Creatine supplementation and endurance performance: surges and sprints to win the race

References

• KreiderRB, KalmanDS, AntonioJ, et al. International society of sports nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr J of the Int Soc of Sports Nutr. 2017;14:18.
   PubMed Web of Science ®Google Scholar
• WaxB, KerksickC, JagimA, et al. Creatine for exercise and sports performance, with recovery considerations for healthy populations. Nutrients [Internet]. 2021 Jul 8];13(6). https://pubmed.ncbi.nlm.nih.gov/34199588/
   PubMed Web of Science ®Google Scholar
• WyssM, Kaddurah-DaoukR. Creatine and creatinine metabolism. Physiol Rev. 2021 Jul 8 2000;80:1107–228. [Internet]. Available from https://pubmed.ncbi.nlm.nih.gov/10893433/
   Google Scholar
• OstojicSM, ForbesSC. Perspective: creatine, a conditionally essential nutrient: building the case. Adv Nutr. 2022 Mar 8;13:34–37. [Internet]. Available from https://pubmed.ncbi.nlm.nih.gov/34662902/
   PubMed Web of Science ®Google Scholar
• KreiderRB, JägerR, PurpuraM. Bioavailability, efficacy, safety, and regulatory status of creatine and related compounds: a critical review. Nutrients. [cited 2022 Dec 17] 2022;14:1035. [Internet]. Available from https://pubmed.ncbi.nlm.nih.gov/35268011/
   PubMed Web of Science ®Google Scholar
• HultmanE, SoderlundK, TimmonsJA, et al. Muscle creatine loading in men. J Appl Physiol. 1996;81(1):232–237.
   PubMed Web of Science ®Google Scholar
• CandowD, ForbesS, ChilibeckP, et al. Variables influencing the effectiveness of creatine supplementation as a therapeutic intervention for sarcopenia. Front Nutr. 2019;6 [[cited 2021 Jul 8]]. [Internet]. Available from: https://pubmed.ncbi.nlm.nih.gov/31448281/
   PubMed Web of Science ®Google Scholar
• BonillaDA, KreiderRB, StoutJR, et al. Metabolic basis of creatine in health and disease: a bioinformatics-assisted review. Nutr. [cited 2021 Aug 31]. 2021;1313:1238–1238. [Internet]. Multidisciplinary Digital Publishing Institute 2021 Available from. https://www.mdpi.com/2072-6643/13/4/1238/htm
   Google Scholar
• DelpinoFM, FigueiredoLM, ForbesSC, et al. Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: a systematic review and meta-analysis of randomized clinical trials. Nutrition [Internet]. 2022 [cited 2022 Sep 28];103–104. Available from: https://pubmed.ncbi.nlm.nih.gov/35986981/
   Google Scholar
• ForbesSC, CandowDG, OstojicSM, et al. Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults. Nutrients. 2021;13(6):1912. Available from. https://doi.org/10.3390/nu13061912
   PubMed Web of Science ®Google Scholar
• JonesAM, AtterT, GeorgKP. Oral creatine supplementation improves multiple sprint performance in elite ice-hockey players. J Sports Med Phys Fitness. [cited 2022 Dec 30] 1999;30:140–196. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/10573659/
   Google Scholar
• GrasD, LanhersC, BagheriR, et al. Creatine supplementation and VO 2 max: a systematic review and meta-analysis. Crit Rev Food Sci Nutr [Internet]. ; 2021 [cited 2022 Sep 15];1–12. Available from: https://pubmed.ncbi.nlm.nih.gov/34859731/
   Google Scholar
• BranchJD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc MetabInt J Sport Nutr Exerc Metab. [cited 2022 Mar 3] 2003;13:198–226. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/12945830/ 2
   PubMed Web of Science ®Google Scholar
• AntonioJ, CandowDG, ForbesSC, et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr J of the Int Soc of Sports Nutr. 2021;18:1–17.
   PubMed Web of Science ®Google Scholar
• BALSOMPD, HARRIDGESDR, SODERLUNDK, et al. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol Scand. [cited 2022 Dec 29]. 1993;149:521–523. [Internet]. John Wiley & Sons, Ltd Available from. 4. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1748-1716.1993.tb09649.x
   PubMedGoogle Scholar
• RobinsonTM, SewellDA, HultmanE, et al. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J Appl Physiol. [cited 2022 Mar 8]. 1985;87:598–604. Internet1999Available from. 2. https://pubmed.ncbi.nlm.nih.gov/10444618/
   Google Scholar
• FosterC, SchragerM, SnyderAC, et al. Pacing strategy and athletic performance. Sport Med an Int J Appl Med Sci Sport Exerc. [cited 2022 Dec 29]. 1994;17:77–85. [Internet]. Springer Available from. 2. https://link.springer.com/article/10.2165/00007256-199417020-00001
   PubMed Web of Science ®Google Scholar
• VanhataloA, JonesAM. Influence of prior sprint exercise on the parameters of the ‘all-out critical power test’ in men. Exp Physiol [Internet]. John Wiley & Sons, Ltd Available from. 2009 [cited 2022 Dec 30];94:255–263. 10.1113/expphysiol.2008.045229.
   PubMed Web of Science ®Google Scholar
• ForbesS, CandowD, Smith-RyanA, et al. Supplements and nutritional interventions to augment high-intensity interval training physiological and performance adaptations—a narrative review. Nutrients. [cited 2021 Jul 8]. 2020;12:390. InternetAvailable from. 2. https://pubmed.ncbi.nlm.nih.gov/32024038/
   PubMed Web of Science ®Google Scholar
• HarrisR, SöderlundK, HultmanE. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci. [cited 2021 Oct 26] 1992;83:367–374. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/1327657/ 3
   PubMed Web of Science ®Google Scholar
• OliverJM, JoubertDP, MartinSE, et al. Oral creatine supplementation’s decrease of blood lactate during exhaustive, incremental cycling. Int J Sport Nutr Exerc MetabInt J Sport Nutr Exerc Metab. [cited 2022 Dec 30]. 2013;23:252–258. InternetAvailable from. 3. https://pubmed.ncbi.nlm.nih.gov/23164647/
   PubMed Web of Science ®Google Scholar
• SmithJC, StephensDP, HallEL, et al. Effect of oral creatine ingestion on parameters of the work rate-time relationship and time to exhaustion in high-intensity cycling. Eur J Appl Physiol Occup Physiol. [cited 2022 Dec 30]. 1998;77:360–365. InternetAvailable from. 4. https://pubmed.ncbi.nlm.nih.gov/9562365/
   PubMed Web of Science ®Google Scholar
• PrevostMC, NelsonAG, MorrisGS. Creatine supplementation enhances intermittent work performance. Res Q Exerc Sport. [cited 2022 Dec 30] 1997;68:233–240. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/9294877/
   PubMed Web of Science ®Google Scholar
• SchäferLU, HayesM, DekerleJ. Creatine supplementation improves performance above critical power but does not influence the magnitude of neuromuscular fatigue at task failure. Exp Physiol [Internet]. John Wiley & Sons, Ltd Available from. 2019 [cited 2022 Dec 30];104:1881–1891. 10.1113/EP087886.
   PubMed Web of Science ®Google Scholar
• EngelhardtM, NeumannG, BerbalkA, et al. Creatine supplementation in endurance sports. Med Sci Sport Exerc. [cited 2022 Sep 22]. 1998;30:1123–1129. InternetAvailable from. 7. https://journals.lww.com/acsm-msse/Fulltext/1998/07000/Creatine_supplementation_in_endurance__sports.16.aspx
   PubMed Web of Science ®Google Scholar
• WallimannT, Tokarska-SchlattnerM, SchlattnerU. The creatine kinase system and pleiotropic effects of creatine. Amino Acids [Internet]. Springer Available from. 2011 [cited 2021 Oct 5];40:1271–1296. https://link.springer.com/article/10.1007/s00726-011-0877-3.
   PubMed Web of Science ®Google Scholar
• AraziH, EghbaliE, SuzukiK. Creatine supplementation physical exercise and oxidative stress markers: a review of the mechanisms and effectiveness. Nutrients. [cited 2022 Sep 15] 2021;13:1–17. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/33800880/
   Web of Science ®Google Scholar
• JuJS, SmithJL, OppeltPJ, et al. Creatine feeding increases GLUT4 expression in rat skeletal muscle. Am J Physiol Endocrinol Metab. [cited 2022 Sep 15]. 2005;288(2):E347–352. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/15494613/
   PubMed Web of Science ®Google Scholar
• Van LoonLJC, MurphyR, OosterlaarAM, et al. Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci (Lond). [cited 2022 Sep 15]. 2004;106(1):99–106. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/14507259/
   PubMed Web of Science ®Google Scholar
• RobertsPA, FoxJ, PeirceN, et al. Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans. Amino Acids 2016;48:1831–1842. InternetAvailable from: [cited 2022 Dec 8] 10.1007/s00726-016-2252-x.
   PubMed Web of Science ®Google Scholar
• BurkeLM, HawleyJA. Swifter, higher, stronger: what’s on the menu? Science. 2018 [[cited 2022 Dec 8]];362:781–787. InternetAvailable from: https://pubmed.ncbi.nlm.nih.gov/30442803/.
   PubMed Web of Science ®Google Scholar
• TomcikKA, CameraDM, BoneJL, et al. Effects of creatine and carbohydrate loading on cycling time trial performance. Med Sci Sports Exerc. [cited 2022 Dec 8]. 2018;50(1):141–150. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/28806275/
   PubMed Web of Science ®Google Scholar
• AnomasiriW, SanguanrungsirkulS, Saichandee. Low dose creatine supplementation enhances sprint phase of 400 meters swimming performance. J Med Assoc Thail. 2004;87:S228–32. [[cited 2022 Dec 8]]. InternetAvailable from https://www.researchgate.net/publication/7677290_Low_dose_creatine_supplementation_enhances_sprint_phase_of_400_meters_swimming_performance
   PubMedGoogle Scholar
• SmithAE, WalterAA, HerdaTJ, et al. Effects of creatine loading on electromyographic fatigue threshold during cycle ergometry in college-aged women. J Int Soc Sports Nutr InternetAvailable from. 2007 cited 2022 Dec 30;4(1). https://pubmed.ncbi.nlm.nih.gov/18039377/
   Google Scholar
• BurnleyM, JonesAM. Power–duration relationship: physiology, fatigue, and the limits of human performance. Eur J Sport SciEur J Sport Sci. [cited 2022 Dec 30] 2018;18(1):1–12. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/27806677/
   PubMed Web of Science ®Google Scholar
• JonesAM, CarterH, PringleJSM, et al. Effect of creatine supplementation on oxygen uptake kinetics during submaximal cycle exercise. J Appl Physiol. [cited 2022 Dec 8]. 2002;92(6):2571–2577. InternetAvailable from. http://www.jap.org
   PubMed Web of Science ®Google Scholar
• ReybrouckT, GhesquiereJ, WeymansM, et al. Ventilatory threshold measurement to evaluate maximal endurance performance. Int J Sports MedInt J Sports Med. [cited 2022 Dec 8]. 1986;7(1):26–29. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/3082780/
   PubMed Web of Science ®Google Scholar
• Rico-SanzJ, MarcoMTM. Creatine enhances oxygen uptake and performance during alternating intensity exercise. Med Sci Sports Exerc. [cited 2022 Dec 30] 2000;32(2):379–385. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/10694120/
   PubMed Web of Science ®Google Scholar
• StroudMA, HollimanD, BellD, et al. Effect of oral creatine supplementation on respiratory gas exchange and blood lactate accumulation during steady-state incremental treadmill exercise and recovery in man. Clin Sci (Lond). [cited 2022 Dec 30]. 1994;87(6):707–710. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/7874863/
   PubMed Web of Science ®Google Scholar
• Van LoonLJC, OosterlaarAM, HartgensF, et al. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Lond). [cited 2022 Dec 30]. 2003;104:153–162. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/12546637/
   PubMed Web of Science ®Google Scholar
• MattosD, SantosCGM, ForbesSC, et al.Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military RecruitsJ Sci Sport Exerc [Internet]. Springer Available from2022[cited 2022 Dec 30]1–7. https://link.springer.com/article/10.1007/s42978-022-00165-1
   Google Scholar
• SyrotuikD, BellG. Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Conditioning Res. [cited 2021 Jul 8] 2004;18(3):610–617. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/15320650/
   PubMed Web of Science ®Google Scholar
• BrannonTA, AdamsGR, ConniffCL, et al. Effects of creatine loading and training on running performance and biochemical properties of rat skeletal muscle. Med & Sci in Sports & Exercise Med & Sci in Sports & Exercise. [cited 2022 Sep 16]. 1997;29:489–495. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/9107631/
   PubMed Web of Science ®Google Scholar
• LiuW, QaedE, ZhuHG, et al. Non-energy mechanism of phosphocreatine on the protection of cell survival. Biomed Pharmacother Elsevier Masson SAS. 2021;141:111839.
   PubMed Web of Science ®Google Scholar
• PutmanCT, GalloM, MartinsKJB, et al. Creatine loading elevates the intracellular phosphorylation potential and alters adaptive responses of rat fast-twitch muscle to chronic low-frequency stimulation. Appl Physiol Nutr Metab. [cited 2022 Sep 16]. 2015;40:671–682. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/26039543/
   PubMed Web of Science ®Google Scholar
• CordingleyDM, CornishSM, CandowDG. Anti-inflammatory and anti-catabolic effects of creatine supplementation: a brief review. Nutrients. [cited 2022 Dec 8] 2022;14:544. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/35276903/
   PubMed Web of Science ®Google Scholar
• SantosRVT, BassitRA, CaperutoEC, et al. The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sci Pergamon. 2004;75(16):1917–1924.
   PubMed Web of Science ®Google Scholar
• BassitRA, CuriR, Rosa LFBPC. CreRatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition. 2007. [cited 2021 Oct 4]. Springer Amin Acids 2007 352 [Internet]. 35(2):425–431. https://link.springer.com/article/10.1007/s00726-007-0582-4.
   Google Scholar
• DeminiceR, RosaFT, FrancoGS, et al. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutr Elsevier. 2013;29:1127–1132.
   PubMed Web of Science ®Google Scholar
• DeminiceR, JordaoAA. Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats. Amin Acids 2011 432 [Internet]. cited 2022 Dec 8 2011;43:709–715. Springer https://link.springer.com/article/10.1007/s00726-011-1121-x 2
   Google Scholar
• JacobsI, BleueS, GoodmanJ. Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. Can J Appl Physiol [Internet]. cited 2022 Dec 30 1997;22:231–243. Available from https://pubmed.ncbi.nlm.nih.gov/9189303/
   PubMedGoogle Scholar
• McNaughtonLR, DaltonB, TarrJ. The effects of creatine supplementation on high-intensity exercise performance in elite performers. Eur J Appl Physiol Occup PhysiolEur J Appl Physiol Occup Physiol. [cited 2022 Dec 30] 1998;78:236–240. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/9721002/
   PubMed Web of Science ®Google Scholar
• VandebuerieF, Vanden EyndeB, VandenbergheK, et al. Effect of creatine loading on endurance capacity and sprint power in cyclists. Int J Sports MedInt J Sports Med. [cited 2022 Dec 30]. 1998;19:490–495. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/9839847/
   PubMed Web of Science ®Google Scholar
• CurrellK, JeukendrupAE. Validity, reliability and sensitivity of measures of sporting performance. Sports Med. [cited 2022 Dec 30] 2008;38:297–316. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/18348590/ 4
   PubMed Web of Science ®Google Scholar
• RossiterHB, CannellER, JakemanPM. The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. J Sports Sci. [cited 2022 Dec 30] 1996;14:175–179. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/8737325/ 2
   PubMed Web of Science ®Google Scholar
• AbbissCR, RossMLR, GarvicanLA, et al. The distribution of pace adopted by cyclists during a cross-country mountain bike World Championships. J Sports Sci. [cited 2022 Dec 30]. 2013;31:787–794. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/23521618/
   PubMed Web of Science ®Google Scholar
• PeifferJJ, AbbissCR, HaakonssenEC, et al. Sprinting for the win: distribution of power output in women’s professional cycling. Int J Sports Physiol Perform. [cited 2022 Dec 30]. 2018;13:1237–1242. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/29688105/
   PubMed Web of Science ®Google Scholar
• MenaspàP, QuodM, MartinDT, et al. Physical demands of sprinting in professional road cycling. Int J Sports MedInt J Sports Med. [cited 2022 Dec 30]. 2015;36:1058–1062. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/26252551/
   PubMed Web of Science ®Google Scholar
• SandersD, HeijboerM. Physical demands and power profile of different stage types within a cycling grand tour. Eur J Sport SciEur J Sport Sci. [cited 2022 Dec 30] 2019;19:736–744. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/30589390/
   PubMed Web of Science ®Google Scholar
• GranierC, AbbissCR, AubryA, et al. Power output and pacing during international cross-country mountain bike cycling. Int J Sports Physiol Perform. [cited 2022 Dec 30]. 2018;13:1243–1249. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/29688109/
   PubMed Web of Science ®Google Scholar
• HaysA, DevysS, BertinD, et al. Understanding the physiological requirements of the mountain bike cross-country olympic race format. Front Physiol. 2018;9 [[cited 2022 Dec 30]]. InternetAvailable from: https://pubmed.ncbi.nlm.nih.gov/30158873/
   PubMed Web of Science ®Google Scholar
• NæssS, SollieO, GløersenØN, et al. Exercise intensity and pacing pattern during a cross-country olympic mountain bike race. Front Physiol. 2021;12 [[cited 2022 Dec 30]]. InternetAvailable from: https://pubmed.ncbi.nlm.nih.gov/34349670/
   PubMed Web of Science ®Google Scholar
• MaunderE, SeilerS, MildenhallMJ, et al. The importance of ‘durability’ in the physiological profiling of endurance athletes. Sports Med. [cited 2022 Dec 30]. 2021;51:1619–1628. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/33886100/
   PubMed Web of Science ®Google Scholar
• JonesAM, VanhataloA. The ‘critical power’ concept: applications to sports performance with a focus on intermittent high-intensity exercise. Sports Med. [cited 2022 Dec 30] 2017;47:65–78. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/28332113/
   PubMed Web of Science ®Google Scholar
• SkibaPF, JackmanS, ClarkeD, et al. Effect of work and recovery durations on w′ reconstitution during intermittent exercise. Med Sci Sports Exerc. [cited 2022 Dec 30]. 2014;46:1433–1440. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/24492634/
   PubMed Web of Science ®Google Scholar
• MiuraA, KinoF, KajitaniS, et al. The effect of oral creatine supplementation on the curvature constant parameter of the power-duration curve for cycle ergometry in humans. Jpn J Physiol. [cited 2022 Dec 30]. 1999;49:169–174. InternetAvailable from. 2. https://pubmed.ncbi.nlm.nih.gov/10393351/
   PubMedGoogle Scholar
• VanhataloA, JonesAM. Influence of creatine supplementation on the parameters of the “all-out critical power test”. J Exerc Sci Fit Elsevier. 2009;7(1):9–17.
   Web of Science ®Google Scholar
• FukudaDH, SmithAE, KendallKL, et al. The effects of creatine loading and gender on anaerobic running capacity. J Strength Cond: Conditioning Res 2011;25:S22. https://journals.lww.com/nsca-jscr/Fulltext/2011/03001/The_Effects_of_Creatine_Loading_and_Gender_on.32.aspx [Internet]. Ovid Technologies (Wolters Kluwer Health) Available from: [cited 2022 Dec 30]
   Google Scholar
• MesaJLM, RuizJR, González-GrossMM, et al. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med. [cited 2022 Dec 30]. 2002;32:903–944. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/12427051/
   PubMed Web of Science ®Google Scholar
• da Silva AzevedoAP, Michelone AcquestaF, Lancha JrAH, et al. Creatine supplementation can improve impact control in high-intensity interval training. Nutrition 2019;61:99–104. https://pubmed.ncbi.nlm.nih.gov/30708260/ InternetAvailable from: [cited 2022 Dec 30]
   PubMed Web of Science ®Google Scholar
• SafdarA, YardleyNJ, SnowR, et al. Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiol Genomics. [cited 2022 Dec 30]. 2008;32:219–228. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/17957000/
   PubMed Web of Science ®Google Scholar
• RibeiroAS, AvelarA, KassianoW, et al. Creatine supplementation does not influence the ratio between intracellular water and skeletal muscle mass in resistance-trained men. Int J Sport Nutr Exerc MetabInt J Sport Nutr Exerc Metab. [cited 2022 Dec 30]. 2020;30:405–411. InternetAvailable from. https://pubmed.ncbi.nlm.nih.gov/32916658/
   PubMed Web of Science ®Google Scholar
• MooreSR, GordonAN, CabreHE, et al. A randomized controlled trial of changes in fluid distribution across menstrual phases with creatine supplementation. Nutrients. [cited 2023 Mar 1]. 2023;15:429. [Internet]. Multidisciplinary Digital Publishing Institute (MDPI) Available from. 2. /pmc/articles/PMC9865497/
   PubMed Web of Science ®Google Scholar
• RønnestadBR, MujikaI. Optimizing strength training for running and cycling endurance performance: a review. Scand J Med Sci Sports. [cited 2022 Dec 30] 2014;24:603–612. InternetAvailable from https://pubmed.ncbi.nlm.nih.gov/23914932/
   PubMed Web of Science ®Google Scholar
• VikmoenO, EllefsenS, Trøen, et al. Strength training improves cycling performance, fractional utilization of VO2max and cycling economy in female cyclists. Scand J Med Sci Sports. [cited 2022 Dec 30]. 2016;26:384–396. InternetAvailable from. 4. https://pubmed.ncbi.nlm.nih.gov/25892654/
   PubMed Web of Science ®Google Scholar
• CandowD, ChilibeckP, GordonJ, et al. Efficacy of creatine supplementation and resistance training on area and density of bone and muscle in older adults. Med Sci Sports Exerc. [cited 2021 Oct 29]. 2021;53:2388–2395. Internet. 10.1249/MSS.0000000000002722
   PubMed Web of Science ®Google Scholar
• ForbesSC, OstojicSM, Souza-JuniorTP, et al. A high dose of creatine combined with resistance training appears to be required to augment indices of bone health in older adults. Ann Nutr Metab [Internet]. 2021 Apr 5; Available from: https://pubmed.ncbi.nlm.nih.gov/34788768/
   Google Scholar
• CandowDG, ChilibeckPD, GordonJJ, et al. Efficacy of creatine supplementation and resistance training on area and density of bone and muscle in older adults. Med Sci Sports Exerc [Internet] 2022 Apr 4 2021;53:2388–2395. Available from. 10.1249/MSS.0000000000002722
   PubMed Web of Science ®Google Scholar
• HelgerudJ, HøydalK, WangE, et al. Aerobic high-intensity intervals improve v˙o2max more than moderate training. Med Sci Sports Exerc [Internet]. 2022 Dec 30 2007;39:665–671. Available from. 4. https://pubmed.ncbi.nlm.nih.gov/17414804/
   PubMed Web of Science ®Google Scholar
• ForbesSC, KrentzJR, CandowDG. Timing of creatine supplementation does not influence gains in unilateral muscle hypertrophy or strength from resistance training in young adults: a within-subject design. J Sports Med Phys Fitness [Internet] 2022 Mar 8] 2021;61:1219–1225. Available from https://pubmed.ncbi.nlm.nih.gov/34610729/
   PubMed Web of Science ®Google Scholar
• CandowDG, ForbesSC, RobertsMD, et al. Creatine O’Clock: does timing of ingestion really influence muscle mass and performance? front sport act living [Internet]. Front Sports Act Living. 2022;4 2022 Dec 30. Available from: https://pubmed.ncbi.nlm.nih.gov/35669557/
   PubMedGoogle Scholar
• ForbesSC, SlettenN, DurrerC, et al. Creatine monohydrate supplementation does not augment fitness, performance, or body composition adaptations in response to four weeks of high-intensity interval training in young females. Int J Sport Nutr Exerc MetabHuman Kinet, Inc [Internet]. . 2017 2021 Oct 5;27:285–292. Available from. 3. https://journals.humankinetics.com/view/journals/ijsnem/27/3/article-p285.xml
   PubMed Web of Science ®Google Scholar
• Smith-RyanAE, CabreHE, EckersonJM, et al. CreatinE supplementation in women’s health: a lifespan perspective. Nutrients [Internet]. 2021 2022 Mar 8;13:1–17. Available from. https://pubmed.ncbi.nlm.nih.gov/33800439/
   Web of Science ®Google Scholar
• ForsbergAM, NilssonE, WernemanJ, et al. Muscle composition in relation to age and sex. Clin Sci (Lond) [Internet]. 1991 2022 Dec 17;81:249–256. Available from. https://pubmed.ncbi.nlm.nih.gov/1716189/
   Google Scholar
• JagimAR, KerksickCM. Creatine supplementation in children and adolescents. Nutrients [Internet]. Multidisciplinary Digital Publishing Institute (MDPI). Oct 26] 2021;13:664. Available from pmc/articles/PMC7922146/
   PubMed Web of Science ®Google Scholar