The interpretation of hair analysis for drugs and drug metabolites

References

• Forshufvud S, Smith H, Wassen A. Arsenic content of Napoleon I's hair probably taken immediately after his death. Nature 1961;192:103–105.
   PubMed Web of Science ®Google Scholar
• Lugli A, Clemenza M, Corso PE, et al. The medical mystery of Napoleon Bonaparte: an interdisciplinary exposé. Adv Anat Pathol. 2011;18:152–158.
   PubMed Web of Science ®Google Scholar
• Hindmarsh JT, Savory J. The death of Napoleon, cancer or arsenic? Clin Chem. 2008;54:2092–2093.
   Google Scholar
• Moeller MR, Fey P, Sachs H. Hair analysis as evidence in forensic cases. Forensic Sci Int. 1993;63:43–53.
   PubMed Web of Science ®Google Scholar
• Blank DL, Kidwell DA. External contamination of hair by cocaine: an issue in forensic interpretation. Forensic Sci Int. 1993;63:145–156.
   PubMed Web of Science ®Google Scholar
• Smith FP, Kidwell DA. Cocaine in hair, saliva, skin swabs, and urine of cocaine users' children. Forensic Sci Int. 1996;83:179–189.
   PubMed Web of Science ®Google Scholar
• Joya X, Papaseit E, Civit E, et al. Unsuspected exposure to cocaine in preschool children from a Mediterranean city detected by hair analysis. Ther Drug Monit. 2009;31:391–395.
   PubMed Web of Science ®Google Scholar
• LeBeau MA, Montgomery MA. Considerations on the utility of hair analysis for cocaine. J Anal Toxicol. 2009;33:343–344.
   PubMed Web of Science ®Google Scholar
• Blank DL, Kidwell DA. Decontamination procedures for drugs of abuse in hair: are they sufficient? Forensic Sci Int. 1995;70:13–38.
   PubMed Web of Science ®Google Scholar
• Cuypers E, Flinders B, Boone CM, et al. Consequences of decontamination procedures in forensic hair analysis using metal-assisted secondary ion mass spectrometry analysis. Anal Chem. 2016;88:3091–3097.
   PubMed Web of Science ®Google Scholar
• Franz F, Angerer V, Hermanns-Clausen M, et al. Metabolites of synthetic cannabinoids in hair-proof of consumption or false friends for interpretation? Anal Bioanal Chem. 2016;408:3445–3452.
   PubMed Web of Science ®Google Scholar
• Sasaki C, Saito T, Shinozuka T, et al. A case of death caused by abuse of a synthetic cannabinoid N-1-naphthalenyl-1-pentyl-1H-indole-3-carboxamide. Forensic Toxicol. 2015;33:165–169.
   Web of Science ®Google Scholar
• Saito T, Sasaki C, Namera A, et al. Experimental study on external contamination of hair by synthetic cannabinoids and effect of hair treatment. Forensic Toxicol. 2015;33:155–158.
   Web of Science ®Google Scholar
• Johnson P. Richmond London Borough Council v B, W, B and CB [2010] EWHC 2903 (Fam). [Internet]. Family Division. Moylan J 2011;1:1345–1359. Available from: http://fourteen.co.uk/wp-content/uploads/2014/03/HL-reported-case-Richmond-London-Borough-Council-v-B.pdf
   Google Scholar
• Dudley T, Bristol City Council v A and A and Others [2012] EWHC 2548 (FAM). [Internet]. Family Division. 2013; 2 FLR 1153. Baker J. Available from: http://www.familylawweek.co.uk/site.aspx?i=ed101124
   Google Scholar
• Gore S, Re Y. A Child: Private Law: Fact Finding. 2014; EWHC 486 (Fam). [Internet]. Judgment. Pauffley J. Available from: http://www.familylawweek.co.uk/site.aspx?i=ed127928
   Google Scholar
• Lang S, Report of the Motherisk Hair Analysis Independent Review. Ontario: Ministry of the Attorney General, [Internet]. 2015. Available from: http://m-hair.ca/
   Google Scholar
• Regal P, Nebot C, Vázquez BI, et al. Determination of the hormonal growth promoter 17alpha-methyltestosterone in food-producing animals: bovine hair analysis by HPLC-MS/MS. Meat Sci. 2010;84:196–201.
   PubMed Web of Science ®Google Scholar
• Tzatzarakis MN, Alegakis AK, Kavvalakis MP, et al. Comparative evaluation of drug deposition in hair samples collected from different anatomical body sites. J Anal Toxicol. 2017;41:214–223.
   PubMed Web of Science ®Google Scholar
• Pragst F. Pitfalls in hair analysis. Toxichem Krimtech. 2004;71:69–83.
   Google Scholar
• Musshoff F, Madea B. Analytical pitfalls in hair testing. Anal Bioanal Chem. 2007;388:1475–1494.
   PubMed Web of Science ®Google Scholar
• Chamberlain RT. Legal review for testing of drugs in hair. Forensic Sci Rev. 2007;19:85–94.
   PubMedGoogle Scholar
• Madry MM, Rust KY, Guglielmello R, et al. Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure. Forensic Sci Int. 2012;223:330–334.
   PubMed Web of Science ®Google Scholar
• Garcia-Bournissen F, Nesterenko M, Karaskov T, et al. Passive environmental exposure to cocaine in Canadian children. Paediatric Drugs. 2009;11:30–32.
   PubMedGoogle Scholar
• Stout PR. Hair testing for Drugs - Challenges for Interpretation. Forensic Sci Rev. 2007;19:69–84.
   PubMedGoogle Scholar
• White RM. Drugs in hair. Part I. Metabolisms of major drug classes. Forensic Sci Rev. 2017;29:23–55.
   PubMedGoogle Scholar
• Vaiano F, Serpelloni G, Furlanetto S, et al. Determination of endogenous concentration of γ-hydroxybutyric acid (GHB) in hair through an ad hoc GC-MS analysis: a study on a wide population and influence of gender and age. J Pharm Biomed Anal. 2016;118:161–166.
   PubMed Web of Science ®Google Scholar
• Busardò FP, Pichini S, Zaami S, et al. Hair testing of GHB: an everlasting issue in forensic toxicology. Clin Chem Lab Med. 2017. doi:10.1515/cclm-2017-0397.
   Web of Science ®Google Scholar
• Pragst F, Balikova MA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin Chim Acta. 2006;370:17–49.
   PubMed Web of Science ®Google Scholar
• Vogliardi S, Tucci M, Stocchero G, et al. Sample preparation methods for determination of drugs of abuse in hair samples: a review. Anal Chim Acta. 2015;857:1–27.
   PubMed Web of Science ®Google Scholar
• Cone EJ, Yousefnejad D, Darwin WD, et al. Testing human hair for drugs of abuse. II. Identification of unique cocaine metabolites in hair of drug abusers and evaluation of decontamination procedures. J Anal Toxicol. 1991;15:250–255.
   PubMed Web of Science ®Google Scholar
• Kintz P, Mangin P. Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromatography/mass spectrometry (GC/MS). Forensic Sci Int. 1995;73:93–100.
   PubMed Web of Science ®Google Scholar
• Martin M, Muller JF, Turner K, et al. Evidence of mephedrone chronic abuse through hair analysis using GC/MS. Forensic Sci Int. 2012;218:44–48.
   PubMed Web of Science ®Google Scholar
• do Nascimento Pantaleão L, Bismara Paranhos BA, Yonamine M. Hollow-fiber liquid-phase microextraction of amphetamine-type stimulants in human hair samples. J Chromatogr A. 2012;1254:1–7.
   PubMed Web of Science ®Google Scholar
• De Kesel PM, Lambert WE, Stove CP. An optimized and validated SPE-LC-MS/MS method for the determination of caffeine and paraxanthine in hair. Talanta. 2015;144:62–70.
   PubMed Web of Science ®Google Scholar
• Ramírez Fernández Mdel M, Wille SM, di Fazio V, et al. Detection of benzodiazepines and z-drugs in hair using an UHPLC-MS/MS validated method: application to workplace drug testing. Ther Drug Monit. 2015; 37:600–608.
   PubMed Web of Science ®Google Scholar
• Gouveia CA, Oliveira A, Pinho S, et al. Simultaneous quantification of morphine and cocaine in hair samples from drug addicts by GC-EI/MS. Biomed Chromatogr. 2012;26:1041–1047.
   PubMed Web of Science ®Google Scholar
• Kim JY, Cheong JC, Lee JI, et al. Improved gas chromatography-negative ion chemical ionization tandem mass spectrometric method for determination of 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid in hair using mechanical pulverization and bead-assisted liquid-liquid extraction. Forensic Sci Int. 2011;206:e99–e102.
   PubMed Web of Science ®Google Scholar
• Joseph RE, Höld KM, Wilkins DG, et al. Drug testing with alternative matrices II. Mechanisms of cocaine and codeine deposition in hair. J Anal Toxicol. 1999;23:396–408.
   PubMed Web of Science ®Google Scholar
• Stout PR, Ropero-Miller JD, Baylor MR, et al. External contamination of hair with cocaine: evaluation of external cocaine contamination and development of performance-testing materials. J Anal Toxicol. 2006;30:490–500.
   PubMed Web of Science ®Google Scholar
• Baumgartner WA, Hill VA. Sample preparation techniques. Forensic Sci Int. 1993;63:121–135.
   PubMed Web of Science ®Google Scholar
• Restolho J, Barroso M, Saramago B, et al. Development, optimization, and validation of a novel extraction procedure for the removal of opiates from human hair's surface. Drug Test Analysis. 2015;7:385–392.
   PubMed Web of Science ®Google Scholar
• Society of Hair Testing. Recommendations for hair testing in forensic cases. Forensic Sci Int. 2004;145:83–84.
   PubMed Web of Science ®Google Scholar
• Romano G, Barbera N, Lombardo I. Hair testing for drugs of abuse: evaluation of external cocaine contamination and risk of false positives. Forensic Sci Int. 2001;123:119–129.
   PubMed Web of Science ®Google Scholar
• Flinders B, Cuypers E, Zeijlemaker H, et al. Preparation of longitudinal sections of hair samples for the analysis of cocaine by MALDI-MS/MS and TOF-SIMS imaging. Drug Test Anal. 2015;7:859–865.
   PubMed Web of Science ®Google Scholar
• Tsanaclis L, Wicks JF. Differentiation between drug use and environmental contamination when testing for drugs in hair. Forensic Sci Int. 2008;176:19–22.
   PubMed Web of Science ®Google Scholar
• Tsanaclis L, Nutt J, Bagley K, et al. Differentiation between consumption and external contamination when testing for cocaine and cannabis in hair samples. Drug Test Anal 2014;6(Suppl 1):37–41.
   PubMed Web of Science ®Google Scholar
• Duvivier WF, Peeters RJ, van Beek TA, et al. Evidence based decontamination protocols for the removal of external Δ9-tetrahydrocannabinol (THC) from contaminated hair. Forensic Sci Int. 2016;259:110–118.
   PubMed Web of Science ®Google Scholar
• Kintz P, Analytical and practical aspects of drug testing in hair. Forensic science series. Boca Raton (FL): CRC/Taylor & Francis; 2007. p. 382.
   Google Scholar
• Miyaguchi H, Kakuta M, Iwata YT, et al. Development of a micropulverized extraction method for rapid toxicological analysis of methamphetamine in hair. J Chromatogr A. 2007;1163:43–48.
   PubMed Web of Science ®Google Scholar
• Broecker S, Herre S, Pragst F. General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Forensic Sci Int. 2012;218:68–81.
   PubMed Web of Science ®Google Scholar
• Wang X, Johansen SS, Nielsen MK, et al. Targeted analysis of 116 drugs in hair by UHPLC-MS/MS and its application to forensic cases. Drug Test Analysis. 2016;9:1137–1151.
   PubMed Web of Science ®Google Scholar
• Ramírez Fernández MD, Wille SM, Hill V, et al. Determination of antidepressants in hair via uhplc-ms/ms as a complementary informative tool for clinical and forensic toxicological assessments. Ther Drug Monit. 2016;38:751–760.
   PubMed Web of Science ®Google Scholar
• Cappelle D, De Doncker M, Gys C, et al. A straightforward, validated liquid chromatography coupled to tandem mass spectrometry method for the simultaneous detection of nine drugs of abuse and their metabolites in hair and nails. Anal Chim Acta. 2017;960:101–109.
   PubMed Web of Science ®Google Scholar
• Vogliardi S, Favretto D, Frison G, et al. A fast screening MALDI method for the detection of cocaine and its metabolites in hair. J Mass Spectrom. 2009;44:18–24.
   PubMed Web of Science ®Google Scholar
• Vogliardi S, Favretto D, Frison G, et al. Validation of a fast screening method for the detection of cocaine in hair by MALDI-MS. Anal Bioanal Chem. 2010;396:2435–2440.
   PubMed Web of Science ®Google Scholar
• Steuer AE, Poetzsch M, Kraemer T. MALDI-MS drug analysis in biological samples: opportunities and challenges. Bioanalysis 2016;8:1859–1878.
   PubMed Web of Science ®Google Scholar
• Shen M, Xiang P, Shi Y, et al. Mass imaging of ketamine in a single scalp hair by MALDI-FTMS. Anal Bioanal Chem. 2014;406:4611–4616.
   PubMed Web of Science ®Google Scholar
• Porta T, Grivet C, Kraemer T, et al. Single hair cocaine consumption monitoring by mass spectrometric imaging. Anal Chem. 2011;83:4266–4272.
   PubMed Web of Science ®Google Scholar
• Musshoff F, Arrey T, Strupat K. Determination of cocaine, cocaine metabolites and cannabinoids in single hairs by MALDI Fourier transform mass spectrometry–preliminary results. Drug Test Analysis. 2013;5:361–365.
   PubMed Web of Science ®Google Scholar
• Poetzsch M, Baumgartner MR, Steuer AE, et al. Segmental hair analysis for differentiation of tilidine intake from external contamination using LC-ESI-MS/MS and MALDI-MS/MS imaging. Drug Test Analysis. 2015;7:143–149.
   PubMed Web of Science ®Google Scholar
• Swales JG, Tucker JW, Strittmatter N, et al. Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis. Anal Chem. 2014;86:8473–8480.
   PubMed Web of Science ®Google Scholar
• Duvivier WF, van Beek TA, Pennings EJ, et al. Rapid analysis of Δ-9-tetrahydrocannabinol in hair using direct analysis in real time ambient ionization orbitrap mass spectrometry. Rapid Commun Mass Spectrom. 2014;28:682–690.
   PubMedGoogle Scholar
• Turfus SC, Beyer J, Gerostamoulos D, et al. A comparison of the performance of quality controls prepared from spiked, fortified and authentic hair for ethyl glucuronide analysis. Forensic Sci Int. 2013;232:60–66.
   PubMed Web of Science ®Google Scholar
• Kintz P, Mangin P. What constitutes a positive result in hair analysis: proposal for the establishment of cut-off values. Forensic Sci Int. 1995;70:3–11.
   PubMed Web of Science ®Google Scholar
• Cooper GA, Kronstrand R, Kintz P. Society of Hair Testing. Society of hair testing guidelines for drug testing in hair. Forensic Sci Int. 2012;218:20–24.
   PubMed Web of Science ®Google Scholar
• Recommendations for Hair Testing in Forensic Cases. Society of Hair Testing. [cited 2017 Aug 10]. Available from: http://www.soht.org/images/pdf/Consensus_on_Hair_Analysis.pdf
   Google Scholar
• Cirimele V, Kintz P, Mangin P. Drug concentrations in human hair after bleaching. J Anal Toxicol. 1995;19:331–332.
   PubMed Web of Science ®Google Scholar
• Ettlinger J, Yegles M. Influence of thermal hair straightening on cannabis and cocaine content in hair. Forensic Sci Int. 2016;265:13–16.
   PubMed Web of Science ®Google Scholar
• Yegles M, Marson Y, Wennig R. Influence of bleaching on stability of benzodiazepines in hair. Forensic Sci Int. 2000;107:87–92.
   PubMed Web of Science ®Google Scholar
• Kidwell DA, Smith FP, Shepherd AR. Ethnic hair care products may increase false positives in hair drug testing. Forensic Sci Int. 2015;257:160–164.
   PubMed Web of Science ®Google Scholar
• Potsch L, Skopp G. Stability of opiates in hair fibers after exposure to cosmetic treatment. Forensic Sci Int. 1996;81:95–102.
   PubMed Web of Science ®Google Scholar
• Skopp G, Potsch L, Moeller MR. On cosmetically treated hair-aspects and pitfalls of interpretation. Forensic Sci Int. 1997;84:43–52.
   PubMed Web of Science ®Google Scholar
• Hill V, Loni E, Cairns T, et al. Identification and analysis of damaged or porous hair. Drug Test Anal. 2014;6(Suppl 1):42–54.
   PubMed Web of Science ®Google Scholar
• Albermann ME, Musshoff F, Aengenheister L, et al. Investigations on the influence of different grinding procedures on measured ethyl glucuronide concentrations in hair determined with an optimized and validated LC–MS/MS method. Anal Bioanal Chem. 2012;403:769–776.
   PubMed Web of Science ®Google Scholar
• Xiang P, Shen M, Drummer OH. Review: Drug concentrations in hair and their relevance in drug facilitated crimes. J Forensic Leg Med. 2015;36:126–135.
   PubMed Web of Science ®Google Scholar
• Kintz P, Evans J, Villain M, et al. Hair analysis to demonstrate administration of sildenafil to a woman in a case of drug-facilitated sexual assault. J Anal Toxicol. 2009;33:553–556.
   PubMed Web of Science ®Google Scholar
• Saisho K, Scott KS, Morimoto S, et al. Hair analysis for pharmaceutical drugs. II. Effective extraction and determination of sildenafil (Viagra) and its N-desmethyl metabolite in rat and human hair by GC-MS. Biol Pharm Bull. 2001;24:1384–1388.
   PubMed Web of Science ®Google Scholar
• Dumestre-Toulet V, Cirimele V, Gromb S, et al. Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample. Forensic Sci Int. 2002;126:71–76.
   PubMed Web of Science ®Google Scholar
• Marchei E, Palmi I, Pichini S, et al. Segmental hair testing to disclose chronic exposure to psychoactive drugs. Adicciones. 2016;28:158–162.
   PubMed Web of Science ®Google Scholar
• Allibe N, Eysseric-Guerin H, Kintz P, et al. Amitriptyline poisoning of a baby: how informative can hair analysis be? Forensic Sci Int. 2015;249:53–58.
   PubMed Web of Science ®Google Scholar
• Boroda A, Gray W. Hair analysis for drugs in child abuse. J R Soc Med. 2005;98:318–319.
   PubMed Web of Science ®Google Scholar
• Kintz P. Interpretation of hair findings in children: about a case involving carbamazepine. Drug Test Anal. 2014;6(Suppl 1):2–4.
   PubMed Web of Science ®Google Scholar
• Kintz P, Evans J, Villain M, et al. Interpretation of hair findings in children after methadone poisoning. Forensic Sci Int. 2010;196:51–54.
   PubMed Web of Science ®Google Scholar
• Wang X, Drummer OH. Review: interpretation of drug presence in the hair of children. Forensic Sci Int. 2015;257:458–472.
   PubMed Web of Science ®Google Scholar
• Kintz P. Contribution of in utero drug exposure when interpreting hair results in young children. Forensic Sci Int. 2015;249:314–317.
   PubMed Web of Science ®Google Scholar
• Cairns T, Hill V, Schaffer M, et al. Levels of cocaine and its metabolites in washed hair of demonstrated cocaine users and workplace subjects. Forensic Sci Int. 2004;145:175–181.
   PubMed Web of Science ®Google Scholar
• Schaffer M, Hill V, Cairns T. Hair analysis for cocaine: the requirement for effective wash procedures and effects of drug concentration and hair porosity in contamination and decontamination. J Anal Toxicol. 2005;29:319–326.
   PubMed Web of Science ®Google Scholar
• Gambelunghe C, Rossi R, Aroni K, et al. Norcocaine and cocaethylene distribution patterns in hair samples from light, moderate, and heavy cocaine users. Drug Test Analysis. 2017;9:161–167.
   PubMed Web of Science ®Google Scholar
• Schaffer M, Cheng CC, Chao O, et al. Analysis of cocaine and metabolites in hair: validation and application of measurement of hydroxycocaine metabolites as evidence of cocaine ingestion. Anal Bioanal Chem. 2016;408:2043–2054.
   PubMed Web of Science ®Google Scholar
• Society of Hair Testing. 2016 Consensus for the Use of Alcohol Markers in Hair for Assessment of both Abstinence and Chronic Excessive Alcohol Consumption. [Internet]. 2017. Available from: http://www.soht.org/images/pdf/Revision%202016_Alcoholmarkers.pdf
   Google Scholar
• Pragst F, Alcohol biomarkers in hair. Chapter 4. In: Kintz P, Salomone A, Vincenti M, editors. Hair analysis in clinical and forensic toxicology. 1st ed. New York: Academic Press; 2015 pp. 71–139.
   Google Scholar
• Boscolo-Berto R, Viel G, Montisci M, et al. Ethyl glucuronide concentration in hair for detecting heavy drinking and/or abstinence: a meta-analysis. Int J Legal Med. 2013;127:611–619.
   PubMed Web of Science ®Google Scholar
• Hastedt M, Büchner M, Rothe M, et al. Detecting alcohol abuse: traditional blood alcohol markers compared to ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) measurement in hair. Forensic Sci Med Pathol. 2013;9:471–477.
   PubMed Web of Science ®Google Scholar
• Kronstrand R, Brinkhagen L, Nyström FH. Ethyl glucuronide in human hair after daily consumption of 16 or 32 g of ethanol for 3 months. Forensic Sci Int. 2012;215:51–55.
   PubMed Web of Science ®Google Scholar
• Kharbouche H, Faouzi M, Sanchez N, et al. Diagnostic performance of ethyl glucuronide in hair for the investigation of alcohol drinking behavior: a comparison with traditional biomarkers. Int J Legal Med. 2012;126:243–250.
   PubMed Web of Science ®Google Scholar
• Lees R, Kingston R, Williams TM, et al. Comparison of ethyl glucuronide in hair with self-reported alcohol consumption. Alcohol Alcohol. 2012;47:267–272.
   PubMed Web of Science ®Google Scholar
• Suesse S, Pragst F, Mieczkowski T, et al. Practical experiences in application of hair fatty acid ethyl esters and ethyl glucuronide for detection of chronic alcohol abuse in forensic cases. Forensic Sci Int. 2012;218:82–91.
   PubMed Web of Science ®Google Scholar
• Salomone A, Palamar JJ, Gerace E, et al. Hair testing for drugs of abuse and new psychoactive substances in a high-risk population. J Anal Toxicol. 2017;41:376–381.
   PubMed Web of Science ®Google Scholar