Advanced search
Publication Cover
Clinical Toxicology Volume 56, 2018 - Issue 3
Submit an article Journal homepage
649
Views
9
CrossRef citations to date
0
Altmetric
Clinical Research

Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol

Anselm WongDepartment of Medicine, School of Clinical Sciences, Monash University, Victoria, Australia; ;Victorian Poisons Centre and Austin Toxicology Service, Heidelberg, Australia; Correspondence[email protected]
View further author information
,
Naren GunjaWestern Sydney Toxicology Service, Sydney, Australia; ;Discipline of Emergency Medicine, Sydney Medical School, Sydney, Australia; View further author information
,
Richard McNultyWestern Sydney Toxicology Service, Sydney, Australia; View further author information
&
Andis GraudinsDepartment of Medicine, Monash Toxicology Service, School of Clinical Sciences at Monash Health, Monash University, Victoria, AustraliaView further author information
Pages 199-203 | Received 14 Jun 2017, Accepted 20 Jul 2017, Published online: 16 Aug 2017

References

  • Senarathna SM, Sri Ranganathan S, Buckley N, et al. A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka. BMC Clin Pharmacol. 2012;12:6.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2014 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 32nd annual report. Clinical Toxicology. 2015;53:962–1147.
  • Sheen CL, Dillon JF, Bateman DN, et al. Paracetamol toxicity: epidemiology, prevention and costs to the health-care system. QJM. 2002;95:609–619.
  • Wong A, Graudins A, Kerr F, et al. Paracetamol toxicity: what would be the implications of a change in Australian treatment guidelines? Emerg Med Australas. 2014;26:183–187.
  • Daly FF, Fountain JS, Murray L, et al. Guidelines for the management of paracetamol poisoning in Australia and New Zealand–explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Med J Aust. 2008;188:296–301.
  • Daly FFS, O’Malley GF, Heard K, et al. Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. Ann Emerg Med. 2004;44:393–398.
  • Chiew A, Fountain JS, Graudins A, et al. Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 2015;203:215–218.
  • Wong A, Graudins A. Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. Clin Toxicol. 2016;54:115–119.
  • Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42:1252–1254.
  • Craig DGN, Bates CM, Davidson JS, et al. Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity. Br J Clin Pharmacol. 2011;71:273–282.
  • Wong A, Graudins A. Risk prediction of hepatotoxicity in paracetamol poisoning. Clin Toxicol. 2017. DOI:10.1080/15563650.2017.1317349
  • Alhelail MA, Hoppe JA, Rhyee SH, et al. Clinical course of repeated supratherapeutic ingestion of acetaminophen. Biol Pharm Bull. 2011;34:349–353.
  • MHRA. Benefit risk profile of acetylcysteine in the management of paracetamol overdose [Internet]. 2012 [cited 2017 Mar 31]. Available from: http://www.mhra.gov.uk/home/groups/pl-p/documents/drugsafetymessage/con184709.pdf
  • Wong A, Landersdorfer C, Graudins A. Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. Eur J Clin Pharmacol. 2017. DOI:10.1007/s00228-017-2277-4

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.