Advanced search
Publication Cover
Clinical Toxicology Volume 54, 2016 - Issue 9
Submit an article Journal homepage
961
Views
7
CrossRef citations to date
0
Altmetric
Short Communication

Zero-order metoprolol pharmacokinetics after therapeutic doses: severe toxicity and cardiogenic shock

Geoffrey K. IsbisterClinical Toxicology Research Group, University of Newcastle, New South Wales, Australia; Correspondence[email protected]
,
Karyn AngDepartment of Intensive Care, John Fawkner Private Hospital, Victoria, Australia;
,
Kieron GormanDepartment of Intensive Care, John Fawkner Private Hospital, Victoria, Australia;
,
Joyce CooperClinical Toxicology Research Group, University of Newcastle, New South Wales, Australia;
,
Ahmed MostafaDepartment of Pharmaceutical Chemistry, Helwan University, Helwan, Egypt; ;Therapeutics Research Centre, School of Medicine, University of Queensland, Brisbane, Australia;
&
Michael S. RobertsTherapeutics Research Centre, School of Medicine, University of Queensland, Brisbane, Australia; ;School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
Pages 881-885 | Received 09 May 2016, Accepted 01 Jul 2016, Published online: 21 Jul 2016

References

  • Reith DM, Dawson AH, Whyte IM, et al. Relative toxicity of beta blockers in overdose. J Toxicol Clin Toxicol. 1996;34:273–278.
  • Love JN, Litovitz TL, Howell JM, et al. Characterization of fatal beta blocker ingestion: a review of the American Association of Poison Control Centers Data from 1985 to 1995. J Toxicol Clin Toxicol. 1997;35:353–359.
  • Love JN, Enlow B, Howell JM, et al. Electrocardiographic changes associated with beta-blocker toxicity. Ann Emerg Med. 2002;40:603–610.
  • Love JN, Howell JM, Litovitz TL, et al. Acute beta blocker overdose: factors associated with the development of cardiovascular morbidity. J Toxicol Clin Toxicol. 2000;38:275–281.
  • Graudins A, Lee HM, Druda D. Calcium channel and beta-blocker antagonist antidotes and adjunct therapies. Br J Clin Pharmacol. 2016;81:453–461.
  • Jordo L, Attman PO, Aurell M, et al. Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function. Clin Pharmacokinet. 1980;5:169–180.
  • Regardh CG, Jordo L, Ervik M, et al. Pharmacokinetics of metoprolol in patients with hepatic cirrhosis. Clin Pharmacokinet. 1981;6:375–388.
  • Bortolotti A, Castelli D, Verotta D, et al. Pharmacokinetic and pharmacodynamic modelling of metoprolol in rabbits with liver failure. Eur J Drug Metab Pharmacokinet. 1989;14:145–151.
  • Li P, Robertson TA, Zhang Q, et al. Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. Pharm Res. 2012;29:1658–1669.
  • Schulz M, Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie. 2003;58:447–474.
  • Page C, Hacket LP, Isbister GK. The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report. J Med Toxicol. 2009;5:139–143.
  • Blake CM, Kharasch ED, Schwab M, et al. A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther. 2013;94:394–399.
  • Wagner F, Jahnchen E, Trenk D, et al. Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. Klin Wochenschr. 1987;65:1164–1168.
  • Bangalore S, Messerli FH, Kostis JB, et al. Cardiovascular protection using beta-blockers: a critical review of the evidence. J Am Coll Cardiol. 2007;50:563–572.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.