3,615
Views
50
CrossRef citations to date
0
Altmetric
Clinical Research

Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department: a case series

, , , , , & ORCID Icon show all
Pages 908-913 | Received 23 Dec 2016, Accepted 21 Apr 2017, Published online: 11 May 2017

References

  • Sorensen CJ, DeSanto K, Borgelt L, et al. Cannabinoid hyperemesis syndrome: diagnosis, pathophysiology, and treatment-a systematic review. J Med Toxicol. 2017;13:71–87.
  • Biary R, Oh A, Lapoint J, et al. Topical capsaicin cream used as a therapy for cannabinoid hyperemesis syndrome [abstract]. Clin Toxicol. 2014;5:787.
  • National Estimates of Marijuana Use and Related Indicators. National survey on drug use and health, United States, 2002–2014. Surv Sum. 2016;65:1–25.
  • Kim HS, Anderson JD, Saghafi O, et al. Cyclic vomiting presentations following marijuana liberalization in Colorado. Acad Emerg Med. 2015;22:694–699.
  • Simonetto DA, Oxentenko AS, Herman ML, et al. Cannabinoid hyperemesis: a case series of 98 patients. Mayo Clin Proc. 2012; 87:114–119.
  • Iacopetti CL, Packer CD. Cannabinoid hyperemesis syndrome: a case report and review of pathophysiology. Clinl Med Res. 2014;12:65–67.
  • Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008;20:10–14.
  • Iannotti FA, Hill CL, Leo A, et al. Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem Neurosci. 2014;5:1131–1141.
  • Rudd JA, Nalivaiko E, Matsuki N, et al. The involvement of TRPV1 in emesis and anti-emesis. Temperature (Austin). 2015;2:258–276.
  • Geraghty DP, Mazzone SB, Carter C, et al. Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat. Pharmacology. 2011; 87:214–223.
  • Joseph J, Wang S, Lee J, et al. Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization. J Bio Chem. 2013;288:35690–35702.
  • Darmani NA, Chebolu S, Zhong W, et al. Additive antiemetic efficacy of low-doses of the cannabinoid CB1/2 receptor agonist 9-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva). Eur J Pharmacol. 2014;722:147–155.
  • Andrew P, Okada F, Woods A, et al. The emetic and antiemetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew. Br J Pharmacol. 2011;130:1247–1254.
  • Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012;166:510–521.
  • Yang F, Xiao X, Cheng W, et al. (2015). Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nat Chem Biol. 2015;11:518–524.
  • Habboushe J, Sedor J. Cannabinoid hyperemesis acute renal failure: a common sequela of cannabinoid hyperemesis syndrome. Am J Emerg Med. 2014;32:690.e1–692.
  • Hickey JL, Witsil JC, Mycyk MB. Haloperidol for treatment of cannabinoid hyperemesis syndrome. Am J Emerg Med. 2013;31:1003.e5–1003.e6.
  • Jones JL, Abernathy KE. Successful treatment of suspected cannabinoid hyperemesis syndrome using haloperidol in the outpatient setting. Case Rep Psychiatry. 2016;2016:Article ID 3614053. doi: 10.1155/2016/3614053.
  • Witsil JC, Mycyk MB. Haloperidol, a novel treatment for cannabinoid hyperemesis syndrome. Am J Ther. 2017;24:e64–e67.
  • Inayat F, Virk HH, Ullah W, et al. Is haloperidol the wonder drug for cannabinoid hyperemesis syndrome? BMJ Case Rep. 2017. doi 10.1136/bcr-2016-218239.
  • Román F, Lloren P, Burillo-Putze G. Capsaicina tópica en el tratamiento del síndrome de hiperemesis por cannabinoides [Topical capsaicin in the treatment of the cannabis hyperemesis syndrome]. Medicina Clínica. 2016;147:517–518. Spanish.
  • Lapoint J. Capsaicin cream for treatment of cannabis hyperemesis syndrome [abstract]. J Med Toxicol. 2014;10:85.
  • Lapoint J. Case series of patients treated for cannabis hyperemesis syndrome with capsaicin cream [abstract]. Clin Toxicol. 2014;52:707.
  • Ellison N, Loprinzi CL, Kugler J, et al. “Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients”. J Clin Oncol. 1997;15:2974–2980.
  • Derry S, Rice AS, Cole P, et al. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;(1):CD007393. doi: 10.1002/14651858.CD007393.pub4

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.