DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B

References

• Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 2011;27:107–132. PubMed PMID: 21801009.
   PubMed Web of Science ®Google Scholar
• Takats S, Nagy P, Varga A, et al. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013 May 13;201(4):531–539. PubMed PMID: 23671310; PubMed Central PMCID: PMC3653357.
   PubMed Web of Science ®Google Scholar
• Itakura E, Kishi-Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 2012 Dec 7;151(6):1256–1269. PubMed PMID: 23217709.
   PubMed Web of Science ®Google Scholar
• Matsui T, Jiang P, Nakano S, et al. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018 Aug 6;217(8):2633–2645. PubMed PMID: 29789439; PubMed Central PMCID: PMCPMC6080929.
   PubMed Web of Science ®Google Scholar
• Daste F, Galli T, Tareste D. Structure and function of longin SNAREs. J Cell Sci. 2015 Dec 1;128(23):4263–4272. PubMed PMID: 26567219.
   PubMed Web of Science ®Google Scholar
• Rossi V, Banfield DK, Vacca M, et al. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem Sci. 2004 Dec;29(12):682–688. PubMed PMID: 15544955.
   PubMed Web of Science ®Google Scholar
• Takats S, Glatz G, Szenci G, et al. Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion. PLoS Genet. 2018 Apr;14(4):e1007359. PubMed PMID: 29694367; PubMed Central PMCID: PMCPMC5937789.
   PubMed Web of Science ®Google Scholar
• Vacca M, Albania L, Della Ragione F, et al. Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms. BMC Mol Biol. 2011 May 24;12:26. PubMed PMID: 21609427; PubMed Central PMCID: PMC3123573.
   PubMed Web of Science ®Google Scholar
• Martinez-Arca S, Rudge R, Vacca M, et al. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A. 2003 Jul 22 100(15):9011–9016. PubMed PMID: 12853575; PubMed Central PMCID: PMCPMC166429.
   PubMed Web of Science ®Google Scholar
• McLelland GL, Lee SA, McBride HM, et al. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J Cell Biol. 2016 Aug 1;214(3):275–291. PubMed PMID: 27458136; PubMed Central PMCID: PMC4970327.
   PubMed Web of Science ®Google Scholar
• Yamashita SI, Jin X, Furukawa K, et al. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J Cell Biol. 2016 Dec 5;215(5):649–665. PubMed PMID: 27903607; PubMed Central PMCID: PMC5147001.
   PubMed Web of Science ®Google Scholar
• Nguyen TN, Padman BS, Usher J, et al. Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol. 2016 Dec 19;215(6):857–874. PubMed PMID: 27864321; PubMed Central PMCID: PMC5166504.
   PubMed Web of Science ®Google Scholar
• Sugo M, Kimura H, Arasaki K, et al. Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy. Embo J. 2018 Nov 2;37(21). PubMed PMID: 30237312; PubMed Central PMCID: PMCPMC6213275.
   PubMed Web of Science ®Google Scholar
• Morrow EM, Yoo SY, Flavell SW, et al. Identifying autism loci and genes by tracing recent shared ancestry. Science. 2008 Jul 11;321(5886):218–223. PubMed PMID: 18621663; PubMed Central PMCID: PMC2586171.
   PubMed Web of Science ®Google Scholar
• Aziz A, Harrop SP, Bishop NE. Characterization of the deleted in autism 1 protein family: implications for studying cognitive disorders. PloS One. 2011 Jan 19;6(1):e14547. PubMed PMID: 21283809; PubMed Central PMCID: PMC3023760.
   PubMed Web of Science ®Google Scholar
• Takatalo MS, Tummers M, Thesleff I, et al. Novel Golgi protein, GoPro49, is a specific dental follicle marker. J Dent Res. 2009 Jun;88(6):534–538. PubMed PMID: 19587158.
   PubMed Web of Science ®Google Scholar
• Hareza A, Bakun M, Swiderska B, et al. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58. PeerJ. 2018;6:e4599. PubMed PMID: 29666759; PubMed Central PMCID: PMC5896498.
   PubMed Web of Science ®Google Scholar
• Dudkiewicz M, Lenart A, Pawlowski K. A novel predicted calcium-regulated kinase family implicated in neurological disorders. PloS One. 2013;86:e66427. PubMed PMID: 23840464; PubMed Central PMCID: PMC3696010.
   PubMed Web of Science ®Google Scholar
• Beigi F, Schmeckpeper J, Pow-Anpongkul P, et al. C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. Circ Res. 2013 Aug 02;113(4):372–380. PubMed PMID: 23784961; PubMed Central PMCID: PMC3870268.
   PubMed Web of Science ®Google Scholar
• Bareja A, Patel S, Hodgkinson CP, et al. Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: effects of LL37 and HASF. Cell Signal. 2018 Jun;46:113–119. PubMed PMID: 29499305.
   PubMed Web of Science ®Google Scholar
• Bareja A, Hodgkinson CP, Payne AJ, et al. HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. Biochem J. 2017 Feb 20;474(5):771–780. PubMed PMID: 28096202.
   PubMedGoogle Scholar
• Huang J, Guo J, Beigi F, et al. HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol. 2014 Jan;66:157–164. PubMed PMID: 24269490; PubMed Central PMCID: PMC3897274.
   PubMed Web of Science ®Google Scholar
• Zheng P, Chen Q, Tian X, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018 Aug;28(8):833–854. PubMed PMID: 30030520; PubMed Central PMCID: PMCPMC6063967.
   PubMed Web of Science ®Google Scholar
• Takatalo M, Jarvinen E, Laitinen S, et al. Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation. Dev Dyn. 2008 Aug;237(8):2243–2255. PubMed PMID: 18651652.
   PubMed Web of Science ®Google Scholar
• Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013 Feb 15;339(6121):819–823. PubMed PMID: 23287718; PubMed Central PMCID: PMC3795411.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010 Feb 5;140(3):313–326. PubMed PMID: 20144757; PubMed Central PMCID: PMC2852113.
   PubMed Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy. 2007 Sep-Oct;3(5):452–460. PubMed PMID: 17534139.
   PubMed Web of Science ®Google Scholar
• Jahn R, Scheller RH. SNAREs–engines for membrane fusion. Nat Rev Mol Cell Biol. 2006 Sep;7(9):631–643. PubMed PMID: 16912714.
   PubMed Web of Science ®Google Scholar
• Vivona S, Liu CW, Strop P, et al. The longin SNARE VAMP7/TI-VAMP adopts a closed conformation. J Biol Chem. 2010 Jun 4;285(23):17965–17973. PubMed PMID: 20378544; PubMed Central PMCID: PMC2878558.
   PubMed Web of Science ®Google Scholar
• Abada A, Levin-Zaidman S, Porat Z, et al. SNARE priming is essential for maturation of autophagosomes but not for their formation. Proc Natl Acad Sci U S A. 2017 Nov 28 114(48):12749–12754. PubMed PMID: 29138318; PubMed Central PMCID: PMCPMC5715740.
   PubMed Web of Science ®Google Scholar
• Marino G, Niso-Santano M, Baehrecke EH, et al. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 2014 Feb;15(2):81–94. PubMed PMID: 24401948; PubMed Central PMCID: PMC3970201.
   PubMed Web of Science ®Google Scholar
• Chandra D, Liu JW, Tang DG. Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J Biol Chem. 2002 Dec 27;277(52):50842–50854. PubMed PMID: 12407106.
   PubMed Web of Science ®Google Scholar
• Wang W, Cheng X, Lu J, et al. Mitofusin-2 is a novel direct target of p53. Biochem Biophys Res Commun. 2010 Oct 01;400(4):587–592. PubMed PMID: 20804729.
   PubMed Web of Science ®Google Scholar
• Guo X, Chen KH, Guo Y, et al. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res. 2007 Nov 26;101(11):1113–1122. PubMed PMID: 17901359.
   PubMed Web of Science ®Google Scholar
• Muzerelle A, Alberts P, Martinez-Arca S, et al. Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain. Neuroscience. 2003;122(1):59–75. PubMed PMID: 14596849.
   PubMed Web of Science ®Google Scholar
• Hua Z, Leal-Ortiz S, Foss SM, et al. v-SNARE composition distinguishes synaptic vesicle pools. Neuron. 2011 Aug 11;71(3):474–487. PubMed PMID: 21835344; PubMed Central PMCID: PMC3155686.
   PubMed Web of Science ®Google Scholar
• Martinez-Arca S, Alberts P, Zahraoui A, et al. Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth. J Cell Biol. 2000 May 15;149(4):889–900. PubMed PMID: 10811829; PubMed Central PMCID: PMC2174569.
   PubMed Web of Science ®Google Scholar
• Proux-Gillardeaux V, Raposo G, Irinopoulou T, et al. Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration. Biol Cell. 2007 May;99(5):261–271. PubMed PMID: 17288539.
   PubMed Web of Science ®Google Scholar
• Ebrahimi-Fakhari D, Sahin M. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr Opin Neurol. 2015 Apr;28(2):91–102. PubMed PMID: 25695134.
   PubMed Web of Science ®Google Scholar
• Giulivi C, Zhang YF, Omanska-Klusek A, et al. Mitochondrial dysfunction in autism. JAMA. 2010 Dec 1;304(21):2389–2396. PubMed PMID: 21119085; PubMed Central PMCID: PMCPMC3915058.
   PubMed Web of Science ®Google Scholar
• Tang G, Gudsnuk K, Kuo SH, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 2014 Sep 3;83(5):1131–1143. PubMed PMID: 25155956; PubMed Central PMCID: PMCPMC4159743.
   PubMed Web of Science ®Google Scholar
• Ebrahimi-Fakhari D, Saffari A, Wahlster L, et al. Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex. Cell Rep. 2016 Oct 18;17(4):1053–1070. PubMed PMID: 27760312; PubMed Central PMCID: PMCPMC5078873.
   PubMed Web of Science ®Google Scholar
• Yan J, Porch MW, Court-Vazquez B, et al. Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice. Proc Natl Acad Sci U S A. 2018 Oct 9 115(41):E9707–E9716. PubMed PMID: 30242133; PubMed Central PMCID: PMCPMC6187122.
   PubMed Web of Science ®Google Scholar
• Napoli E, Song G, Panoutsopoulos A, et al. Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy. Sci Rep. 2018 Jul 27;8(1):11348. PubMed PMID: 30054502; PubMed Central PMCID: PMCPMC6063930.
   PubMed Web of Science ®Google Scholar
• Poultney CS, Goldberg AP, Drapeau E, et al. Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder. Am J Hum Genet. 2013 Oct 3;93(4):607–619. PubMed PMID: 24094742; PubMed Central PMCID: PMCPMC3791269.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang JX, Zhang QL. PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder. Brain Res Bull. 2016 Jul;125:152–158. PubMed PMID: 27320472.
   PubMed Web of Science ®Google Scholar
• Wang Q, Feng H, Zheng P, et al. The intracellular transport and secretion of calumenin-1/2 in living cells. PloS One. 2012;7(4):e35344. PubMed PMID: 22514732; PubMed Central PMCID: PMCPMC3325945.
   PubMed Web of Science ®Google Scholar
• Rizzuto R, Nakase H, Darras B, et al. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. J Biol Chem. 1989 Jun 25;264(18):10595–10600. PubMed PMID: 2543673.
   PubMed Web of Science ®Google Scholar
• Chang N, Sun C, Gao L, et al. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res. 2013 Apr;23(4):465–472. PubMed PMID: 23528705; PubMed Central PMCID: PMCPMC3616424.
   PubMed Web of Science ®Google Scholar
• Chen L, Xu S, Xu Y, et al. Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling. Oncogene. 2016 Jan 7;35(1):35–46. PubMed PMID: 25772237.
   PubMed Web of Science ®Google Scholar