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Clinical Research

Trends in intentional abuse or misuse of benzodiazepines and opioid analgesics and the associated mortality reported to poison centers across the United States from 2000 to 2014

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Pages 1107-1114 | Received 26 Nov 2017, Accepted 14 Mar 2018, Published online: 03 Apr 2018

References

  • Prevention CfDCa. CDC grand rounds: prescription drug overdoses - a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61:10–13.
  • Prevention CfDCa Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008. MMWR Morb Mortal Wkly Rep. 2011;60:1487.
  • Calcaterra S, Glanz J, Binswanger IA. National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths: 1999-2009. Drug Alcohol Depend. 2013;131:263–270.
  • Jones CM, Paulozzi LJ, Mack KA. Alcohol involvement in opioid pain reliever and benzodiazepine drug abuse-related emergency department visits and drug-related deaths - United States, 2010. MMWR Morb Mortal Wkly Rep. 2014;63:881–885.
  • American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63:2227–2246.
  • Bakken MS, Engeland A, Engesaeter LB, et al. Risk of hip fracture among older people using anxiolytic and hypnotic drugs: a nationwide prospective cohort study. Eur J Clin Pharmacol. 2014;70:873–880.
  • Billioti de Gage S, Moride Y, Ducruet T, et al. Benzodiazepine use and risk of Alzheimer's disease: case-control study. BMJ. 2014;349:g5205.
  • Zhang Y, Zhou XH, Meranus DH, et al. Benzodiazepine use and cognitive decline in elderly with normal cognition. Alzheimer Dis Assoc Disord. 2016;30:113–117.
  • Bronstein AC, Spyker DA, Cantilena Jr LR, et al. 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol 2012;50:911–1164.
  • Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ. 2000;162:225–233.
  • Wood AJ, Shader RI, Greenblatt DJ. Use of benzodiazepines in anxiety disorders. N Engl J Med. 1993;328:1398–1405.
  • Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol. 2015;14:615–624.
  • Amato L, Minozzi S, Davoli M. Efficacy and safety of pharmacological interventions for the treatment of the alcohol withdrawal syndrome. The Cochrane Library 2011; CD008537.
  • Hwang CS, Kang EM, Kornegay CJ, et al. Trends in the concomitant prescribing of opioids and benzodiazepines, 2002-2014. Am J Prev Med. 2016;51:151–160.
  • Bachhuber MA, Hennessy S, Cunningham CO, et al. Increasing benzodiazepine prescriptions and overdose mortality in the United States, 1996-2013. Am J Public Health. 2016;106:686–688.
  • Dasgupta N, Funk MJ, Proescholdbell S, et al. Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Med. 2016;17:85–98.
  • Weisberg DF, Gordon KS, Barry DT, et al. Long-term prescription of opioids and/or benzodiazepines and mortality among HIV-infected and uninfected patients. J Acquir Immune Defic Syndr. 2015;69:223–233.
  • Jann M, Kennedy WK, Lopez G. Benzodiazepines: a major component in unintentional prescription drug overdoses with opioid analgesics. J Pharm Pract. 2014;27:5–16.
  • Dunn KM, Saunders KW, Rutter CM, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152:85–92.
  • Park TW, Saitz R, Ganoczy D, et al. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ. 2015;350:h2698.
  • Jones CM, McAninch JK. Emergency department visits and overdose deaths from combined use of opioids and benzodiazepines. Am J Prev Med. 2015;49:493–501.
  • Kapil V, Green JL, Le Lait C, et al. Misuse of benzodiazepines and Z-drugs in the UK. Br J Psychiatry. 2014;205:407–408.
  • Jones JD, Mogali S, Comer SD. Polydrug abuse: a review of opioid and benzodiazepine combination use. Drug Alcohol Depend. 2012;125:8–18.
  • Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. (SMA) 14-4863. Rockville (MD): Substance Abuse and Mental Health Services Administration;2014.
  • Wise RA, Bozarth MA. Brain mechanisms of drug reward and euphoria. Psychiatr Med. 1985;3:445–460.
  • Kan CC, Hilberink SR, Breteler MH. Determination of the main risk factors for benzodiazepine dependence using a multivariate and multidimensional approach. Compr Psychiatry. 2004;45:88–94.
  • Fenton MC, Keyes KM, Martins SS, et al. The role of a prescription in anxiety medication use, abuse, and dependence. Am J Psychiatry. 2010;167:1247–1253.
  • Jones CM, Mack KA, Paulozzi LJ. Pharmaceutical overdose deaths, United States, 2010. JAMA. 2013;309:657–659.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2014 annual report of the American association of poison control centers' National Poison Data System (NPDS): 32nd annual report. Clin Toxicol . 2015;53:962–1147.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2015 annual report of the American association of poison control centers' National Poison Data System (NPDS): 33rd annual report. Clin Toxicol. 2016;54:924–1109.
  • National Poison Data System (NPDS). NPDS Coding Users’ Manual© Version 3.1. Approved by the AAPCC Board of Directors May 7, 2014 © 2014 American Association of Poison Control Centers NPDS Coding Users’ Manual.
  • Rosner B. Fundamentals of biostatistics. 7th edi. Boston: Brooks/Cole, Cengage Learning; 2011.
  • White JM, Irvine RJ. Mechanisms of fatal opioid overdose. Addiction. 1999;94:961–972.
  • Volkow ND, Swanson JM. Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry. 2003;160:1909–1918.
  • Compton WM, Volkow ND. Abuse of prescription drugs and the risk of addiction. Drug Alcohol Depend. 2006;83(Suppl 1):S4–S7.
  • Darke S, Ross J, Mills K, et al. Benzodiazepine use among heroin users: baseline use, current use and clinical outcome. Drug Alcohol Rev. 2010;29:250–255.
  • Ross J, Darke S. The nature of benzodiazepine dependence among heroin users in Sydney, Australia. Addiction. 2000;95:1785–1793.
  • Rooney S, Kelly G, Bamford L, et al. Co-abuse of opiates and benzodiazepines. Ir J Med Sci. 1999;168:36–41.
  • Coffin PO, Galea S, Ahern J, et al. Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98. Addiction. 2003;98:739–747.
  • Kerr T, Marsh D, Li K, et al. Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver. Drug Alcohol Depend. 2005;80:329–335.
  • Substance Abuse and Mental Health Services Administration. Results from the 2009 National Survey on Drug Use and Health. Vol. I, Summary of national findings (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4586Findings). Rockville (MD): Substance Abuse and Mental Health Services Administration; 2010.
  • Warner M, Chen LH, Makuc DM, et al. Drug poisoning deaths in the United States, 1980–2008. NCHS Data Brief. 2011;p. 1–8.
  • Manchikanti L, Helm S, 2nd, Fellows B, et al. Opioid epidemic in the United States. Pain Physician. 2012;15:ES9–E38.
  • Haffajee RL, Jena AB, Weiner SG. Mandatory use of prescription drug monitoring programs. JAMA. 2015;313:891–892.
  • Severtson SG, Ellis MS, Kurtz SP, et al. Sustained reduction of diversion and abuse after introduction of an abuse deterrent formulation of extended release oxycodone. Drug Alcohol Depend. 2016;168:219–229.
  • Behar E, Rowe C, Santos GM, et al. Acceptability of naloxone co-prescription among primary care providers treating patients on long-term opioid therapy for pain. J Gen Intern Med. 2017;32:291–295.
  • Doe-Simkins M, Walley AY, Epstein A, et al. Saved by the nose: bystander-administered intranasal naloxone hydrochloride for opioid overdose. Am J Public Health. 2009;99:788–791.
  • Dart RC, Surratt HL, Cicero TJ, et al. Trends in opioid analgesic abuse and mortality in the United States. N Engl J Med. 2015;372:241–248.
  • Paulozzi LJ, Mack KA, Hockenberry JM. Vital signs: variation among States in prescribing of opioid pain relievers and benzodiazepines - United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;63:563–568.
  • Griffin CE, Kaye AM, Bueno FR, et al. Benzodiazepine pharmacology and central nervous system–mediated effects. Ochsner J. 2013;13:214–223.
  • Gaudreault P, Guay J, Thivierge RL, et al. Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment. Drug Saf.1991;6:247–265.
  • Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008. MMWR Morb Mortal Wkly Rep. 2011;60:1487–1492.

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