Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw

References

• Yarom N, Shapiro CL, Peterson DE, et al. Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline. J Clin Oncol. 2019 Sep 1;37(25):2270–2290. doi: 10.1200/JCO.19.01186
   PubMed Web of Science ®Google Scholar
• Ruggiero SL, Dodson TB, Aghaloo T, et al. American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022 May;80(5):920–943.
   PubMed Web of Science ®Google Scholar
• Ziebart T, Halling F, Heymann P, et al. Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). Dent J (Basel). 2016 Oct 25;4(4):36. doi: 10.3390/dj4040036
   PubMedGoogle Scholar
• Yuan A, Munz A, Reinert S, et al. Gingival fibroblasts and medication-related osteonecrosis of the jaw: Results by real-time and wound healing in vitro assays. J Craniomaxillofac Surg. 2019 Sep;47(9):1464–1474.
   PubMed Web of Science ®Google Scholar
• Li M, Wang J, Yu Y, et al. Characterization of Mesenchymal Stem Cells Derived from Bisphosphonate-Related Osteonecrosis of the Jaw Patients’ Gingiva. Stem Cell Rev And Rep. 2022 Jan;18(1):378–394.
   PubMed Web of Science ®Google Scholar
• Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018 Jun;19(6):349–364. doi: 10.1038/s41580-018-0003-4
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011 Nov 11;147(4):728–741. doi: 10.1016/j.cell.2011.10.026
   PubMed Web of Science ®Google Scholar
• Akinduro O, Sully K, Patel A, et al. Constitutive Autophagy and Nucleophagy during Epidermal Differentiation. J Invest Dermatol. 2016 Jul;136(7):1460–1470.
   PubMed Web of Science ®Google Scholar
• Qiang L, Yang S, Cui YH, et al. Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing. Autophagy. 2020 Sep;18:1–16.
   Google Scholar
• Guo Y, Zhang X, Wu T, et al. Autophagy in Skin Diseases. Dermatology. 2019;235(5):380–389. doi: 10.1159/000500470
   PubMed Web of Science ®Google Scholar
• Xu X, Lai Y, Hua ZC. Apoptosis and apoptotic body: disease message and therapeutic target potentials. Biosci Rep. 2019 Jan 31;39(1). doi: 10.1042/BSR20180992
   Google Scholar
• Grilo AL, Mantalaris A. Apoptosis: A mammalian cell bioprocessing perspective. Biotechnol Adv. 2019 May - Jun;37(3):459–475. doi: 10.1016/j.biotechadv.2019.02.012
   PubMed Web of Science ®Google Scholar
• Manzano-Moreno FJ, Ramos-Torrecillas J, de Luna-Bertos E, et al. Influence of pH on osteoclasts treated with zoledronate and alendronate. Clin Oral Investig. 2019 Feb;23(2):813–820.
   PubMed Web of Science ®Google Scholar
• Yazici T, Kocer G, Naziroglu M, et al. Zoledronic Acid, Bevacizumab and Dexamethasone-Induced Apoptosis, Mitochondrial Oxidative Stress, and Calcium Signaling are Decreased in Human Osteoblast-Like Cell Line by Selenium Treatment. Biol Trace Elem Res. 2018 Aug;184(2):358–368.
   PubMed Web of Science ®Google Scholar
• Li M, Wang J, Yu Y, et al. Characterization of Mesenchymal Stem Cells Derived from Bisphosphonate-Related Osteonecrosis of the Jaw Patients' Gingiva. Stem Cell Rev Rep. 2021 Jan;18(1): 378–394 .
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
   PubMed Web of Science ®Google Scholar
• Peng H, Yang F, Hu Q, et al. The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. Autophagy. 2020 Apr;16(4):698–708.
   PubMed Web of Science ®Google Scholar
• Jin X, Wang K, Wang L, et al. RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging. Autophagy. 2022 Mar;18(3):643–660.
   PubMed Web of Science ®Google Scholar
• Kim T, Kim S, Song M, et al. Removal of Pre-Existing Periodontal Inflammatory Condition before Tooth Extraction Ameliorates Medication-Related Osteonecrosis of the Jaw-Like Lesion in Mice. Am J Pathol. 2018 Oct;188(10):2318–2327.
   PubMed Web of Science ®Google Scholar
• Kuchitsu Y, Fukuda M. Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies. Cells. 2018 Nov 19;7(11):215. doi: 10.3390/cells7110215
   PubMed Web of Science ®Google Scholar
• Cai CZ, Yang C, Zhuang XX, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2021 May;17(5):1112–1130.
   PubMed Web of Science ®Google Scholar
• Guerra F, Bucci C. Multiple Roles of the Small GTPase Rab7. Cells. 2016 Aug 18;5(3):34. doi: 10.3390/cells5030034
   PubMed Web of Science ®Google Scholar
• Miettinen Teemu P, Björklund M. Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. Cell Rep. 2015;13(11):2610–2620. doi: 10.1016/j.celrep.2015.11.045
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 2019 Jan 10;176(1–2):11–42. doi: 10.1016/j.cell.2018.09.048
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Petroni G, Amaravadi RK, et al. Autophagy in major human diseases. Embo J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863
   PubMed Web of Science ®Google Scholar
• Yang H, Wen Y, Zhang M, et al. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Autophagy. 2020 Feb;16(2):271–288.
   PubMed Web of Science ®Google Scholar
• Matsuzawa-Ishimoto Y, Hwang S, Cadwell K. Autophagy and Inflammation. Annu Rev Immunol. 2018 Apr 26;36(1):73–101. doi: 10.1146/annurev-immunol-042617-053253
   PubMedGoogle Scholar
• Kuo CJ, Hansen M, Troemel E. Autophagy and innate immunity: Insights from invertebrate model organisms. Autophagy. 2018;14(2):233–242. doi: 10.1080/15548627.2017.1389824
   PubMed Web of Science ®Google Scholar
• Gonzalez-Rodriguez A, Mayoral R, Agra N, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014 Apr 17;5:e1179. doi: 10.1038/cddis.2014.162
   PubMed Web of Science ®Google Scholar
• Zhao YG, Codogno P, Zhang H. Machinery, regulation and pathophysiological implications of autophagosome maturation. Nat Rev Mol Cell Biol. 2021 Nov;22(11):733–750. doi: 10.1038/s41580-021-00392-4
   PubMed Web of Science ®Google Scholar
• Sergin I, Evans TD, Zhang X, et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun. 2017 Jun 7;8(1):15750. doi: 10.1038/ncomms15750
   PubMedGoogle Scholar
• Wang Y, Tang M. PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells. Sci Total Environ. 2020 Mar 25;710:136397.
   PubMed Web of Science ®Google Scholar
• Yao L, Chen H, Wu Q, et al. Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. Int J Mol Med. 2019 Sep;44(3):1048–1062.
   PubMed Web of Science ®Google Scholar
• Chen HX, Liang FC, Gu P, et al. Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy. Cell Death Dis. 2020 Apr 27;11(4):288. doi: 10.1038/s41419-020-2473-5
   PubMed Web of Science ®Google Scholar
• Di YQ, Han XL, Kang XL, et al. Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. Autophagy. 2021 May;17(5):1170–1192.
   PubMed Web of Science ®Google Scholar
• Luo Z, Xu X, Sho T, et al. ROS-induced autophagy regulates porcine trophectoderm cell apoptosis, proliferation, and differentiation. Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C198–C209. doi: 10.1152/ajpcell.00256.2018
   PubMed Web of Science ®Google Scholar
• Yang L, Guan G, Lei L, et al. Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy. Cell Stress Chaperones. 2018 Nov;23(6):1283–1294.
   PubMed Web of Science ®Google Scholar
• Gump JM, Thorburn A. Autophagy and apoptosis: what is the connection? Trends Cell Biol. 2011 Jul;21(7):387–392. doi: 10.1016/j.tcb.2011.03.007
   PubMed Web of Science ®Google Scholar
• Fairlie WD, Tran S, Lee EF. Crosstalk between apoptosis and autophagy signaling pathways. Int Rev Cell Mol Biol. 2020;352:115–158.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang J, Cheng Z, et al. Adenovirus-Mediated LAMA3 Transduction Enhances Hemidesmosome Formation and Periodontal Reattachment during Wound Healing. Mol Ther Methods Clin Dev. Mol Ther Methods Clin Dev. 2020 Sep 11;18:291–303. doi: 10.1016/j.omtm.2020.06.001
   PubMed Web of Science ®Google Scholar
• Ferreira LE, Muniz BV, Dos Santos CP, et al. Comparison of liposomal and 2-hydroxypropyl-beta-cyclodextrin-lidocaine on cell viability and inflammatory response in human keratinocytes and gingival fibroblasts. J Pharm Pharmacol. 2016 Jun;68(6):791–802.
   PubMed Web of Science ®Google Scholar
• Williams DW, Kim RH. Epithelial cells release IL-36alpha in extracellular vesicles following mechanical damage. Biochem Biophys Res Commun. 2022 May 21;605:56–62.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang H, Wang Y, et al. Substrate-mediated gene transduction of LAMA3 for promoting biological sealing between titanium surface and gingival epithelium. Colloids Surf B Biointerfaces. 2018 Jan 1;161:314–323. doi: 10.1016/j.colsurfb.2017.10.030
   PubMed Web of Science ®Google Scholar
• Shaikh-Kader A, Houreld NN, Rajendran NK, et al. The link between advanced glycation end products and apoptosis in delayed wound healing. Cell Biochem Funct. 2019 Aug;37(6):432–442.
   PubMed Web of Science ®Google Scholar