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Clinical Toxicology Volume 56, 2018 - Issue 11
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Clinical Research

Iron overdose epidemiology, clinical features and iron concentration-effect relationships: the UK experience 2008–2017

D. Nicholas BatemanDepartment of Pharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Correspondence[email protected]
View further author information
,
Victoria EaglingNational Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; View further author information
,
Euan A. SandilandsNational Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; View further author information
,
Gill JacksonNational Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; View further author information
,
Catherine CrawfordNational Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; View further author information
,
Leonard HawkinsNational Poisons Information Service – Newcastle, Regional Drugs & Therapeutics Centre and Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK; View further author information
,
Ted CheungNational Poisons Information Service – Birmingham, City Hospital, Birmingham, UK; View further author information
,
Gillian CooperNational Poisons Information Service – Cardiff, University Hospital Llandough, Cardiff, UKView further author information
,
Sally M. BradberryNational Poisons Information Service – Birmingham, City Hospital, Birmingham, UK; View further author information
,
John P. ThompsonNational Poisons Information Service – Cardiff, University Hospital Llandough, Cardiff, UKView further author information
,
Simon H. L. ThomasNational Poisons Information Service – Newcastle, Regional Drugs & Therapeutics Centre and Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK; View further author information
&
Michael EddlestonDepartment of Pharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ;National Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; ORCID Iconhttp://orcid.org/0000-0002-6857-3441View further author information
ORCID Icon show all
Pages 1098-1106 | Received 23 Nov 2017, Accepted 15 Mar 2018, Published online: 28 Mar 2018

References

  • Banner W Jr, Tong TG. Iron poisoning. Pediatr Clin North Am. 1986;33:393–409.
  • Robertson A, Tenenbein M. Hepatotoxicity in acute iron poisoning. Hum Exp Toxicol. 2005; 24:559–562.
  • Kroeker S, Minuk GY. Intentional iron overdose: an institutional review. CMAJ. 1994;150:45–48.
  • Tenenbein M. Unit-dose packaging of iron supplements and reduction of iron poisoning in young children. Arch Pediatr Adolesc Med. 2005;159:557–560.
  • Pavord S, Myers B, Robinson S, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2012;156:588–600.
  • Gummin DD, Mowry JB, Spyker DA, et al. 2016 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th annual report. Clin Toxicol. 2017;55:1072–1254.
  • TOXBASE. Iron poisoning. UK: NPIS; 2017.
  • Proudfoot AT, Simpson D, Dyson EH. Management of acute iron poisoning. Med Toxicol. 1986;1:83–100.
  • Chang TP, Rangan C. Iron poisoning: a literature-based review of epidemiology, diagnosis, and management. Pediatr Emerg Care. 2011;27:978–985.
  • Tenenbein M. Benefits of parenteral deferoxamine for acute iron poisoning. J Toxicol Clin Toxicol. 1996;34:485–489.
  • Howland MA. Risks of parenteral deferoxamine for acute iron poisoning. J Toxicol Clin Toxicol. 1996;34:491–497.
  • Chifman J, Laubenbacher R, Torti SV. A systems biology approach to iron metabolism. Adv Exp Med Biol. 2014;844:201–225.
  • Geisser P, Burckhardt S. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 2011;3:12–33.
  • Gulec S, Anderson GJ, Collins JF. Mechanistic and regulatory aspects of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol. 2014;307:G397–G409.
  • Tenenbein M. Toxicokinetics and toxicodynamics of iron poisoning. Toxicol Lett. 1998;102–103:653–656.
  • Chyka PA, Butler AY, Holley JE. Serum iron concentrations and symptoms of acute iron poisoning in children. Pharmacotherapy. 1996;16:1053–1058.
  • Chyka PA, Butler AY. Assessment of acute iron poisoning by laboratory and clinical observations. Am J Emerg Med. 1993;11:99–103.
  • Eagling VA, Sandilands EA, Hawkins LC, et al. Utilisation of desferrioxamine in iron poisoning: experience of the UK National Poisons Information Service (NPIS) 2014–2016. Clin Toxicol. 2017;55:427.

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