Advanced search
Publication Cover
Autophagy Volume 16, 2020 - Issue 5
Submit an article Journal homepage
1,732
Views
0
CrossRef citations to date
0
Altmetric
Editor’s Corner

As (and when) you like it: on-demand phospholipid synthesis drives phagophore expansion during autophagy

Shree Padma MeturLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USAView further author information
&
Daniel J. KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7828-8118View further author information
ORCID Icon
Pages 779-781 | Received 17 Feb 2020, Accepted 18 Feb 2020, Published online: 25 Feb 2020

References

  • Lahiri V, Hawkins WD, Klionsky DJ. Watch what you (self-) eat: autophagic mechanisms that modulate metabolism. Cell Metab. 2019;29(4):803–826.
  • Gatica D, Lahiri V, Klionsky DJ. Cargo recognition and degradation by selective autophagy. Nat Cell Biol. 2018;20(3):233–242.
  • Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–473.
  • Hurley JH, Young LN. Mechanisms of autophagy initiation. Annu Rev Biochem. 2017;86:225–244.
  • Feng Y, Backues SK, Baba M, et al. Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation. Autophagy. 2016;12(4):648–658.
  • Yamamoto H, Kakuta S, Watanabe TM, et al. Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol. 2012;198(2):219–233.
  • Mari M, Griffith J, Rieter E, et al. An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol. 2010;190(6):1005–1022.
  • Davis S, Wang J, Zhu M, et al. Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation. Elife. 2016;5:e21167.
  • Yin Z, Pascual C, Klionsky DJ. Autophagy: machinery and regulation. Microb Cell. 2016;3(12):588–596.
  • Ge L, Melville D, Zhang M, et al. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife. 2013;2:e00947.
  • Li D, Zhao YG, Li D, et al. The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation. Cell Rep. 2019;27(2):343–358 e5.
  • Dupont N, Chauhan S, Arko-Mensah J, et al. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr Biol. 2014;24(6):609–620.
  • Hailey DW, Rambold AS, Satpute-Krishnan P, et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell. 2010;141(4):656–667.
  • Puri C, Renna M, Bento C, et al. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 2013;154(6):1285–1299.
  • Girardi JP, Pereira L, Bakovic M. De novo synthesis of phospholipids is coupled with autophagosome formation. Med Hypotheses. 2011;77(6):1083–1087.
  • Lahiri S, Toulmay A, Prinz WA. Membrane contact sites, gateways for lipid homeostasis. Curr Opin Cell Biol. 2015;33:82–87.
  • Fagone P, Jackowski S. Membrane phospholipid synthesis and endoplasmic reticulum function. J Lipid Res. 2009;50:S311–S316.
  • Biazik J, Ylä-Anttila P, Vihinen H, et al. Ultrastructural relationship of the phagophore with surrounding organelles. Autophagy. 2015;11(3):439–451.
  • Kotani T, Kirisako H, Koizumi M, et al. The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation. Proc Natl Acad Sci U S A. 2018;115(41):10363–10368.
  • Gomez-Sanchez R, Rose J, Guimarães R, et al. Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores. J Cell Biol. 2018;217(8):2743–2763.
  • Maeda S, Otomo C, Otomo T. The autophagic membrane tether ATG2A transfers lipids between membranes. Elife. 2019;8:e45777.
  • Maximilian Schütter PG, Brodesser S, Graef M. Local fatty acid channeling into phospholipid synthesis drives phagophore expansion during autophagy. Cell. 2019;180(1):135–149.e14.
  • Coleman RA. It takes a village: channeling fatty acid metabolism and triacylglycerol formation via protein interactomes. J Lipid Res. 2019;60(3):490–497.
  • Black PN, DiRusso CC. Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim Biophys Acta. 2007;1771(3):286–298.
  • Leibundgut M, Maier T, Jenni S, et al. The multienzyme architecture of eukaryotic fatty acid synthases. Curr Opin Struct Biol. 2008;18(6):714–725.
  • Andrejeva G, Gowan S, Lin G, et al. De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy. Autophagy. 2020;16:in press.
  • Nishimura T, Tamura N, Kono N, et al. Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains. EMBO J. 2017;36(12):1719–1735.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.