetically-modified crops. Regul Toxicol Pharmacol. 56:212–224.
   PubMed Web of Science ®Google Scholar
• Ladics GS, Bartholomaeus A, Bregitzer P, Doerrer NG, Gray A, Holzhauser T, Jordan M, Keese P, Kok E, Macdonald P, et al. 2015. Genetic basis and detection of unintended effects in genetically-modified crop plants. Transgenic Res. 24:587–603.
   PubMed Web of Science ®Google Scholar
• Ladics G, Fry J, Goodman R, Herouet-Guicheney C, Hoffmann-Sommergruber K, Madsen C, Penninks A, Pomes A, Roggen E, Smit J. 2014. Allergic sensitization: Screening methods. Clin Transl Allergy. 4:10.
   PubMed Web of Science ®Google Scholar
• Larsen J, Bogh K. 2018. Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities. Clin Exp Allergy.
   Web of Science ®Google Scholar
• Lee G, Houston N, Stevenson S, Ladics G, McClain S, Privalle L, Thelen J. 2010. Mass spectrometry analysis of soybean seed proteins: Optimization of gel-free quantitative workflow. Anal Meth. 2:1577–1583.
   Web of Science ®Google Scholar
• Liu B, Teng D, Wang X, Yang Y, Wang J. 2012. Expression of the soybean allergenic protein P34 in Escherichia coli and its indirect ELISA detection method. Appl Microbiol Biotechnol. 94:1337–1345.
   PubMed Web of Science ®Google Scholar
• Ma X, Sun P, He P, Han P, Wang J, Qiao S, Li D. 2010. Development of monoclonal antibodies and a competitive ELISA detection method for glycinin, an allergen in soybean. Food Chem. 121:546–551.
   Web of Science ®Google Scholar
• Mandalari G, Adel-Patient K, Barkholt V, Baro C, Bennett L, Bublin M, Gaier S, Graser G, Ladics GS, Mierzejewska D, et al. 2009. In vitro digestibility of beta-casein and beta-lactoglobulin under simulated human gastric and duodenal conditions: A multi-laboratory evaluation. Regul Toxicol Pharmacol. 55:372–381.
   PubMed Web of Science ®Google Scholar
• Mari A. 2002. IgE to cross-reactive carbohydrate determinants: Analysis of the distribution and appraisal of the in vivo and in vitro reactivity. Intl Arch Allergy Immunol. 129:286–295.
   PubMed Web of Science ®Google Scholar
• Martin W, Travers P. 1989. Worldwide abundance and distribution of Bacillus thuringiensis isolates. Appl Environ Microbiol. 55:2437–2442.
   PubMed Web of Science ®Google Scholar
• McClain S, Bannon G. 2006. Animal models of food allergy: Opportunities and barriers. Curr Allergy Asthma Rep. 6:141–144.
   PubMed Web of Science ®Google Scholar
• McClain S, Bowman C, Fernández-Rivas M, Ladics G, van Ree R. 2014. Allergic sensitization: Food- and protein-related factors. Clin Transl Allergy. 4:11–18.
   PubMed Web of Science ®Google Scholar
• McClain S, Stevenson S, Brownie C, Herouet-Guicheney C, Herman R, Ladics G, Privalle L, Ward J, Doerrer N, Thelen J. 2018. Variation in seed allergen content from three varieties of soybean cultivated in nine different locations in Iowa, Illinois, and Indiana. Front Plant Sci. https://doi.org/10.3389/fpls.2018.01025
   PubMed Web of Science ®Google Scholar
• Mendelsohn M, Kough J, Vaituzis Z, Matthews K. 2003. Are Bt crops safe?. Nat Biotechnol. 21:1003–1009.
   PubMed Web of Science ®Google Scholar
• Metcalfe D, Astwood J, Townsend R, Sampson H, Taylor S, Fuchs R. 1996. Assessment of the allergenic potential of foods from genetically-engineered crop plants. Crit Rev Food Sci Nutr. 36:165–186.
   PubMed Web of Science ®Google Scholar
• Mills E, Jenkins J, Alcocer M, Shewry P. 2004. Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract. Crit Rev Food Sci Nutr. 44:379–407.
   PubMed Web of Science ®Google Scholar
• Mills ENC, Sancho AI, Rigby NM, Jenkins JA, Mackie AR. 2009. Impact of food processing on the structural and allergenic properties of food allergens. Mol Nutr Food Res. 53:963–969.
   PubMed Web of Science ®Google Scholar
• Mirsky H, Cressman R, Ladics G. 2013. Comparative assessment of multiple criteria for the in silico prediction of allergenic cross-reactivity. Regul Toxicol Pharmacol. 67:232–239.
   PubMed Web of Science ®Google Scholar
• Mitea C, Salentijn EMJ, van Veelen P, Goryunova SV, van der Meer IM, van den Broeck HC, Mujico JR, Montserrat V, Monserrat V, Gilissen LJWJ, et al. 2010. A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease. PLoS One. 5:e15637.
   PubMed Web of Science ®Google Scholar
• Navuluri L, Parvataneni S, Hassan H, Birmingham N, Kelly C, Gangur V. 2006. Allergic and anaphylactic response to sesame seeds in mice: Identification of Ses I 3 and basic subunit of 11s globulins as allergens. Intl Arch Allergy Immunol. 140:270–276.
   PubMed Web of Science ®Google Scholar
• Nelde A, Teufel M, Hahn C, Duschl A, Sebald W, Brocker E, Grunewald S. 2001. The impact of the route and frequency of antigen exposure on the IgE response in allergy. Int Arch Allergy Immunol. 124:461–469.
   PubMed Web of Science ®Google Scholar
• OECD (Organization for Economic Co-operation and Development). 2007. Consensus document on safety information on transgenic plants expressing Bacillus thuringiensis-derived insect control protein. Paris, France: OECD.
   Google Scholar
• Oezguen N, Zhou B, Negi S, Ivanciuc O, Schein C, Labesse G, Braun W. 2008. Comprehensive 3D-modeling of allergenic proteins and amino acid composition of potential conformational IgE epitopes. Mol Immunol. 45:3740–3747.
   PubMed Web of Science ®Google Scholar
• Ofori-Anti A, Ariyarathna H, Chen L, Lee H, Pramod S, Goodman R. 2008. Establishing objective detection limits for the pepsin digestion assay used in the assessment of genetically modified foods. Regul Toxicol Pharmacol. 52:94–103.
   PubMed Web of Science ®Google Scholar
• Okunuki H, Teshima R, Shigeta T, Sakushima S, Akiyama H, Goda Y, Toyoda M, Sawada M. 2002. Increased digestibility of two products in genetically modified food (CP4-EPSPS and Cry1Ab) after preheating. Shokuhin Eiseigaku Zasshi. 43:68–73.
   PubMedGoogle Scholar
• Osterballe M, Hansen T, Mortz C, Host A, Bindslev-Jensen C. 2005. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediat Allergy Immunol. 16:567–573.
   PubMed Web of Science ®Google Scholar
• Oyoshi MK, Oettgen HC, Chatila TA, Geha RS, Bryce PJ. 2014. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 133:309–317.
   PubMed Web of Science ®Google Scholar
• Panda R, Ariyarathna H, Amnuaycheewa P, Tetteh A, Pramod S, Taylor S, Ballmer-Weber B, Goodman R. 2013. Challenges in testing genetically modified crops for potential increases in endogenous allergen expression for safety. Allergy. 68:142–151.
   PubMed Web of Science ®Google Scholar
• Parrott W, Chassy B, Ligon J, Meyer L, Petrick J, Zhou J, Herman R, Delaney B, Levine M. 2010. Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops. Food Chem Toxicol. 48:1773–1790.
   PubMed Web of Science ®Google Scholar
• Paschke A. 2009. Aspects of food processing and its effect on allergen structure. Mol Nutr Food Res. 53:959–962.
   PubMed Web of Science ®Google Scholar
• Pastorello EA, Vieths S, Pravettoni V, Farioli L, Trambaioli C, Fortunato D, Lüttkopf D, Calamari M, Ansaloni R, Scibilia J, et al. 2002. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol. 109:563–570.
   PubMed Web of Science ®Google Scholar
• Pearson W. 2000. Flexible sequence similarity searching with the FASTA3 program package. Methods Mol Biol. 132:185–219.
   PubMedGoogle Scholar
• Pearson W, Lipman D. 1988. Improved tools for biological comparison. Proc Natl Acad Sci USA. 85:2440–2448.
   Web of Science ®Google Scholar
• Polovic N, Blanusa M, Gavrovic-Jankulovic M, Atanaskovic-Markovic M, Burazer L, Jankov R, Velickovic TC. 2007. A matrix effect in pectin-rich fruits hampers digestion of allergen by pepsin in vivo and in vitro. Clin Exp Immunol. 37:764–771.
   Google Scholar
• Poulsen L, Ladics G, McClain S, Doerrer N, van Ree R. 2014. Sensitizing properties of proteins: Executive summary. Clin Transl Allergy. 4:10–11.
   PubMed Web of Science ®Google Scholar
• Privalle L, Bannon G, Herman R, Ladics G, McClain S, Stagg N, Ward J, Herouet-Guicheney C. 2011. Heat stability, its measurement, and its lack of utility in the assessment of the potential allergenicity of novel proteins. Regul Toxicol Pharmacol. 61:292–295.
   PubMed Web of Science ®Google Scholar
• Radauer C, Breiteneder H. 2006. Pollen allergens are restricted to few protein families and show distinct patterns of species distribution. J Allergy Clin Immunol. 117:141–147.
   PubMed Web of Science ®Google Scholar
• Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H. 2008. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol. 121:847–852.
   PubMed Web of Science ®Google Scholar
• Ricroch A, Berge J, Kuntz M. 2011. Evaluation of genetically engineered crops using transcriptomic, proteomic, and metabolomic profiling techniques. Plant Physiol. 155:1752–1761.
   PubMed Web of Science ®Google Scholar
• Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, Sigurdardottir ST, Lindner T, Goldhahn K, Dahlstrom J, et al. 2007. The prevalence of food allergy: A meta-analysis. J Allergy Clin Immunol. 120:638–646.
   PubMed Web of Science ®Google Scholar
• Rouquié D, Capt A, Eby W, Sekar V, Herouet-Guicheney C. 2010. Investigation of endogenous soybean food allergens by using a 2-D gel electrophoresis approach. Regul Toxicol Pharmacol. 58:S47–S53.
   PubMed Web of Science ®Google Scholar
• Sallusto F, Cella M, Danieli C, Lanzavecchia A. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products. J Exp Med. 182:389–400.
   PubMed Web of Science ®Google Scholar
• Sánchez-Monge R, Blanco C, Perales AD, Collada C, Carrillo T, Aragoncillo C, Salcedo G. 2000. Class I chitinases, the pan-allergens responsible for the latex fruit syndrome, are induced by ethylene treatment and inactivated by heating. J Allergy Clin Immunol. 106:190–195.
   PubMed Web of Science ®Google Scholar
• Sancho A, Foxall R, Rigby N, Browne T, Zuidmeer L, van Ree R, Waldron K, Mills E. 2006. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a non-specific lipid transfer protein. J Agric Food Chem. 54:5098–5104.
   PubMed Web of Science ®Google Scholar
• Sancho AI, Foxall R, Browne T, Dey R, Zuidmeer L, Marzban G, Waldron KW, van Ree R, Hoffmann-Sommergruber K, Laimer M, et al. 2006. Effect of postharvest storage on the expression of the apple allergen Mal d 1. J Agric Food Chem. 54:5917–5923.
   PubMed Web of Science ®Google Scholar
• Sathe S, Sharma G. 2009. Effects of food processing on food allergens. Mol Nutr Food Res. 53:970–978.
   PubMed Web of Science ®Google Scholar
• Scheurer S, Son D, Boehm M, Karamloo F, Franke S, Hoffmann A, Haustein D, Vieths S. 1999. Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Mol Immunol. 36:155–167.
   PubMed Web of Science ®Google Scholar
• Silvanovich A, Bannon G, McClain S. 2009. The use of E-scores to determine the quality of protein alignments. Regul Toxicol Pharmacol. 54:S26–S31.
   PubMed Web of Science ®Google Scholar
• Silvanovich A, Nemeth M, Song P, Herman R, Tagliani L, Bannon G. 2006. The value of short amino acid sequence matches for prediction of protein allergenicity. Toxicol Sci. 90:252–258.
   PubMed Web of Science ®Google Scholar
• Skamstrup Hansen K, Ballmer-Weber B, Lüttkopf D, Skov P, Wuthrich B, Bindslev-Jensen C, Vieths S, Poulsen L. 2003. Roasted hazelnuts - allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy. 58:132–138.
   PubMed Web of Science ®Google Scholar
• Stadler M, Stadler B. 2003. Allergenicity prediction by protein sequence. Faseb J. 17:1141–1143.
   PubMed Web of Science ®Google Scholar
• Sten E, Skov P, Andersen S, Torp A, Olesen A, Bindslev-Jensen U, Poulsen L, Bindslev-Jensen C. 2004. A comparative study of the allergenic potency of wild-type and glyphosate-tolerant gene-modified soybean cultivars. APMIS. 112:21–28.
   PubMed Web of Science ®Google Scholar
• Stepniak D, Vader L, Kooy Y, van Veelen P, Moustakas A, Papandreou N, Eliopoulos E, Drijfhout J, Papadopoulos G, Koning F. 2005. T-Cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1. Immunogenetics. 57:8–15.
   PubMed Web of Science ®Google Scholar
• Stepniak D, Wiesner M, de Ru AH, Moustakas AK, Drijfhout JW, Papadopoulos GK, van Veelen PA, Koning F. 2008. Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2. J Immunol. 180:3268–3278.
   PubMed Web of Science ®Google Scholar
• Stevenson S, Houston N, Thelen J. 2010. Evolution of seed allergen quantification - from antibodies to mass spectrometry. Regul Toxicol Pharmacol. 58:S36–S41.
   PubMed Web of Science ®Google Scholar
• Stevenson S, Woods C, Hong B, Kong X, Thelen J, Ladics G. 2012. Environmental effects on allergen levels in commercially-grown non-genetically-modified soybeans: Assessing variation across North America. Front Plant Sci. 3:1–13.
   PubMed Web of Science ®Google Scholar
• Sun N, Zhou C, Pu Q, Wang J, Huang K, Che H. 2013. Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin. J Immunotoxicol. 10:67–74.
   PubMed Web of Science ®Google Scholar
• Szekacs A, Lauber E, Juracsek J, Darvas B. 2010. Cry1Ab toxin production of MON 810 transgenic maize. Environ Toxicol Chem. 29:182–190.
   PubMed Web of Science ®Google Scholar
• Tan M, Mommaas A, Drijfhout J, Jordens R, Onderwater J, Verwoerd D, Mulder A, van der Heiden A, Scheidegger D, Oomen L. 1997. Mannose receptor mediated uptake of antigens strongly enhances HLA-Class II restricted antigen presentation by cultured dendritic cells. Adv Exp Biol Med. 417:171–174.
   PubMed Web of Science ®Google Scholar
• Taylor S, Hefle S. 2001. Food allergies and other food sensitivities. Food Technol. 55:68–83.
   Web of Science ®Google Scholar
• Taylor SL, Hefle SL, Bindslev-Jensen C, Bock SA, Burks AW, Christie L, Hill DJ, Host A, Hourihane JOB, Lack G, et al. 2002. Factors affecting the determination of threshold doses for allergenic foods: How much is too much? J Allergy Clin Immunol. 109:24–30.
   PubMed Web of Science ®Google Scholar
• Taylor S, Hourihane J. 2008. Food allergen thresholds of reactivity. In: Metcalfe D, Sampson H, Simon R, editors. Food allergy: Adverse reactions to foods and food additives. Hoboken, (NJ): Wiley and Sons; p. 82–89.
   Google Scholar
• Teuber S, del Val G, Morigasaki S, Jung H, Eisele H, Frick O, Buchanan B. 2002. The atopic dog as a model of peanut and tree nut food allergy. J Allergy Clin Immunol. 110:921–927.
   PubMed Web of Science ®Google Scholar
• Thomas K, Bannon G, Hefle S, Herouet C, Holsapple M, Ladics G, MacIntosh S, Privalle L. 2005. In silico methods for evaluating human allergenicity to novel proteins: International Bioinformatics Workshop Meeting Report Mallorca, Spain, February 24-25, 2005. Toxicol Sci. 88:307–310.
   PubMed Web of Science ®Google Scholar
• Thomas K, Aalbers M, Bannon GA, Bartels M, Dearman RJ, Esdaile DJ, Fu TJ, Glatt CM, Hadfield N, Hatzos C, et al. 2004. A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins. Regul Toxicol Pharmacol. 39:87–98.
   PubMed Web of Science ®Google Scholar
• USEPA. 2011. Bacillus thuringiensis preliminary work plan and summary document for registration review: Initial docket. United States Environmental Protection Agency. Bethesda, (MD): USEPA.
   Google Scholar
• van Ree R, Hummelshoj L, Plantinga M, Poulsen L, Swindle E. 2014. Allergic sensitization: Host-immune factors. Clin Transl Allergy. 4:1–9.
   PubMed Web of Science ®Google Scholar
• Vojdani A. 2009. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutr Metab (Lond). 6:22–39.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO), Environmental. 1999. Health criteria 217: Microbial pest control agent Bacillus thuringiensis. Geneva, Switzerland: WHO.
   Google Scholar
• Yokoi H, Yoshitake H, Matsumoto Y, Kawada M, Takato Y, Shinagawa K, Sakurai H, Saito K. 2017. Involvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing. Asia Pac Allergy. 7:29–36.
   PubMed Web of Science ®Google Scholar
• You J, Li D, Qiao S, Wang Z, He P, Ou D, Dong B. 2008. Development of a monoclonal antibody-based competitive ELISA for detection of β-conglycinin, an allergen from soybean. Food Chem. 106:352–360.
   Web of Science ®Google Scholar
• Young G, Zhang S, Mirsky H, Cressman R, Cong B, Ladics G, Zhong C. 2012. Assessment of possible allergenicity of hypothetical ORFs in common food crops using current bioinformatic guidelines and its implications for the safety assessment of GM crops. Food Chem Toxicol. 50:3741–3751.
   PubMed Web of Science ®Google Scholar