1,659
Views
16
CrossRef citations to date
0
Altmetric
Short Communication

Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics

, , , &
Pages 519-522 | Received 29 Mar 2016, Accepted 01 Apr 2016, Published online: 27 Apr 2016

References

  • Mowry JB, Spyker DA, Brooks DE, et al. 2014 annual report of the American association of poison control centers' national poison data system (NPDS): 32nd annual report. Clin Toxicol (Phila). 2015;53:962–1147.
  • Gosselin S, Juurlink DN, Kielstein JT, et al. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2014;52:856–867.
  • Shah AD, Wood DM, Dargan PI. Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. Br J Clin Pharmacol. 2011;71:20–28.
  • Roth B, Woo O, Blanc P. Early metabolic acidosis and coma after acetaminophen ingestion. Ann Emerg Med. 1999;33:452–456.
  • Wiegand TJ, Margaretten M, Olson KR. Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venous hemodiafiltration. Clin Toxicol (Phila). 2010;48:156–159.
  • Hendrickson RG, Howland MA. N-Acetylcysteine. In: Hoffman RS, Howland MA, Lewin NA, et al., editors. Goldfrank's toxicologic emergencies. 10th ed. New York: McGraw-Hill Education; 2015. p. 465–472.
  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3–20.
  • Sivilotti ML, Juurlink DN, Garland JS, et al. Antidote removal during haemodialysis for massive acetaminophen overdose. Clin Toxicol (Phila). 2013;51:855–863.
  • Soldini D, Zwahlen H, Gabutti L, et al. Pharmacokinetics of N-acetylcysteine following repeated intravenous infusion in haemodialysed patients. Eur J Clin Pharmacol. 2005;60:859–864.
  • Hernandez SH, Howland M, Schiano TD, et al. The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies. Clin Toxicol (Phila). 2015;53:941–949.
  • Prescott LF, Donovan JW, Jarvie DR, et al. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol. 1989;37:501–506.
  • Smilkstein MJ, Bronstein AC, Linden C, et al. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991;20:1058–1063.
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319:1557–1562.
  • Hendrickson RG. Acetaminophen. In: Hoffman RS, Howland MA, Lewin NA, et al., editors. Goldfrank's toxicologic emergencies. 10th ed. New York: McGraw-Hill Education; 2015. p. 447–464.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.