CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

References

• Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001 Sep 13;345(11):784–789. PubMed PMID: 11556297.
   PubMed Web of Science ®Google Scholar
• Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127–1131. PubMed PMID: 1891020.
   PubMed Web of Science ®Google Scholar
• Rieder G, Merchant JL, Haas R. Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology. 2005 May;128(5):1229–1242. PubMed PMID: 15887107.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Iwasaki E, Hibi T. Helicobacter pylori and gastric cancer. PubMed PMID: 19562461 Gastric Cancer. 2009;122:79–87.
   PubMed Web of Science ®Google Scholar
• Ohnishi N, Yuasa H, Tanaka S, et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1003–1008. PubMed PMID: 18192401; PubMed Central PMCID: PMCPMC2242726.
   PubMed Web of Science ®Google Scholar
• Hatakeyama M. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer. 2004 Sep;4(9):688–694. . PubMed PMID: 15343275.
   PubMed Web of Science ®Google Scholar
• Higashi H, Tsutsumi R, Muto S, et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 2002 Jan 25;295(5555):683–686. PubMed PMID: 11743164.
   PubMed Web of Science ®Google Scholar
• Tsugawa H, Suzuki H, Saya H, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe. 2012 Dec 13;12(6):764–777. PubMed PMID: 23245321.
   PubMed Web of Science ®Google Scholar
• Raju D, Hussey S, Ang M, et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology. 2012 May;142(5):1160–1171. PubMed PMID: 22333951; PubMed Central PMCID: PMCPMC3336037.
   PubMed Web of Science ®Google Scholar
• Terebiznik MR, Raju D, Vazquez CL, et al. Effect of Helicobacter pylori’s vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy. 2009 Apr;5(3):370–379. PubMed PMID: 19164948.
   PubMed Web of Science ®Google Scholar
• Yahiro K, Satoh M, Nakano M, et al. Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA. J Biol Chem. 2012 Sep 7;287(37):31104–31115. PubMed PMID: 22822085; PubMed Central PMCID: PMCPMC3438942.
   PubMed Web of Science ®Google Scholar
• Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med. 2006 Oct-Dec;27(5–6):495–502. . PubMed PMID: 16973206.
   PubMedGoogle Scholar
• Kilimann MW, Isenberg G. Actin filament capping protein from bovine brain. EMBO J. 1982;1(7): 889–894. PubMed PMID: 7188363; PubMed Central PMCID: PMCPMC553127.
   PubMed Web of Science ®Google Scholar
• Matsuo K, Xiang Y, Nakamura H, et al. Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther. 2006;8(6):R175. PubMed PMID: 17125526; PubMed Central PMCID: PMCPMC1794520.
   PubMed Web of Science ®Google Scholar
• Hopmann R, Cooper JA, Miller KG. Actin organization, bristle morphology, and viability are affected by actin capping protein mutations in Drosophila. J Cell Biol. 1996 Jun;133(6):1293–1305. PubMed PMID: 8682865; PubMed Central PMCID: PMCPMC2120907.
   PubMed Web of Science ®Google Scholar
• Takeda S, Minakata S, Koike R, et al. Two distinct mechanisms for actin capping protein regulation–steric and allosteric inhibition. PLoS Biol. 2010;8(7):e1000416. PubMed PMID: 20625546; PubMed Central PMCID: PMCPMC2897767.
   PubMed Web of Science ®Google Scholar
• Bombardier JP, Eskin JA, Jaiswal R, et al. Single-molecule visualization of a formin-capping protein ‘decision complex’ at the actin filament barbed end. Nat Commun. 2015;6:8707. PubMed PMID: 26566078; PubMed Central PMCID: PMCPMC4660045.
   PubMed Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy. 2007 Sep-Oct;3(5):452–460. PubMed PMID: 17534139.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222. PubMed PMID: 26799652; PubMed Central PMCID: PMCPMC4835977.
   PubMed Web of Science ®Google Scholar
• Zurhove K, Nakajima C, Herz J, et al. Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal. 2008;1(47):ra15. PubMed PMID: 19036715; PubMed Central PMCID: PMCPMC2694618.
   PubMed Web of Science ®Google Scholar
• Engel K, Kotlyarov A, Gaestel M. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J. 1998 Jun 15;17(12):3363–3371. . PubMed PMID: 9628873; PubMed Central PMCID: PMCPMC1170674.
   PubMed Web of Science ®Google Scholar
• Huang D, Cao L, Zheng S. CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma. J Exp Clin Cancer Res. 2017 Jan 16;36(1):13. . PubMed PMID: 28093067; PubMed Central PMCID: PMCPMC5240199.
   PubMedGoogle Scholar
• Lee YJ, Jeong SH, Hong SC, et al. Prognostic value of CAPZA1 overexpression in gastric cancer. Int J Oncol. 2013 May;42(5):1569–1577. PubMed PMID: 23545944; PubMed Central PMCID: PMCPMC3661194.
   PubMed Web of Science ®Google Scholar
• Lee YS, Lee Do Y, Yu Da Y, et al. Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells. Helicobacter. 2014 Dec;19(6):465–475. PubMed PMID: 25052887.
   PubMed Web of Science ®Google Scholar
• Bagnoli F, Buti L, Tompkins L, et al. Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16339–16344. PubMed PMID: 16258069; PubMed Central PMCID: PMCPMC1274241.
   PubMed Web of Science ®Google Scholar
• Wroblewski LE, Noble PJ, Pagliocca A, et al. Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J Cell Sci. 2003 Jul 15;116(Pt 14):3017–3026. PubMed PMID: 12808021.
   PubMed Web of Science ®Google Scholar
• Hatakeyama M. Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. PubMed PMID: 28413197; PubMed Central PMCID: PMCPMC5489429 Proc Jpn Acad Ser B Phys Biol Sci. 2017;934:196–219.
   PubMed Web of Science ®Google Scholar
• Higashi H, Tsutsumi R, Fujita A, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428–14433. PubMed PMID: 12391297; PubMed Central PMCID: PMCPMC137900.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Senda M, Suzuki N, et al. Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep. 2017 Sep 19;20(12):2876–2890. PubMed PMID: 28930683.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Nishizawa T, Tsugawa H, et al. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr. 2012 Jan;50(1):35–39. PubMed PMID: 22247598; PubMed Central PMCID: PMCPMC3246180.
   PubMed Web of Science ®Google Scholar
• Lieberman PM. Chromatin regulation of virus infection. Trends Microbiol. 2006 Mar;14(3):132–140. . PubMed PMID: 16458005.
   PubMed Web of Science ®Google Scholar
• Fukayama M, Hino R, Uozaki H. Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma. Cancer Sci. 2008 Sep;99(9):1726–1733. . PubMed PMID: 18616681.
   PubMed Web of Science ®Google Scholar
• Cotter MA 2nd, Robertson ES. Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha. Mol Cell Biol. 2000 Aug;20(15):5722–5735. PubMed PMID: 10891508; PubMed Central PMCID: PMCPMC86050.
   PubMed Web of Science ®Google Scholar
• Saju P, Murata-Kamiya N, Hayashi T, et al. Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein–barr virus. Nat Microbiol. 2016;1. 10.1038/nmicrobiol.2016.26.
   Web of Science ®Google Scholar
• Henne WM, Buchkovich NJ, Emr SD. The ESCRT pathway. Dev Cell. 2011 Jul 19;21(1):77–91. . PubMed PMID: 21763610.
   PubMed Web of Science ®Google Scholar
• Jager S, Bucci C, Tanida I, et al. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci. 2004 Sep 15;117(Pt 20):4837–4848. PubMed PMID: 15340014.
   PubMed Web of Science ®Google Scholar
• Gutierrez MG, Munafo DB, Beron W, et al. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci. 2004 Jun 01;117(Pt 13):2687–2697. PubMed PMID: 15138286.
   PubMed Web of Science ®Google Scholar
• Fraldi A, Annunziata F, Lombardi A, et al. Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders. EMBO J. 2010 Nov 03;29(21):3607–3620. PubMed PMID: 20871593; PubMed Central PMCID: PMCPMC2982760.
   PubMed Web of Science ®Google Scholar
• Fukuda M. Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. J Biol Chem. 1991 Nov 15;266(32):21327–21330. PubMed PMID: 1939168.
   PubMed Web of Science ®Google Scholar
• Saftig P, Klumperman J. Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol. 2009 Sep;10(9):623–635. . PubMed PMID: 19672277.
   PubMed Web of Science ®Google Scholar
• Saftig P, Beertsen W, Eskelinen EL. LAMP-2 : a control step for phagosome and autophagosome maturation. Autophagy. 2008 May;4(4):510–512. PubMed PMID: 18376150.
   PubMed Web of Science ®Google Scholar
• Eskelinen EL, Illert AL, Tanaka Y, et al. Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell. 2002 Sep;13(9):3355–3368. PubMed PMID: 12221139; PubMed Central PMCID: PMCPMC124165.
   PubMed Web of Science ®Google Scholar
• Eskelinen EL, Schmidt CK, Neu S, et al. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell. 2004 Jul;15(7):3132–3145. PubMed PMID: 15121881; PubMed Central PMCID: PMCPMC452571.
   PubMed Web of Science ®Google Scholar
• Han C, Ding Z, Shi H, et al. The role of probiotics in lipopolysaccharide-induced autophagy in intestinal epithelial cells. Cell Physiol Biochem. 2016;38(6):2464–2478. PubMed PMID: 27309845.
   PubMed Web of Science ®Google Scholar
• Tsugawa H, Suzuki H, Matsuzaki J, et al. FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach. Free Radic Biol Med. 2012 Mar 15;52(6):1003–1010. PubMed PMID: 22245091.
   PubMed Web of Science ®Google Scholar
• Sato A, Naito T, Hiramoto A, et al. Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J. 2010 Nov;277(21):4464–4473. PubMed PMID: 20875083.
   PubMed Web of Science ®Google Scholar
• Sato A, Satake A, Hiramoto A, et al. Protein expression profiles of necrosis and apoptosis induced by 5-fluoro-2ʹ-deoxyuridine in mouse cancer cells. J Proteome Res. 2010 May 7;9(5):2329–2338. PubMed PMID: 20155980.
   PubMed Web of Science ®Google Scholar
• Seton-Rogers SE, Lu Y, Hines LM, et al. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A. 2004 Feb 03;101(5):1257–1262. PubMed PMID: 14739340; PubMed Central PMCID: PMCPMC337040.
   PubMed Web of Science ®Google Scholar
• Jegga AG, Schneider L, Ouyang X, et al. Systems biology of the autophagy-lysosomal pathway. Autophagy. 2011 May;7(5):477–489. PubMed PMID: 21293178; PubMed Central PMCID: PMCPMC3127210.
   PubMed Web of Science ®Google Scholar
• Dehghan-Nayeri N, Eshghi P, Kg P, et al. Differential expression pattern of protein markers for predicting chemosensitivity of dexamethasone-based chemotherapy of B cell acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2017 Jul;80(1):177–185. PubMed PMID: 28585036.
   PubMed Web of Science ®Google Scholar