3,827
Views
57
CrossRef citations to date
0
Altmetric
Clinical Research

Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2)

, , , , & ORCID Icon
Pages 1055-1065 | Received 14 Mar 2017, Accepted 19 May 2017, Published online: 23 Jun 2017

References

  • Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology (Baltimore, MD). 2005;42:1364–1372.
  • Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: an updated review. Arch Toxicol. 2015;89:193–199.
  • Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45:402–408.
  • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16:34–39.
  • Buckley NA, Whyte IM, O'Connell DL, et al. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol. 1999;37:759–767.
  • Chiew AL, Fountain JS, Graudins A, et al. Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 2015;203:215–218.
  • Rumack BH, Bateman DN. Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol. 2012;50:91–98.
  • Cairney DG, Beckwith HK, Al-Hourani K, et al. Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. Clin Toxicol. 2016;54:405–410.
  • Marks DJB, Dargan PI, Archer JRH, et al. Outcomes from massive paracetamol overdose: a retrospective observational study. Br J Clin Pharmacol. 2017;83:1263–1272.
  • Juma SA, Villeneuve E, Elliot A, Palmer RB, Gosselin S, editors. Doubling the third dose of intravenous N-acetylcysteine survey: an international practice perspective (abstract). XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015; St Julian’s, Malta: Clin Toxicol. 2015; 53:233–403.
  • Buckley NA, Whyte IM, O’Connell DL, et al. Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose. J Toxicol Clin Toxicol. 1999;37:753–757.
  • Duffull SB, Isbister GK. Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clin Toxicol. 2013;51:772–776.
  • Mowry JB, Spyker DA, Cantilena LR, et al. 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report. Clin Toxicol. 2014;52:1032–1283.
  • Graudins A. Paracetamol poisoning in adolescents in an Australian setting: not quite adults. Emerg Med Austral. 2015;27:139–144.
  • Buckley NA, Dawson AH, Isbister GK. Treatments for paracetamol poisoning. BMJ (Clin Res Ed). 2016;353:i2579.
  • Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. British Medical Journal. 1979;2:1097–1100.
  • Antoine DJ, Dear JW, Lewis PS, et al. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology (Baltimore, Md). 2013;58:777–787.
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976–1985). N Engl J Med. 1988;319:1557–1562.
  • Australian Bureau of Statistics: Height and weight 2012 [cited 2016 July]. Available from: http://www.abs.gov.au/ausstats/[email protected]/Lookup/by%20Subject/4338.0∼2011-13∼Main%20Features∼Height%20and%20weight∼21.
  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3–20.
  • Hendrickson RGMN, West PL, Burke CR. Bactrian (“Double Hump”) acetaminophen pharmacokinetics: a case series and review of the literature. J Med Toxicol. 2010;6:337–344.
  • Smith SW, Howland MA, Hoffman RS, et al. Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. Ann Pharmacother. 2008;42:1333–1339.
  • Schmidt LE. Age and paracetamol self-poisoning. Gut. 2005;54:686–690.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.