Improved Depressive Symptoms in Adults with Schizophrenia During a Smoking Cessation Attempt with Varenicline and Behavioral Therapy

References

• Addington, D., Addington, J., & Maticka-Tyndale, E. (1993). Assessing depression in schizophrenia: The Calgary Depression Scale. The British Journal of Psychiatry, Supplement, (22), 39–44.
   Google Scholar
• Andreasen, N. C. (1989). Scale for the Assessment of Negative 605 Symptoms (SANS). The British Journal of Psychiatry, 155(7), 53–58.
   Google Scholar
• Anthenelli, R. M., Benowitz, N. L., West, R., St. Aubin, L., McRae, T., Lawrence, D., … Evins, A. E. (2016). Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): A double-blind, randomised, placebo-controlled clinical trial. The Lancet, 387(10037), 2507–2520. doi:10.1016/S0140-6736(16)30272-0
   PubMed Web of Science ®Google Scholar
• Anthenelli, R. M., Morris, C., Ramey, T. S., Dubrava, S. J., Tsilkos, K., Russ, C., & Yunis, C. (2013). Effects of varenicline on smoking cessation in adults with stably treated current or past major depression: A randomized trial. Annals of Internal Medicine, 159(6), 390–400. doi:10.7326/0003-4819-159-6-201309170-00005
   PubMed Web of Science ®Google Scholar
• Avery, N., Kenny, A. M., Kleppinger, A., Brindisi, J., Litt, M. D., & Oncken, C. A. (2014). Effects of varenicline, nicotine or placebo on depressive symptoms in postmenopausal smokers. The American Journal on Addictions, 23(5), 459–465. doi:10.1111/j.1521-0391.2014.12130.x
   PubMed Web of Science ®Google Scholar
• Berlin, I., Chen, H., & Covey, L. S. (2010). Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day. Addiction, 105(12), 2209–2216. doi:10.1111/j.1360-0443.2010.03109.x
   PubMed Web of Science ®Google Scholar
• Buchanan, R. W., Kreyenbuhl, J., Kelly, D. L., Noel, J. M., Boggs, D. L., Fischer, B. A., … Keller, W. (2010). The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements. Schizophrenia Bulletin, 36(1), 71–93. doi:10.1093/schbul/sbp116
   PubMed Web of Science ®Google Scholar
• Callaghan, R. C., Veldhuizen, S., Jeysingh, T., Orlan, C., Graham, C., Kakouris, G., … Gatley, J. (2014). Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression. Journal of Psychiatric Research, 48(1), 102–110. doi:10.1001/jama.2013.284985
   PubMed Web of Science ®Google Scholar
• Capron, D. W., Allan, N. P., Norr, A. M., Zvolensky, M. J., & Schmidt, N. B. (2014). The effect of successful and unsuccessful smoking cessation on short-term anxiety, depression, and suicidality. Addictive Behaviors, 39(4), 782–788. doi:10.1016/j.addbeh.2013.12.014
   PubMed Web of Science ®Google Scholar
• Cather, C., Barr, R., & Evins, A. (2008). Smoking and schizophrenia: Prevalence, mechanisms and implications for treatment. Clinical Schizophrenia & Related Psychoses, 2(1), 70–78. doi:10.3371/CSRP.2.1.5
   Google Scholar
• Chengappa, K. N. R., Perkins, K. A., Brar, J. S., Schlicht, P. J., Turkin, S. R., Hetrick, M. L., … George, T. P. (2014). Varenicline for smoking cessation in bipolar disorder: A randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry, 75(07), 765–772. doi:10.4088/JCP.13m08756
   PubMed Web of Science ®Google Scholar
• Cinciripini, P. M., Blalock, J. A., Minnix, J. A., Robinson, J. D., Brown, V. L., Lam, C., … Dolan-Mullen, P. (2010). Effects of an intensive depression-focused intervention for smoking cessation in pregnancy. Journal of Consulting and Clinical Psychiatry, 78(1), 44–54. doi:10.1037/a0018168
   PubMed Web of Science ®Google Scholar
• Cinciripini, P. M., Robinson, J. D., Karam-Hage, M., Minnix, J. A., Lam, C., Versace, F., … Wetter, D. W. (2013). Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. Journal of the American Medical Association–Psychiatry, 70(5), 522–533. doi:10.1001/jamapsychiatry.2013.678
   Web of Science ®Google Scholar
• Cook, B., Wayne, G., Kafali, E., Liu, Z., Shu, C., & Flores, M. (2014). Trends in smoking among adults with mental illness and association between mental health treatment and smoking cessation. Journal of the American Medical Association, 311(2), 172–182. doi:10.1001/jama.2013.28498
   PubMed Web of Science ®Google Scholar
• Druss, B. G., Bradford, W. D., Rosenheck, R. A., Radford, M. J., & Krumholz, H. M. (2001). Quality of medical care and excess mortality in older patients with mental disorders. Archives of General Psychiatry, 58(6), 565–572. doi:10.1136/bmjopen-2011-000778
   PubMed Web of Science ®Google Scholar
• Dutra, S., Stoeckel, L., Carlini, S., Pizzagalli, D., & Evins, A. E. (2012). Varenicline as a smoking cessation aid in schizophrenia: Effects on smoking behavior and reward sensitivity. Psychopharmacology, 219(1), 25–34. doi:10.1007/s00213-011-2373-6
   PubMed Web of Science ®Google Scholar
• Everett, A., Mahler, J., Biblin, J., Ganguli, R., & Mauer, B. (2008). Improving the health of mental health consumers: Effective policies and practices. International Journal of Mental Health, 37(2), 8–48. doi:10.2753/IMH0020-7411370201
   Web of Science ®Google Scholar
• Evins, A. E., Cather, C., Culhane, M. A., Birnbaum, A., Horowitz, J., Hsieh, E., … Goff, D. C. (2007). A 12-week double-blind, placebo-controlled study of bupropion SR added to high-dose dual nicotine replacement therapy for smoking cessation or reduction in schizophrenia. Journal of Clincial Psychopharmacology, 27(4), 380–386. doi:10.1097/01.jcp.0b013e3180ca86fa
   PubMed Web of Science ®Google Scholar
• Evins, A. E., Cather, C., Deckersbach, T., Freudenreich, O., Culhane, M. A., Olm-Shipman, C. M., … Rigotti, N. A. (2005). A double-blind placebo-controlled trial of bupropion sustained-release for smoking cessation in schizophrenia. Journal of Clincial Psychopharmacology, 25(3), 218–225.
   PubMed Web of Science ®Google Scholar
• Evins, A. E., Cather, C., Pratt, S. A., Pachas, G. N., Hoeppner, S. S., Goff, D. C., … Schoenfeld, D. A. (2014). Maintenance treatment with varenicline for smoking cessation in patients with schizophrenia and bipolar disorder: A randomized clinical trial. Journal of the American Medical Association, 311(2), 145–154. doi:10.1001/jama.2013.285113
   PubMed Web of Science ®Google Scholar
• Evins, A. E., Culhane, M. A., Alpert, J. E., Pava, J., Liese, B. S., Farabaugh, A., & Fava, M. (2008). A controlled trial of bupropion added to nicotine patch and behavioral therapy for smoking cessation in adults with unipolar depressive disorders. Journal of Clinical Psychopharmacology, 28(6), 660–666. doi:10.1097/JCP.0b013e31818ad7d6
   PubMed Web of Science ®Google Scholar
• Evins, A. E., Cather, C., & Laffer, A. (2015). Treatment of tobacco use disorders in smokers with serious mental illness: Toward clinical best practices. Harvard Review of Psychiatry, 23(2), 90–98. doi:10.1097/HRP.0000000000000063
   PubMed Web of Science ®Google Scholar
• Evins, A. E., Maravic, M. C., Russ, C., McRae, T., Dubrava, S., Benowitz, N., … Anthenelli, R. (2017a). Efficacy and neuropsychiatric safety of varenicline, bupropion, and nicotine patch for smoking cessation in smokers with psychiatric disorders. American Psychiatric Association Annual Meeting, San Diego, CA, USA.
   Google Scholar
• Evins, A. E., Maravic, M. C., Russ, C., McRae, T., Dubrava, S., Benowitz, N., … Anthenelli, R. (2017b). Change in anxiety and depression symptoms as measured by the hospital anxiety and depression scale in a study of varenicline, bupropion and nicotine patch in non-psychiatric and psychiatric cohorts (EAGLES study). Society for Research on Nicotine and Tobacco. 23rd Annual Meeting, Florence, Italy.
   Google Scholar
• Freudenreich, O., Tranulis, C., Cather, C., Henderson, D., Evins, A., & Goff, D. (2008). Depressive symptoms in schizophrenia outpatients—prevalence and clinical correlates. Clinical Schizophrenia & Related Psychoses, 2(2), 127–135. doi:10.3371/CSRP.2.2.2
   Google Scholar
• George, T. P., Sacco, K. A., Vessicchio, J. C., Weinberger, A. H., & Shytle, R. D. (2008). Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: A preliminary study. Journal of Clinical Psychopharmacology, 28(3), 340–344. doi:10.1097/JCP.0b013e318172b49e
   PubMed Web of Science ®Google Scholar
• Goff, D. C., Cather, C., Evins, A. E., Henderson, D. C., Freudenreich, O., Copeland, P. M., … Sacks, F. M. (2005). Medical morbidity and mortality in schizophrenia: Guidelines for psychiatrists. Journal of Clinical Psychiatry, 66(2), 183–194.
   PubMed Web of Science ®Google Scholar
• Hall, S. M. (2007). Nicotine interventions with comorbid populations. American Journal of Preventive Medicine, 33(6), S406–S413. doi:10.1016/j.amepre.2007.09.004
   PubMed Web of Science ®Google Scholar
• Hall, S. M., Tsoh, J. Y., Prochaska, J. J., Eisendrath, S., Rossi, J. S., Redding, C. A., … Gorecki, J. A. (2006). Treatment for cigarette smoking among depressed mental health outpatients: A randomized clinical trial. American Journal of Public Health, 96(10), 1808–1814. doi:10.2105/AJPH.2005.080382
   PubMed Web of Science ®Google Scholar
• Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009). Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics, 42(2), 377–381. doi:10.1016/j.jbi.2008.08.010
   PubMed Web of Science ®Google Scholar
• Heatherton, T. F., Kozlowski, L. T., Frecker, R. C., & Fagerstrom, K. O. (1991). The Fagerström Test for Nicotine Dependence: A revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction, 86(9), 1119–1127.
   PubMedGoogle Scholar
• Heffner, J. L., Strawn, J. R., DelBello, M. P., Strakowski, S. M., & Anthenelli, R. M. (2011). The co-occurrence of cigarette smoking and bipolar disorder: Phenomenology and treatment considerations. Bipolar Disorders, 13(5–6), 439–453. doi:10.1111/j.1399-5618.2011.00943.x
   PubMed Web of Science ®Google Scholar
• Himelhoch, S., & Daumit, G. (2003). To whom do psychiatrists offer smoking-cessation counseling? American Journal of Psychiatry, 160(12), 2228–2230. doi:10.1176/appi.ajp.160.12.2228
   PubMed Web of Science ®Google Scholar
• Hong, L. E., Thaker, G. K., McMahon, R. P., Summerfelt, A., Rachbeisel, J., Fuller, R. L., … Nye, A. (2011). Effects of moderate-dose treatment with varenicline on neurobiological and cognitive biomarkers in smokers and nonsmokers with schizophrenia or schizoaffective disorder. Archives of General Psychiatry, 68(12), 1195–1206. doi:10.1001/archgenpsychiatry.2011.83
   PubMed Web of Science ®Google Scholar
• Huang, Y., Lewis, S., & Britton, J. (2014). Use of varenicline for smoking cessation treatment in UK primary care: An association rule mining analysis. BMC Public Health, 14(1), 1024. doi:10.1186/1471-2458-14-1024
   PubMed Web of Science ®Google Scholar
• Kroon, L. A. (2007). Drug interactions with smoking. American Journal of Health-System Pharmacy, 64(18), 1917–1921. doi:10.2146/ajhp060414
   PubMed Web of Science ®Google Scholar
• Leucht, S., Samara, M., Heres, S., Patel, M. X., Woods, S. W., & Davis, J. M. (2014). Dose equivalents for second-generation antipsychotics: The minimum effective dose method. Schizophrenia Bulletin, 40(2), 314–326. doi:10.1093/schbul/sbu001
   PubMed Web of Science ®Google Scholar
• Lutterman, T., Ganju, V., Schacht, L., Shaw, R., Monihan, K., & Huddle, M. (2003). Sixteen state study on mental health performance measures. Rockville, MD: Center for Mental Health Services, Substance Abuse and Mental Health Services Administration.
   Google Scholar
• McClure, J. B., Swan, G. E., Jack, L., Catz, S. L., Zbikowski, S. M., McAfee, T. A., … Javitz, H. (2009). Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline. Journal of General Internal Medicine, 24(5), 563–569. doi:10.1007/s11606-009-0926-8
   PubMed Web of Science ®Google Scholar
• Olfson, M., Gerhard, T., Huang, C., Crystal, S., & Stroup, T. S. (2015). Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry, 72(12), 1172–1181. doi:10.1001/jamapsychiatry.2015.1737
   PubMed Web of Science ®Google Scholar
• Overall, J. E., & Gorham, D. R. (1962). The brief psychiatric rating scale. Psychological Reports, 10(3), 799–812.
   Web of Science ®Google Scholar
• Pachas, G. N., Cather, C., Pratt, S. A., Hoeppner, B., Nino, J., Carlini, S. V., … Evins, A. E. (2012). Varenicline for smoking cessation in schizophrenia: Safety and effectiveness in a 12-week, open-label trial. Journal of Dual Diagnosis, 8(2), 117–125. doi:10.1080/15504263.2012.663675
   PubMed Web of Science ®Google Scholar
• Philip, N. S., Carpenter, L. L., Tyrka, A. R., Whiteley, L. B., & Price, L. H. (2009). Varenicline augmentation in depressed smokers: An 8-week, open-label study. The Journal of Clinical Psychiatry, 70(7), 1026–1031.
   PubMed Web of Science ®Google Scholar
• Pfizer Inc. (n.d.). Chantix™ (varenicline) tablets: Prescribing information. Retrieved from http://www.chantix.com
   Google Scholar
• Prescriber's Digital Reference. (2017). Varenicline–drug summary. Retrieved from http://www.pdr.net/drug-summary/chantix?druglabelid=466
   Google Scholar
• Prochaska, J. J. (2011). Smoking and mental illness–breaking the link. New England Journal of Medicine, 365(3), 196–198. doi:10.1056/NEJMp1105248
   PubMed Web of Science ®Google Scholar
• Prochaska, J. J., Hall, S. M., Tsoh, J. Y., Eisendrath, S., Rossi, J. S., Redding, C. A., … Gorecki, J. A. (2008). Treating tobacco dependence in clinically depressed smokers: Effect of smoking cessation on mental health functioning. American Journal of Public Health, 98(3), 446–448. doi:10.2105/AJPH.2006.101147
   PubMed Web of Science ®Google Scholar
• Schroeder, S. A., & Morris, C. D. (2010). Confronting a neglected epidemic: Tobacco cessation for persons with mental illnesses and substance abuse problems. Annual Review of Public Health, 31(1), 297–314. doi:10.1146/annurev.publhealth.012809.103701
   PubMed Web of Science ®Google Scholar
• Shim, J. C., Jung, D. U., Jung, S. S., Seo, Y. S., Cho, D. M., Lee, J. H., … Kelly, D. L. (2012). Adjunctive varenicline treatment with antipsychotic medications for cognitive impairments in people with schizophrenia: A randomized double-blind placebo-controlled trial. Neuropsychopharmacology, 37(3), 660–668. doi:10.1038/npp.2011.238
   PubMed Web of Science ®Google Scholar
• Siru, R., Hulse, G. K., & Tait, R. J. (2009). Assessing motivation to quit smoking in people with mental illness: A review. Addiction, 104(5), 719–733. doi:10.1111/j.1360-0443.2009.02545.x
   PubMed Web of Science ®Google Scholar
• Smith, R. C., Amiaz, R., Si, T. M., Maayan, L., Jin, H., Boules, S., … Youseff, M. (2016). Varenicline effects on smoking, cognition, and psychiatric symptoms in schizophrenia: A double-blind randomized trial. PloS one, 11(1), e0143490. doi:10.1371/journal.pone.0143490
   PubMed Web of Science ®Google Scholar
• Taylor, G., McNeill, A., Girling, A., Farley, A., Lindson-Hawley, N., & Aveyard, P. (2014). Change in mental health after smoking cessation: Systematic review and meta-analysis. British Medical Journal, 348. doi:10.1136/bmj.g1151
   Web of Science ®Google Scholar
• Thorndike, A. N., Achtyes, E. D., Cather, C., Pratt, S., Pachas, G. N., Hoeppner, S. S., & Evins, A. E. (2016). Weight gain and 10-year cardiovascular risk with sustained tobacco abstinence in smokers with serious mental illness: A subgroup analysis of a randomized trial. The Journal of Clinical Psychiatry, 77(3), 320–326. doi:10.4088/JCP.15m10074
   Web of Science ®Google Scholar
• Torres, L., Barrera, A., Delucchi, K., Penilla, C., Perez-Stable, E., & Muñoz, R. (2010). Quitting smoking does not increase the risk of major depressive episodes among users of Internet smoking cessation interventions. Psychological Medicine, 40(3), 441–449. doi:10.1017/S0033291709990560
   PubMed Web of Science ®Google Scholar
• Tsoi, D. T., Porwal, M., & Webster, A. C. (2013). Interventions for smoking cessation and reduction in individuals with schizophrenia. The Cochrane Database of Systematic Reviews, 2(2), CD007253. doi:10.1002/14651858.CD007253.pub3
   Web of Science ®Google Scholar
• Weinberger, A. H., Pilver, C. E., Desai, R. A., Mazure, C. M., & McKee, S. A. (2013). The relationship of dysthymia, minor depression, and gender to changes in smoking for current and former smokers: Longitudinal evaluation in the US population. Drug and Alcohol Dependence, 127(1), 170–176. doi:10.1016/j.drugalcdep.2012.06.028
   PubMed Web of Science ®Google Scholar
• Weiner, E., Buchholz, A., Coffay, A., Liu, F., McMahon, R. P., Buchanan, R. W., & Kelly, D. L. (2011). Varenicline for smoking cessation in people with schizophrenia: A double blind randomized pilot study. Schizophrenia Research, 129(1), 94–95. doi:10.1016/j.schres.2011.02.003
   PubMed Web of Science ®Google Scholar
• Welsch, S. K., Smith, S. S., Wetter, D. W., Jorenby, D. E., Fiore, M. C., & Baker, T. B. (1999). Development and validation of the Wisconsin Smoking Withdrawal Scale. Experimental and Clinical Psychopharmacology, 7(4), 354–361.
   PubMed Web of Science ®Google Scholar
• Williams, J. M., Anthenelli, R. M., Morris, C. D., Treadow, J., Thompson, J. R., Yunis, C., & George, T. P. (2012). A randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of varenicline for smoking cessation in patients with schizophrenia or schizoaffective disorder. Journal of Clinical Psychiatry, 73(5), 654–660. doi:10.4088/JCP.11m07522
   PubMed Web of Science ®Google Scholar
• Zevin, S., & Benowitz, N. L. (1999). Drug interactions with tobacco smoking. Clinical Pharmacokinetics, 36(6), 425–438.
   PubMed Web of Science ®Google Scholar
• Ziedonis, D., Hitsman, B., Beckham, J. C., Zvolensky, M., Adler, L. E., Audrain-McGovern, J., … Riley, W. T. (2008). Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health Report. Nicotine and Tobacco Research, 10(12), 1691–1715. doi:10.1080/14622200802443569
   PubMed Web of Science ®Google Scholar