985
Views
11
CrossRef citations to date
0
Altmetric
Clinical Research

Lipid emulsion for acute organophosphate insecticide poisoning – a pilot observational safety study

, , , , &
Pages 318-324 | Received 23 Mar 2018, Accepted 30 Aug 2018, Published online: 11 Oct 2018

References

  • Dawson AH, Eddleston M, Senarathna L, et al. Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Med. 2010;7:e1000357.
  • Gunnell D, Eddleston M. Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int J Epidemiol. 2003;32:902–909.
  • Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM: Int J Med. 2000;93:715–731.
  • Buckley NA, Eddleston M, Li Y, et al. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst Rev. 2011;2:CD005085.
  • Basarslan SK, Alp H, Senol S, et al. Is intralipid fat emulsion a promising therapeutic strategy on neurotoxicity induced by malathion in rats? Eur Rev Med Pharmacol Sci. 2014;18:471–476.
  • Cao D, Heard K, Foran M, et al. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015;48:387–397.
  • Kostic MA, Gorelick M. Review of the use of lipid emulsion in nonlocal anesthetic poisoning. Pediatr Emergency Care. 2014;30:427–433.
  • Foxall G, McCahon R, Lamb J, et al. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007;62:516–518.
  • Ciechanowicz S, Patil V. Lipid emulsion for local anesthetic systemic toxicity. Anesthesiol Res Pract. 2012;2012:1.
  • Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emergency Med Australasia: EMA. 2011;23:123–141.
  • Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51:412–415.
  • Dunn C, Bird SB, Gaspari R. Intralipid fat emulsion decreases respiratory failure in a rat model of parathion exposure. Acad Emergency Med: Official J Soc Acad Emergency Med. 2012;19:504–509.
  • Mir SA, Rasool R. Reversal of cardiovascular toxicity in severe organophosphate poisoning with 20% intralipid emulsion therapy: case report and review of literature. Asia Pacific J Med Toxicol. 2014;3:169–172.
  • Buckley NA, Dawson AH. The intralipid genie is out of the bottle-spin and wishful thinking. Anaesth Intensive Care. 2013;41:154–156.
  • Bucklin MH, Gorodetsky RM, Wiegand TJ. Prolonged lipemia and pancreatitis due to extended infusion of lipid emulsion in bupropion overdose. Clin Toxicol (Phila). 2013;51:896–898.
  • Cole JB, Stellpflug SJ, Engebretsen KM. Asystole immediately following intravenous fat emulsion for overdose. J Med Toxicol. 2014;10:307–310.
  • Levine M, Brooks DE, Franken A, et al. Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy. Pediatrics. 2012;130:e432–e438.
  • West PL, McKeown NJ, Hendrickson RG. Iatrogenic lipid emulsion overdose in a case of amlodipine poisoning. Clin Toxicol (Phila). 2010;48:393–396.
  • Senanayake N, de Silva HJ, Karalliedde L. A scale to assess severity in organophosphorus intoxication: POP scale. Hum Exp Toxicol. 1993;12:297–299.
  • Eddleston M, Buckley NA, Eyer P, et al. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597–607.
  • Eisenkraft A, Falk A. The possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoning. Toxicol Rep. 2016;3:202–210.
  • Hallberg D, Holm I, Obel AL, et al. Fat emulsions for complete intravenous nutrition. Postgrad Med J. 1967;43:307–316.
  • Sehgal LR, Sehgal HL, Rosen AL, et al. Effect of Intralipid on measurements of total hemoglobin and oxyhemoglobin in whole blood. Crit Care Med. 1984;12:907–909.
  • Cane RD, Harrison RA, Shapiro BA, et al. The spectrophotometric absorbance of intralipid®. Anesthesiology. 1980;53:53–55.
  • Lee WC, Yang CC, Deng JF, et al. The clinical significance of hyperamylasemia in organophosphate poisoning. J Toxicol Clin Toxicol. 1998;36:673–681.
  • Rothschild L, Bern S, Oswald S, et al. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med. 2010;18:51.
  • Weinberg GL. Lipid infusion therapy: translation to clinical practice. Anesth Analg. 2008;106:1340–1342.
  • Weinberg GL. Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology. 2012;117:180–187.
  • Zilker T. Acute intoxication in adults—what you should know. Dtsch Med Wochenschr. 2014;139:31–46.
  • Stellpflug SJ, Harris CR, Engebretsen KM, et al. Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin. Clin Toxicol (Phila). 2010;48:227–229.
  • Dean P, Ruddy JP, Marshall S. Intravenous lipid emulsion in propranolol [corrected] overdose. Anaesthesia. 2010;65:1148–1150.
  • Tebbutt S, Harvey M, Nicholson T, et al. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med. 2006;13:134–139.
  • Finn SD, Uncles DR, Willers J, et al. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anaesthesia. 2009;64:191–194.
  • Weinberg G, Di Gregorio G, Hiller D, et al. Reversal of haloperidol-induced cardiac arrest by using lipid emulsion. Ann Intern Med. 2009;150:737–738.
  • Yoav G, Odelia G, Shaltiel C, et al. A lipid emulsion reduces mortality from clomipramine overdose in rats. Vet Hum Toxicol. 2002;44:30.
  • Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med. 2007;49:178–185.
  • Kaplan A, Whelan M. The use of IV lipid emulsion for lipophilic drug toxicities. J Am Anim Hosp Assoc. 2012;48:221–227.
  • Taftachi F, Sanaei-Zadeh H, Sepehrian B, et al. Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning–a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2012;16:38–42.
  • Levine M, Hoffman RS, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clin Toxicol (Phila). 2016;54:194–221.
  • Kasnavieh FH, Kasnavier MH, Noddoushan SJ. Intravenous lipid emulsion for the treatment of tricyclic antidepressant toxicity a randomized controlled trial. VIIth Mediterranean Emergency Medicine Congress; 2013 Sep; Marseille, France.
  • Turner-Lawrence DE, Kerns Ii W. Intravenous fat emulsion: a potential novel antidote. J Med Toxicol. 2008;4:109–114.
  • Moshiri M, Vahabzadeh M, Etemad L, et al. Failure of Intravenous lipid emulsion to reduce diazinon-induced acute toxicity: a pilot study in rats. Iran J Pharma Res: IJPR 2013;12:897–902.
  • Kayipmaz AE, Gulalp B, Benli S, et al. The effects of a combined treatment of lipid emulsion and conventional therapy on tissues of rats poisoned with methyl parathion. HealthMED. 2014;8:433–441.
  • Celikel E, Arslan E, Yilmaz F, et al. Evaluation of the effect of lipid emulsion therapy on the rat model in organophosphate intoxication and tissue pathologies. Acta Medica Mediterranea. 2014;30:1279.
  • Weinberg GL, Ripper R, Murphy P, et al. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med. 2006;31:296–303.
  • Weinberg G, Lin B, Zheng S, et al. Partitioning effect in lipid resuscitation: further evidence for the lipid sink. Crit Care Med. 2010;38:2268–2269.
  • French D, Smollin C, Ruan W, et al. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol. 2011;49:801–809.
  • Fettiplace MR, Weinberg G. Past, present, and future of lipid resuscitation therapy. JPEN J Parenter Enteral Nutr. 2015;39:72S–83S.
  • Yamashita M, Yamashita M, Tanaka J, et al. Human mortality in organophosphate poisonings. Vet Hum Toxicol. 1997;39:84–85.
  • Munidasa UA, Gawarammana IB, Kularatne SA, et al. Survival pattern in patients with acute organophosphate poisoning receiving intensive care. J Toxicol Clin Toxicol. 2004;42:343–347.
  • Kang E-J, Seok S-J, Lee K-H, et al. Factors for determining survival in acute organophosphate poisoning. Korean J Intern Med. 2009;24:362–367.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.