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Clinical Toxicology Volume 56, 2018 - Issue 8
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Basic Research

Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study

Michael EddlestonPharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ;Wellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6857-3441View further author information
ORCID Icon,
Nicolas FabresseLaboratoire de Pharmacologie – Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP et MassSpecLab, Plateforme de Spectrométrie de Masse, Inserm U-1173, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Garches, France; View further author information
,
Adrian ThompsonPharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ;Wellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK; View further author information
,
Ibrahim Al AbdullaMicropharm Ltd, Newcastle Emlyn, UK; View further author information
,
Rachael GregsonWellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK; View further author information
,
Tim KingWellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK; View further author information
,
Alain AstierSchool of Medicine Paris 12, Paris, France; View further author information
,
Frederic J. BaudUniversity Paris Diderot, Assistance Publique - Hopitaux de Paris, Paris, FranceView further author information
,
R Eddie CluttonWellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK; View further author information
&
Jean-Claude AlvarezLaboratoire de Pharmacologie – Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP et MassSpecLab, Plateforme de Spectrométrie de Masse, Inserm U-1173, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Garches, France; View further author information
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Pages 773-781 | Received 20 Nov 2017, Accepted 21 Dec 2017, Published online: 15 Jan 2018

References

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