Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism?

Philippe HantsonDepartment of Intensive Care, Clinique St-Luc, Bouge, Belgium; Correspondence[email protected]

Claire WuidartLaboratory of Toxicology, Cliniques Universitaires St-Luc, Brussels, Belgium; Louvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain, Brussels, Belgium;

Vincent HaufroidDepartment of Intensive Care, Cliniques Universitaires St-Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium; Louvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain, Brussels, Belgium

References

Corkeron MA, van Heerden PV, Newman SM, et al. Extracorporeal circulatory support in near-fatal flecainide overdose. Anaesth Intensive Care. 1999;27:405–408.
PubMed Web of Science ®Google Scholar
Auzinger GM, Scheinkestel CD. Successful extracorporeal life support in a case of severe flecainide intoxication. Crit Care Med. 2001;29:887–890.
PubMed Web of Science ®Google Scholar
Mandawat A, McCullough SA, Gilstrap LG, et al. Successful treatment of flecainide overdose with sustained mechanical circulatory support. Heart Rhythm Case Rep. 2015;1:137–140.
PubMedGoogle Scholar
Boriani G, Strocchi E, Capucci R, et al. Flecainide: evidence of non-linear kinetics. Eur J Clin Pharmacol. 1991;41:57–59.
PubMed Web of Science ®Google Scholar
Doki K, Homma M, Kuga K, et al. Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia. Eur J Clin Pharmacol. 2006;62:919–926.
PubMed Web of Science ®Google Scholar
Swen JJ, Nijenhuis M, de Boer A, et al. Pharmacogenetics: from bench to byte--an update of guidelines. Clin Pharmacol Ther. 2011;89:662-673. Available from: https://www.pharmgkb.org/guidelineAnnotation/PA166104969 (Accessed October 2, 2018).
Google Scholar

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Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism?

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Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism?

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