Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity

Meghan B. SpyresDepartment of Emergency Medicine, Division of Medical Toxicology, University of Southern California, Los Angeles, CA, USA; Correspondence[email protected]

Ayrn D. O’ConnorDepartment of Medical Toxicology, Banner-University Medical Center Phoenix, Phoenix, AZ, USA;

Richard D. GerkinDepartment of Emergency Medicine, Division of Medical Toxicology, University of Southern California, Los Angeles, CA, USA; ;University of Arizona College of Medicine, Phoenix, AZ, USA

References

Yarema MC, Green JP, Sivilotti MLA, et al. Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Clin Toxicol. 2017;55:102–108.
PubMed Web of Science ®Google Scholar
Froberg BA, King KJ, Kurera TD, et al. Negative predictive value of acetaminophen concentrations within four hours of ingestion. Acad Emerg Med. 2013;20:1072–1075.
PubMed Web of Science ®Google Scholar
Spyres MB, O’Connor AD. Pitfalls of early acetaminophen concentrations in prediction of toxicity. J Med Toxicol. 2015;11:40.
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Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity

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