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Clinical Research

Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen

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Pages 182-188 | Received 25 May 2017, Accepted 07 Jul 2017, Published online: 31 Jul 2017

References

  • Mowry JB, Spyker DA, Brooks DE, et al. 2014 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 32nd annual report. Clin Toxicol. 2015;53:962–1147.
  • Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–954.
  • Wong A, Sivilotti ML, Dargan PI, et al. External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clin Toxicol. 2015;53:807–814.
  • Chomchai S, Chomchai C. Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter. Clin Toxicol. 2014;52:506–511.
  • Bailey GP, Najafi J, Elamin ME, et al. Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. Br J Clin Pharmacol. 2016;82:1358–1363.
  • Schmidt LE. Identification of patients at risk of anaphylactoid reactions to N-acetylcysteine in the treatment of paracetamol overdose. Clin Toxicol. 2013;51:467–472.
  • Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J. 1979;2:1097–1100.
  • Wong A, Graudins A. Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. Clini Toxicol. 2016;54:115–119.
  • MonashHealth. Welcome to Monash Health webpage. [cited 2017 Mat 27] 2016. Available from: http://www.monashhealth.org/page/About_Us1
  • WSLHD, Western Sydney Local Health District Strategic Plan. [2017 Mar 10] 2017. Available from: https://www.wslhd.health.nsw.gov.au/About-Us/Performance
  • Daly FF, Fountain JS, Murray L, et al. Guidelines for the management of paracetamol poisoning in Australia and New Zealand – explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Med J Australia. 2008;188:296–301.
  • Yarema MC, Johnson DW, Berlin RJ, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2009;54:606–614.
  • Sivilotti MLA, Green TJ, Langmann C, et al. Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose. Clin Toxicol. 2010;48:793–799.
  • Curtis RM, Sivilotti ML. A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose. Clin Toxicol. 2015;53:849–855.
  • Wong A, Sivilotti MLA, Graudins A. Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clin Toxicol. 2017;55:346–351.
  • Cairney DG, Beckwith HK, Al-Hourani K, et al. Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. Clin Toxicol. 2016;54:405–410.
  • Offerman S, Young M. Use of the initial acetaminophen concentration times serum aminotransferase product to predict significant liver enzyme elevations after acetaminophen overdose. Clin Toxicol. 2011;49(6):591; Conference: 2011 North American Congress of Clinical Toxicology Annual Meeting Washington, DC United States. Conference Start: 20110921 Conference End: 6. Conference Publication: (var.pagings).
  • Laskey D, Neavyn M. APAPxAT as a hepatotoxicity predictor in patients with acetaminophen ingestions of chronic, subacute, or unknown time. Clin Toxicol. 2015;53(7):677–678; Conference: 2015 Annual Meeting of the North American Congress of Clinical Toxicology, NACCT San Francisco, CA United States. Conference Start: 20151008 Conference End: 12. Conference Publication: (var.pagings).
  • Nacca NE, Hodgman M. APAP x AT in staggered, chronic and time unknown acetaminophen overdoses. Clin Toxicol. 2015;53(4):391; Conference: 35th International Congress of the European Association of Poisons Centres and Clinical Toxicologists, EAPCCT 2015 St Julian’s Malta. Conference Start: 20150526 Conference End: 9. Conference Publication: (var.pagings).
  • Green TJ, Sivilotti ML, Langmann C, et al. When do the aminotransferases rise after acute acetaminophen overdose? Clin Toxicol. 2010;48:787–792.
  • Al-Hourani K, Mansi R, Pettie J, et al. The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose. QJM. 2013;106:541–546.
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). Biochem Pharmacol. 1988;37:4763–4774.
  • Sivilotti ML, Yarema MC, Juurlink DN, et al. A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine. Ann Emerg Med. 2005;46:263–271.
  • MHRA. Benefit risk profile of acetylcysteine in the management of paracetamol overdose. [2017 Mar 31] 2012. Available from: http://www.mhra.gov.uk/home/groups/pl-p/documents/drugsafetymessage/con184709.pdf
  • Chiew A, Fountain JS, Graudins A, et al. Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 2015;203:215–218.
  • Graudins A. Overdose with modified-release paracetamol (Panadol osteo) presenting to a metropolitan emergency medicine network: a case series. Emerg Med Australas. 2014;26:398–402.
  • Salmonson H, Sjoberg G, Brogren J, et al. The standard treatment protocol is inadequate following overdose of extended release paracetamol: a pharmacokinetic and clinical analysis of 53 cases. Clin Toxicol. 2016;54:344–519; 36th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 24-27 May, 2016, Madrid, Spain.
  • Wong A, Graudins A. Risk prediction of hepatotoxicity in paracetamol poisoning. Clin Toxicol. 2017;55:879–892. DOI:10.1080/15563650.2017.1317349

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