Advanced search
Publication Cover
Clinical Toxicology Volume 55, 2017 - Issue 2
Submit an article Journal homepage
559
Views
13
CrossRef citations to date
0
Altmetric
Short Communication

Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations

Dushan JayaweeraDepartment of Clinical Pharmacology & Toxicology, Western Sydney Health, Sydney, Australia;
,
Shawkat IslamDepartment of Clinical Pharmacology & Toxicology, Western Sydney Health, Sydney, Australia;
,
Naren GunjaDepartment of Clinical Pharmacology & Toxicology, Western Sydney Health, Sydney, Australia;
,
Chris CowieShimadzu Australasia, Sydney, Australia;
,
James BroskaShimadzu Australasia, Sydney, Australia;
,
Latesh PoojaraIntensive Care Unit, Blacktown Hospital, Sydney, Australia;
,
Michael S. RobertsTherapeutics Research Centre, University of Queensland, Brisbane, Australia; ;School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia;
&
Geoffrey K. IsbisterClinical Toxicology Research Group, University of Newcastle, Newcastle, AustraliaCorrespondence[email protected]
 show all
Pages 147-150 | Received 13 Jul 2016, Accepted 13 Oct 2016, Published online: 28 Oct 2016

References

  • International Programme on Chemical Safety (IPCS). Chloroform. Poisons Information Monograph. PIM 121. Geneva: WHO; 1989–2002.
  • Lee J, Kim S, Lee J, et al. Rapid determination of volatile organic compounds in human whole blood using static headspace sampling with gas chromatography and mass spectrometry. Bull Korean Chem Soc. 2012;33:3963–3970.
  • Chloroform toxicological overview [Internet]. 2007 [cited 2015 Nov 5]. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/338535/Chloroform_Toxicological_Overview.pdf.
  • Sridhar N, Krishnakishore C, Sandeep Y, et al. Chloroform poisoning – a case report. Ren Fail. 2011;33:1037–1039.
  • Dell’Aglio DM, Sutter ME, Schwartz MD, et al. Acute chloroform ingestion successfully treated with intravenously administered N-acetylcysteine. J Med Toxicol. 2010;6:143–146.
  • Pandit AST, Bafna P. Drug-induced hepatotoxicity: a review. J Appl Pharm Sci. 2012;2:233–243.
  • Pohl LR, Bhooshan B, Whittaker NF, Krishna G. Phosgene: a metabolite of chloroform. Biochem Biophys Res Commun. 1977;79:684–691.
  • Fang C, Behr M, Xie F, et al. Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism. Toxicol Appl Pharmacol. 2008;227:48–55.
  • Kang YJ, Ahn J, Hwang YI. Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report. Ann Occup Environ Med. 2014;26:49.
  • Boyer ELS, Perrone J, de Roos F. Limited hepatotoxicity following a massive chloroform ingestion treated with oral N-acetyl-cysteine. J Toxicol Clin Toxicol. 1998;36:427–534.
  • Wang PY, Kaneko T, Tsukada H, et al. Time courses of hepatic injuries induced by chloroform and by carbon tetrachloride: comparison of biochemical and histopathological changes. Arch Toxicol. 1997;71:638–645.
  • Green TJ, Sivilotti ML, Langmann C, et al. When do the aminotransferases rise after acute acetaminophen overdose? Clin Toxicol. 2010;48:787–792.
  • Vlad IA, Armstrong J, Gault A. A painless burn: systemic toxicity after dermal exposure to chloroform. Emerg Med Australas. 2014;26:648–649.
  • Dick D, Ng KM, Sauder DN, Chu I. In vitro and in vivo percutaneous absorption of 14C-chloroform in humans. Hum Exp Toxicol. 1995;14:260–265.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.