A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells

References

• Ronnau CG, Verhaegh GW, Luna-Velez MV, Schalken JA. Noncoding RNAs as novel biomarkers in prostate cancer. Biomed Res Internatl 2014; 2014:591703; http://dx.doi.org/10.1155/2014/591703
   PubMed Web of Science ®Google Scholar
• Perkel JM. Visiting “noncodarnia.” Biotechniques 2013; 54:301, 3-4
   PubMed Web of Science ®Google Scholar
• Clark MB, Amaral PP, Schlesinger FJ, Dinger ME, Taft RJ, Rinn JL, Ponting CP, Stadler PF, Morris KV, Morillon A, et al. The reality of pervasive transcription. PLoS Biol 2011; 9:e1000625; discussion e1102; http://dx.doi.org/10.1371/journal.pbio.1000625
   PubMed Web of Science ®Google Scholar
• van Bakel H, Nislow C, Blencowe BJ, Hughes TR. Most “dark matter” transcripts are associated with known genes. PLoS Biol 2010; 8:e1000371; PMID:20502517; http://dx.doi.org/10.1371/journal.pbio.1000371
   PubMed Web of Science ®Google Scholar
• Heard E, Disteche CM. Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 2006; 20:1848-67; PMID:16847345; http://dx.doi.org/10.1101/gad.1422906
   PubMed Web of Science ®Google Scholar
• Payer B, Lee JT. X chromosome dosage compensation: how mammals keep the balance. Ann Rev Genet 2008; 42:733-72; PMID:18729722; http://dx.doi.org/10.1146/annurev.genet.42.110807.091711
   PubMed Web of Science ®Google Scholar
• Hung T, Chang HY. Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 2010; 7:582-5; PMID:20930520; http://dx.doi.org/10.4161/rna.7.5.13216
   PubMed Web of Science ®Google Scholar
• Rapicavoli NA, Poth EM, Blackshaw S. The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev Biol 2010; 10:49; PMID:20459797; http://dx.doi.org/10.1186/1471-213X-10-49
   PubMed Web of Science ®Google Scholar
• Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 2010; 39:925-38; PMID:20797886; http://dx.doi.org/10.1016/j.molcel.2010.08.011
   PubMed Web of Science ®Google Scholar
• Moreno-Moya JM, Vilella F, Simon C. MicroRNA: key gene expression regulators. Fertility Sterility 2014; 101:1516-23; PMID:24314918; http://dx.doi.org/10.1016/j.fertnstert.2013.10.042
   PubMed Web of Science ®Google Scholar
• Yoon JH, Abdelmohsen K, Gorospe M. Functional interactions among microRNAs and long noncoding RNAs. Seminars Cell Dev Biol 2014; 34:9-14; http://dx.doi.org/10.1016/j.semcdb.2014.05.015
   PubMed Web of Science ®Google Scholar
• Yoon JH, Abdelmohsen K, Srikantan S, Yang X, Martindale JL, De S, Huarte M, Zhan M, Becker KG, Gorospe M. LincRNA-p21 suppresses target mRNA translation. Mol Cell 2012; 47:648-55; PMID:22841487; http://dx.doi.org/10.1016/j.molcel.2012.06.027
   PubMed Web of Science ®Google Scholar
• Yoon JH, Abdelmohsen K, Kim J, Yang X, Martindale JL, Tominaga-Yamanaka K, White EJ, Orjalo AV, Rinn JL, Kreft SG, et al. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nature Commun 2013; 4:2939; http://dx.doi.org/10.1038/ncomms3939
   PubMed Web of Science ®Google Scholar
• Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G, 3rd, Wahlestedt C. Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol 2010; 11:R56; PMID:20507594; http://dx.doi.org/10.1186/gb-2010-11-5-r56
   PubMed Web of Science ®Google Scholar
• Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 2011; 147:358-69; PMID:22000014; http://dx.doi.org/10.1016/j.cell.2011.09.028
   PubMed Web of Science ®Google Scholar
• Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W. The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol 2012; 14:659-65; PMID:22684254; http://dx.doi.org/10.1038/ncb2521
   PubMed Web of Science ®Google Scholar
• Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 2011; 146:353-8; PMID:21802130; http://dx.doi.org/10.1016/j.cell.2011.07.014
   PubMed Web of Science ®Google Scholar
• Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 2010; 465:1033-8; PMID:20577206; http://dx.doi.org/10.1038/nature09144
   PubMed Web of Science ®Google Scholar
• Ge D, Han L, Huang S, Peng N, Wang P, Jiang Z, Zhao J, Su L, Zhang S, Zhang Y, et al. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy 2014; 10:957-71; PMID:24879147; http://dx.doi.org/10.4161/auto.28363
   PubMed Web of Science ®Google Scholar
• Peng N, Meng N, Wang S, Zhao F, Zhao J, Su L, Zhang S, Zhang Y, Zhao B, Miao J. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E(-)/(-) mice. Scientific Rep 2014; 4:5519
   PubMed Web of Science ®Google Scholar
• Jones SA, Mills KH, Harris J. Autophagy and inflammatory diseases. Immunol Cell Biol 2013; 91:250-8; PMID:23318657; http://dx.doi.org/10.1038/icb.2012.82
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323-35; PMID:21248839; http://dx.doi.org/10.1038/nature09782
   PubMed Web of Science ®Google Scholar
• Manley S, Williams JA, Ding WX. Role of p62/SQSTM1 in liver physiology and pathogenesis. Exp Biol Med 2013; 238:525-38; http://dx.doi.org/10.1177/1535370213489446
   PubMed Web of Science ®Google Scholar
• Choe JY, Jung HY, Park KY, Kim SK. Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1b expression. Rheumatology 2014; 53:1043-53; PMID:24587486; http://dx.doi.org/10.1093/rheumatology/ket474
   PubMed Web of Science ®Google Scholar
• Meng N, Zhao J, Su L, Zhao B, Zhang Y, Zhang S, Miao J. A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells. Int J Biochem Cell Biol 2012; 44:311-9; PMID:22085531; http://dx.doi.org/10.1016/j.biocel.2011.11.001
   PubMed Web of Science ®Google Scholar
• Jiang W, Ogretmen B. Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Autophagy 2013; 9:258-9; PMID:23182807; http://dx.doi.org/10.4161/auto.22739
   PubMed Web of Science ®Google Scholar
• Pessentheiner AR, Pelzmann HJ, Walenta E, Schweiger M, Groschner LN, Graier WF, Kolb D, Uno K, Miyazaki T, Nitta A, et al. NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes. J Biol Chem 2013; 288:36040-51; PMID:24155240; http://dx.doi.org/10.1074/jbc.M113.491324
   PubMed Web of Science ®Google Scholar
• Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37:495-500; PMID:15806104; http://dx.doi.org/10.1038/ng1536
   PubMed Web of Science ®Google Scholar
• Blagden SP, Gatt MK, Archambault V, Lada K, Ichihara K, Lilley KS, Inoue YH, Glover DM. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev Biol 2009; 334:186-97; PMID:19631203; http://dx.doi.org/10.1016/j.ydbio.2009.07.016
   PubMed Web of Science ®Google Scholar
• Burrows C, Abd Latip N, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, et al. The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res 2010; 38:5542-53; PMID:20430826; http://dx.doi.org/10.1093/nar/gkq294
   PubMed Web of Science ®Google Scholar
• Pursiheimo JP, Rantanen K, Heikkinen PT, Johansen T, Jaakkola PM. Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62. Oncogene 2009; 28:334-44; PMID:18931699; http://dx.doi.org/10.1038/onc.2008.392
   PubMed Web of Science ®Google Scholar
• Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010; 142:409-19; PMID:20673990; http://dx.doi.org/10.1016/j.cell.2010.06.040
   PubMed Web of Science ®Google Scholar
• Hu W, Alvarez-Dominguez JR, Lodish HF. Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep 2012; 13:971-83; PMID:23070366; http://dx.doi.org/10.1038/embor.2012.145
   PubMed Web of Science ®Google Scholar
• Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464:1071-6; PMID:20393566; http://dx.doi.org/10.1038/nature08975
   PubMed Web of Science ®Google Scholar
• Lee JT, Bartolomei MS. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell 2013; 152:1308-23; PMID:23498939; http://dx.doi.org/10.1016/j.cell.2013.02.016
   PubMed Web of Science ®Google Scholar
• Yan B, Liu J, Yao J, Li X, Wang X, Li Y, Tao Z, Song Y, Chen Q, Jiang Q. LncRNA-MIAT Regulates Microvascular Dysfunction by Functioning as a Competing Endogenous RNA. Circ Res 2015; 116(7):1143-56; PMID:25587098; http://dx.doi.org/10.1161/CIRCRESAHA.116.305510
   PubMed Web of Science ®Google Scholar
• Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science 2013; 341:789-92; PMID:23907535; http://dx.doi.org/10.1126/science.1240925
   PubMed Web of Science ®Google Scholar
• Chen SS, Hu W, Wang Z, Lou XE, Zhou HJ. p8 attenuates the apoptosis induced by dihydroartemisinin in cancer cells through promoting autophagy. Cancer Biol Ther 2015; 16(5):1-10
   PubMed Web of Science ®Google Scholar
• Weis S, Schlaich TC, Dehghani F, Carvalho T, Sommerer I, Fricke S, Kahlenberg F, Mossner J, Hoffmeister A. p8 Deficiency causes siderosis in spleens and lymphocyte apoptosis in acute pancreatitis. Pancreas 2014; 43:1277-85; PMID:25098696; http://dx.doi.org/10.1097/MPA.0000000000000172
   PubMed Web of Science ®Google Scholar
• Weis S, Bielow T, Sommerer I, Iovanna J, Malicet C, Mossner J, Hoffmeister A. P8 deficiency increases cellular ROS and induces HO-1. Arch Biochem Biophy 2015; 565:89-94; http://dx.doi.org/10.1016/j.abb.2014.11.007
   PubMed Web of Science ®Google Scholar
• Sanchez-Jimenez C, Ludena MD, Izquierdo JM. T-cell intracellular antigens function as tumor suppressor genes. Cell Death Dis 2015; 6:e1669; PMID:25741594; http://dx.doi.org/10.1038/cddis.2015.43
   PubMed Web of Science ®Google Scholar
• Forch P, Valcarcel J. Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1. Apoptosis 2001; 6:463-8; http://dx.doi.org/10.1023/A:1012441824719
   PubMed Web of Science ®Google Scholar
• Anderson P, Kedersha N. Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation. Cell Stress Chaperones 2002; 7:213-21; PMID:12380690; http://dx.doi.org/10.1379/1466-1268(2002)007<0213:VSTROE>2.0.CO;2
   PubMed Web of Science ®Google Scholar
• Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, et al. A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem 2011; 286:12328-39; PMID:21324897; http://dx.doi.org/10.1074/jbc.M110.176099
   PubMed Web of Science ®Google Scholar
• Pewzner-Jung Y, Ben-Dor S, Futerman AH. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. J Biol Chem 2006; 281:25001-5; PMID:16793762; http://dx.doi.org/10.1074/jbc.R600010200
   PubMed Web of Science ®Google Scholar
• Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C(1)(8)-ceramide as a novel biomarker for monitoring response. Clin Cancer Res 2011; 17:6097-105; PMID:21791630; http://dx.doi.org/10.1158/1078-0432.CCR-11-0930
   PubMed Web of Science ®Google Scholar
• Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol 2012; 8:831-8; PMID:22922758; http://dx.doi.org/10.1038/nchembio.1059
   PubMed Web of Science ®Google Scholar
• Wiame E, Tyteca D, Pierrot N, Collard F, Amyere M, Noel G, Desmedt J, Nassogne MC, Vikkula M, Octave JN, et al. Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochem J 2010; 425:127-36; http://dx.doi.org/10.1042/BJ20091024
   Web of Science ®Google Scholar
• Ariyannur PS, Moffett JR, Manickam P, Pattabiraman N, Arun P, Nitta A, Nabeshima T, Madhavarao CN, Namboodiri AM. Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. Brain Res 2010; 1335:1-13; PMID:20385109; http://dx.doi.org/10.1016/j.brainres.2010.04.008
   PubMed Web of Science ®Google Scholar
• Moscat J, Diaz-Meco MT. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep 2000; 1:399-403; PMID:11258478; http://dx.doi.org/10.1093/embo-reports/kvd098
   PubMed Web of Science ®Google Scholar
• Dryden NH, Sperone A, Martin-Almedina S, Hannah RL, Birdsey GM, Khan ST, Layhadi JA, Mason JC, Haskard DO, Gottgens B, et al. The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-kappaB p65. J biol Chem 2012; 287:12331-42; PMID:22337883; http://dx.doi.org/10.1074/jbc.M112.346791
   PubMed Web of Science ®Google Scholar
• Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, et al. Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis. Cancer Cell 2014; 26:121-35; PMID:25002027; http://dx.doi.org/10.1016/j.ccr.2014.05.004
   PubMed Web of Science ®Google Scholar
• Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52:2745-56; PMID:4355998; http://dx.doi.org/10.1172/JCI107470
   PubMed Web of Science ®Google Scholar
• Wang W, Liu X, Zhao J, Zhao B, Zhang S, Miao J. A novel butyrolactone derivative inhibited apoptosis and depressed integrin beta4 expression in vascular endothelial cells. Bioorganic Med Chem Lett 2007; 17:482-5; http://dx.doi.org/10.1016/j.bmcl.2006.10.023
   PubMed Web of Science ®Google Scholar