Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction

References

• Nguyen LD, Ehrlich BE. Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases. EMBO Mol Med. 2020;12(6):e12075.
   PubMed Web of Science ®Google Scholar
• Vitali M, Ripamonti CI, Roila F, et al. Cognitive impairment and chemotherapy: a brief overview. Crit Rev Oncol Hematol. 2017;118:7–14.
   PubMed Web of Science ®Google Scholar
• Gutmann DH. Clearing the Fog surrounding Chemobrain. Cell. 2019;176(1–2):2–4.
   PubMed Web of Science ®Google Scholar
• Mounier NM, Abdel-Maged AE, Wahdan SA, et al. Chemotherapy-induced cognitive impairment (CICI): an overview of etiology and pathogenesis. Life Sci. 2020;258:118071.
   PubMed Web of Science ®Google Scholar
• Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nat Rev Neurosci. 2011;12(12):723–738.
   PubMed Web of Science ®Google Scholar
• Wang W, Swenson S, Cho HY, et al. Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models. J Neurosurg. 2019;132(3):959–967.
   PubMed Web of Science ®Google Scholar
• Fischer M, Schmutzhard E. Posterior reversible encephalopathy syndrome. J Neurol. 2017;264(8):1608–1616.
   PubMed Web of Science ®Google Scholar
• Ho CH, Lo CP, Tu MC. Bortezomib-induced posterior reversible encephalopathy syndrome: clinical and imaging features. Intern Med. 2014;53(16):1853–1857.
   PubMed Web of Science ®Google Scholar
• Terwiel E, Hanrahan R, Lueck C, et al. Reversible posterior encephalopathy syndrome associated with bortezomib. Intern Med J. 2010 Jan;40(1):69–71.
   PubMed Web of Science ®Google Scholar
• Leeman DS, Hebestreit K, Ruetz T, et al. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018;359(6381):1277–1283.
   PubMed Web of Science ®Google Scholar
• Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013;19(8):983–997.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Cho MH, Shim WH, et al. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol Psychiatry. 2017;22(11):1576–1584.
   PubMed Web of Science ®Google Scholar
• Luo J. Autophagy and ethanol neurotoxicity. Autophagy. 2014;10(12):2099–2108.
   PubMed Web of Science ®Google Scholar
• Nawrocki ST, Carew JS, Pino MS, et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res. 2006;66(7):3773–3781.
   PubMed Web of Science ®Google Scholar
• Bosch M, Castro J, Saneyoshi T, et al. Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron. 2014;82(2):444–459.
   PubMed Web of Science ®Google Scholar
• Bohlen CJ, Friedman BA, Dejanovic B, et al. Microglia in brain development, homeostasis, and neurodegeneration. Annu Rev Genet. 2019;53(1):263–288.
   PubMedGoogle Scholar
• Nguyen PT, Dorman LC, Pan S, et al. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. 2020;182(2):388–403.
   PubMed Web of Science ®Google Scholar
• Lui H, Zhang J, Makinson SR, et al. Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation. Cell. 2016;165(4):921–935.
   PubMed Web of Science ®Google Scholar
• Vasek MJ, Garber C, Dorsey D, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534(7608):538–543.
   PubMed Web of Science ®Google Scholar
• Spangenberg E, Severson PL, Hohsfield LA, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model. Nat Commun. 2019;10(1):3758.
   PubMedGoogle Scholar
• Huang Y, Xu Z, Xiong S, et al. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nat Neurosci. 2018;21(4):530–540.
   PubMed Web of Science ®Google Scholar
• Wang H, Hong LJ, Huang JY, et al. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res. 2015;25(6):674–690.
   PubMed Web of Science ®Google Scholar
• Tan C, Lu NN, Wang CK, et al. Endothelium-derived semaphorin 3G regulates hippocampal synaptic structure and plasticity via Neuropilin-2/PlexinA4. Neuron. 2019;101(5):920–937.
   PubMed Web of Science ®Google Scholar
• Wu H, Liu C, Yang Q, et al. MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4. Autophagy. 2020;16(4):683–697.
   PubMed Web of Science ®Google Scholar
• Lee H, Kim MN, Ryu KY. Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite. Biochem Biophys Res Commun. 2017;486(3):839–844.
   PubMed Web of Science ®Google Scholar
• Wang S, Ni HM, Chao X, et al. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019;15(11):1954–1969.
   PubMed Web of Science ®Google Scholar
• Yamamoto F, Taniguchi K, Mamada N, et al. TFEB-mediated enhancement of the autophagy-lysosomal pathway dually modulates the process of amyloid beta-protein generation in neurons. Neuroscience. 2019;402:11–22.
   PubMed Web of Science ®Google Scholar
• Medina DL, Ballabio A. Lysosomal calcium regulates autophagy. Autophagy. 2015;11(6):970–971.
   PubMed Web of Science ®Google Scholar
• Nitsch L, Schneider L, Zimmermann J, et al. Microglia-derived interleukin 23: a crucial cytokine in Alzheimer’s disease? Front Neurol. 2021;12:639353.
   PubMed Web of Science ®Google Scholar
• Muller G, Lubow C, Weindl G. Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells. Autophagy. 2020;16(8):1380–1395.
   PubMed Web of Science ®Google Scholar
• Liu B, Palmfeldt J, Lin L, et al. STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH. Cell Res. 2018;28(10):996–1012.
   PubMed Web of Science ®Google Scholar
• Dubovy P, Hradilova-Svizenska I, Klusakova I, et al. Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury. Histochem Cell Biol. 2018;150(1):37–47.
   PubMed Web of Science ®Google Scholar
• Montagne A, Nation DA, Sagare AP, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020;581(7806):71–76.
   PubMed Web of Science ®Google Scholar
• Nation DA, Sweeney MD, Montagne A, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019;25(2):270–276.
   PubMed Web of Science ®Google Scholar
• Chang J, Mancuso MR, Maier C, et al. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med. 2017;23(4):450–460.
   PubMed Web of Science ®Google Scholar
• Martinez-Sanchez J, Palomo M, Torramade-Moix S, et al. The induction strategies administered in the treatment of multiple myeloma exhibit a deleterious effect on the endothelium. Bone Marrow Transplant. 2020;55(12):2270–2278.
   PubMed Web of Science ®Google Scholar
• Chen Y, Langsish CL, McKenzie B, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest. 2006;116(5):1317–1326.
   PubMed Web of Science ®Google Scholar
• Komuczki J, Tuzlak S, Friebel E, et al. Fate-mapping of GM-CSF expression identifies a discrete subset of inflammation-driving t helper cells regulated by Cytokines IL-23 and IL-1beta. Immunity. 2019;50(5):1289–1304.
   PubMed Web of Science ®Google Scholar
• Langowski JL, Zhang X, Wu L, et al. IL-23 promotes tumour incidence and growth. Nature. 2006;442(7101):461–465.
   PubMed Web of Science ®Google Scholar
• Li H, Yao Q, Mariscal AG, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9(1):1420.
   PubMedGoogle Scholar
• Korbelin J, Dogbevia G, Michelfelder S, et al. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med. 2016;8(6):609–625.
   PubMed Web of Science ®Google Scholar
• Vaquer-Alicea J, Diamond MI. Propagation of protein aggregation in neurodegenerative diseases. Annu Rev Biochem. 2019;88(1):785–810.
   PubMedGoogle Scholar
• La Spada AR. PPARGC1A/PGC-1alpha, TFEB and enhanced proteostasis in Huntington disease: defining regulatory linkages between energy production and protein-organelle quality control. Autophagy. 2012;8(12):1845–1847.
   PubMed Web of Science ®Google Scholar
• Zhang YD, Zhao JJ. TFEB participates in the abeta-ind uced pathogenesis of Alzheimer’s Disease by regulating the autophagy-lysosome pathway. DNA Cell Biol. 2015;34(11):661–668.
   PubMed Web of Science ®Google Scholar
• Konstantinou DM, Karvounis H, Giannakoulas G. Digoxin in heart failure with a reduced ejection fraction: a risk factor or a risk marker. Cardiology. 2016;134(3):311–319.
   PubMed Web of Science ®Google Scholar
• Shi H, Mao X, Zhong Y, et al. Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice. Br J Pharmacol. 2016;173(9):1517–1528.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Gao Y, Wang C, et al. Nitration of TRPM2 as a molecular switch induces autophagy during brain pericyte injury. Antioxid Redox Signal. 2017;27(16):1297–1316.
   PubMed Web of Science ®Google Scholar
• Liu Y, Xue X, Zhang H, et al. Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. Autophagy. 2019;15(3):493–509.
   PubMed Web of Science ®Google Scholar
• Morioka M, Fukunaga K, Yasugawa S, et al. Regional and temporal alterations in Ca2+/calmodulin-dependent protein kinase II and calcineurin in the hippocampus of rat brain after transient forebrain ischemia. J Neurochem. 1992;58(5):1798–1809.
   PubMed Web of Science ®Google Scholar
• Young K, Morrison H. Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ. J Vis Exp. 2018;136:e57648.
   Google Scholar
• Erny D, Hrabe de Angelis AL, Jaitin D, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18(7):965–977.
   PubMed Web of Science ®Google Scholar
• Wang CK, Ahmed MM, Jiang Q, et al. Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator. J Pineal Res. 2017;63(4):e12440.
   PubMed Web of Science ®Google Scholar
• Yu T, Guo F, Yu Y, et al. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell. 2017;170(3):548–563.e16.
   PubMed Web of Science ®Google Scholar
• Li Y, Lopez-Huerta VG, Adiconis X, et al. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020;583(7818):819–824.
   PubMed Web of Science ®Google Scholar
• Isakson BE, Ramos SI, Duling BR. Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction. Circ Res. 2007;100(2):246–254.
   PubMed Web of Science ®Google Scholar
• Chen DY, Sun NH, Chen X, et al. Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating beta-catenin-dependent vascular remodeling. J Clin Invest. 2021;131(4):4.
   Web of Science ®Google Scholar