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Clinical Toxicology Volume 54, 2016 - Issue 8
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Lack of significant bleeding despite large acute rivaroxaban overdose confirmed with whole blood concentrations

Daniel J. RepplingerDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA; Correspondence[email protected]
,
Robert S. HoffmanDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA;
,
Lewis S. NelsonDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA;
,
Elizabeth Q. HinesDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA;
,
MaryAnn HowlandDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA; ;Health Sciences, St. John’s University College of Pharmacy, Jamaica, NY, USA
&
Mark K. SuDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA; ;New York City Poison Control Center, New York, NY, USA;
Pages 647-649 | Received 14 Mar 2016, Accepted 03 May 2016, Published online: 02 Jun 2016

References

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  • Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124:1573–1579.
  • Siegal DM, Curnutte JT, Connolly SJ, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015;373:2413–2424.

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