Quantification of the Androgen and Estrogen Receptors in the Penile Tissues of Hypospadias in Comparison with Normal Children

References

• Snodgrass WT. Hypospadias. In Pediatric urology. Springer; 2011. p. 177–90.
   Google Scholar
• Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi A-M, Toppari J, Skakkebaek NE, Main KM. Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. J Clin Endocrinol Metab. 2005;90(7):4041–6. doi:10.1210/jc.2005-0302.
   PubMed Web of Science ®Google Scholar
• Duckett JW, Keating MA. Technical challenge of the megameatus intact prepuce hypospadias variant: the pyramid procedure. J Urol. 1989;141(6):1407–9. doi:10.1016/s0022-5347(17)41325-5.
   PubMed Web of Science ®Google Scholar
• Sorensen HR. Hypospadias with special reference to aetiology. Copenhagen: Munksgaard; 1953.
   Google Scholar
• Fisher J. Study of the incidence of hypospadias in Rochester, Minnesota 1940–1970, and a case control comparison of possible etiologic factors. Plast Reconstr Surg. 1974;54:238.
   Google Scholar
• Baskin L. Hypospadias and urethral development. J Urol. 2000;163(3):951–6. doi:10.1016/S0022-5347(05)67861-5.
   PubMed Web of Science ®Google Scholar
• Wein A, Campbell M, Walsh P. Campbell-Walsh urology. Philadelphia, PA: Elsevier Saunders; 2012.
   Google Scholar
• Wang MH, Baskin LS. Endocrine disruptors, genital development, and hypospadias. J Androl. 2008;29(5):499–505. doi:10.2164/jandrol.108.004945.
   PubMedGoogle Scholar
• Qiao L, Rodriguez E, Weiss DA, Ferretti M, Risbridger G, Cunha GR, Baskin LS. Expression of estrogen receptor alpha and beta is decreased in hypospadias. J Urol. 2012;187(4):1427–33. doi:10.1016/j.juro.2011.12.008.
   PubMed Web of Science ®Google Scholar
• McPhaul MJ. Androgen receptor mutations and androgen insensitivity. Mol Cell Endocrinol. 2002;198(1-2):61–7. doi:10.1016/S0303-7207(02)00369-6.
   PubMed Web of Science ®Google Scholar
• Allera A, Herbst M, Griffin J, Wilson J, Schweikert H, McPhaul M. Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias. J Clin Endocrinol Metab. 1995;80(9):2697–9. doi:10.1210/jcem.80.9.7673412.
   PubMed Web of Science ®Google Scholar
• Aaronson IA, Cakmak MA, Key LL. Defects of the testosterone biosynthetic pathway in boys with hypospadias. J Urol. 1997;157(5):1884–8.
   PubMed Web of Science ®Google Scholar
• Silver RI, Rodriguez R, Chang TS, Gearhart JP. In vitro fertilization is associated with an increased risk of hypospadias. J Urol. 1999;161(6):1954–7.
   PubMed Web of Science ®Google Scholar
• Nonomura K, Fujieda K, Sakakibara N, Terasawa K, Matsuno T, Matsuura N, Koyanagi T. Pituitary and gonadal function in prepubertal boys with hypospadias. J Urol. 1984;132(3):595–8. doi:10.1016/s0022-5347(17)49755-2.
   PubMed Web of Science ®Google Scholar
• Gearhart JP, Donohoue PA, Brown TR, Walsh PC, Berkovitz GD. Endocrine evaluation of adults with mild hypospadias. J Urol. 1990;144(2 Pt 1):274–7. doi:10.1016/s0022-5347(17)39430-2.
   PubMed Web of Science ®Google Scholar
• MacDonald M, Barthold J, Kass E. 2007. Abnormalities of the penis and scrotum. In Docimo S, Canning D, Khoury A, editors. The Kelalis-King-Belman textbook of clinical pediatric urology. 5th ed. London: CRC Press, p. 1201–32.
   Google Scholar
• Horton C, Devine C, Baran N. Pictorial history of hypospadias repair techniques. Plast Reconstr Surg Genital Area. 1973;1:237–48.
   Google Scholar
• Meireles B, Maria A. Hypospadias: Analysis of a complex genetic disorder [PhD dissertation]. Stockholm, Sweden: Karolinska Institute; 2007.
   Google Scholar
• Cunha GR, Risbridger G, Wang H, Place NJ, Grumbach M, Cunha TJ, Weldele M, Conley AJ, Barcellos D, Agarwal S, et al. Development of the external genitalia: Perspectives from the spotted hyena (Crocuta crocuta). Differentiation. 2014;87(1-2):4–22. doi:10.1016/j.diff.2013.12.003.
   PubMed Web of Science ®Google Scholar
• Vottero A, Minari R, Viani I, Tassi F, Bonatti F, Neri TM, Bertolini L, Bernasconi S, Ghizzoni L. Evidence for epigenetic abnormalities of the androgen receptor gene in Foreskin from children with Hypospadias. J Clin Endocrinol Metab. 2011;96(12):E1953–E1962. doi:10.1210/jc.2011-0511.
   PubMed Web of Science ®Google Scholar
• Celayir A, Moralioglu S, Cetiner H, Kir G, Celayir S. Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias. North Clin Istanb. 2019;6(2):110–6.
   PubMed Web of Science ®Google Scholar
• Källén B. Case‐control study of hypospadias, based on registry informations. Teratology. 1988;38(1):45–50. doi:10.1002/tera.1420380107.
   PubMedGoogle Scholar
• Pierik FH, Burdorf A, Nijman JR, de Muinck Keizer-Schrama SM, Juttmann R, Weber RF. A high hypospadias rate in The Netherlands. Human Reprod. 2002;17(4):1112–5. doi:10.1093/humrep/17.4.1112.
   PubMed Web of Science ®Google Scholar
• Kraft KH, Shukla AR, Canning DA. Proximal hypospadias. Sci World J. 2011;11:894–906. doi:10.1100/tsw.2011.76.
   Google Scholar
• Bhat A. General considerations in hypospadias surgery. Indian J Urol. 2008;24(2):188–94. doi:10.4103/0970-1591.40614.
   PubMedGoogle Scholar
• Qiao L, Tasian GE, Zhang H, Cao M, Ferretti M, Cunha GR, Baskin LS. Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cells. Pediatr Res. 2012;71(1-4):393–8. doi:10.1038/pr.2011.49.
   PubMed Web of Science ®Google Scholar
• Bentvelsen F, Brinkmann A, Van der Linden J, Schröder F, Nijman J. Decreased immunoreactive androgen receptor levels are not the cause of isolated hypospadias. Br J Urol. 1995;76(3):384–8. doi:10.1111/j.1464-410x.1995.tb07719.x.
   PubMedGoogle Scholar
• An Y, Liu X, Tang Y, Liu J, Li J, Luo Y, et al. Expression of androgen receptor in genital tissue of patients with congenital hypospadias and simple chordee. Chin J Reparat Reconstr Surg. 2012;26(4):461–5.
   Google Scholar
• Pichler R, Djedovic G, Klocker H, Heidegger I, Strasak A, Loidl W, Bektic J, Skradski V, Horninger W, Oswald J, et al. Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias. BJU Int. 2013;112(2):265–70. doi:10.1111/j.1464-410X.2012.11731.x.
   PubMedGoogle Scholar
• Kim KS, Liu W, Cunha GR, Russell DW, Huang H, Shapiro E, Baskin LS. Expression of the androgen receptor and 5α-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res. 2002;307(2):145–53. doi:10.1007/s004410100464.
   PubMed Web of Science ®Google Scholar