Di-(2-ethylhexyl)-phthalate interferes with T-follicular helper cell differentiation and cytokine secretion through signaling lymphocytic activation molecule family member-1

References

• Andris F, Denanglaire S, Anciaux M, Hercor M, Hussein H, Leo O. 2017. The transcription factor c-Maf promotes the differentiation of follicular helper T-cells. Front Immunol. 8:480.
   PubMed Web of Science ®Google Scholar
• Beko G, Callesen M, Weschler C, Toftum J, Langer S, Sigsgaard T, Host A, Kold Jensen T, Clausen G. 2015. Phthalate exposure through different pathways and allergic sensitization in pre-school children with asthma, allergic rhinoconjunctivitis and atopic dermatitis. Environ Res. 137:432–439.
   PubMed Web of Science ®Google Scholar
• Braun J, Sathyanarayana S, Hauser R. 2013. Phthalate exposure and children's health. Curr Opin Pediatr. 25(2):247–254.
   PubMed Web of Science ®Google Scholar
• Butler NS, Kulu DI. 2015. The regulation of T-follicular helper responses during infection. Curr Opin Immunol. 34:68–74.
   PubMed Web of Science ®Google Scholar
• Cannons J, Lu K, Schwartzberg P. 2013. T-follicular helper cell diversity and plasticity. Trends Immunol. 34(5):200–207.
   PubMed Web of Science ®Google Scholar
• Cannons J, Tangye S, Schwartzberg P. 2011. SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol. 29:665–705.
   PubMed Web of Science ®Google Scholar
• Chen S, Cai C, Li Z, Liu G, Wang Y, Blonska M, Li D, Du J, Lin X, Yang M, et al. 2017. Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med. 214(2):475–489.
   PubMed Web of Science ®Google Scholar
• Crotty S. 2014. T-follicular helper cell differentiation, function, and roles in disease. Immunity. 41(4):529–542.
   PubMed Web of Science ®Google Scholar
• de Calisto J, Wang N, Wang G, Yigit B, Engel P, Terhorst C. 2014. SAP-dependent and -independent regulation of innate T-cell development involving SLAMF receptors. Front Immunol. 5:186.
   PubMed Web of Science ®Google Scholar
• Dong Z, Davidson D, Perez-Quintero L, Kurosaki T, Swat W, Veillette A. 2012. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 36(6):974–985.
   PubMed Web of Science ®Google Scholar
• Dragovich M, Mor A. 2018. The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases. Autoimmun Rev. 17(7):674–682.
   PubMed Web of Science ®Google Scholar
• Erythropel H, Maric M, Nicell J, Leask R, Yargeau V. 2014. Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure. Appl Microbiol Biotechnol. 98(24):9967–9981.
   PubMed Web of Science ®Google Scholar
• Galli S, Tsai M. 2012. IgE and mast cells in allergic disease. Nat Med. 18(5):693–704.
   PubMed Web of Science ®Google Scholar
• Gao D, Wen Z. 2016. Phthalate esters in the environment: A critical review of their occurrence, biodegradation, and removal during wastewater treatment processes. Sci Total Environ. 541:986–1001.
   PubMed Web of Science ®Google Scholar
• Gensous N, Charrier M, Duluc D, Contin-Bordes C, Truchetet M, Lazaro E, Duffau P, Blanco P, Richez C. 2018. T-follicular helper cells in autoimmune disorders . Front Immunol. 9:1637.
   PubMed Web of Science ®Google Scholar
• Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko S. 2018. SLAMF1/CD150 in hematologic malignancies: Silent marker or active player? Clin Immunol. pii: S1521-6616(18)30437-6.
   PubMed Web of Science ®Google Scholar
• Han Y, Wang X, Chen G, Xu G, Liu X, Zhu W, Hu P, Zhang Y, Zhu C, Miao J. 2014. Di-(2-ethylhexyl)-phthalate adjuvantly induces imbalanced humoral immunity in ovalbumin-sensitized BALB/c mice ascribing to T-follicular helper cells hyperfunction. Toxicology. 324:88–97.
   PubMed Web of Science ®Google Scholar
• Holgate S. 2012. Innate and adaptive immune responses in asthma. Nat Med. 18(5):673–683.
   PubMed Web of Science ®Google Scholar
• Hu J, Havenar-Daughton C, Crotty S. 2013. Modulation of SAP-dependent T:B-cell interactions as a strategy to improve vaccination. Curr Opin Virol. 3(3):363–370.
   PubMed Web of Science ®Google Scholar
• Jogdand G, Mohanty S, Devadas S. 2016. Regulators of Tfh cell differentiation. Front Immunol. 7:520.
   PubMed Web of Science ®Google Scholar
• Johns L, Cooper G, Galizia A, Meeker J. 2015. Exposure assessment issues in epidemiology studies of phthalates. Environ Intl. 85:27–39.
   PubMed Web of Science ®Google Scholar
• Johnston R, Poholek A, DiToro D, Yusuf I, Eto D, Barnett B, Dent A, Craft J, Crotty S. 2009. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T-follicular helper cell differentiation. Science. 325(5943):1006–1010.
   PubMed Web of Science ®Google Scholar
• Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, Crotty S. 2012. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 188(8):3734–3744.
   PubMed Web of Science ®Google Scholar
• Li M, Chen C, Guo Y. 2017. Phthalate esters and childhood asthma: A systematic review and congener-specific meta-analysis. Environ Pollut. 229:655–660.
   PubMed Web of Science ®Google Scholar
• Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, et al. 2012. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med. 209(10):1841–1852.
   PubMed Web of Science ®Google Scholar
• Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG, Anderson SM, Wei L, Sun H, O'Shea JJ, et al. 2011. Functional and epigenetic studies reveal multi-step differentiation and plasticity of in vitro-generated and in vivo-derived follicular T-helper cells. Immunity. 35(4):622–632.
   PubMed Web of Science ®Google Scholar
• Luthje K, Kallies A, Shimohakamada Y, Belz G, Light A, Tarlinton D, Nutt S. 2012. The development and fate of follicular helper T-cells defined by an IL-21 reporter mouse. Nat Immunol. 13(5):491–498.
   PubMed Web of Science ®Google Scholar
• Ma C, Deenick E. 2011. The role of SAP and SLAM family molecules in the humoral immune response. Ann N Y Acad Sci. 1217:32–44.
   PubMed Web of Science ®Google Scholar
• Ma C, Deenick E. 2014. Human T-follicular helper (Tfh) cells and disease. Immunol Cell Biol. 92(1):64–71.
   PubMed Web of Science ®Google Scholar
• North M, Takaro T, Diamond M, Ellis A. 2014. Effects of phthalates on the development and expression of allergic disease and asthma. Ann Allergy Asthma Immunol. 112(6):496–502.
   PubMed Web of Science ®Google Scholar
• Nurieva R, Chung Y, Martinez G, Yang X, Tanaka S, Matskevitch T, Wang Y, Dong C. 2009. Bcl6 mediates the development of T-follicular helper cells. Science. 325(5943):1001–1005.
   PubMed Web of Science ®Google Scholar
• Proust R, Bertoglio J, Gesbert F. 2012. The adaptor protein SAP directly associates with CD3ζ chain and regulates T-cell receptor signaling. PloS One. 7(8):e43200.
   PubMed Web of Science ®Google Scholar
• Qi H, Chen X, Chu C, Lu P, Xu H, Yan J. 2014. Follicular T-helper cells: Controlled localization and cellular interactions. Immunol Cell Biol. 92(1):28–33.
   PubMed Web of Science ®Google Scholar
• Qin L, Waseem T, Sahoo A, Bieerkehazhi S, Zhou H, Galkina E, Nurieva R. 2018. Insights into the molecular mechanisms of T-follicular helper-mediated immunity and pathology. Front Immunol. 9:1884.
   PubMed Web of Science ®Google Scholar
• Read K, Powell M, Oestreich K. 2016. T-follicular helper cell programming by cytokine-mediated events. Immunology. 149(3):253–261.
   PubMed Web of Science ®Google Scholar
• Romero X, Sintes J, Engel P. 2014. Role of SLAM family receptors and specific adapter SAP in innate-like lymphocytes. Crit. Rev. Immunol. 34(4):263–299.
   PubMed Web of Science ®Google Scholar
• Sahoo A, Wali S, Nurieva R. 2016. T-helper 2 and T-follicular helper cells: Regulation and function of interleukin-4. Cytokine Growth Factor Rev. 30:29–37.
   PubMed Web of Science ®Google Scholar
• Samanta S, Mukherjee S. 2017. Microscopic insight into thermodynamics of conformational changes of SAP-SLAM complex in signal transduction cascade. J Chem Phys. 146(16):165103.
   PubMed Web of Science ®Google Scholar
• Sawada S. 2012. SLAM-associated protein plays a key role in development of autoimmunity. Autoimmun Rev. 11(11):804–805.
   PubMed Web of Science ®Google Scholar
• Ueno H, Banchereau J, Vinuesa C. 2015. Pathophysiology of T-follicular helper cells in humans and mice. Nat Immunol. 16(2):142–152.
   PubMed Web of Science ®Google Scholar
• van Driel B, Liao G, Engel P, Terhorst C. 2016. Responses to microbial challenges by SLAMF receptors. Front Immunol. 7:4.
   PubMed Web of Science ®Google Scholar
• Varricchi G, Harker J, Borriello F, Marone G, Durham S, Shamji M. 2016. T-follicular helper (Tfh) cells in normal immune responses and in allergic disorders. Allergy. 71(8):1086–1094.
   PubMed Web of Science ®Google Scholar
• Vilar M, Frutuoso M, Arruda S, Lima D, Bezerra C, Pompeu M. 2011. The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T-cell responses. Braz J Med Biol Res. 44(4):276–282.
   PubMed Web of Science ®Google Scholar
• Wali S, Sahoo A, Puri S, Alekseev A, Nurieva R. 2016. Insights into the development and regulation of T-follicular helper cells. Cytokine. 87:9–19.
   PubMed Web of Science ®Google Scholar
• Wang I, Lin C, Lin Y, Hsieh W, Chen P. 2014. Early-life phthalate exposure and atopic disorders in children: A prospective birth cohort study. Environ Intl. 62:48–54.
   PubMed Web of Science ®Google Scholar
• Wang R, Wang Q, Ma C, Li S, Han R. 2018. Phthalates in soft glass (a soft transparent PVC plastic sheet used extensively in household and public place in developing countries in recent years): Implication for oral exposure to young children. Chemosphere. 211:861–866.
   PubMed Web of Science ®Google Scholar
• Webb L, Linterman M. 2017. Signals that drive T-follicular helper cell formation. Immunology. 152(2):185–194.
   PubMed Web of Science ®Google Scholar
• Wittassek M, Angerer J. 2008. Phthalates: Metabolism and exposure. Int J Androl. 31(2):131–138.
   PubMedGoogle Scholar
• Wu N, Veillette A. 2016. SLAM family receptors in normal immunity and immune pathologies. Curr Opin Immunol. 38:45–51.
   PubMed Web of Science ®Google Scholar
• Yusuf I, Kageyama R, Monticelli L, Johnston R, Ditoro D, Hansen K, Barnett B, Crotty S. 2010. Germinal center T-follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol. 185(1):190–202.
   PubMed Web of Science ®Google Scholar
• Zhao F, Cannons J, Dutta M, Griffiths G, Schwartzberg P. 2012. Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity. 36(6):1003–1016.
   PubMed Web of Science ®Google Scholar
• Zhong M, Veillette A. 2013a. Critical role of SAP in progression and reactivation but not maintenance of T-cell-dependent humoral immunity. Mol Cell Biol. 33(6):1223–1232.
   PubMed Web of Science ®Google Scholar
• Zhong M, Veillette A. 2013b. The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis. J Biol Chem. 288(44):31423–31436.
   PubMed Web of Science ®Google Scholar