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Autophagy Volume 20, 2024 - Issue 1

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Autophagic Punctum

The CTNS-MTORC1 axis couples lysosomal cystine to epithelial cell fate decisions and is a targetable pathway in cystinosis

Alessandro Luciania Institute of Physiology, University of Zurich, Zurich, SwitzerlandCorrespondence[email protected]

https://orcid.org/0000-0001-7219-3719 View further author information

Olivier Devuysta Institute of Physiology, University of Zurich, Zurich, Switzerland;b Institute for Rare Diseases, UCLouvain Medical School, Brussels, BelgiumView further author information

Pages 202-204 | Received 23 Jul 2023, Accepted 11 Aug 2023, Published online: 24 Aug 2023

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https://doi.org/10.1080/15548627.2023.2250165
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Berquez M, Chen Z, Festa BP, et al. Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization. Nat Commun. 2023;14(1):3994. doi: 10.1038/s41467-023-39261-3
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