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Journal of Immunotoxicology Volume 16, 2019 - Issue 1
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Research Articles

An ELISA for detection of complement-bound circulating immune complexes in mice

Lykke BoysenGlobal Discovery and Development Sciences, Novo Nordisk A/S, Måløv, Denmark; ;Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, DenmarkView further author information
,
Brian LauritzenGlobal Discovery and Development Sciences, Novo Nordisk A/S, Måløv, Denmark; View further author information
,
Birgitte Martine ViuffGlobal Discovery and Development Sciences, Novo Nordisk A/S, Måløv, Denmark; View further author information
,
Jens LykkesfeldtFaculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, DenmarkView further author information
&
Lone Hummelshøj LandsyGlobal Discovery and Development Sciences, Novo Nordisk A/S, Måløv, Denmark; Correspondence[email protected]
View further author information
Pages 82-86 | Received 14 Jan 2019, Accepted 21 Mar 2019, Published online: 04 Jul 2019

References

  • Abrass C, Border W, Glassock R. 1980. Circulating immune complexes in rats with autologous immune complex nephritis. Lab Invest. 43:18–27.
  • Bourke B, Moss I, Mumford P, Horsfall A, Maini R. 1982. The complement fixing ability of putative circulating immune complexes in rheumatoid arthritis and its relationship to extra-articular disease. Clin Exp Immunol. 48:726–732.
  • Brennan F, Morton L, Spindeldreher S, Kiessling A, Allenspach R, Hey A, Muller P, Frings W, Sims J. 2010. Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies. MAbs. 2:233–255.
  • Chen J, Chen A, Chang L, Chang W, Lee H, Lin S, Lin Y. 2004. Mouse model of membranous nephropathy induced by cationic bovine serum albumin: Antigen dose-response relations and strain differences. Nephrol Dial Transplant. 19:2721–2728.
  • Devanarayan V, Smith W, Brunelle R, Seger M, Krug K, Bowsher R. 2017. Recommendations for systematic statistical computation of immunogenicity cut points. AAPS J. 19:1487–1498.
  • Devey M, Bleasdale K, Collins M, Steward M. 1982. Experimental antigen-antibody complex disease in mice. The role of antibody levels, antibody affinity and circulating antigen-antibody complexes. Int Arch Allergy Appl Immunol. 68:47–53.
  • Devey M, Taylor J, Steward M. 1980. Measurement of antigen-antibody complexes in mouse sera by conglutinin, C1q and rheumatoid factor solid phase binding assays. J Immunol Meth. 34:191–203.
  • Devey M, Steward M. 1980. The induction of chronic antigen-antibody complex disease in selectively bred mice producing either high or low affinity antibody to protein antigens. Immunology. 41:303–311.
  • Gabriel A, Agnello V. 1977. Detection of immune complexes. The use of radioimmunoassays with Clq and monoclonal rheumatoid factor. J Clin Invest. 59:990–1001.
  • Hewicker M, Kromschröder E, Trautwein G. 1990. Detection of circulating immune complexes in MRL mice with different forms of glomerulonephritis. Zeitsch Versuch. 33:149–156.
  • Hori M, Abrass C. 1990. Isolation and characterization of circulating immune complexes from rats with experimental membranous nephropathy. J Immunol. 144:3849–3855.
  • Krishna M, Nadler S. 2016. Immunogenicity to biotherapeutics - the role of anti-drug immune complexes. Front Immunol 7:21.
  • Lambert P, Dixon F, Zubler R. 1978. A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum. J Clin Lab Immunol. 1:1–15.
  • Lutz H, Stammler P, Jelezarova E, Nater M, Späth P. 1996. High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn-IgG complexes. Blood. 88:184–193.
  • Machida T, Sakamoto N, Ishida Y, Takahashi M, Fujita T, Sekine H. 2018. Essential roles for mannose-binding lectin-associated serine protease-1/3 in the development of lupus-like glomerulonephritis in MRL/lpr mice. Front Immunol. 9:19911.
  • Mayadas T, Tsokos G, Tsuboi N. 2009. Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation. 120:2012–2024.
  • Muratsugu M. 1996. Mechanism of aggregates generated by heating human serum. Biol Pharm Bull. 19:132–135.
  • Murphy K, Weaver C. (Eds). 2016. Janeway’s immunobiology. New York (NY): Garland Science.
  • Noble B, Steward M, Vladutiu A, Brentjens J. 1987. Relationship of the quality and quantity of circulating anti-BSA antibodies to the severity of glomerulonephritis in rats with chronic serum sickness. Clin Exp Immunol. 67:277–282.
  • Pangburn M, Muller-Eberhard H. 1983. Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3. Ann NY Acad Sci. 421:291–298.
  • Pereira A, Theofilopoulos A, Dixon F. 1980. Detection and partial characterization of circulating immune complexes with solid-phase anti-C3. J Immunol. 125:763–770.
  • Rojko JL, Evans MG, Price SA, Han B, Waine G, DeWitte M, Haynes J, Freimark B, Martin P, Raymond JT, et al. 2014. Formation, clearance, deposition, pathogenicity, and identification of biopharmaceutical-related immune complexes: Review and case studies. Toxicol Pathol. 42:725–764.
  • Soares N, Santiago M, deCarvalho L. 2001. An improved anti-C3/IgG ELISA for quantification of soluble immune complexes. J Immunol Methods. 249:199–205.
  • Stanilova S, Slavov E. 2001. Comparative study of circulating immune complexes quantity detection by three assays-CIF-ELISA, C1q-ELISA, and anti-C3 ELISA. J Immunol Meth. 253:13–21.
  • Theofilopoulos A, Dixon F. 1979. The biology and detection of immune complexes. Adv Immunol. 28:89–220.
  • van Dam A, Hack C. 1987. Formation of C3-IgG complexes in serum by aggregated IgG and by non-immunoglobulin activators of complement. Immunology. 61:105–110.

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