References
- Collaborators H DALYs GBD. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1603–1658. PubMed PMID: 27733283; PubMed Central PMCID: PMC5388857.
- Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs–overview and meta-analyses. J Hypertens. 2015 Feb;33(2):195–211. PubMed PMID: 25485720.
- Rubattu S, Giliberti R, Volpe M. Etiology and pathophysiology of stroke as a complex trait. Am J Hypertens. 2000 Oct;13(10):1139–1148. PubMed PMID: 11041170.
- Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008 Jan 11;132(1):27–42. PubMed PMID: 18191218; PubMed Central PMCID: PMC2696814.
- Sciarretta S, Maejima Y, Zablocki D, et al. The Role of Autophagy in the Heart. Annu Rev Physiol. 2018 Feb 10;80:1–26. PubMed PMID: 29068766.
- Saito T, Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 2015 Apr 10;116(8):1477–1490. PubMed PMID: 25858070; PubMed Central PMCID: PMC4419704.
- Siasos G, Tsigkou V, Kosmopoulos M, et al. Mitochondria and cardiovascular diseases-from pathophysiology to treatment. Ann Transl Med. 2018 Jun;6(12):256. PubMed PMID: 30069458; PubMed Central PMCID: PMCPMC6046286.
- Rubattu S, Volpe M, Kreutz R, et al. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nat Genet. 1996 Aug;13(4):429–434. PubMed PMID: 8696337.
- Di Castro S, Scarpino S, Marchitti S, et al. Differential modulation of uncoupling protein 2 in kidneys of stroke-prone spontaneously hypertensive rats under high-salt/low-potassium diet. Hypertension. 2013 Feb;61(2):534–541. PubMed PMID: 23297375.
- Volpe M, Iaccarino G, Vecchione C, et al. Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats. J Clin Invest. 1996 Jul 15;98(2):256–261. PubMed PMID: 8755632; PubMed Central PMCID: PMCPMC507425.
- Rubattu S, Di Castro S, Schulz H, et al. Ndufc2 gene inhibition is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease. J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. PubMed PMID: 26888427; PubMed Central PMCID: PMC4802485.
- Ikeda Y, Shirakabe A, Maejima Y, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015 Jan 16;116(2):264–278. PubMed PMID: 25332205.
- Shirakabe A, Zhai P, Ikeda Y, et al. Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure. Circulation. 2016 Mar 29;133(13):1249–1263. PubMed PMID: 26915633; PubMed Central PMCID: PMC4811679.
- Houtkooper RH, Canto C, Wanders RJ, et al. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev. 2010 Apr;31(2):194–223. PubMed PMID: 20007326; PubMed Central PMCID: PMC2852209.
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464–471. PubMed PMID: 24786309; PubMed Central PMCID: PMC4112140.
- Verdin E. NAD(+) in aging, metabolism, and neurodegeneration. Science. 2015 Dec 4;350(6265):1208–1213. PubMed PMID: 26785480.
- Zhang DX, Zhang JP, Hu JY, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454–462. PubMed PMID: 26975537.
- Rubattu S, Hubner N, Ganten U, et al. Reciprocal congenic lines for a major stroke QTL on rat chromosome 1. Physiol Genomics. 2006 Oct 11;27(2):108–113. PubMed PMID: 16835352.
- Volpe M, Camargo MJ, Mueller FB, et al. Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats. Hypertension. 1990 Mar;15(3):318–326. PubMed PMID: 2406201.
- Schreiber S, Bueche CZ, Garz C, et al. Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats. PloS One. 2011;6(10):e26287. PubMed PMID: 22031827; PubMed Central PMCID: PMC3198774.
- Shoji-Kawata S, Sumpter R, Leveno M, et al. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013 Feb 14;494(7436):201–206. PubMed PMID: 23364696; PubMed Central PMCID: PMC3788641.
- Wang P, Guan YF, Du H, et al. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. 2012 Jan;8(1):77–87. PubMed PMID: 22113203.
- Ginet V, Spiehlmann A, Rummel C, et al. Involvement of autophagy in hypoxic-excitotoxic neuronal death. Autophagy. 2014 May;10(5):846–860. PubMed PMID: 24674959; PubMed Central PMCID: PMC5119065.
- Wen YD, Sheng R, Zhang LS, et al. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy. 2008 Aug;4(6):762–769. PubMed PMID: 18567942.
- Raffa S, Scrofani C, Valente S, et al. In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. Hum Mol Genet. 2017 Dec 1;26(23):4541–4555. PubMed PMID: 28973657; PubMed Central PMCID: PMCPMC5886163.
- Rubattu S, Cotugno M, Bianchi F, et al. A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines. J Hypertens. 2017 Sep;35(9):1857–1871. PubMed PMID: 28399045.
- De Falco E, Carnevale R, Pagano F, et al. Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells. Mech Ageing Dev. 2016 Oct;159:37–43. PubMed PMID: 27181082.
- De Falco E, Avitabile D, Totta P, et al. Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J Cell Mol Med. 2009 Sep;13(9B):3405–3414. PubMed PMID: 20196780; PubMed Central PMCID: PMC4516496.
- Stanzione R, Bianchi F, Cotugno M, et al. A decrease of brain MicroRNA-122 level is an early marker of cerebrovascular disease in the stroke-prone spontaneously hypertensive rat. Oxid Med Cell Longev. 2017;2017:1206420. PubMed PMID: 28751928; PubMed Central PMCID: PMCPMC5494068.
- Mauro-Lizcano M, Esteban-Martinez L, Seco E, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11(5):833–843. PubMed PMID: 25945953; PubMed Central PMCID: PMCPMC4509449.
- Putignani L, Raffa S, Pescosolido R, et al. Preliminary evidences on mitochondrial injury and impaired oxidative metabolism in breast cancer. Mitochondrion. 2012 May;12(3):363–369. PubMed PMID: 22366096.
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 Dec;25(4):402–408. PubMed PMID: 11846609.