Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m² methotrexate is ingested?”

Betty S. ChanClinical Toxicology Unit & Emergency Department, Prince of Wales Hospital, Sydney, New South Wales, Australia; ;New South Wales Poisons Information Centre, Sydney, Australia; Correspondence[email protected]

Andrew H. DawsonNew South Wales Poisons Information Centre, Sydney, Australia; ;Drug Health, Royal Prince Alfred Hospital, Sydney, Australia;

Nicholas A. BuckleyNew South Wales Poisons Information Centre, Sydney, Australia; ;Clinical Pharmacology, University of Sydney, Sydney, Australia

References

Warren RD, Nichols AP, Bender RA. Membrane transport of methotrexate in human lymphoblastoid cells. Cancer Res. 1978;38:668–671.
PubMed Web of Science ®Google Scholar
Ogungbenro K, Aarons L, Cresim, et al. Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate. J Pharmacokinet Pharmacodyn. 2014;41:173–185.
PubMed Web of Science ®Google Scholar
Chan BS, Dawson AH, Buckley NA. What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning? Clin Toxicol (Phila). 2017;55:88–96.
PubMed Web of Science ®Google Scholar
Harvey VJ, Slevin ML, Woollard RC, et al. The bioavailability of oral intermediate-dose methotrexate. Effect of dose subdivision, formulation, and timing in the chemotherapy cycle. Cancer Chemother Pharmacol. 1984;13:91–94.
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m² methotrexate is ingested?”

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m2 methotrexate is ingested?”

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m² methotrexate is ingested?”